Isifo sikashukela i-mellitus sibhekwa njengenye yezindlela ezivame kakhulu emhlabeni. E-Russian Federation, cishe izizigidi eziyishumi ezihlaselwa yilesi sifo. Abaningi babo bakhetha ukusebenzisa umuthi uJardins ngenxa yokusebenza kwawo.
Igama
Igama lesiLatini yiJardiance. Isidakamizwa se-INN: Empagliflozin (Empagliflozin).
UJardins unomphumela we-antidiabetes.
I-ATX
Ukuhlukaniswa kwe-ATX: A10BK03.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo samaphilisi anyibilikisiwe. Ithebhulethi eyi-1 iqukethe u-25 noma u-10 mg we-empagliflozin (isithako esisebenzayo). Ezinye izinto:
- i-talc;
- titanium dioxide;
- i-iron iron oxide (udayi);
- i-lactose monohydrate;
- i-hyprolosis;
- i-cellulose microcrystals.
Umuthi uyatholakala ngesimo samaphilisi anyibilikisiwe.
Ithebhulethi zigcwele emabhulashini ama-10 ama-pcs. Ibhokisi eli-1 liqukethe amanxeba ama-1 noma ama-3.
Isenzo se-Pharmacological
Umuthi unomphumela we-antidiabetes. Igculisa igazi lesiguli ngesifo sikashukela sohlobo 2 ngesilinganiso esifanele seglucose.
Umuthi osebenzayo wesidakamizwa ugcizelela izinga le-dextrose ku-serum yegazi. Ngaphezu kwalokho, into exhomeke nge-insulin inciphisa amathuba we-hypoglycemia. Umgomo wesenzo somuthi awuxhomekile kumetabolism ye-insulin nomsebenzi wama-islets weLangerhans. Imiphumela yocwaningo oluningi ikhombisa ukuthi kuma-diabetes (nge-Type 2 pathology), umthamo we-glucose ocishwe emzimbeni ukhuphuke ngemuva kokuthatha ithebhulethi eyi-1.
Umuthi osebenzayo wesidakamizwa ugcizelela izinga le-dextrose ku-serum yegazi.
Umuthi kwesinye isikhathi uvame ukusetshenziselwa ukunciphisa isisindo, njengoba ukususwa kakhulu kwe-glucose emzimbeni kuholela ekushisweni kwamakhalori ngokushesha.
I-Pharmacokinetics
Umuthi udonswa ezinso, ngakho-ke abavunyelwe ukuwusebenzisa ezigulini ezine-renal pathologies. I-dextrose eyeqile yethulwe umchamo. Into esebenzayo ifinyelela ekuhlushweni kwayo okuphezulu ngemuva kwamahora angu-1.5-2. Isikhathi sokuphila senqubo singamahora ayi-12.
Izici ze-pharmacokinetic zomuthi azithinteki ngenxa yohlanga, isisindo somzimba, ubulili nobudala besiguli.
Izinkomba zokusetshenziswa
Umuthi usetshenziselwa ukwelapha iziguli ezinesifo sikashukela sohlobo 2:
- ezimweni uma ukwelashwa okusetshenzisiwe kunganikeli umphumela omuhle noma njengengxenye yokwelashwa okuhlanganisayo nemithi ye-Insulin ne-hypoglycemic (Glimepiride, njll);
- nge-glycemia engalawulwa ngokuhlanganiswa kokudla nokuzivocavoca okukhethekile, kanye nokuzwela okwengeziwe kwe-Metformin - ngesimo se-monotherapy.
Umuthi usetshenziselwa ukwelapha iziguli ezinesifo sikashukela sohlobo 2.
Contraindication
- ukungabekezelelani ngakunye;
- ukucaphuna nokukhulelwa;
- uhlobo lwesifo sikashukela se-ketoacidosis;
- ukwehluleka kwesifo sezinso okwenzeka kakhulu;
- thayipha i-1 isifo sikashukela;
- ungaphansi kweminyaka eyi-18 nangaphezulu kweminyaka engama-85;
- inhlanganisela ne-GLP-1.
Ngokunakekela
Umuthi unqunywa ngokucophelela lapho:
- umsebenzi oyimfihlo ongaphansi wamaseli akhiwe kumanyikwe;
- ukuhlanganiswa kwe-sulfonylurea kanye ne-insulin;
- izifo zesisu, kuphakamisa ukulahleka okukhulu koketshezi;
- ukuguga.
Imithamo nokuphatha
Amaphilisi athathwa ngomlomo. Umthamo wokuqala ngu-10 mg 1 isikhathi ngosuku. Uma leli nani lemithi lingakwazi ukuhlinzeka ngokulawulwa kwe-glycemic, khona-ke umthamo ukhuphuka ufike kuma-25 mg. Isilinganiso esiphezulu ngu-25 mg / ngosuku.
Amaphilisi athathwa ngomlomo.
Ukusetshenziswa kwamathebhulethi akuxhunyiwe esikhathini sosuku noma ekudleni kokudla. Kuyinto engathandeki ngosuku olu-1 ukufaka umthamo ophindwe kabili.
Ukwelashwa Kwesifo Sikashukela okwenziwa uJardins
Izivivinyo zomtholampilo ziveze ukuthi umuthi okukhulunywa ngawo uwukuphela kwesidakamizwa ekwelapheni isifo sikashukela i-mellitus (uhlobo II), lapho izingozi zokuthola izifo zeCVD kanye namazinga okushona okuvela kulawo ma-pathologies ancishisiwe. Kwenqatshelwe ukusebenzisa umuthi weziguli ezinesifo sikashukela sohlobo 1.
Imiphumela emibi
Lapho usebenzisa umuthi esigulini, kuboniswa okungekuhle okulandelayo. Uma kwenzeka, kufanele uyeke ukuthatha umuthi futhi ubonane nodokotela.
Amapheshana wesisu
- isicanucanu
- ukuhlanza
- ukungakhululeki esiswini.
Engxenyeni yesikhumba namafutha angaphansi
- ukulunywa
- ukukhonkotha;
- imishayo;
- ukudumba;
- ubomvu.
Isistimu yezinzwa ephakathi
- ikhanda
- ukozela
- ukuvuka.
Kusuka ohlelweni lomchamo
- ukuchama njalo;
- dysuria;
- i-urology ye-pathology;
- izifo zangasese kwabesifazane;
Kusuka ohlelweni lwezinhliziyo
- izimo zokwehluleka;
- ukuncipha kwengcindezi yegazi;
- i-hypovolemia;
- ukomisa.
Ngasohlangothini lwe-metabolism
- i-hypoglycemia, eyenzeka lapho umuthi uhlanganiswa nezinsizakalo ze-insulin ne-sulfonylurea.
Imiyalo ekhethekile
Ngokubonakala kobuhlungu besisu, ukugabha, isicanucanu, ukoma kanye nezinye izinkinga, kufanele kubhekwe ukuthi kungenzeka ukuthi unesifo sikashukela se-ketoacidosis.
Ukuhambisana notshwala
Kwenqatshelwe ukuphuza utshwala ngenkathi ulashwa nomuthi.
Kwenqatshelwe ukuphuza utshwala ngenkathi ulashwa nomuthi.
Umthelela ekhonweni lokulawula izindlela
Lapho usebenzisa umuthi, kufanele kuqashelwe ngokwedlulele lapho wenza umsebenzi ongaba yingozi futhi ushayela izimoto.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Kuyenqatshelwa ukuthatha nge-lactation nokukhulelwa. Ezimweni ezihlukile, ukuncelisa ibele kufanele kuyekwe.
Ukuqokwa kukaJardins ezinganeni
Amaphilisi we-film-camera aqoshwe ukuthi asetshenziswa ezinsaneni nasezinganeni.
Sebenzisa ebudaleni
Ebudaleni, ukuphuza umuthi kufanele kube ngokuqapha ngokweqile nangaphansi kokuqondisa udokotela.
Kwenqatshelwe ukusebenzisa amaphilisi okwehluleka kwesibindi okukhulu.
Sebenzisa umsebenzi wesibindi okhubazekile
Kwenqatshelwe ukusebenzisa amaphilisi okwehluleka kwesibindi okukhulu.
Sebenzisa umsebenzi wezinso ongasebenzi kahle
Kuphikiswa ukuthi kuthathwe amaphilisi okwehluleka kakhulu noma kwehluleke kakhulu kwe-renal kanye nokukhubazeka okuphambili kwezinso.
Ukweqisa
Izifundo zemitholampilo azizange zibhale amacala okuphendula okungathandeki nge-overdose yomuthi. Ezimweni ezingavamile, kunengozi yokusabela okungekuhle okwenyukayo. Uma umthamo wedluliwe, kunconywa ukuthi uhlambe isisu bese uhlola ushukela we-serum. Ukwelashwa okuthe xaxa kuyimpawu.
Uma umthamo wedlulisiwe, kunconywa ukuhlanza isisu.
Ukuxhumana nezinye izidakamizwa
Yandisa umsebenzi we-diuretics, okungaholela ekwakhiweni kwe-hypotension kanye nokuphelelwa ngamandla komzimba. Ukulungiswa kwe-insulin kungavusa i-hypoglycemia ngokuhambisana namaphilisi okukhulunywa ngawo.
Into esebenzayo yesidakamizwa ayizithinti izakhiwo zeTorasemide, iRamipril, iDigoxin, iPioglitazone, Foorsig neMetformin. Ngokuvamile, lapho kuhlangene, ukulungiswa kwamthamo akudingeki.
Ama-Analog
Emakethe yezokwelapha yeRussian Federation azikho izidakamizwa ezenziwe ngesisekelo sezinto ezifanayo. Ezinye izidakamizwa ze-hypoglycemic zinemigomo ehlukile yokwenza. Lokhu kufaka phakathi:
- I-Diaglinide;
- I-NovoNorm.
Ukuthenga umuthi, udinga ukuthola ukunikezwa kadokotela kusuka kudokotela.
Imibandela yekhefu lekhemisi
Ukuthenga umuthi, udinga ukuthola ukunikezwa kadokotela kusuka kudokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Ngaphandle komuthi, umuthi awunakuthengwa.
Intengo kaJardins
Ukusuka kuma-ruble angama-2600 ngephakethe ngalinye (amaphilisi angama-30 we-10 mg). Iphakethe lamaphilisi ayi-10 libiza kusuka kuma-ruble ayi-1100.
Izimo zokugcina zomuthi
Emazingeni okushisa angadluli ku + 25 ° C, endaweni emnyama, eyomile futhi epholile.
Isikhathi sokuphelelwa yisikhathi
Kufika eminyakeni emi-3 kusukela ngosuku lokukhiqizwa.
Ubufakazi bodokotela neziguli ngoJardins
UGalina Aleksanina (owelaphi), oneminyaka engama-45 ubudala, eSt.
Ikhambi eliphephile elingabangeli imiphumela emibi (ekusebenzeni kwami). Izindleko eziphakeme zivunyelwe ngokuphelele ngomsebenzi we-pharmacological wesidakamizwa. Umphumela we-placebo unqunyelwe ngokuphelele. Ngaphezu kwalokho, akanazo iziphikiso eRussia, futhi izidakamizwa ezifanayo zisebenza ngokuhlukile.
U-Anton Kalinkin, oneminyaka engama-43, uVoronezh.
Ithuluzi lihle. Mina, njengesifo sikashukela esinolwazi, ngiyaneliseka ngokuphelele ngesenzo salo. Into ebaluleke kakhulu ukutadisha ngokucophelela imiyalo esetshenzisiwe. Kulesi simo kuphela lapho imiphumela emibi ingagwenywa, eqinisekiswa uqobo ekusebenzeni. Phakathi kokushiyeka, umuntu angahlukanisa kuphela izindleko eziphakeme nokuthi iqiniso lokuthi umuthi awuthengiswa kuwo wonke amakhemisi.
