Ukulandela umkhondo we-glycemia kubalulekile kwiziguli ezinesifo sikashukela. Kepha akulula ngaso sonke isikhathi ukukala izinga likashukela wegazi kukhombisa ngokusobala inkambo yesifo. Ukugxila kweglue glucose kungathonywa isikhathi sosuku lapho kuthathwa khona isilinganiso, umsebenzi wokuzivocavoca ngaphambi kokuhlolwa, kanye nezinye izinto eziningi. Ngakho-ke, ukuphendula umbuzo mayelana nobunzima be-glycemia kubantu, uhlobo lwesifo sikashukela, kanye nokuphumelela ekwelashweni kwalesi sifo, kusetshenziswa izibalo zegazi ezifundisayo.
I-glucose, engena egazini elivela ezingxenyeni zegciwane lesisu, ngenxa yomsebenzi wayo wamakhemikhali, ibopha amaprotheni amangqamuzana egazi. Uma izinga le-glycemia lingaphezulu kakhulu kokugxila kweglucose ejwayelekile, khona-ke ushukela owedlulele ubopha kunoma imuphi ama-molecule amaprotheni, hhayi nje abathutha amaprotheni abajwayelekile. Ngakho-ke, kukhona ukukhuphuka kwezinga le-glycosylated hemoglobin kanye ne-fructosamine (i-protein glucose ne-albhamuin ye-plasma yegazi), kanye namaphrotheni elungu le-membrane, nalo abangela izinkinga zesifo sikashukela ngendlela yama-macro ne-microangiopathies.
Ngokuphikisana ne-glycosylated hemoglobin, okuyisinkomba esibalulekile sesikhathi nobungako be-glycemia, ezinyangeni ezimbalwa ezedlule, i-fructosamine ikuvumela ukuthi unqume ukuba khona kwe-glycemia ezinsukwini eziyi-14-20 ezedlule. Lokhu kuvumela ukuqapha okusebenzayo kwamazinga kashukela ezigulini ezinesifo sikashukela mellitus.
Kuhlolwa nini ukuhlolwa kwe-fructosamine futhi kwenziwa kanjani isifundo
Kulolu cwaningo, kuthathwa igazi lomuntu nge-venous, engxenyeni yokuqala yosuku esiswini esingenalutho bese kuhlaziywa elabhorethri ngudokotela ohlaziya okhethekile. Amanani ama-fructosamine wegazi ajwayelekile aqala ku-200 kuye ku-300 μmol / L futhi ancike ohlotsheni lohlaziyo oluhlola izinto eziphilayo.
Ukucaciswa kokuhlushwa kwe-fructosamine esegazini lomuntu kwenziwa ngenhloso:
- Isiqinisekiso sokuxilonga bokuba khona kwesifo sikashukela.
- Ukunquma ukusebenza ngempumelelo kokwelashwa kwesifo sikashukela.
Ukwanda kwamazinga we-fructosamine, akuvezi kuphela ubukhona besifo sikashukela, kepha kungaqapheleka nokwehluleka kwe-renal, kanye ne-hypothyroidism (kunciphise ukusebenza kwe-thyroid). Ngakho-ke, lokhu kuhlaziywa kwelebhu kufanele kunqunywe kuphela ngudokotela futhi kuhlanganiswe nezinye izifundo (i-glucose yegazi, ukuhlaziywa kwe-c-peptide, njll).
