Umuthi olwa nama-antidiabetesic uHumulin NPH wenzelwe ukugcina ushukela egazini ngezinga elijwayelekile, unesikhathi esilinganiselwe sokwenza.
Igama Lezwe elingafanele
I-Humulin NPH, njengesidakamizwa esinefomula yamakhemikhali engenakuphikiswa, inikezwe i-International Nonpuffetary Igama - i-Insulin-Isophan (Ubunjiniyela Bofuzo Babantu).
Futhi, lesi sidakamizwa sihambisana negama lokuhweba elithi Humulin® NPH negama lesiLatini elithi Insulinum isophanum (i-humanum biosynt syntum).
I-Humulin NPH yakhelwe ukugcina ushukela wegazi ezingeni elijwayelekile futhi inobude besikhathi besenzo.
I-ATX
Umuthi uhambelana nekhodi i-A10AC01, okusho ukuthi kungokwesigaba sokufakwa kwabantu ezimiseni ngabantu.
Khipha amafomu nokwakheka
Ukwakheka kwalesi sidakamizwa njengento esemqoka kufaka i-insulin yomuntu kumthamo we-100 IU / ml. Ukuqinisekisa izakhiwo ezidingekayo, ifomu lomthamo lihlanganiswa nezinto ezisizayo: i-metacresol, phenol, glycerol, protamine sulfate, sodium hydrogen phosphate heptahydrate, zinc oxide, hydrochloric acid solution, solution ye-sodium hydroxide namanzi.
Umuthi ufakelwe ku-vials (10 ml) kanye nama-cartridge (3 ml) wengilazi engathathi hlangothi. Izindondo ze-1 pc. ibekwe emabhokisini amakhadibhodi, kanye nama-cartridge we-5 PC. ibekwe emabhulashini. Ukwahluka kungenzeka lapho kuthengiswa khona amabhokhethi angakakhiwa emapeni wesirinji (emabhokisini ama-5 PC.).
Ukumiswa
Okokulawula okungaphansi. Lokhu kumiswa okumhlophe kungahle kudungeke ukwakha i-white precipitate kanye noluketshezi olucacile, ongenawo umbala noma ocishe ube nombala ungqimba olungaphezulu. Ngaphambi kokuwusebenzisa, hlikihla umuthi ngobumnene kuze kutholakale uketshezi oluningi.
Umuthi ufakelwe emabhodleleni (10 ml) naku-cartridge (3 ml) wengilazi engathathi hlangothi, ukwakheka kufaka i-insulin yomuntu kumthamo we-100 IU / ml.
Isenzo se-Pharmacological
Lo muthi yi-DNA ephindaphindayo insulin yabantu, isetshenziswa njengesiqondisi se-glucose metabolism. Izici ze-Anabolic ziphawulwa njengezengeziwe kuHumulin NPH. I-insulin inegalelo ekuhanjisweni okusheshayo kwe-glucose ne-amino acid kwezicubu zomzimba ezithweni zomzimba (ngaphandle kwengqondo), kanye nokwanda kwe-protein anabolism. Ngenxa ye-insulin, ushukela uguqulwa esibindini uye ku-glycogen. Umuthi usebenza njenge-inhibitor ye-gluconeogenesis futhi usiza ukuguqula ushukela ngokweqile abe ngamafutha.
I-Pharmacokinetics
Umuthi uqala ukusebenza imizuzu engama-50-60 ngemuva kokuphatha, usebenza kahle kakhulu esikhathini esivela ehoreni lesibili ngemuva kokuphatha, ubude besikhathi sokuvezwa kungamahora angama-18-20.
Ukusebenza kanye nokuphelele kokufakwa kwesidakamizwa kuthintwa yindawo yomjovo, umthamo kanye nokuhlushwa. Kubonakala ngokusabalalisa okungalingani ngaphezulu kwezicubu zomzimba. Ucwaningo luqinisekisile ukungabikho kweHumulin NPH obisini lwebele nokuhluleka kwalo ukungena ekuvinjelweni kwe-placental. I-30-80% idlulwa yizinso.
Izinkomba zokusetshenziswa
Umuthi unqunyelwe uhlobo lwe-1 kanye nohlobo 2 lwesifo sikashukela, kanye nangesikhathi sokukhulelwa, okwenzeka ngohlobo lwe-2 mellitus yesifo sikashukela.
Umuthi i-Humulin NPH umiselwe uhlobo 1 nesifo sikashukela sohlobo 2.
Contraindication
Ukusetshenziswa kweHumulin NPH kuyaphikiswa uma kwenzeka kuyi-hypoglycemia nangokuzwela okwengeziwe kwe-insulin kanye nanoma yikuphi okutholwayo ekwakhekeni kwalo muthi.
Ngokunakekela
Ngesikhathi sokukhulelwa nokuncelisa, isidingo samazinga we-insulin singashintsha, ngenxa yalokho kuyadingeka ukuthi uqaphele ngokuthatha imishanguzo, ubheke isimo futhi ulungise imithamo uma kunesidingo.
Ungayithatha kanjani iHululin NPH
Umthamo wesidakamizwa unqunywe udokotela futhi kuya kokuqukethwe kweglucose egazini. Ukuphathwa kwe-intramuscular of Umuthi kuvunyelwe, noma kunjalo, indlela eyinhloko ukujova ngaphansi kwesikhumba ezinqeni, ehlombe, ethangeni noma esiswini. Kuyenqatshelwa ukungena ngokungena ngaphakathi.
Ngaphambi kokuphathwa, izinga lokushisa lokumiswa lilethwa ekushiseni kwamakamelo, amasayithi womjovo ayaguqulwa ngaphandle kokusebenzisa indawo efanayo isikhathi esingaphezu kwe-1 ngenyanga. Ngokuphathwa kwe-subcutaneous, kuyadingeka ukuqinisekisa ukuthi imithambo yegazi ayithinteki. Indawo yomjovo ngemuva kokuthi umjovo ungahlungwa.
Ngoshukela
Ngaphambi kokuphatha, i-insulin kumele ivuselelwe, lapho amabhodlela egingqwa kaningi ezandleni, futhi ama-cartridge aqokelelwa amahlandla ayishumi ezintendeni zezandla zawo, bese ephendulwa amanye amahlandla ayi-10 nge-180 °. Ukwakheka kufanele kubonakale kungamanzi ajwayelekile we-turbid. Awukwazi ukushukumisa umkhiqizo ngamandla ukuze amagwebu angaveli, ophazamisa isethi efanele. Ngaphambi komjovo, isiguli kumele sifunde imiyalo yokuphatha i-insulin ngepeni yesirinji.
I-Syringe pen Use umhlahlandlela
Ipeni elisheshayo kulula futhi kulula ukulisebenzisa. Ukwethulwa kwe-insulin kwenziwa ngezigaba eziningana.
- Ngemuva kokugeza izandla zakho kahle, khetha indawo yomjovo bese uyesula.
- Susa isicephu sepeni yesirinji ngokuyihudula, kepha hhayi ukujikeleza. Ungayisusi ilebula. Qinisekisa ukuthi i-insulin ihlangabezana nazo zonke izinto ezidingekayo (uhlobo, usuku, ukubukeka). Phinda usebenzise ikhambi.
- Lungisa inaliti entsha ngokususa ilebula lephepha kwikholamu yangaphandle. Sula idiski yerabha esicucwini se-cartridge ephethe ngotshwala, bese ufaka inaliti, okuyi-cap, ngqo eduze ne-eksisi epeni lesirinji. Skena ngenaliti uze ujoyine ngokuphelele.
- Susa isicephu esingaphandle ekugcineni kwenaliti, kepha ungalahli, bese ususa cap yangaphakathi uyilahle.
- Hlola ukungena kwe-insulin kusuka kusirinji yepeni esheshayo.
- Faka inaliti ngaphansi kwesikhumba, ulandela inqubo enconywe udokotela ohambelayo. Cindezela ngokuqinile inkinobho yokujova kwezidakamizwa ngokuqinile ngesithupha sakho. Ukufaka umthamo ngokuphelele, inkinobho ibanjelwa ekubaleni kancane kwe-5.
- Ngemuva kokususa inaliti, cindezela ngokucophelela indawo yomjovo nge-swab yoboya bekotini, ngaphandle kokuyihlikihla.
- Khipha inaliti nge-cap futhi uyilahle.
I-Humulin NPH ingena ngaphansi kwesikhumba, kulandela inqubo enconywe udokotela oholayo, cindezela inkinobho yomjovo omncane ngesithupha.
Imiphumela emibi yeHumulin NPH
Uhlelo lwe-Endocrine
Umphumela wecala ongaba khona njengomphumela womphumela omkhulu womuthi yi-hypoglycemia. Ezimweni ezimbi kakhulu, lesi simo kungaholela ekutheni ukhubazeke kakhulu emzimbeni futhi ulahlekelwe ukwazi, futhi esimweni esiyingqayizivele, ekufeni.
Allergies
Ukubonakaliswa kokuphendula okwenziwa yindawo yonke, okuvezwa ubomvu, ukuvuvukala nokulunywa esakhiweni somjovo, kungenzeka. Kulokhu, udinga ukuthi uqiniseke ukuthi ukusabela kubangelwa umuthi, hhayi ngokungezwani nomuntu ohlanzayo noma ezinye izinto.
Ezimweni ezingafane zivele, ukubonakaliswa kokusabela okuqinile kakhulu komzimba ngendlela yokumiswa okubanzi, ukuphefumula, ukuphefumula, ukuncipha kwegazi, ukukhuphuka kwenhliziyo nokwanda kokujuluka kungenzeka. Izimo ezinjalo zingasongela impilo futhi zidinga ukwelashwa ngokushesha. Kungase kudingeke ukuthi ushintshe umuthi noma wenze i-desensitization.
Kuyaqabukela (kungenzeka ngamathuba we-0.001-0.01%) lipodystrophy eba.
Umthelela ekhonweni lokulawula izindlela
Ukuthatha lo muthi akukuthinti ukuphathwa kwezokuhamba nezinye izindlela. Kodwa-ke, umphumela ongemuhle unomphumela oseceleni - i-hypoglycemia, ebonakala ngokunakwa okuphazamisekile, noma ukulahleka kwengqondo kungenzeka.
Imiyalo ekhethekile
Ukulungiswa kwemithamo ohlangothini lokwenyusa kungadingeka lapho uguqula ukondleka, ukhulisa noma uncipha umsebenzi ngokomzimba, ukucindezeleka ngokomzwelo. Ukulungiswa komthamo ohlangothini lokuncishiswa kungadingeka uma kungasebenzi kahle i-thyroid gland, i-pituitary gland kanye nezindlala ze-adrenal.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Imvamisa isidingo se-insulin sincishiswa ngesikhathi se-trimester yokuqala futhi sikhuphuke ngesikhathi sesibili nesesithathu, ngakho-ke kubalulekile ukuqapha izinkomba. Xhumana nodokotela wakho ngalo lonke ushintsho ekwelashweni. Ukukhulelwa nokuhlelelwa kwayo kufanele kuxoxwe nochwepheshe ngokushesha okukhulu.
Ngesikhathi sokukhishwa komzimba, ushintsho lomthamo lungadingeka.
Isicelo sokusebenza kokulimala kwezinso
Isidingo se-insulin singancipha; ukulungiswa komthamo kuzodingeka.
Sebenzisa umsebenzi wesibindi okhubazekile
Isidingo se-insulin singancipha; ukulungiswa komthamo kuzodingeka.
Ukweqisa kwe-Humulin NPH
Uma izinga le-insulin egazini lingahambisani nokudla okwamukelwayo kanye nokusebenzisa amandla, i-hypoglycemia kungenzeka, okukhonjiswa ngokubulawa ngamandla, ukujuluka ngokweqile, i-tachycardia, isikhumba, ikhanda, ukuqhaqhazela, ukugabha nokudideka. Ubukhulu kanye nesethi yezimpawu ezandulelayo ze-hypoglycemia zingahluka ngokuya ngezimo.
Ukuxhumana nezinye izidakamizwa
Umphumela we-hypoglycemic we-insulin ukhuliswa izidakamizwa ze-hypoglycemic zomlomo, ama-inhibitors we-MAO, ama-inhibitors we-carbonic anhydrase inhibitors, ama-beta-adrenergic blocking agents, i-bromocriptine, i-okreotide, i-sulfanilamides, i-anabolic steroid, i-tetracyclinof, i-clofofide, i-clofofide. izidakamizwa eziqukethe i-ethanol.
Umphumela we-hypoglycemic we-insulin wehliswa amandla ngezindlela zokuvimbela inzalo ngomlomo, ama-glucocorticoids, ama-hormone we-thyroid, ama-thiazide diuretics, i-heparin, ama-antidepressants ama-trathiscyl, i-sympathomimetics, i-danazole, i-clonidine, i-BKK, i-diazoxide, i-morphine, i-phenytoin ne-nicotine.
Ama-Reserpine nama-salicylates angasebenza buthaka futhi aqinise isenzo seHumulin NPH.
Ukuhambisana notshwala
Ukuphuza utshwala kuyisici esikhulisa ukuthambekela kwe-hypoglycemia, ngakho-ke, ukuqapha ngokucophelela, ukwelulekwa ngochwepheshe futhi, kungenzeka, ukulungiswa kwemithamo elungiselelwe kuyadingeka.
Kwezinye izimo, ukuphuza utshwala ngamalungiselelo we-insulin kungadala i-lactic acidosis, i-ketoacidosis, kanye nokuvela okuyinkimbinkimbi komzimba.
Ukuphuza utshwala ngezidakamizwa ze-insulin kungadala i-lactic acidosis kanye nokusabela okuyinkimbinkimbi komzimba.
Ama-Analog
Umuthi ungashintshwa kuphela ngemuva kokubonana nochwepheshe. Njengama-analogues anganikezwa amathuluzi alandelayo:
- I-Insuman Bazal GT;
- Biosulin N;
- I-Protafan HM;
- I-Protafan HM Penfill.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi ovela ku-B B ongeke uthenge ngaphandle kokubhalwe ngudokotela.
Intengo yeHumulin NPH
Izindleko zincike ohlotsheni lokukhululwa, inani lamabhodlela noma ama-cartridges amaphakethe. Izintengo ezisondele kakhulu zeHumulin NPH 100 IU / ml:
- I-3 ml cartridge, ama-5 ama-PC. kwisikhwama sekhadibhodi (nge-QuickPen) - kusuka kuma-ruble ayi-1107 .;
- ibhodlela lika-10 ml, 1 pc. kwisikhwama sekhadibhodi - kusuka kuma-ruble angama-555.
Izimo zokugcina zomuthi
Ukuze ugcine umkhiqizo udinga izinga lokushisa lika + 2 ... + 8 ° C nendawo evikelwe ukukhanya kwelanga. Akufanele kube nezinto zokufudumeza eduzane. Kuyenqatshelwa ukuthi iqhwa.
Analogue kungaba yisidakamizwa i-Insuman Bazal GT.
Gcina ungafinyeleleki ezinganeni.
Isikhathi sokuphelelwa yisikhathi
Ukumiswa kwifomu elingavunyelwe kugcina izakhiwo zalo iminyaka emi-3. Ngemuva kokuqala kokusetshenziswa - izinsuku ezingama-28 (ku + 15 ... + 25 ° C).
Umkhiqizi
Lowo ophethe isitifiketi sokubhalisa lesi sidakamizwa yinkampani yaseSwitzerland "Eli Lilly Vostok S.A."
Amabhotela akhiqizwa e-USA (Indianopolis), e-Eli Lilly naseNkampanini, kanye nama-cartridges anamasende wesirinji - eFrance, eLilly France.
Ukubuyekezwa mayelana neHumulin NPH
Odokotela
U-Ana, oneminyaka engama-45, uSaratov
Sekuyiminyaka engaphezu kwengu-20 ngisebenza e-endocrinology. Ngicabanga ukuthi uHumulin usebenza ngempumelelo ezimweni eziningi, kuyaqabukela anikeze impendulo yokungezwani komzimba.
U-Andrey, 38, Kaliningrad
Umuthi unezimpawu ezinamandla ngokwengeziwe. Ngimqoka uma bengabekezeleli.
Iziguli
U-Alexandra, 32, eMoscow
Ingane evela eHumulin iba nobuhlungu ezindaweni zomjovo, yize ngizama ukujova kancane. Kuyafana, kuvela izimpawu, ezixazulula kuphela ezinsukwini ezimbalwa. Kufanele sizame ukushintshela ku-analogue, yize kungekho ezinye izikhalazo.
UMikhail, 42, Kazan
Ngizamile ukulahla i-Humulin NPH ngithanda i-Biosulin, kodwa ngabona ukuthi ayifanele, ngoba izinkinga zomthamo zaqala ukuvela, ubukwenza kahle, futhi izinga likashukela alinikezi imiphumela oyifunayo. Lokhu akukaze kwenzeke nge-NPH.
U-Alexander, 52, Khanty-Mansiysk
Sekuphele iminyaka eyi-10 ngihlaselwa yisifo sikashukela. Ngisebenzise uHumulin NPH ekuqaleni kwesifo. Izinga likashukela lalijwayelekile, ngicabanga kuphela inani eliphakeme lesenzo salo njenge -backback, ngazitholela ezinye izinketho.
