I-Lipase yinto esetshenziswa ngumzimba womuntu ekhuthaza ukwahlukaniswa, ukugaya, kanye nokuqhekeka kwama-lipids angathathi hlangothi. Ngokubambisana ne-bile, i-enzyme e-encibilikiswa ngamanzi iqala ukugaya ama-acid acid, amanoni, amavithamini A, D, K, E, ayicubungula ibe ukushisa namandla.
Umuthi ubandakanyeka ekuqhekekeni kwe-triglycerides egazini, ngenxa yale nqubo, ukuthuthwa kwamafutha acid kumaseli kuyaqinisekiswa. Ama-pancreas, amathumbu, amaphaphu nesibindi zinomthwalo wokukhulula kwe-pancreatic lipase.
Ezinganeni ezincane, ukukhiqizwa kwe-enzyme nakho kwenziwa ngobuningi bezindlala ezikhethekile, okwasendaweni yabo emgodini womlomo. Noma yiziphi izinto ze-pancreatic zenzelwe ukugaya kwamaqembu athile wamafutha .. I-pancreatic lipase esegazini kuyinto enophawu oluqondile lokuqalwa kwenqubo yokuvuvukala okunamandla emzimbeni.
Umsebenzi weLipase
Umsebenzi oyinhloko we-lipase ukucubungula amanoni, ukudiliza nokuhlukanisa. Ngaphezu kwalokho, lo muthi ubamba iqhaza ekwamukelweni kwamavithamini amaningi, ama-asidi omzimba we-polyunsaturated, kanye ne-metabolism.
I-pancreatic lipase ekhiqizwa yi-pancreas iba yinto ebaluleke kakhulu eqinisekisa ukufakwa kwamafutha okugcwele futhi okufika ngesikhathi. Ingena ohlelweni lokugaya ngesimo se-prolipase, i-enzyme engasebenzi; enye i-enzyme ye-pancreatic, i-colipase ne-bile acid, iyoba yisishoshovu sento.
I-pancreatic lipase yephulwe phansi yi-lipids emulsated yi-hepatic bile, esheshisa ukuhlukana kwamafutha angathathi hlangothi atholakalayo emikhiqizweni yokudla kuyi-glycerol, enamafutha aphezulu. Ngenxa ye-lipp ye-hepatic, ukumuncwa kwama-lipoprotein asezingeni eliphansi, ama-chylomicrons, kanye nokugcwala kwamafutha ku-plasma yegazi kulawulwa.
I-Gastric lipase ivuselela ukugcwala kwe-tributyrin, into ehlukahlukene yolimi iphula ama-lipids atholakala ebisini lwebele.
Kunemibandela ethile yokuqukethwe kwe-lipase emzimbeni, kwabesilisa nabesifazane abadala, inombolo 0-190 IU / ml izoba yinkomba ejwayelekile, ezinganeni ezingaphansi kweminyaka engu-17 - 0-130 IU / ml.
I-pancreatic lipase kufanele ibe no-13-60 U / ml.
Kuyini ukwanda kwe-lipase
Uma i-pancreatic lipase ikhuphuka, lolu lwazi lubalulekile lapho wenza ukuxilongwa, kuba yinkomba yokuthuthuka kokuphazamiseka okuthile kumanyikwe.
Izifo ezinamandla ziyakwazi ukukhulisa ukuhanjiswa kwento, kufaka phakathi uhlobo lwenyumba lwe-pancreatitis, i-biliary colic, i-malignant kanye ne-benign neoplasms, ukulimala kwepancreatic, inkambo yesifo se-gall.
Imvamisa, ukukhuphuka kwe-lipase kukhombisa ama-cysts kanye nama-pseudocysts kuma-pancreas, ukuvaleka kwe-pancreatic duct ngamatshe, isikhafu, i-cholestasis ye-intracranial. Izimbangela zesimo se-pathological kuzoba ukuvinjwa kwamathumbu kakhulu, i-peritonitis, ukwehluleka kwezinso okulimazayo nokungaphatheki kahle, ukugcotshwa kwezilonda esiswini.
Ngaphezu kwalokho, ukukhuphuka kwe-lipase kuba isibonakaliso se:
- ukugcotshwa kwesitho esiyize;
- isifo se-metabolic;
- ukukhuluphala
- yiluphi uhlobo lwesifo sikashukela;
- ama-mumps ngomonakalo wamanyikwe;
- isifo samathambo
- ukufakelwa kwezitho zangaphakathi.
Inkinga kwesinye isikhathi iba nokusetshenziswa okungapheli kwemithi ethile: ama-barbiturates, ama-analcics-uhlobo lwe-narcotic, uHeparin, Indomethacin.
Kungenzeka ukuthi ukwenziwa kwe-lipase ye-pancreatic kubangelwe ukulimala, ukuqhekeka kwamathambo eshubhu. Kodwa-ke, ukuguquguquka okuhlukahlukene kumingcele yento ye-enzyme esegazini akunakubhekwa njengophawu oluthile lomonakalo.
Ngakho-ke, ukuhlaziywa kwe-lipase cishe akunqunyelwe ekutholeni ukulimala kwemithi ehlukahlukene.
Ngabe yiziphi izifo ekhula nazo i-lipase?
Ucwaningo lwama-indices wegazi lipase luthola ukubaluleka kwezilonda ezahlukahlukene zezicubu zomzimba. Ngemuva kwalokho ukuhlaziywa kwalesi enzyme kunconywa ukuba kwenziwe kanye nokucaciswa kwenani lama-amylase, i-enzyme ekhuthaza ukuhlukana kwezinto ezinesitashi kuma-oligosaccharides. Uma izinkomba zombili zokweqiwa kakhulu, lokhu kubonisa ukuthuthuka kwenqubo ye-pathological enzima kumanyikwe.
Ngesikhathi sokulashwa nokwenziwa okujwayelekile kwesimo sesiguli, ama-amylase ne-lipase afika emazingeni anele ngasikhathi sinye, imvamisa i-lipase ihlala iphakeme kakhulu kune-amylase.
Ucwaningo lwelebhu lukhombisile ukuthi ngenqubo yokuvuvukala kumanyikwe:
- ukunakekelwa kwe-lipase kukhuphuka kuphela ezinombolweni ezilinganiselayo;
- izinkomba kuyaqabukela zifinyelela ezingeni lapho ngokungangabazeki udokotela angakwazi ukuthola khona ukuthi kunembile yini;
- isifo singasungulwa kuphela ngosuku lwesithathu.
Kuzodingeka ukuthi unake ukuthi ngokulimala kanzima, izinga lezinto lihlala lilijwayelekile, i-enzyme evamile ibonwa lapho kunamafutha e-pancreatic necrosis. Izinga lomsebenzi we-lipase lenyuka cishe kathathu ngefomu le-hemorrhagic le-pancreatic necrosis.
I-lipase ephezulu ithatha izinsuku ezingama-3-7 ukusuka ekuqaleni kokuvuvukala okukhulu, ukuthambekela kokujwayelekile kwento kubhekwa kuphela ngosuku lwe-7-14th lwesimo se-pathological. Lapho i-enzyme ye-pancreatic igxuma ifinyelele ezingeni le-10 nangaphezulu, ukuvezwa kwalesi sifo kubhekwa njengokungekuhle, ikakhulukazi uma i-biochemistry yegazi ikhombisile ukuthi lo msebenzi uphikelela izinsuku eziningana, awuphindeki kathathu njengokujwayelekile.
Ukwanda okusheshayo kwe-pancreatic lipase indices kucacisiwe, kuhlobene kakhulu nembangela yokuphazamiseka. I-pancreatitis ye-acute ibonakala ngokukhula kwe-enzyme amahora angama-2-6 ngemuva kokukhula ngokweqile, ngemuva kwamahora ayi-12-30, i-lipase ifinyelela amazinga aphezulu futhi kancane kancane iqala ukwehla. Ngemuva kwezinsuku ezingama-2-4, umsebenzi wento ufinyelela kokujwayelekile.
Enkambweni engapheli yesifo, ekuqaleni kunokukhuphuka okuncane kwe-lipase, njengoba lesi sifo sikhula, ukuguquka kwesigaba sokuxolelwa, kuvamile.
Izimbangela zeL low Lipase
Ukuthuthukiswa kwe-neoplasms enobungozi yanoma iyiphi ingxenye yomzimba, hhayi kuphela i-pathology ye-pancreas, kunganciphisa ukuqina kwe-lipase. Futhi, izizathu kufanele zifunwe ekwehleni kokusebenza kwe-pancreatic, ukuphazamiseka kofuzo ngenkambo enzima kakhulu eyenzeka ngenxa yokulimala kwezindlala ze-endocrine (isifo se-cystic fibrosis).
Ngemuva kokwenza ukwelashwa kokuhlinzwa ukuze ususe ama-pancreas, nokuqukethwe ngokweqile kwe-triglycerides egazini, okubangele ukudla okungafanele okunamafutha amaningi, i-heeritary hyperlipidemia nayo yehlisa izinga le-encyme ye-pancreatic. Imvamisa, ukwehla kwamazinga we-lipase kubonwa ngokushintshwa kwe-pancreatitis kusuka ku-acute to chronic.
Ukungabikho ngokuphelele kwe-pancreatic lipase kwenzeka ngokungapheleli kokukhiqizwa kwayo.
Yimaphi ama-enzyme atholakala kumanyikwe achazwe kuvidiyo kule ndatshana.
