Isisindo esikhulu somzimba sikashukela umthwalo owandayo womzimba, onomthelela ekwakhekeni kwezinye izifo: ukushaya kwenhliziyo, i-dyspnea, i-osteoarthritis. IFommetin ilwa nalolu daba ngaphandle kokubanga izinkinga.
Igama Lezwe elingafanele
INN - Metformin hydrochloride.
IFomine yi-ejenti ye-hypoglycemic esetshenziswa kushukela.
I-ATX
Ikhodi ye-ATX yi-A10BA02.
Khipha amafomu nokwakheka
Kukhona uhlobo lwethebhulethi lomuthi. Ephaketheni lekhadibhodi kungaba ngamaphilisi angama-30, 60 noma ayi-100. Ngendlela yokumiswa kanye nezinye izinhlobo ze-pharmacological, umuthi awukhiqizwa.
Into esebenzayo yi-metformin hydrochloride ngenani le-500, 850 noma i-1000 mg. Izici ezingeziwe zomuthi yilezi:
- i-croscarmellose sodium;
- i-magnesium stearate;
- polyvinylpyrrolidone.
Kukhona uhlobo lwethebhulethi lomuthi. Ephaketheni lekhadibhodi kungaba ngamaphilisi angama-30, 60 noma ayi-100. Ngendlela yokumiswa kanye nezinye izinhlobo ze-pharmacological, umuthi awukhiqizwa.
Isenzo se-Pharmacological
Kungumenzeli we-hypoglycemic owenzelwe ukufeza izinhloso ezilandelayo:
- ukuthuthukisa ukusetshenziswa kwe-glucose;
- ukunciphisa ijubane inqubo yokwakheka koshukela okwenzeka esibindini;
- ukukhulisa ukuzwela kwezicubu emiphumeleni ye-insulin (ngenxa yalokho, indlela evamile kashukela wegazi kufinyelelwa);
- ukulungiswa kwesisindo;
- ukwehla kwezinga le-lipoprotein ephansi ne-triglycerides;
- yehlisa ukufakwa kweglucose etholakala emathunjini.
Ngaphezu kwalokho, umuthi awuthinti ukucasulwa kwe-insulin emanyikweni futhi akuholeli ekuqhamukeni kwe-hypoglycemic.
I-Pharmacokinetics
Izici ze-formmetin:
- ukumbiwa kumchamo;
- buthelela ezinso, isibindi, izicubu zomsipha kanye nezindlala zamathe;
- ayihlanganisi kumaprotheni egazi;
- bioavailability cishe 50-60%.
Okusizayo
Umuthi lo usetshenziselwa uhlobo 2 lwe-mellitus yesifo sikashukela, ukuthuthukiswa kwalo okuhambisana nokukhuluphala ngokweqile kwesizinda sokungasebenzi kahle kokudla kokudla.
Umuthi usetshenziselwa isifo sikashukela sohlobo 2, ukuthuthukiswa kwako okuhambisana nokukhuluphala.
Contraindication
Ngokwemiyalo esetshenziswayo, kufanele ugweme ukuthatha i-formin uma une-contraindication elandelayo:
- ukungasebenzi kahle kwesibindi nezinso;
- isikhathi ngemuva kokulimala okuyingozi nokusebenza okuyinkimbinkimbi;
- ubuthi obunobungozi obukhulu;
- izimo ezinegalelo ekwandeni kwe-lactic acid egazini (i-lactic acidosis): ukomisa, ukwehluleka ukuphefumula, izinkinga zokujikeleza kwe-cerebral, ukushaya kwenhliziyo esigabeni esibi, ukuhluleka kwenhliziyo;
- i-coma ne-precoma yemvelo yesifo sikashukela;
- ukuzwela okuphezulu kwesidakamizwa;
- isikhathi isiguli sikuthola ekudleni oku-hypocaloric;
- ukuphazamiseka kwe-carbohydrate metabolism, ebivele ngemuva kwesifo sikashukela (ketoacidosis).
Futhi kwenqatshelwe ukuphuza umuthi kubantu abaneminyaka engaphezu kwengu-60 abasebenza kanzima.
Ngokunakekela
Umuthi ubekelwa ngokuqapha kwabanesifo sikashukela abaneminyaka engaphezu kwengu-65, okuhambisana nokukhula okungenzeka kwe-lactic acidosis.
Ungayithatha kanjani i-FORMETINE
Umthamo wesidakamizwa uqokwa ngamunye, kucatshangelwa amanani eglucose egazini lesiguli. Qala ngenani lama-500 mg izikhathi ezingama-1-2 ngosuku noma ukusetshenziswa okukodwa kuka-850 mg wesidakamizwa.
Kancane kancane, umthamo unyuka uye ku-2-3 g ngosuku. Isilinganiso esiphezulu somuthi akufanele singeqi i-3 g ngosuku.
Umthamo wesidakamizwa uqokwa ngamunye, kucatshangelwa amanani eglucose egazini lesiguli.
Ngaphambi noma ngemuva kokudla
Ukwemukelwa kweFometin kungenziwa ngemuva kokudla nangesikhathi sokudla. Umuthi uvunyelwe ukuphuza ngamanzi.
Ekuseni noma kusihlwa
Kunconywa ukusebenzisa umuthi kusihlwa, okuzogwema imiphumela emibi emgudwini we-gastrointestinal. Lapho uthatha umuthi amahlandla ama-2 ngosuku, umuthi uphuzwa ekuseni nakusihlwa.
Ukwelashwa kwesifo sikashukela
Ukusetshenziswa kwe-formin ku-mellitus yesifo sikashukela kwenziwa ngokuya ngezincomo ezitholwe kudokotela.
Ukwehla kwesisindo
Kukhona imininingwane ngokusetshenziswa kwomuthi ukwehlisa isisindo, kepha imiyalo esemthethweni ayikwamukeli ukusetshenziswa kwalolo muthi.
Kunconywa ukusebenzisa umuthi kusihlwa, okuzogwema imiphumela emibi emgudwini we-gastrointestinal.
Imiphumela emibi
Amapheshana wesisu
Ngokuthuthuka kwemiphumela emibi ethinta uhlelo lokugaya ukudla, isiguli siqala ukukhononda ngalezi zimpawu ezilandelayo:
- ukulahleka kwesifiso sokudla;
- ukungakhululeki esiswini;
- isicanucanu
- ukuthopha;
- ukunambitheka okubi emlonyeni;
- isifo sohudo
- izikhathi zokuhlanza.
Ukuqhaqhaqaza kanye nesicanucanu kungenye yemiphumela emibi yomuthi ovela emapheshana emathunjini.
Izitho zeHematopoietic
Ezimweni ezingavamile, abantu abasebenzisa umuthi bathuthukisa i-anemiablastic anemia. Kulokhu, ukwephulwa kubonakaliswa yizimpawu:
- umuzwa wokubanda;
- isihlalo sokucasuka;
- ukuphambukela inyama;
- ubuthakathaka obujwayelekile;
- ama-paresthesias;
- ukushuba kwemilenze;
- ukungaphatheki kahle.
Isistimu yezinzwa ephakathi
Imiphumela emibi ingaholela kulezi zimpawu ezilandelayo:
- imibono;
- iminyakazo
- Ukukhathazeka
- ukungahambi kahle;
- ukukhathala.
Ngasohlangothini lwe-metabolism
Ngokulashwa isikhathi eside ngeFormetin, ukuntuleka kwevithamini B12 kwenzeka. Ezimweni ezingavamile, kwakheka i-lactic acidosis.
Uhlelo lwe-Endocrine
Ukuqokwa komuthi emithanjeni engafanele kungabangela ukwehla kokuxineka koshukela (hypoglycemia).
Allergies
Ukungezwani komzimba kubonakaliswa ukuvela kwamaqhubu esikhunjeni.
Imiyalo ekhethekile
Ngesikhathi sokwelashwa, ukusebenza kwezinso kufanele kugadwe.
Umthelela ekhonweni lokulawula izindlela
Lapho uthatha iFomuetin, akukho miphumela emibi ekuphatheni kwezokuthutha. Kodwa-ke, ukusetshenziswa kwalesi sidakamizwa kuhlanganiswa ne-insulin noma i-sulfonylurea okuholela ekuwohlokeni kwekhono lokushayela imoto ngenxa yokuphazamiseka ekusebenzeni kwemisebenzi ye-psychomotor.
Ukunqunyelwa Ifomula Ezinganeni
Akukho mininingwane ngokusetshenziswa kwalesi sidakamizwa ukwelashwa kwezingane ezingaphansi kweminyaka eyi-10, ngakho-ke, awukho umuthi obekiwe ngalesi sikhathi.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Lapho uncelisa ibele futhi ngenkathi uthwele ingane, umuthi awusetshenziswa.
Isicelo sokusebenza kokulimala kwezinso
Ukuba khona kwama-pathologies wezinhlungu ezinzima kungukuphikisana.
Sebenzisa umsebenzi wesibindi okhubazekile
Sebenzisa umuthi ukwephula isibindi kuvinjelwe.
Ukweqisa
Ukuthatha umuthi ngemithamo emikhulu kuholela ku-lactic acidosis. Uma kungekho ukungenelela, isimo singabulala.
Ukuxhumana nezinye izidakamizwa
Akunconywa ukuhlanganisa ukusetshenziswa kanyekanye kwe-formin nemithi elandelayo.
- ama-anticoagulants ahlobene nokutholwa kwe-coumarin - imiphumela yezidakamizwa iyenziwa buthaka;
- i-phenothiazine, izidakamizwa ezi-diuretic zohlobo lwe-thiazide, ushukela, izindlela zokuvimbela inzalo ngomlomo - umphumela wengxenye esebenzayo yomuthi uyancishiswa;
- i-cimetidine - ukumbiwa kwe-metformin kusuka emzimbeni wesiguli kuya ngokuba kubi kakhulu;
- i-chlorpromazine - ingozi ye-hyperglycemia iyanda;
- danazol - umphumela we-hyperglycemic uyathuthukiswa;
- Ama-inhibitors e-ACE nama-MAO avela ku-clofibrate nama-NSAIDs - izakhiwo zokwanda kwe-formin
Ukuhambisana notshwala
Ukusetshenziswa kweziphuzo eziqukethe utshwala kukhulisa ubungozi be-lactic acidosis.
Kufanele wenqabe ukuphuza utshwala ukugwema ukuthuthukiswa kwe-lactic acidosis.
Ama-Analog
Umuthi ungashintshwa nge-analogues.
Lawa mathuluzi:
- I-Glucophage - umuthi wokunciphisa i-hyperglycemia.
- I-Siofor - ikhambi elingeqembu le-Biguanides. Inomphumela omuhle kuma-lipid metabolism futhi yehlisa i-gluconeogeneis.
- IForom Long yindlela ende yesidakamizwa equkethe i-500, 750, 850 noma i-1000 mg yento esebenzayo.
- IGlatiniin umuthi ohlose ukunciphisa inani le-triglycerides ne-LDL. Umuthi ungabambezela inqubo ye-gluconeogeneis.
- I-Metformin - isidakamizwa esinezakhi ezifanayo, esikhona ngesilinganiso esingu-0.5 noma 0,85 g.
- I-Bagomet umuthi we-hypoglycemic okuhloswe ngawo ukusetshenziswa komlomo.
Imibandela yekhefu lekhemisi
Ukuthenga i-Formetin, udinga ukuthola ukunikezwa kadokotela kusuka kudokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Kukhululwa lapho kwethulwa iresiphi.
Intengo ye-formin
Umuthi ungathengwa ngama-ruble angama-50-240.
Izimo zokugcina zomuthi
Umuthi kumele uvikeleke ekushiseni nasekubonakalisweni kwe-ultraviolet.
Isikhathi sokuphelelwa yisikhathi
Umkhiqizo uvunyelwe ukugcinwa iminyaka emi-2.
Umkhiqizi
Inkampani yasePalmstandard-Leksredstva iyabandakanyeka ekukhishweni kweFomumetin.
Ikhambi likhishwa lapho kwethulwa incwadi kadokotela.
Ubufakazi bodokotela neziguli mayelana neFormetin
U-Arseny Vladimirov, i-endocrinologist, eneminyaka engama-54 ubudala, eMoscow
Ukusetshenziswa kwe-formin kungukusindiswa kweziguli ezinenkinga yokukhuluphala ngenxa yesifo sikashukela. Ithuluzi lifanana nokuzwela kokuzwela kwezicubu ukungena kwe-insulin, ngaphandle kokufaka umphumela olimazayo esimweni sesiguli. Enye inzuzo intengo engabizi.
UValentina Korneva, i-endocrinologist, iminyaka engama-55, iNovosibirsk
Umuthi uyasebenza. Nginikeza iziguli zami kaningi. Akekho oke wakhononda ngemiphumela emibi okwamanje. Futhi isimo sivamile.
UVictoria, oneminyaka engama-45 ubudala, uVolgograd
Ngosizo lweFomuethin, ngigcina isisindo sijwayelekile, njengoba ngenxa yesifo sikashukela, yaqala ukuqina. Umuthi awubizi, uyatholakala eRussia. Ngiphuza umuthi kusihlwa. Kodwa-ke, kufanele ulandele ukudla, ngaphandle kwezitsha kanye nemikhiqizo ecebile kilojoule.
UDmitry, oneminyaka engama-41 ubudala, eYekaterinburg
Sekuphele isikhathi eside ngilapha i-formethine, Nginesifo sikashukela iminyaka engaphezu kwengu-15. Umuthi uyasiza, ngaphandle kwemiphumela emibi. Umuthi uthathwa amahlandla ama-2 ngosuku ngethebhulethi.
UMaria, oneminyaka engama-56, uSaratov
Sekuphele iminyaka emihlanu ngihlaselwa yisifo sikashukela. Sonke lesi sikhathi, uGliformin wasebenzisa, esasichazwe udokotela. Umuthi usizile, ngakho-ke bengizowusebenzisa ngokuqhubekayo, kepha ngenkathi ngivakashele esibhedlela bathi awukho umuthi onjalo. IFethethine yanqunywa njengokushintsha okunye. Ngangesaba ukuthi uma ushintsha umuthi ungaholela kwezinye izinguquko ezimbi, kodwa kwavela. Umzimba wawubekezelela kahle lesi sidakamizwa, ngakho ngiyaqhubeka ukusisebenzisa.
