Imbangela ejwayelekile yesifo senhliziyo i-hypertension ye-arterial, ebonakaliswa emfuthweni wegazi ophakeme oqhubeka isikhathi eside. Lokhu kwehlisa ikhwalithi yempilo yomuntu. Ochwepheshe batusa ukusebenzisa izidakamizwa ezahlukahlukene zama-antihypertensive ezivimba ama-oligopeptide mahormone (angiotensins) abangela i-vasoconstriction. Le mishanguzo ifaka iLorista noma iLosartan.
Ngabe isebenza kanjani le mishanguzo?
Umfutho wegazi ophakeme ungadala ushintsho lwe-pathological ezindongeni zemithambo yegazi kuzo zonke izitho. Lokhu kuyingozi kakhulu enhliziyweni, ebuchosheni, e-retina nasezinso. Isakhi esisebenzayo sale mishanguzo emibili (i-losartan potassium) sivimba ama-angiotensins, sibangele i-vasoconstriction kanye nengcindezi eyandayo, okuholele ekutheni kukhishwe amanye ama-hormone (ama-aldosterones) kusuka emithanjeni ye-adrenal engena egazini.
I-Lorista noma i-Losartan izidakamizwa ze-antihypertensive ezivimbela ama-oligopeptide mahormone (angiotensins) abangela i-vasoconstriction.
Ngaphansi kwethonya le-aldosterone:
- i-reabsorption (ukumuncwa) kwe-sodium ithuthukiswa ngokubambezeleka kwayo emzimbeni (uNa unyusa i-hydration, ubandakanyeka ekumbeni kwemikhiqizo ye-metabolic yezinso, uhlinzeka nge-alkaline reservation plasma);
- ama-N-ions amaningi ne-amoni ayedluliswa;
- emzimbeni, ama-chloride athuthwa ngaphakathi kwamaseli futhi asize ekugwemeni ukomisa;
- umthamo wokujikeleza kwegazi uyanda;
- ibhalansi ye-acid-base ibhalwe phansi.
ULorista
Umuthi we-antihypertensive wenziwa ngendlela yamathebulethi afakwe ngaphakathi, afaka i-potassium losartan, nezinye izithako ezingeziwe:
- cellactose;
- i-silicon dioxide (i-sorbent);
- i-magnesium stearate (i-binder);
- isitashi sommbila se-micatinized;
- i-hydrochlorothiazide (i-diuretic engezwa ukuvikela umsebenzi wezinso otholakala kuma-analogues kaLorista, afana neLorista H ne-ND).
Njengengxenye yegobolondo langaphandle:
- into evikela i-hypromellose (isakhiwo esithambile);
- propylene glycol plasticizer;
- amadayi - i-quinoline (i-E104 ephuzi) ne-titanium dioxide (i-E171 emhlophe);
- i-talcum powder.
Yikuphi ukupheka ikhekhe okungasetshenziswa kwabanesifo sikashukela?
I-Cardioactive Taurine: izinkomba kanye nokuphikisana kwezidakamizwa.
Funda ngezimbangela eziphambili zesifo sikashukela kule ndatshana.
Umuthi osebenzayo, ovimbela i-angiotensin, wenza ukuthambeka kwemithambo kungenzeki. Lokhu kusiza ukulinganisela ingcindezi. I-Losartan yabelwe:
- nezimpawu zokuqala ze-hypertension ye-arterial ku-monotherapy;
- ngesifo se-hypertension ephezulu esakhiweni sokwelapha esihlanganisiwe;
- isifo sikashukela.
I-Lorista ikhiqizwa ngo-12.5, 25, 50 no-100 mg wento esemqoka kwithebhulethi eyi-1. Kuhlanganiswe kuma-pcs angama-30, 60 kanye nama-90. emasakeni amakhadibhodi. Ezigabeni zokuqala zokuqina komfutho wegazi, 12,5 noma 25 mg ngosuku inqunyelwe. Ngokukhuphuka kwezinga le-hypertension, umthamo wokusetshenziswa nawo uyakhuphuka. Isikhathi sesifundo kanye nomthamo kumele kuvunyelwane ngaso nodokotela oholayo.
Umuthi osebenzayo weLorista ovimbela i-angiotensin wenza ukusikwa kwamathambo kungenzeki. Lokhu kusiza ukulinganisela ingcindezi.
Losartan
Amafomu athathwa ngomlomo futhi aqukethe i-25, 50 noma i-100 mg yesakhi esiyinhloko nezinto ezingeziwe kwithebhulethi e-1:
- i-lactose (polysaccharide);
- cellulose (i-fiber);
- i-silicon dioxide (i-emulsifier kanye nesengezo sokudla i-E551);
- i-magnesium stearate (emulsifier E572);
- i-croscarmellose sodium (i-sol-grade solvent);
- i-povidone (enterosorbent);
- i-hydrochlorothiazide (kumalungiselelo weLozartan N Richter neLozortan Teva).
Ukuhlanganiswa kwefilimu kufaka:
- i-emollient hypromellose;
- amadayi (i-titanium dioxide emhlophe, i-iron ironideide);
- i-macrogol 4000 (inyusa inani lamanzi emzimbeni);
- i-talcum powder.
ILosartan, ecindezela i-angiotensin, isiza ukubuyisela ukusebenza okujwayelekile komzimba wonke:
- azithinti isenzo sokusanhlamvu;
- akubangeli i-vasoconstriction (vasoconstriction);
- kunciphisa ukumelana kwabo kokuthontelana;
- ilawula ingcindezi ku-aorta nakwimibuthano yokugeleza kwegazi okuphansi;
- kunciphisa i-myocardial hypertrophy;
- ikhulula ithoni emikhunjini yamaphaphu;
- isebenza njenge-diuretic;
- kuyahluka ngesikhathi sokusebenza (ngaphezu kosuku).
Umuthi udonswa kalula emgudwini wokugaya ukudla, owenziwe ngamaseli wesibindi, ukuvelela okuphezulu kakhulu egazini kwenzeka ngemuva kwehora, okubopha amaprotheni e-plasma 95% we-metabolite esebenzayo. ILosartan iphuma ingashintshiwe ngomchamo (35%) ne-bile (60%). Umthamo ovumelekile ungafika kuma-200 mg ngosuku (uhlukaniswe ngemithamo emi-2).
ILosartan, ecindezela i-angiotensin, isiza ukubuyisela ukusebenza okujwayelekile komzimba wonke.
Ukuqhathanisa kukaLorista noLosartan
Isenzo salezi zidakamizwa zombili sihlose ukunciphisa ingcindezi. Iziguli ezinomfutho wegazi ophakeme zivame ukubekwa zona, ngoba kutholakala umphumela ophumelelayo ekuvimbeleni izifo zenhliziyo nezemithambo, nanjengendlela yokwelapha enkulu yezimo ezingamahlalakhona. Imithi akuvamile kubangele imiphumela emibi, ibe nezinkomba eziningi ezifanayo futhi umehluko omncane.
Ukufana
Ukusebenza kwezidakamizwa sekufakazelwe iziguli ezinomfutho wegazi ophakeme, ezihambisana nezinto ezifana nengozi:
- ubudala
- i-bradycardia;
- ushintsho lwe-pathological ku-myocardium yesibeletho sobunxele esidalwe yi-tachycardia;
- ukwehluleka kwenhliziyo;
- isikhathi ngemuva kokuhlaselwa yinhliziyo.
Imithi esekwe potassium e-losartan ilungele ukuthi:
- faka isikhathi esiyi-1 ngosuku (noma kaningi, kodwa njengoba kuchazwe uchwepheshe);
- ukwamukelwa akuxhomeki ekudleni;
- into esebenzayo inomphumela wokuqongelelwayo;
- inkambo efaneleyo isukela ngesonto kuye enyangeni.
Izidakamizwa zinokuphikisana okufananayo:
- ukwehlukaniswa kwezakhi;
- hypotension;
- ukukhulelwa (kungadala ukufa kwe-fetus);
- inkathi yokuhlanza;
- iminyaka efinyelela eminyakeni eyi-18 (ngenxa yokuthi umphumela ezinganeni awuqondakali ngokuphelele);
- ukungasebenzi kahle kwe-hepatic.
Ezigulini ezinezinkinga zezinso, umuthi awuphulwa futhi ungachazwa uma kukhona i-hydrochlorothiazide ekwakhiweni, okuthi:
- kusheshise ukuphuma kwegazi le-renal;
- kudala umphumela we-nephroprotective;
- kuthuthukisa ukumbumbuluzwa kwe-urea;
- Isiza ukubambezela ukuqala kwe-gout.
Uyini umehluko?
Umehluko okhona phakathi kwala mathuluzi unqunywa ikakhulukazi ngentengo nomenzi. I-Lorista ingumkhiqizo wenkampani yaseSlovenia i-KRKA (i-Lorista N neLorista ND ikhiqizwa yiSlovenia kanye neRussia). Ngenxa yocwaningo lobuchwepheshe, inkampani enkulu yemithi enegama emakethe yamazwe omhlaba iqinisekisa ikhwalithi yomuthi.
ILosartan ikhiqizwa e-Ukraine yiVertex (Losartan Richter - Hungary, Losartan Teva - Israel). Le yi-analogue eshibhile yeLorista, engasho ukuthi izimfanelo ezimbi kakhulu noma ukusebenza okuncane. Ochwepheshe ababeka lo muthi noma lowo muthi, baphawule umehluko othile, oqukethe imiphumela emibi.
Lapho usebenzisa uLorista:
- ku-1% yamacala, i-arrhythmia ibangelwa;
- ukubonakaliswa kuyabonakala, kucasulwa yi-diuretic hydrochlorothiazide (ukulahleka kwe-potassium nosawoti we-sodium, i-anuria, i-gout, i-proteinuria).
Kukholelwa ukuthi i-losartan kulula ukuyithwala, kepha akuqondisi ukuthi:
- ku-2% yeziguli - ekuthuthukisweni kwesifo sohudo (isakhi se-macrogol siyi provocateur);
- I-1% - ku-myopathy (izinhlungu emuva kanye nemisipha ngokwakhiwa kwemisipha ekhubazekile).
Ezimweni ezingavamile, i-losartan ingathinta ukukhula kwesifo sohudo.
Yikuphi okushibhile?
Izindleko zithonywe yizici ezifana nesifunda sezwe, ukukhuphula kanye nezaphulelo, inani kanye nevolumu yendlela yezinkinga ehlongozwayo.
Intengo yeLorista:
- Ama-30 ama-pcs I-12.5 mg ngayinye - ama-ruble angama-113-152. (I-Lorista N - ama-ruble angama-220.);
- Ama-30 ama-pcs I-25 mg ngayinye - ama-ruble ayi-158-211. (I-Lorista N - 302 ruble, i-Lorista ND - ama-ruble angama-372);
- Ama-60 ama-PC. I-25 mg ngayinye - ama-ruble ayi-160- 245. (I-Lorista ND - ama-ruble angama-570);
- Ama-30 ama-pcs I-50 mg ngayinye - ama-ruble ayi-161-280. (I-Lorista N - ama-ruble angama-330);
- Ama-60 ama-PC. I-50 mg ngayinye - ama-ruble angama-284-353;
- Ama-90 ama-PC I-50 mg ngayinye - ama-ruble angama-386-491;
- Ama-30 ama-pcs I-100 mg ngayinye - ama-ruble angama-270-330;
- Ithebhu engu-60. I-100 mg - ama-ruble ayi-450-540;
- Ama-90 ama-PC I-100 mg ngayinye - ama-ruble angama-593-667.
Izindleko ze-losartan:
- Ama-30 ama-pcs I-25 mg ngayinye - ama-ruble angama-74-80. (I-Losartan N Richter) - ama-ruble angama-310 .;
- Ama-30 ama-pcs I-50 mg ngayinye - ama-ruble angama-87-102;
- Ama-60 ama-PC. I-50 mg ngayinye - ama-ruble ayi-110-157;
- Ama-30 ama-pcs 100 mg - ama-ruble ayi-120 -138;
- Ama-90 ama-PC I-100 mg ngayinye - kuze kufike kuma-ruble angama-400.
Kusukela ochungechungeni olungenhla kuyacaca ukuthi kunenzuzo ethe xaxa ukuthenga i-losartan noma yisiphi isidakamizwa, kodwa ngenani elikhulu lamathebulethi kwiphakethe elilodwa.
Yini engcono i-lorista noma i-losartan?
Yimuphi umuthi ongcono, akunakwenzeka ukusho ngokungalingani, ngoba asuselwa entweni efanayo esebenzayo. Lokhu kufanele kudalwe udokotela ohambelayo, ngokusekelwe ezimweni zesiguli ngasinye. Kepha uma isetshenziswa, umphumela wezithako ezingeziwe ezifakiwe kumalungiselelo kumele unakwe.
Ngenxa yokuthi uLorista kwenzeka ngomthamo ophansi (12,5 mg), unqunyelwe ukuvimbela isimo se-hypertgency, ukuba khona kwenhliziyo okungajwayelekile, ezimweni zokushintsha kwe-spasmodic kuzinga lokucindezela. Ngempela, nge-hypotension ye-arterial overdose engalawulwa kungenzeka, futhi kuyingozi esigulini, ngoba izimpawu zayo azibonakali ngokushesha. Umfutho we-Hypertension okhonjwe ngokunyuka okujwayelekile kanye nokwehla okukhulu komfutho wegazi kungalawulwa ngethamo elincane lomuthi othathwe kabili.
Ukubuyekezwa kweziguli
U-Olga, oneminyaka engama-56, uPodolsk
Angikwazanga ukuthatha le mithi enqunywe ngumelaphi. Okokuqala ngaphuza umthamo wansuku zonke wama-50 mg we-losartan. Ngemuva kwenyanga, kwavela izihlakala zegazi ezandleni (okokukhuphuka kwaqhuma nezandla). U-Askorutin wayeka ukuyithatha waqala ukuphuza, kwaba sengathi isimo semikhumbi sesinciphisile. Kepha ingcindezi ihlala. Kuhanjiswe kuLorista ebiza kakhulu. Ngemuva kwesikhashana, konke kwaphindwa. Ngifunde emiyalweni - kunomphumela omubi onjalo. Qaphela!
UMargarita, oneminyaka engama-65 ubudala, idolobha laseTambov
Kubekelwe uLorista, kepha ngokuzimela ushintshele kuLosartan. Kungani ukhokhela kakhulu umuthi onento efanayo esebenzayo?
Nina, oneminyaka engama-40, uMurmansk
I-Hypertension yisifo sekhulu leminyaka. Izingcindezi emsebenzini nasekhaya nganoma yisiphi isikhathi ziphakamisa ingcindezi. Bacebise uLorista njengezindlela eziphephile, kepha esichasisweni somuthi kunokuphikisana okuningi. Ngemuva kokufunda imiyalo, nganquma ukuhlangana nodokotela futhi.
Ukukhulelwa kungukuphikisana nokuthatha izidakamizwa zombili.
Ukubuyekezwa kwezazi zezenhliziyo kuLorista naseLosartan
I-M.S. I-Kolganov, isazi sezinhliziyo, eMoscow
Lezi zimali zinobungozi bendalo balo lonke iqembu lama-angiotensin blockers. Zihambisana neqiniso lokuthi umphumela wenzeka kancane, ngakho-ke ayikho indlela yokwelapha ngokushesha umfutho wegazi ophakeme.
S.K. USapunov, udokotela wezifo zenhliziyo, uKimry
Ngokwakheka kwazo zonke izithinteli ze-angiotensin ezitholakala zohlobo lwesibili, yiLosartan kuphela ehlangabezana nezinkomba ezi-4 ezisemthethweni ezisetshenziswayo: i-arterial hypertension; umfutho wegazi ophakeme ngenxa yehypertular hypertrophy engakwesobunxele; thayipha i-nephropathy yesifo sikashukela 2; ukwehluleka kwenhliziyo okungapheli.
T.V. UMironova, udokotela wenhliziyo, u-Irkutsk
Lawa maphilisi okucindezela alawula kahle isimo uma siphuzwa ngokuqhubekayo. Ngokuselapha okuhleliwe, amathuba ezinkinga ancishiswa kakhulu. Kepha esimeni esibi abasizi. Kuthengiswe ngomuthi.
