I-Fenofibrate isidakamizwa esisebenzayo se-hypolipidemic sesizukulwane sanamuhla. Lo muthi unconyelwa ukwelashwa kwe-cholesterol ephezulu ne-triglycerides.
Isidakamizwa sithengiswa kwifomu lethebhulethi kunoma iyiphi ikhemisi, ungasithenga kuphela ngokuyalelwa. Ukusetshenziswa kwe-ejensi yemithi kukhonjiselwa i-hyperlipidemia eyisisekelo, i-dyslipidemia exubekile.
Njengoba kukhona ama-contraindication, kubalulekile ukubonana nodokotela ngaphambi kokuqala ukwelashwa ngezidakamizwa. Kulokhu, umuntu akufanele azibandakanye ezokwelapha ukuze avimbele ukwanda kwezinkinga.
Indlela yokusebenza yesidakamizwa
Amathebulethi ayisidakamizwa esinciphisa i-lipid, sifaka i-fibroic acid. Umuthi osebenzayo uqinisa inqubo ye-metabolic yokuqhekeka kwe-lipoprotein ye-atherogenic ngaphansi kwesenzo se-lipase, ikhulisa okuqukethwe kwe-cholesterol enenzuzo futhi inciphise ukuqoqwa kokulimazayo, futhi futhi kunciphise i-triglycerides.
Ngesikhathi sokulashwa, kukhona ukwehla kwamaprotheni e-C-reactive, amazinga e-fibrinogen ne-uric acid, ukwehla kwe-tendon xanthomas. Ku-diabetes, ushukela wegazi nokuhlanganiswa kweplatelet kuyancishiswa.
Ngemuva kokuthi into esebenzayo isidlulile micronization, ithola i-bioavailability ephezulu. Ukhuphula ukumuncwa, umuthi uyanconywa ukuba uphathwe ngokudla. Uma umuthi usetshenziswa njalo futhi isikhathi eside, ngenxa yokuqina okuzinzile egazini, umphumela wokwelapha uqhubeka isikhathi eside ngokwanele.
- I-Fenofibrate ayiqoqeki futhi ichazwa ngokusebenzisa izinso.
- Isigamu sempilo singamahora angama-20.
- Igazi lisulwa ngokuphelele kulo muthi ngesonto.
Ungawuthenga lo muthi ekhemisi ngokuletha incwadi kadokotela. I-Fenofibrate iyatholakala ngesimo samacwecwe we-145 mg camera.
Ukwakheka kwalesi sidakamizwa kufaka i-fenofibrate esetshenziswayo, i-magnesium stearate, i-povidone, i-sodium mannitol croscarmellose, isitashi sommbila, i-silicon dioxide.
Fenofibrate: imiyalo yokusebenzisa nentengo
Udokotela unquma ukusetshenziswa komuthi lapho kudingekile ukwehlisa ukugcwala kwama-triglycerides egazini. Nge-atherossteosis, isifo sikashukela i-mellitus, izifo zenhliziyo ezi-coronary, umuthi uthathwa ngokubambisana nemibhede namanye amaphilisi. Futhi, umuthi unqunywa uma kukhona i-hyperlipidemia eyisisekelo.
I-Fenofibrate ifaka imiyalo esetshenzisiwe, intengo yomuthi, ngokuya ngezibuyekezo, ayidluli izindleko zama-analogues. Ngokusho kwencwajana, umthamo omkhulu wansuku zonke yi-145 mg. Ithebhulethi ligwinywa ngaphandle kokuhlafuna ngesikhathi sokudla.
Ukufeza umphumela wokwelapha, umuthi uthathwa isikhathi eside ngaphandle kokuphazamiseka. Ngaphezu kwalokho, isiguli kufanele silandele indlela eqinile yokudla ye-hypocholesterolemic.
- Ukuhlola ukusebenza ngempumelelo kokwelashwa, ukuhlolwa kwegazi kufanele kuthathwe izinyanga ezintathu ngemuva kokuqala kokwelashwa. Lokhu kuvama kugcinwa unyaka wonke.
- Uma izinga lama-transaminases egazini landa ngaphezu kokuphindwe kathathu, umuthi kufanele umiswe.
- Kubandakanya ukusetshenziswa kwamathebulethi kufanele kushiywe uma izinkomba ze-creatinine phosphokinase zanda amahlandla ayisihlanu futhi kunomthelela onobuthi ezicutshini zemisipha.
- Lapho kukhona ingozi enkulu yokuba nesifo senhliziyo kanye nezinga eliphakeme le-dyslipidemia, udokotela unquma ukuthathwa okwengeziwe kwama-statins.
Ukwelashwa kwezidakamizwa kwenziwa ngaphansi kokuqashwa okuqinile kwezokwelapha. Ngaphezu kwalokho, isiguli kufanele sicabangele kabusha indlela yaso yokuphila, sakha ukudla okunekhono futhi senqabe ukudla ukudla okunamafutha. Uma ngemuva kwezinyanga eziyisithupha kungabonakali amandla amahle aqaphelekayo, kukhethwe uhlobo oluthile lokwelashwa.
Ngaphambi kokuthi uqale ukuthatha amaphilisi, imbangela yokwanda kwe-cholesterol yegazi inqunywa. Uma i-pathology ibangelwa ukuthi umuntu uthatha i-estrogen, udinga ukukhansela lokhu kwelashwa ukwenza izinkomba zijwayelekile.
- Umuthi lo ubekwa ngecala uma kwenzeka kuba ne-hypersensitivity, hepatic kanye ne-renal ehluleka ukwehluleka, izifo ze-gallbladder, i-pancreatitis engapheli kanye ne-acute. Ukwelashwa kuboniswa kuphela eminyakeni engaphezu kwe-18.
- Ukuqapha kumele kusetshenziswe uma kukhona i-hypothyroidism, isifiso sokuthola ifa lesifo semisipha, umuntu usebenzisa kabi utshwala. Abesifazane abakhulelwe bavunyelwe ukuthi basebenzise i-fenofibrate kuphela uma kungekho bungozi obukhona e-fetus.
Gcina amathebhulethi kude nezingane endaweni emnyama ekushiseni okungaphansi kwama-25 degrees. Impilo yeshalofu yomkhiqizo iyiminyaka emibili.
Intengo ingahluka kusuka kuma-ruble angama-450 kuya kwangama-550, kuya ngesitolo.
Imiphumela emibi
Kumele kukhunjulwe ukuthi umuthi unemiphumela emibi eminingi, ngakho-ke kufanele uqiniseke ukuthi akukho mibiko ephula umthetho. Ngemuva kokuthatha amaphilisi, isiguli singathola ukusabela kokungezwani komzimba ngokuxhamazela, ukulunywa, ukusikeka noma ukusabela kwe-photosensitivity, futhi ukukhula kwe-creatinine ne-urea kunganda.
Imiphumela emibi ingenzeka ngendlela yobuhlungu besisu, isicanucanu, ukugabha, isifo sohudo, ukuthopha. Ezimweni ezingavamile, kuvela i-pancreatitis ebabayo, ifomu le-gallstones, futhi akuvamile ukuba i-hepatitis ikhule. Uma umuntu enezimpawu ze-jaundice noma ukulunywa, isiguli kufanele sihlolelwe i-hepatitis futhi siyeke ukuthatha i-Fenofibrate.
Kwesinye isikhathi imiphumela emibi ibonakaliswa ngendlela yokufaka i-myalgia, i-myositis, imisipha yemisipha, ubuthakathaka, i-rhabdomyolysis, umsebenzi owandisiwe we-creatine phosphokinase. Abanye abantu bahlakulela i-vein thrombosis ejulile, i-pulmonary embolism, kwandise i-hemoglobin kanye nokubala kwamangqamuzana amhlophe egazi, ikhanda nekhanda nokungasebenzi komzimba. Ezimweni ezihlukile, kutholakala ukuthi i-pneumopathy ehlukile.
Amacala okweqa awakaze akhonjwe, kepha uma kukhona izinsolo zokusebenzisa kabi umuthi, kunikezwa izimpawu zokwelapha ezisekelayo. Ukusetshenziswa kwe-hemodialysis akuphumeleli. Ama-antidot acacisiwe awaziwa.
Lapho usebenzisa ukwelashwa okuyinkimbinkimbi nokusetshenziswa kwezinye izidakamizwa, ukunakekelwa okukhethekile kumele kuthathwe.
- I-Fenofibrate ithuthukisa imiphumela ye-anticoagulants yomlomo, lo mphumela uvame ukudala ukopha. Ngakho-ke, esigabeni sokuqala sokwelashwa, umthamo wama-anticoagulants wehliswa ngu-1/3. Ngokulandelayo, udokotela ukhetha umthamo ngamunye, agxile esimweni esivamile sesiguli kanye nemiphumela yokuhlolwa.
- I-cyclosporin, esetshenziswe ngokubambisana ne-fenofibrate, yehlisa umsebenzi wezinso, kulokhu, ngezinguquko ezinkulu emingceleni yaselebhu, ukwelashwa kukhanseliwe. Uma izidakamizwa ze-nephrotoxic zisetshenziswa ndawonye, inzuzo nengozi ziyahlolwa, emva kwalokho kuzonqunywa umthamo omncane oyingozi.
- Uma uhlanganisa ukuthatha umuthi neqembu le-HMG-CoA reductase inhibitors, ukwehluleka kwe-renal acute, myopathy, rhabdomyolysis kungakhula. Lapho kuvezwa ama-sequence we-bile acid, ukumuncwa kwe-fenofibrate kuyancipha, ngakho-ke amaphilisi e-hypolipidemic athathwa ihora elilodwa noma amahora ayisithupha ngemuva kokusebenzisa umuthi owengeziwe.
Ukufana kwezidakamizwa
Kunezidakamizwa ezimbalwa ezinokwakheka okufanayo. Lokhu kufaka phakathi i-Trilipix, i-Exlip, i-Tsiprofibrat, i-Lipantil, amaphilisi we-Tricor. Futhi ekhemisi ungathenga izidakamizwa nomphumela ofanayo emzimbeni - iLivostor, Storvas, Tulip, Atorvakor.
Isiguli singazikhethela ngokuzimele umuthi wokufaka esikhundleni, inikezwe ifomu nomthamo obekwe udokotela. Uma kuqhathaniswa nokubuyekezwa, amaphilisi enziwe eJapan, e-USA, eNtshonalanga naseMpumalanga Yurophu abhekwa njengosebenza kakhulu.
Ngakho-ke, i-fenofibrate iyasebenza ekwelapheni i-hypercholesterolemia ngokumelene nohlobo 2 lwesifo sikashukela. Ukuthola umphumela osheshayo futhi osebenza kangcono, ama-statin athathwa ngokungeziwe. Umuthi usetshenziswa ngempumelelo ekwelapheni kwabantu abadala. Amaphilisi anciphisa ama-triglycerides, ayeke ukukhula kwezinguquko ze-fundus, athuthukise isimo semilenze.
Ukwelashwa kwe-atherosclerosis kuchazwe kule vidiyo kule ndatshana.