Abantu abaphethwe yisifo sikashukela sohlobo 2 akuvamile ukuba bakwazi ukugcina amazinga eglucose ajwayelekile ngokudla nangokuvivinya umzimba. Ngakho-ke, abanye abanesifo sikashukela kufanele basebenzise ama-hypoglycemic agents, ikakhulukazi uGlidiab.
Lo muthi usiza ukuqinisa izinga le-glucose egazini, futhi ukhuphule ukusebenza kahle kokulashwa kokudla uma onesifo sikashukela ephethwe ukukhuluphala. Futhi, lapho usebenzisa i-Glidiab MV 30, inani eliphakeme kakhulu le-insulin secretion liyabuyiselwa.
Ngingawuthenga kanjani umuthi kaGlidiab? Ekhemisi, intengo yomuthi ingama-ruble ayi-120-200. Izindleko zizoncika kunani lesithako esisebenzayo kuthebhulethi. IGlidiab MB 30 mg no-80 mg iyatholakala ngokuhweba.
Indlela yokusebenza nezinkomba zokusetshenziswa
UGlidiab MV ngumenzeli we-hypoglycemic okuvela eqenjini lokuphuma kwe-sulfonylurea kwesizukulwane sesibili. Umuthi uqukethe i-gliclazide nabatholi. IGlyclazide kuthebhulethi eyodwa iqukethe ama-80 mg noma ama-30 mg.
Ngabe isakhi esisebenzayo somuthi sisebenza kanjani? I-Glyclazide phezu kokumuncwa ivusa imisipha ye-glycogen synthetase function secretion ne-insulin. Futhi, le nto ikhinyabeza umphumela wemfihlo we-insulin ye-glucose, futhi inomthelela ekwandeni kokuzwela kwezicubu zepherishi ku-insulin.
Ngaphezu kwalokho, i-gliclazide isiza ukunciphisa igebe phakathi kokudla ukudla kanye nokuqala kokukhululwa okusebenzayo kwe-insulin. Uma ubheka imiyalo okufanele isetshenziswe ku-Glidiab, ungathola ukuthi uma usebenzisa amaphilisi, inani le-hyperglycemia liyancipha, futhi inani eliphakeme lokuqala le-insulin secretion liyabuyiselwa.
Zonke lezi zinto zithinta ngqo i-carbohydrate metabolism kanye ne-microcirculation. Uma ukholelwa imiyalo, khona-ke i-Glidiab MV isiza ukunciphisa ukunamathela nokuhlanganiswa kwamaplatelet, futhi ngasikhathi sinye ukuvumeleka kokuqina kwemithambo. Kalula nje, ngokusetshenziswa kwamathebhulethi, amathuba okuthuthuka kwe-microthrombosis ne-atherosclerosis ancishiswa kakhulu.
Ucwaningo luphinde lwathola ukuthi i-ejog ye-hypoglycemic iyasiza ekunciphiseni ukuthuthukiswa kwezinkinga ezifana nesifo sikashukela sikashukela endaweni engeyona eyandayo. Ngaphezu kwalokho, ukusebenzisa amaphilisi we-Glidiab MV kungakhuphula kakhulu ukusebenza kokulashwa kokudla ezigulini eziphethwe ngokweqile.
Ngithanda ukuqaphela ukuthi ama-metabolites omuthi akhululwa kanye nomchamo ngendlela engashintshiwe, futhi nangama-ndondomu ngendlela yama-metabolites.
Imiyalo yokusebenzisa umuthi
Kukuziphi izimo lapho kusebenzisa khona amaphilisi we-Glidiab 80? Imiyalo ithi kungcono ukusebenzisa umuthi ekwelapheni uhlobo lwesifo sikashukela sohlobo 2, uma ukwelashwa kokudla kanye nokuzivocavoca umzimba kungasizi ukuqinisa amazinga kashukela.
Ngokuhlangana neminye imithi, i-Glidiab MB ayisetshenziswa kakhulu. Kepha kufanele kuqashelwe ukuthi umphumela we-hypoglycemic womuthi ungakhuphuka uma, kanye nokwelashwa kwezidakamizwa, ukudla nokudlala imidlalo kulinganiselwe.
Ungawaphuza kanjani umuthi? Umthamo wokuqala ngu-80 mg. Ngaphezu kwalokho, imvamisa yokusetshenziswa izikhathi 2 ngosuku - ekuseni nakusihlwa. Kunconywa ukuthatha amaphilisi imizuzu engama-30-60 ngaphambi kokudla.
Uma umthamo omncane we-80 mg awunamphumela we-hypoglycemic, khona-ke umthamo uyakhuphuka kancane kancane. Imvamisa, kwisifo sikashukela sohlobo 2, umthamo we-160 mg ulungile. Isilinganiso esiphezulu somuthi esivunyelwe yi-320 mg.
Kodwa kufanele sikhumbule ukuthi nge-doses eyandayo, amathuba okuqhubeka kwe-hypoglycemia nezinye izinkinga kukhuphuka kakhulu.
Ukusebenzelana kwezidakamizwa kanye ne-Contraindication
Kumele kukhunjulwe ukuthi iningi lezidakamizwa lingakhuphula umphumela we-hypoglycemic wezidakamizwa i-Glidiab MB. Ngakho-ke, imiyalo ibeka ukuthi umuthi kufanele uhlanganiswe ngokucophelela kakhulu ne-histamine H2-receptor blockers, izidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala, ama-antifungal agents, ama-inhibitors we-ACE.
Izidakamizwa ezilwa nesifo sofuba, i-beta-adrenoblockers, i-anticoagulants engaqondile, ama-anabolic steroid, ama-inhibitors we-MAO, ama-salicylates nabanye bayakwazi ukwandisa imiphumela ye-hypoglycemic.
Kungebangelo ngaphambi kokusebenzisa amaphilisi weGlidiab, kufanele utadishe imiyalo ngokucophelela bese uthintana nodokotela.
Phakathi kokuphikisana nokusetshenziswa kwamathebulethi kungabonakala:
- Uhlobo 1 sikashukela luthembele kwe-insulin.
- Isifo sikashukela sikashukela.
- Kuyathandeka noma kukhexile. Ngaphezu kwalokho, i-contraindication eqinile yi-hyperosmolar coma.
- I-Leukopenia
- Isikhathi sokukhulelwa.
- Isikhathi sokuzala.
- Ukwehluleka okukhulu kakhulu kwe-hepatic ne-reso.
- Izimo ezihambisana nokuphulwa kwenqubo yokufaka ukudla, kanye nokuthuthukiswa kwe-hypoglycemia. Izimo ezinjalo zifaka phakathi ukuvimbela kwamathumbu, i-paresis yesisu nezifo ezithathelanayo.
- Ukungezwani komzimba kwizakhi zamathebhulethi.
- Izimo lapho ukwelashwa kwe-insulin kungadingeka khona. Lezi zimo zifaka ukushiswa, ukulimala, noma ukuhlinzwa.
- Utshwala
- Isifo se-Febrile.
Futhi, isidakamizwa kufanele sisetshenziswe ngokuqapha kubantu abahlushwa ukungasebenzi kahle kwe-yegilo.
Ukubuyekezwa kanye nemiphumela emibi ye-Glidiab
Yini ukubuyekeza mayelana neGlidiab? Abantu abanesifo sikashukela baphendula kahle kulo muthi. Abantu abaningi bakhangwa yizindleko eziphansi zomuthi, nezinkomba zokusebenza okuphezulu.
Ngaphezu kwalokho, uGlidiab, ngokusho kwabanesifo sikashukela, muhle ngoba akuvamile ukuthi abangele imiphumela emithethweni ephansi. Enye imfanelo yomuthi kubantu iqiniso lokuthi kwandisa ukusebenza kahle kokulashwa kokudla.
Imiphi imiphumela emibi engadalwa umuthi we-hypoglycemic? Ngokusho kwemiyalo, umuthi ungadala:
- Ukwephulwa kohlelo lwe-endocrine. Zibonisa njenge-hypoglycemia. Kodwa kufanele kuqashelwe ukuthi le nkinga yenzeka kuphela ngomthamo okhethwe ngokungafanele womuthi.
- Ukucasuka, ukozela, ukuhlaselwa ngobudlova, ukuqhaqha kwamalunga, ikhanda, isiyezi, ukukhathala okwandayo.
- Kwehliswe ukubonwa okubonakalayo.
- Aphasia.
- Bradycardia
- Ukuphefumula okujulile.
- I-Delirium.
- I-Thrombocytopenia, i-anemia, i-leukopenia.
- Ukungezwani komzimba.
- Ukungasebenzi kahle kohlelo lokugaya. Umuntu angahlaselwa yisifo sohudo, umuzwa wobunzima esifundeni se-epigastric, isicanucanu, i-anorexia, i-cholestatic jaundice, umsebenzi owengeziwe wama-hepatic transaminases.
Imvamisa, imiphumela emibi iyazixazulula ngemuva kokuyekisa umuthi futhi ilashwa ngokufanele izimpawu.
I-analogue enhle kakhulu yeGlidiab
Iziphi izifaniso zikaGlidiab? Esikhundleni salokho, ama-ejenti ahlukahlukene we-hypoglycemic asuselwa ku-metformin hydrochloride angasetshenziswa. I-analog yeqembu eliphumelela kakhulu yiFomu. Lo muthi uyindawo enhle kaGlidiab.
Intengo yesidakamizwa icishe ibe ngama-ruble ayi-180-260. IFommetin itholakala kumthamo ka-500 mg, 850 mg no-1 gram. Iphakethe elilodwa liqukethe amaphilisi angama-60. Ukwakheka kwalesi sidakamizwa kufaka i-metformin hydrochloride, i-povidone, i-primellose, i-magnesium stearate.
Ngabe isakhi esisebenzayo se-formin sisebenza kanjani? Imiyalo ikhombisa ukuthi i-metformin hydrochloride ivimbela inqubo ye-gluconeogenesis esibindini, futhi isize ukunciphisa ukumuncwa kwe-glucose esiswini.
Futhi, isakhi esisebenzayo sandisa ukusetshenziswa kwe-glucose okuphathelene nokusizakala, futhi kusiza ukwandisa ukuzwela kwezicubu emiphumeleni ye-insulin. Kulokhu, i-metformin hydrochloride ayithinti inqubo yokugcinwa kwe-insulin ngamangqamuzana e-beta, ngenxa yokuthi amathuba okuba ne-hypoglycemia ancishisiwe.
Ngosizo lweFomuetin, uhlobo 2 lwesifo sikashukela lungalashwa. Ikakhulu ikakhulukazi, umuthi uyasetshenziswa lapho umuntu onesifo sikashukela ephethwe ukukhuluphala futhi ezimweni lapho ukwelashwa kokudla kungasizi ukuguqula amanani eglue kashukela. Ngithanda ukuqaphela ukuthi lesi sidakamizwa kwesinye isikhathi sisetshenziswa ngokuhlangana nezidakamizwa ezihlobene nokutholwa kwe-sulfonylurea.
Ungayithatha kanjani i-formin? Umthamo wokuqala ngu-1000-1700 mg ngosuku. Ngaphezu kwalokho, umthamo uhlukaniswe ngemithamo emi-2. Kungcono ukuthatha amaphilisi ngemuva kokudla nenani elikhulu lamanzi.
Uma ushukela wegazi ungazinzile, khona-ke isilinganiso siyakhuphuka kancane kancane sibe amagremu ama-2-3 ngosuku. Umthamo omkhulu ovunyelwe nsuku zonke weFomuetin amagremu ama-3, hhayi ngaphezulu. Kepha iziguli esezikhulile ziyanconywa ukuthi zingadli u-gram ongaphezu kuka-1 ngosuku.
Ukuxhumana kokusetshenziswa kwesidakamizwa:
- Ukungezwani komzimba kwizakhi.
- Umsebenzi wezinso ongalungile.
- Isigaba esibi se-myocardial infarction.
- Ukomisa.
- Ukuhluleka kwenhliziyo noma ukuphefumula.
- Ingozi ye-Cerebrovascular.
- Uphuzo oludakayo
- Ukukhulelwa nokukhulelwa.
- Izimo lapho kunesidingo sokusetshenziswa kwe-insulin. Kungaba ukulimala okukhulu, ukusha noma ukungenelela kokuhlinzwa.
- I-Lactic acidosis.
- Ukuhambisana nokudla okuqinile, okunikezela ukuncishiswa kwama-kilojoule nsuku zonke kuya kuma-kilocalories ayi-1000.
- Faka isicelo ezinsukwini ezi-2 zokugcina ze-x-ray zezifundo ngokufakwa kwento equkethe iodine equkethe okuthile. Ngendlela, umuthi akufanele udliwe ezinsukwini ezi-2 ngaphambi kokuhlolwa okunjalo kwe-X-ray.
Phakathi kwemiphumela emibi yesidakamizwa, kunokuphazamiseka ekusebenzeni kwendlela yokugaya ukudla, ukuphazamiseka kwe-metabolic, i-anemia, i-hypoglycemia kanye ne-allergic reaction. Ividiyo ekulesi sihloko izokutshela ukuthi imiphi imithi yesifo sikashukela.
