Isifo sikashukela i-mellitus kungaholela ekubhujisweni kwezicubu zezitho eziningi zomzimba. Kubalulekile ukulawula izinga likashukela egazini, ukuligcina lisesezingeni elifanele. Kulokhu, iziguli zinqunyelwe izidakamizwa ezinciphisa ukuqina kwayo. Izidakamizwa ezidumile kakhulu yiMetformin noGlformin.
Isimilo se-Gliformin
Lesi sidakamizwa kungokwama-biguanides, enzelwe ukwelapha isifo sikashukela. Into yayo eyinhloko yi-metformin. Indlela yokukhishwa kwesidakamizwa ngamathebulethi. Thatha i-glyformin ngaphakathi. Inqanda ukwakheka koshukela esibindini futhi ithuthukise ukwehlukana kwayo. Idizayinelwe isifo sikashukela sohlobo 2.
Izidakamizwa ezaziwa kakhulu zokwehlisa ushukela wegazi yiMetformin ne-Gliformin.
Umuthi ubopha kangcono i-insulin namaseli azwelayo kuwo. Umuthi usiza ukwehlisa isifiso sokudla, ngakho-ke iziguli ezinokukhuluphala ngokweqile zehlisa isisindo. Lokhu kuchazwa yiqiniso lokuthi amazinga we-plasma we-cholesterol ne-triglycerides ancishisiwe. Isenzo salo muthi sihloselwe ukuqeda ukuhlukaniswa kwegazi nokunciphisa ingozi yokunamathela kwe-platelet. Kwehlisa ngempumelelo inani loshukela egazini.
Izinkomba zokusetshenziswa kweGliformin zingokulandelayo:
- uhlobo 2 sikashukela;
- ukusebenza kahle kwe-sulfonylurea;
- ngesifo sikashukela sohlobo 1 - njengethuluzi elingeziwe ekwelapheni okuyinhloko.
Contraindication ifaka:
- okomuntu onesifo sikashukela;
- ukwephulwa kwesibindi nezinso;
- ukwehluleka kwamaphaphu, infarction e-acute myocardial;
- ukukhulelwa nokuqunjelwa;
- uphuzo oludakayo ngenxa yokuba khona kokudakwa okuyi-acute;
- ukulimala okukhulu;
- Ukungenelela kokuhlinzwa, lapho i-insulin yelashwa khona;
- isifo sikashukela sikashukela;
- ukungabekezelelani komuntu ngamunye ezingxenyeni zomkhiqizo;
- ukunamathela ekudleni okuphansi kwekhalori.
Uma kunesifundo se-X-ray sisebenzisa umehluko, khona-ke izinsuku ezimbili ngaphambi kokuba umuthi umiswe ukuthathwa. Qhubeka nokwelashwa nomuthi ezinsukwini ezi-2 emva kokuhlolwa.
Ukuthatha i-Gliformin kwesinye isikhathi kuholela ekuthuthukisweni kwemiphumela emibi elandelayo:
- ukunambitheka kwensimbi emlonyeni;
- isikhumba ukuqubuka komzimba;
- isicanucanu
- ukulahleka kwesifiso
- i-lactic acidosis;
- i-malabsorption ye-vithamini B12;
- i-hypoglycemia;
- i-megaloblastic anemia.
Umkhiqizi weGliformin ngu-Akrikhin HFK, OJSC, eRussia. Kukhona esikhundleni salolu muthi, olunqunywe ngudokotela. Ukufana kwemithi kufaka phakathi:
- I-Metformin;
- IGlucophage;
- Siofor.
IGlucophage ingenye yezimpawu zikaGlyformin.
Izici zeMetformin
Lesi sidakamizwa esise-hypoglycemic esinciphisa ushukela wegazi ngohlobo 2 sikashukela. Isakhi sayo esikhulu yi-metformin hydrochloride. Kuyatholakala ngesimo sethebhulethi.
Umuthi unezakhiwo ezilandelayo:
- kunciphisa ukufakwa kweglucose egazini kusuka ku-lumen yamathumbu;
- kusebenze ukusetshenziswa kwama-carbohydrate, okwenzeka izicubu zomzimba;
- kwandisa ukuzwela kwezicubu receptors ku-insulin.
I-Metformin ayithinti amaseli we-pancreas, abhekele ukwakheka kwe-insulin, futhi futhi ayiholeli ku-hypoglycemia. Faka isicelo futhi ulahlekelwe isisindo.
I-Metformin iyatholakala ngesimo sethebulethi.
Umuthi unqunywe emacaleni alandelayo:
- Uhlobo 2 isifo sikashukela i-mellitus, uma ukwelashwa kokudla kungaphumelelanga;
- kanye ne-insulin - nesifo sikashukela sohlobo 2, ikakhulukazi uma isiguli sinezinga lokukhathazeka ngokweqile.
Kunokuphikisana okuningi ukwelashwa nalesi sidakamizwa:
- isifo sikashukela, ukoma;
- i-infraction ye-myocardial eyingozi, ukwehluleka kwenhliziyo;
- izifo ze-bronchi namaphaphu, i-sepsis, ukushaqeka;
- ukomisa;
- umkhuhlane
- umsebenzi wezinso ongonakalisiwe;
- izifo ezithathelwanayo ezinzima;
- ukungenelela kokuhlinzwa nokulimala;
- ubuthi obukhulu nge-ethyl utshwala, ukuluthwa utshwala okungapheli;
- ukukhulelwa nokuqunjelwa;
- ukuzwela ngokweqile izingxenye zomkhiqizo;
- ukunamathela ekudleni okuphansi kwekhalori.
Kwenqatshelwe ukuthatha iMetformin kubantu abaneminyaka engaphezu kwengu-60 ubudala umsebenzi wabo ohambisana nokusebenza kanzima ngokomzimba, ngoba kungenzeka ukuthi i-lactic acidosis yenzeke.
Umuthi ungaholela ekubonakaleni kwemiphumela emibi evela ezinhlelweni eziningi zomzimba:
- ukugaya: isicanucanu, ukuhlanza, Ubuhlungu besisu, uhudo, ukuntuleka kokudla;
- i-hematopoietic: i-megaloblastic anemia;
- i-endocrine: hypoglycemia.
Kuyaqabukela, kusuka ohlangothini lwe-metabolism, ukuthuthukiswa kwe-lactic acidosis kanye nokumuncwa kwe-vitamini B12 kuyabonakala. Ukuvela komzimba ngesimo sokuqhuma kwesikhumba kungavela.
Umenzi weMetformin nguHemofarm A.D., Serbia. Ukufana kwalo kubandakanya izidakamizwa:
- IFommetin;
- IGlucophage;
- Metfogamm;
- Glyformin;
- ISofamet.
ISofamet ingesinye sezifanekiso zeMetformin.
Ukuqhathaniswa kweGlformin neMetformin
Zombili lezi zidakamizwa zinomphumela ofanayo, kepha kukhona umehluko phakathi kwazo.
Ukufana
IGliformin neMetformin zingama-analogues ahlelekile futhi izidakamizwa ze-hypoglycemic ezithathwa ngomlomo. Kutholakala ngesimo samathebulethi, ukwakheka kumelwa yinto efanayo esebenzayo. Imikhiqizo yezokwelapha iyathengiswa emaphaketheni ekhadibhodi.
Ingxenye esebenzayo yezidakamizwa isiza ukuguqula ushukela wegazi ngokujwayelekile. Ukuthatha le mishanguzo akukona ukukhuthaza ukukhiqizwa kwe-insulin, ngakho-ke akukho bungozi bokwehla ngokushesha ushukela. Baphinde banconywe ngabezempilo zokudla ukunciphisa umzimba.
IGliformin neMetformin zihlanganiswe nezinye izidakamizwa ze-hypoglycemic.
Kuyenqatshelwa ukubaphuza ngotshwala, ngaphandle kwalokho i-lactic acidosis ingahle ikhule.
Banokuphikisana okuningi.
Uyini umehluko
Izidakamizwa zingabakhiqizi abahlukile nezindleko. I-Gliformin ithathwa njengohlobo 1 nohlobo 2 lwesifo sikashukela, kuthi iMetformin isetshenziselwe uhlobo 2 sikashukela.
Yikuphi okushibhile
Izindleko ezijwayelekile zeGlformin ngama-ruble angama-230, iMetformin ngama-ruble angama-440.
Yikuphi okungcono - i-Gliformin noma iMetformin
Udokotela, ekunqumeni ukuthi yisiphi isidakamizwa esinezinkomba ezingcono - uGliformin noma iMetformin, unaka amaphuzu amaningi:
- inkambo yesifo;
- izici zomzimba wesiguli;
- contraindication.
Zinezinkomba ezifanayo zokusetshenziswa, ngakho-ke izidakamizwa zingashintshwa nomunye. Ngokwesifo sikashukela sohlobo 1, iMetformin ivunyelwe.
Ukubuyekezwa kweziguli
U-Irina, oneminyaka engama-56, uVladivostok: "Ngibhaliswe kudokotela obulala isifo sikashukela sohlobo 2 isikhathi eside. Bengilokhu ngidla izidakamizwa ezahlukahlukene ngaso sonke lesi sikhathi, futhi muva nje udokotela ebekise uGliformin. Angikaze ngibe nokuthile okungahambi kahle ngesikhathi sokuthatha. Ukulawula ushukela wegazi lami, anginikezeli Izikhathi ezi-3 ngeviki. Umuthi awusizi, izinga likashukela liphansi kunangaphambi kokuba lisebenzise. "
UValentina, oneminyaka engama-35, uSamara: "Ngitholile kahle ngemuva kokuzalwa kwesibili. Angithandi ukuya emidlalweni, angikwazi ukudla ukudla okuqinile. Umngani wami uncoma uMetformin. Ezinsukwini zokuqala zokwelashwa, kwaba nobuthakathaka obukhali futhi ngaba nenhliziyo encane yokuhlanza. Umzimba wabe usujwayele lo makhambi futhi konke lokho Izimpawu zanyamalala. Emavikini ama-3 bakwazile ukwehla ngo-12 kg. "
Odokotela babuyekeza ngeGlformin neMetformin
U-Ana, owezokwelapha, uKazan: "Ngincoma umuthi iGlyformin kwiziguli eziningi zokunciphisa isisindo. Kwenqatshelwe ukusithatha ngaphandle kokubhekwa kwezokwelashwa, ngoba kungaba yingozi empilweni. Uma kuthathwe ngendlela efanele, ukukhiqizwa kwe-oxidation kuyasheshiswa, futhi ukugayeka kwama-carbohydrate emgodini wokugaya ukudla kuyancishiswa. awukwazi ukudla ngaphezu kwamaviki amathathu ngoba imiphumela emibi ayikhishwa. "
U-Elena, udokotela we-endocrinologist, eYekaterinburg: "Engikwenzayo, ngivame ukunikela ngeMetformin yohlobo lwe-2 yesifo sikashukela, ukubekezelela okungahambi kahle kuma-carbohydrate, iziguli ezinesifo se-hypothyroidism. Ngikuncoma kakhulu ezigulini ezikhuluphele kakhulu futhi ezinesifo sokuqaqamba kwamalunga ngokumelana ne-insulin, ngoba kwandisa amathuba okukhulelwa. Isifo sohudo singabonakala ekuqaleni kokwelashwa. "
