I-Amprilan umuthi obekelwe abantu abanokuhluleka kwenhliziyo okuhlala njalo.
Igama Lezwe elingafanele
URamipril
I-ATX
C09AA05 - URamipril.
Khipha amafomu nokwakheka
Amathebhulethi ayancwebeka, agcwele ngomphetho ophathwe, omhlophe (1.25 noma 10 mg ngamunye), ophuzi (2,5 mg ngamunye), umbala opinki (5 mg ngamunye). Kuhlanganiswe emabhulokini enhlanganisela ka-7 (ebhokisini lekhadibhodi le-3, 6, 9 napkins) noma ama-10 ama-PC. (ebhokisini - 2, 4, 8, 12 noma 14 napkins).
Amathebhulethi ayancwebeka, afafazwa ngomphetho ophathisiwe.
Iyunithi ngayinye yezidakamizwa iqukethe into esebenzayo - ramipril 1.25 mg, 2,5 mg, 5 mg noma 10 mg;
Ngaphezu kwalokho, amaphilisi aqukethe udayi ohambelana nokhonzayo:
- I-2,5 mg - "PB 22886 ophuzi";
- I-5.0 mg - "PB 24899 pink."
Isenzo se-Pharmacological
Kwenziwe ngokusebenzisana nama-biocatalysts e-hepatic, i-ramipril metabolite - i-ramiprilat - yehlisa ukubekeka kwe-ACE. Ngenxa yalokhu, umphumela we-vasodilating, ubangela ukwanda kwengcindezi ohlelweni lokujikeleza kwegazi. I-metabolite eyakhekile isiza ukunciphisa izithikamezo zemithambo yegazi ejikelezayo futhi ayibangeli ukuphazamiseka kwegazi lokupholisa.
Ngesikhathi esifanayo, ukwakheka kwama-prostaglandins kuyanda. Lokhu kuholela ekwandisweni okwandisiwe kwe-nitric oxide kuma-endotheliocytes, okunikeza umphumela we-cardioprotective.
Ukuqiniswa kwezinga elikhulayo lomfutho wegazi kwenzeka emahoreni angama-1-2 ngemuva kokuthatha ingxenye yokuqala yomuthi. Umphumela olindelwe kakhulu wenzeka ngemuva kwamahora angama-3-6 futhi uhlala usuku. Umphumela we-antihypertensive ukhula kancane kancane, futhi ngemuva kwenyanga engu-1 yokusebenzisa uyakwazi ukuhlala isikhathi eside. Awunayo i-draining syndrome, ngakho-ke, ngokunqamuka kokusetshenziswa okungazelelwe, ukwanda okubucayi kwengcindezi yegazi akwenzeki.
Kubantu abane-hypertension ye-arterial, lesi sidakamizwa singanciphisa ukuthuthukiswa kwe-myocardial hypertrophy nezindonga ze-vascular.
Kubantu abanokwehluleka kwenhliziyo okungapheli, kuyasiza ukwehlisa ukulayisha kuqala nenhliziyo futhi kuqinise umphumela wokukhipha kwenhliziyo.
Nge-nephropathy, kuyasiza ukwehlisa ukukhula kokuhluleka kwe-renal futhi kunciphise isidingo se-hemodialysis noma ukufakelwa kwezinso. Ezigabeni zokuqala, kunciphisa izehlakalo ze-proteinuria.
Ebantwini abasengozini ye-cardiopathologies enzima eyakheka ngenxa yokungasebenzi kahle kwe-venous noma isifo sikashukela, i-ramipril ivimbela ukwakheka kokuhluleka kwenhliziyo. Inciphisa ubungozi be-myocardial infarction kanye nesifo sohlangothi.
Kubantu abane-pathologies ye-inhliziyo, amathuba okulaliswa esibhedlela ancishiswa ngama-27%, kanti ingozi yokufa kungazelelwe incishiswe ngama-31%.
I-Pharmacokinetics
Ngemuva kokusetshenziswa, ngokushesha kumunwa kusuka emgudwini ophezulu wesisu. Ukugaya kanyekanye ngokudla kuvimbela ukumunyiswa kwawo, kepha lokhu akulithinti ikhwalithi yokutholwa.
Ishintshwe esibindini, yakha i-ramiprilat ne-diketopiperazine. Ukuqongelela okuphezulu kakhulu kwenzeka emahoreni angama-1-3. Kwenziwe umchamo nezindunduma. Ngokungasebenzi kahle kwezinso, isikhathi sokuqeda umuthi singathatha isikhathi eside. Ngemuva kokudlula ezigabeni eziningana zokuguqulwa, ushiya umzimba kungakapheli usuku, kepha inani elincane lalezi zinto zitholwa ezinye izinsuku ezingama-3-4.
Izinkomba zokusetshenziswa
Inconyelwe izimpawu:
- i-arterial hypertension;
- ukwehluleka kwenhliziyo okungapheli;
- i-nephropathy yesifo sikashukela futhi engenashukela nesifo sezinso.
I-Amprilan ibekelwe izingozi eziphezulu zenhliziyo.
Ngaphezu kwalokho, kubekelwe izingozi eziphezulu zenhliziyo kanye nokuba khona kwe-myocardial infarction ku-anamnesis nangemva kwe-percutaneous translateuminal angioplasty kanye ne-coronary artery bypass grafting.
Contraindication
Akuvunyelwe ukusebenzisa ezimeni ezinjengokuthi:
- ukungabekezelelani komuntu ngamunye ku-ramipril kanye ne-biocomponents yamaphilisi;
- umlando we-angioedema noma amathuba we-arogeneis yayo lapho usebenzisa i-ACE inhibitors;
- Izifo ezivelela ku-autosomal ezivezwa yi-hypertrophy yemithambo yenhliziyo nemithambo yezinso;
- izinkomba zegazi ezingazinzi;
- ukuphazamiseka kwenhliziyo yesigqi senhliziyo;
- hemodialysis;
- ukukhulelwa nokukhipha umunyu.
Ungabeki izingane nasebusheni abangaphansi kweminyaka engu-18 ubudala.
Ngokunakekela
Izinkomba ezifana:
- izilonda ze-atherossteotic zemithambo ye-coronary and cerebral artery;
- Izimpawu ezinzima ze-hypertension ye-arterial;
- ukwelashwa kokuqala nge-diuretics;
- ukwehluleka kwenhliziyo, lapho kusetshenziswa ezinye izidakamizwa ze-antihypertensive;
- ukwehluleka kwesibindi;
- ukufakelwa kwezinso;
- isifo sikashukela kanye nengozi yokukhula kwe-hyperkalemia;
- ukuncipha komzimba.
Ngokuqapha, thatha umuthi ngokwehluleka kwesibindi.
Ngokuqapha kubekelwe abantu asebekhulile.
Ungayithatha kanjani i-Amprilan
Ngaphakathi ngaphandle kokuhlafuna. Ukuqokwa kanye nomuthi owodwa wesidakamizwa wenziwa udokotela. Kuya ngesimo sesiguli kanye nemiphumela yokwelashwa elindelekile. Inkambo yokwelashwa yinde futhi idinga ukubhekwa njalo ngudokotela.
Uma kwenzeka kuba ne-hypertension ye-arterial: umthamo wansuku zonke wesikhathi esisodwa ngu-0,0025 g Uma uhlelo lwesenzo lungasebenzi amaviki ama-3, umthamo uphindwe kabili. Kancane kancane, i-single service ikhuphuka ifike kumthamo wezinsuku eziphezulu kakhulu we-0,01 g. Ukukhetha ukwelashwa kungenzeka kuvumele ukujoyina ezinye izidakamizwa kuleli qembu.
Engcupheni yokuqunjelwa yi-myocardial infarction, unhlangothi, noma ngokwesabisa ngokufa, umthamo wansuku zonke osheshayo ngu-0,0025 g.
Uma kwenzeka ukwehluleka kwenhliziyo: isabelo sosuku sinye kuphela siku-0,00125 g. Uma ngabe ukwehluleka ngokweqiniso, imithamo ethathiwe kancane kancane iphindwe kabili. Umthamo wezinsuku eziphezulu kakhulu ngu-0,01 g.
Uma kwenzeka unesifo sikashukela / esingeyona isifo sikashukela: ingxenye ejwayelekile yesikhathi esisodwa - 0,00125 g. Uma isifundo singasebenzi - khuphukela ku-0,005 g.
Uma ubhekene nobungozi bokuqunjelwa yi-myocardial infarction, unhlangothi noma ukufa, umthamo wansuku zonke osheshayo ngu-0,0025 g. Kancane kancane, ingxenye yedosi elilodwa ikhuphuka ibe yivolumu yansuku zonke ephezulu ye-0,01 g.
Ukuthatha umuthi wesifo sikashukela
Ingxenye yokuqala yansuku zonke ye-ramiprilat ingu-0.00125 g ngokukhuphuka kancane kancane ukuya ku-0,005 g.
Imiphumela emibi
Ukwelashwa kuqala ngesilinganiso sokuqala sosuku esisodwa se-0.00125 g. Imiphumela yokuphuza ngaphezu kwe-0,01 g ayizange ifundwe ezifundweni ezilawulwayo. Uma usebenzisa inkambiso ye-dosing ehamba kancane kancane ukusuka ku-0.00125 kuya ku-0,01 g, ukuphendula okunganele komzimba kungenzeka.
Amapheshana wesisu
I-Phenomena yesicanucanu, ukugabha, ukuhudula noma ukuvinjelwa kwamathumbu, ukungaphumeleli kahle kwe-epigastric, ukoma, ukungasebenzi kahle kwe-hepatic kanye nokunyuka kokuhlushwa kwe-bilirubin.
Umphumela wecala elilodwa uhudo.
Izitho zeHematopoietic
Kwesinye isikhathi kuvela izimpawu ze-agranulocytosis, erythrocytopenia, thrombocytopenia, hemoglobinemia, neutropenia, i-eosinophilia.
Isistimu yezinzwa ephakathi
Ubuthakathaka obujwayelekile, obuhambisana nobuhlungu bekhanda nokudangala, ukungasebenzi kahle kwemizwelo yengqondo, ukwethuka nemisipha.
Kusuka ohlelweni lwe-musculoskeletal
Izimpawu ze-myositis, myalgia, arthralgia, isifo samathambo kwesinye isikhathi ziyavezwa.
Kusuka ohlelweni lokuphefumula
I-Dyspnea, ukuvela kokhwehlela okungazalisi.
Kusuka ohlelweni lwezitho zofuzo
Ukwanda kwe-pathologies yohlelo lwezinso.
Kusuka ohlelweni lwezinhliziyo
Izimpawu ze-hypotension, hypotension, tachycardia.
Uhlelo lwenhliziyo lungakhombisa izimpawu ze-hypotension.
Allergies
Ukubonakaliswa kokuphendula kwesikhumba kanye ne-dermatitis, angioedema.
Imiyalo ekhethekile
Kudinga ukuqashwa kwesimo esejwayelekile sesiguli. Uma kuvela izimpawu ze-SARS, bonana nodokotela.
Ukuhambisana notshwala
Ukwabelana ngemikhiqizo equkethe utshwala kuyenqatshelwe. Kwenyusa umphumela we-ethanol kuhlelo lwangaphakathi lwezinzwa.
Umthelela ekhonweni lokulawula izindlela
Ngokuqapha lapho wenza imisebenzi edinga ukugxilwa. Kuyinto engathandeki ukushayela noma ukusebenzisa amayunithi athwala usongo olungaba khona.
Kuyinto engathandeki ukushayela noma ukusebenzisa amayunithi athwala usongo olungaba khona.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Yeqa ukwakheka kwesibeletho. Kuyenqatshelwa ngesikhathi sokukhishwa komzimba.
Ukunquma i-Amprilan ezinganeni
Ekuvivinyweni okulawulwayo, umphumela emzimbeni wezingane awuzange ufundwe.
Sebenzisa ebudaleni
Ngokuqapha.
Ebudaleni, phuza umuthi ngokuqapha.
Isicelo sokusebenza kokulimala kwezinso
I-single ekhonzayo ephezulu kakhulu ingu-0.0025 g.
Sebenzisa umsebenzi wesibindi okhubazekile
Ngokuphulwa okunzima kokusebenza kwesibindi, ukukhonza okukodwa okukhulu kunama-0.005 g.
Ukweqisa
Ukubonakaliswa kwemitholampilo: ukwehla kwengcindezi yegazi ukuya emazingeni abucayi, ukwehluleka kwe-renal acute.
Ngokubonakaliswa okunamandla kwe-overdose, ukungena esibhedlela esiphuthumayo kuyadingeka.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa kanyekanye kwemithi eqhamuka kuma-NSAID amaningi kungavusa ukwakheka kwezimpawu zezinso futhi kufake isandla ekugcineni kwe-potassium emzimbeni.
Usawoti we-sodium ukhuthaza ukugcwala kwe-sodium ku-serum yegazi, okwenza buthaka izakhiwo ze-antihypertensive. Ngokufanayo, kukhona ukwanda kwe-estrogen emzimbeni.
Ukusetshenziswa kanyekanye kwemithi ekwehlisa umfutho wegazi kuvusa umphumela we-hypotensive.
Inhlanganisela ehlanganisiwe
Ayihlanganisiwe nokusetshenziswa kokugeleza okuphezulu okungakhokhisi kahle ngesikhathi se-hemodialysis.
Umuthi awunqunyelwe ezigabeni zokwelashwa kwe-nephropathy.
Umuthi awunqunyelwe ngokuhambisana ne-Aliskiren yesifo sikashukela noma ukwehluleka okuyinso okuyinkimbinkimbi, kanye ne-Dextran sulfate ukwehlisa i-cholesterol.
Ngaphezu kwalokho, ayinqunyelwe ezigabeni zokwelashwa kwe-nephropathy ene-glucocorticosteroids, ama-immunomodulators kanye / noma ezinye izinto ze-cytostatic.
Akuhlanganisiwe ukuhlanganisa
Ukusetshenziswa kwezidakamizwa eziqukethe i-potassium kunomthelela ekuqongeleleni i-potassium.
I-vasopressor sympathomimetics iyanda izakhiwo ze-antihypertensive ze-ramipril.
Inhlanganisela edinga ukuqashelwa
Ngokuhlanganiswa nama-antihypertensives, ama-diuretics, ama-sedative, ama-anesthetics.
Ngosawoti we-lithium - kunomthelela ekugcineni kwabo emzimbeni womuntu.
Kwandisa izakhiwo ze-hypoglycemic ze-insulin nemithi ethathwe ku-sulfonylurea.
Ukuhlanganiswa kwama-inhibitors e-ACE ahlukahlukene nge-ramipril kuvusa ukwakheka kwe-angioedema.
Ama-Analog
I-Amprilan ND inezikhundla eziningi. Ziyafana ekwakhiweni, kepha ziyahlukahluka phambi kobukhona bento eyisisekelo. Kutholakale ngaphansi kwamagama:
- Wazolong;
- I-Corpril;
- Dilaprel;
- URamigamm
- URamilong;
- I-Ramimed;
- Rampril;
- Amaphiramidi;
- IHartil;
- Landela umkhondo.
Enye yezimpawu zika-Amprilin nguCorpril.
Umphumela ofanayo olindelekile ungatholakala ngemuva kokusetshenziswa kwe-Amprilan NL.
Imibandela yekhefu lekhemisi
Ngokusebenzisa umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Amanye amakhemikhali aku-inthanethi angathengwa ngaphezulu kwekhawuntara.
Intengo ye-Amprilan
Izindleko zincike kwinani lamaphilisi akule phakethe kanye nenani lezinto eziphambili ezikhona kuzo. Ngakho-ke, ngokwesibonelo, inani eliphakathi kwephakeji eliqukethe amaphilisi angama-30 ngomthamo we-ramipril 5 mg kumakhemisi ahlukene ahlukahluka ukusuka kuma-ruble angama-600 kuya kwangama-900. Ngasikhathi sinye, izindleko zephakethe elifanayo nomthamo we-1.25 mg zisezingeni lentengo ukusuka kuma-ruble angama-260 kuya kwangama-290.
Izimo zokugcina zomuthi
Ibanga lokushisa lokugcina - 0 ... + 25 + ะก. Fihla ezinganeni.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
I-KRKA, eSlovenia
Ukubuyekezwa kwe-Amprilan
Odokotela neziguli kwesinye isikhathi bahlukaniswa ngokusebenza kwe-ramipril. Imvamisa lokhu kubangelwa ukusetshenziswa hhayi kwesidakamizwa sokuqala, kepha ama-generics awo.
Odokotela
Senkov G.N., udokotela wezifo zenhliziyo, uKemerovo
Ngibhalela iziguli ezinezimpawu zomfutho we-arterial hypertension kanye nokwehluleka kwenhliziyo okuhlala njalo. Ngibeka zombili i-monogamous futhi ngihambisane neminye imithi. Imithamo umuntu ngamunye kuzo zonke iziguli. Kwakungekho ukusabela okubi kumkhuba wami.
I-Kiryukhina I.D., isazi sezinhliziyo, uPenza
URamipril wazibonakalisa kahle mayelana nokusimamisa ukugeleza kwegazi nokunciphisa umfutho wawo. Ngiyincoma ezigulini ezihlaselwa umfutho wegazi ophezulu, isifo se-coronary noma isifo sikashukela. Inezimfanelo ezithinta kahle ukusebenza kwezinso nenhliziyo. Kudinga iminyaka eminingi yokusebenzisa. Umphumela wecala - kwesinye isikhathi ubangela ukukhwehlela.
Iziguli
UMaria, oneminyaka engama-48, uRostov-on-Don
Iminyaka eminingi, gxuma ekucindezelweni kwegazi kuhlukunyezwe - umphumela wokwelashwa kwe-urolithiasis. Umeluleki uwunqume lo muthi. Kunconywe ukuthatha ipilisi eli-1 njalo emahoreni angama-24. Kepha isikhathi eside ngiyiphuza kuphela lapho ngizwa kabi. Lo nyaka, ukuhlaselwa sekuye kwenzeka kaningi, manje kufanele usiphuze cishe nsuku zonke. Ngemuva kwengxenye yehora, ingcindezi ibuyele kwesejwayelekile, kepha kwavela ukukhwehlela.
UNikolay, oneminyaka engama-60, uBiysk
Le makhambi inqunywe ngudokotela wesifunda maqondana namacala ajwayelekile omfutho wegazi. Umthamo wokuqala ngu-1.25 mg, kepha awukho umphumela. Kancane kancane bakhuphukela ku-5 mg. Manje ngizwa kahle: ngiphuza iphilisi elilodwa ekuseni - ngakhohlwa ngamanye amaphilisi usuku lonke. Ingcindezi ayisasizi.
