I-Rosuvastatin SZ (North Star) ingeqembu le-statins elinomphumela ophansi we-lipid.
Umuthi usetshenziswa ngempumelelo ezifweni ezihambisana nokungasebenzi kahle kwe-lipid metabolism, kanye nokuvimbela i-pathologies ethile ye-inhliziyo. Imininingwane eminingi mayelana nomuthi ingatholakala kulokhu okuqukethwe.
Emakethe yemithi, ungathola izidakamizwa eziningi eziqukethe i-rosuvastatin esebenzayo, ngaphansi kwemikhiqizo ehlukahlukene. I-Rosuvastatin SZ ikhiqizwa ngumkhiqizi wasekhaya i-North Star.
Ithebhulethi eyodwa iqukethe i-5, 10, 20, noma i-40 mg ye-rosuvastatin calcium. Isisekelo sayo sifaka ushukela wobisi, i-povidone, i-sodium stearyl fumarate, i-primellose, i-MCC, i-aerosil ne-calcium hydrophosphate dihydrate. Amathebulethi eRosuvastatin SZ yi-biconvex, anomumo oyindilinga futhi ambozwe ngegobolondo elipinki.
Ingxenye esebenzayo iyi-inhibitor ye-HMG-CoA reductase. Isenzo saso sihlose ukukhulisa inani lama-enzymes e-hepatic LDL, ukuthuthukisa ukubonakala kweLDL kanye nokunciphisa inani labo.
Njengomphumela wokusebenzisa umuthi, isiguli siyakwazi ukwehlisa izinga le-cholesterol "embi" futhi sandise ukuqoqwa "okuhle". Umphumela omuhle ungabonakala ezinsukwini eziyi-7 ngemuva kokuqala kokwelashwa, futhi ngemuva kwezinsuku eziyi-14 kungenzeka ukufezekisa umphumela we-90%. Ngemuva kwezinsuku ezingama-28, i-lipid metabolism ibuyela kokujwayelekile, ngemuva kwalokho ukwelashwa kwesondlo kuyadingeka.
Okuqukethwe okuphezulu kakhulu kwe-rosuvastatin kuqashelwa amahora angama-5 ngemuva kokuphathwa ngomlomo.
Cishe i-90% yento esebenzayo ibopha i-albhamuin. Ukususwa kwaso emzimbeni kwenziwa ngamathumbu nezinso.
Izinkomba kanye ne-contraindication ukuze zisetshenziswe
I-Rosuvastatin-SZ imiselwe ukuphazanyiswa kwe-lipid metabolism kanye nokuvikela izifo zenhliziyo.
Njengomthetho, ukusetshenziswa kwalezi zibhebhe kudinga ukubambelela ekudleni kwe-hypocholesterol kanye nemidlalo.
Incwajana yezemfundo inezinkomba ezilandelayo ezisetshenziswayo:
- i-hypercholesterolemia eyisisekelo, yomndeni (njenge-engeza kwezokwelapha ezingezona izidakamizwa);
- i-hypertriglyceridemia (IV) njengesengezo sokudla okhethekile;
- i-atherossteosis (ukuvimbela ukufakwa kwamakhemikhali e-cholesterol kanye nokwenza ngokwejwayelekile izinga le-cholesterol ephelele ne-LDL);
- ukuvimbela ukushaywa unhlangothi, i-arterial revascularization kanye nokuhlaselwa yisifo senhliziyo (uma kunezici ezifana nokuguga, amazinga aphakeme e-C-reactive protein, ukubhema, ufuzo kanye nomfutho wegazi ophakeme).
Udokotela uyenqabela ukuthatha umuthi iRosuvastatin SZ 10mg, 20mg no-40mg uma kuthola isiguli:
- I-Hypersensitivity yomuntu ngamunye kwizakhi.
- Ukwehluleka okukhulu kwe-renal (nge-CC <30 ml / min).
- IGlucose-galactose malabsorption, ukuntuleka kwe-lactase noma ukungabekezelelani kwe-lactose.
- Iminyaka yobudala eyi-18;
- Isifo sesibindi esiqhubekayo.
- Ukubamba okuphelele kwe-HIV proteinase kanye ne-cyclosporin blockers.
- Ukweqisa izinga le-CPK ngezikhathi ezi-5 noma ngaphezulu komkhawulo ojwayelekile.
- Ukuhambisana nezinkinga ze-myotoxic.
- Ukukhulelwa nesikhathi sokubeletha.
- Ukuntuleka kokuvimbela inzalo (kwabesifazane).
Ukwephulwa kokusetshenziswa kweRosuvastatin SZ ngomthamo wama-40 mg ngokungeziwe ngaphezulu kuyangezwa:
- okulinganiselayo kuya kokuhluleka kakhulu kwezinso;
- i-hypothyroidism;
- ongowomjaho wamaMongoloid;
- umlutha wotshwala;
- izimo ezibangela ukwanda kwamazinga e-rosuvastatin.
Futhi i-contraindication ukuba khona komlando womuntu siqu / womndeni we-pathologies yemisipha.
Imiyalo yokusebenzisa umuthi
Amathebulethi kufanele aginywe wonke ngamanzi okuphuza. Zithathwa kungakhathalekile ukuthi kudliwe ngasiphi isikhathi sosuku.
Ngaphambi kokuqala nangesikhathi sokulashwa kwezidakamizwa, isiguli senqaba imikhiqizo efana nokufakwa emzimbeni (izinso, ubuchopho), izikhupha zamaqanda, ingulube, isinqe, ezinye izitsha ezinamafutha, izimpahla ezibhakiwe kusuka kufulawa we-premium, ushokoledi namaswidi.
Udokotela unquma umthamo wezidakamizwa ngokuya ngezinga le-cholesterol, izinhloso zokwelashwa kanye nezimpawu zomuntu ngamunye.
Umthamo wokuqala we-rosuvastatin ngu-5-10 mg ngosuku. Uma kungenzeki ukufeza umphumela ofiselekile, umthamo uyandiswa ufinyelele kuma-20 mg ngaphansi kokuqashwa okuqinile kongcweti. Ukuqapha ngokucophelela kuyadingeka futhi lapho kunqunywa i-40 mg yomuthi, lapho isiguli sitholakala sinezinga elikhulu le-hypercholesterolemia kanye namathuba aphezulu wokuphazamiseka kwengqondo.
Izinsuku eziyi-14- 28 ngemuva kokuqala kokwelashwa kwezidakamizwa, kuyadingeka ukuqapha i-lipid metabolism.
Asikho isidingo sokushintsha umthamo womuthi ezigulini esezikhulile nalabo abahlushwa ukuqina kwezinhlungu. Nge-genetic polyformism, ukuthambekela kwe-myopathy noma yokuba ngumjaho wamaMongoloid, umthamo wommeli ophansi we-lipid akufanele udlule i-20 mg.
Umbuso wokushisa wokulondolozwa kokufakwa kwezidakamizwa awudluli ngaphezulu kwama-25 degrees Celsius. Impilo yeshelf iyiminyaka emithathu. Gcina okuhlanganisiwe endaweni evikelwe umswakama nokukhanya kwelanga.
Imiphumela Emibi nokuhambisana
Lonke uhlu lwemiphumela emibi engaba khona eyenzeka lapho usebenzisa umuthi luchazwe emiyalweni yokusetshenziswa.
Njengomthetho, imiphumela emibi lapho uthatha lesi sidakamizwa ivamile kakhulu.
Noma kubonakala njengokusabela okungekuhle, amnene futhi azenzele yedwa.
Emiyalweni yokusetshenziswa, uhla olulandelayo lwemiphumela emibi luyethulwa:
- Uhlelo lwe-Endocrine: ukuthuthukiswa kwe-mellitus engaxineki ne-insulin (uhlobo 2).
- Uhlelo lomzimba: I-Quincke edema nokunye ukusabela kwe-hypersensitivity.
- CNS: isiyezi ne-migraine.
- Uhlelo lwe-Urinary: proteinuria.
- Amapheshana emathunjini: i-dyspeptic disorder, ubuhlungu be-epigastric.
- Uhlelo lwe-musculoskeletal: myalgia, myositis, myopathy, rhabdomyolysis.
- Isikhumba: ukulunywa, okhalweni, kanye nokuqhuma.
- Uhlelo lwe-Biliary: pancreatitis, umsebenzi ophakeme wama-hepatic transaminases.
- Izinkomba zaselabhorethri: i-hyperglycemia, amazinga aphezulu e-bilirubin, i-alkaline phosphatase, umsebenzi we-GGT, ukungasebenzi kahle kwe-thyroid.
Njengomphumela wokucwaninga ngemuva kokuthengisa, kutholakale ukungaphenduki okuhle:
- i-thrombocytopenia;
- i-jaundice ne-hepatitis;
- I-Stevens-Johnson syndrome;
- ukukhubazeka kwenkumbulo;
- ukukhukhumala kwe-peripheral;
- isifo sikashukela se-polyneuropathy;
- gynecomastia;
- i-hematuria;
- ukuphefumula kanye nokukhwehlela komile;
- i-arthralgia.
Kwezinye izimo, ukusetshenziswa kweRosuvastatin SZ neminye imithi kungaholela emiphumeleni engalindelekile. Ngezansi yizici zokuphathwa kanyekanye kwezidakamizwa okukhulunywa ngazo nabanye:
- Ama-protein blockers - ukwanda kwamathuba we-myopathy kanye nokwanda kwenani le-rosuvastatin.
- Ama-blocker e-HIV protease - ukukhushulwa okwandisiwe kwento esebenzayo.
- I-cyclosporine - ukwanda kwezinga le-rosuvastatin izikhathi ezingaphezu kwezingu-7.
- I-Gemfibrozil, i-fenofibrate namanye ama-fibrate, i-nicotinic acid - izinga eliphakeme lezinto ezisebenzayo kanye nengozi ye-myopathy.
- I-Erythromycin nama-antacid aqukethe i-aluminium ne-magnesium hydroxide - ukwehla kokuqukethwe kwe-rosuvastatin.
- I-Ezetimibe - ukwanda kokuhlungwa kwengxenye esebenzayo.
Ukuvimbela ukuthuthukiswa kokusabela okungekuhle ngenxa yokusetshenziswa kanyekanye kwezidakamizwa ezingahambisani, kuyadingeka ukwazisa udokotela ngazo zonke izifo ezihlangene.
Intengo, ukubuyekezwa kanye nama-analogues
Njengoba umuthi i-Rosuvastatin ukhiqizwa isitshalo samakhemikhali sasekhaya "North Star", intengo yaso ayiphezulu. Ungathenga umuthi kunoma iyiphi ikhemisi edolobhaneni.
Intengo yephakeji elilodwa equkethe amaphilisi angama-30 ama-5 mg ngalinye ngama-ruble ayi-190; I-10 mg ngayinye - ama-ruble angama-320; I-20 mg ngayinye - ama-ruble angama-400; I-40 mg ngayinye - ama-ruble ayi-740.
Phakathi kweziguli nodokotela, ungathola izibuyekezo eziningi ezinhle mayelana nomuthi. Ukuhlanganisa okukhulu izindleko ezingabizi kanye nomphumela onamandla wokwelapha. Noma kunjalo, kwesinye isikhathi kunezibuyekezo ezingezinhle ezihambisana nokuba khona kwemiphumela emibi.
U-Eugene: "Ngithole i-lipid metabolism kudala. Ngazama izidakamizwa eziningi sonke isikhathi. Ngathatha i-Liprimar ekuqaleni, kodwa ngayiyeka, ngoba izindleko zayo zazibukeka. Kepha njalo ngonyaka kwakufanele ngenze ama-droppers ukuhambisa imithambo yobuchopho. Ngemuva kwalokho udokotela wabe esethola udokotela. UKrestor uyangiyalela, kodwa futhi kwavela ukuthi akusona isidakamizwa esishibhile. Ngazitholela i-analogues yayo ngokuzimela, phakathi kwayo okuyiRosuvastatin SZ. Bengiwaphuza la maphilisi kuze kube manje, ngizwa kahle, cholesterol yami ibuyele kwesejwayelekile. "
UTatyana: "Ehlobo, izinga le-cholesterol lenyuke laya ku-10, kanti leli nani lingu-5.8. Ngaya kudokotela wezokwelapha wabe esenginikeza iRosuvastatin. Udokotela wathi lesi sidakamizwa sinemiphumela emincane eshubeni. Okwamanje ngithatha i-Rosuvastatin SZ, njengamanje, yonke into ifanele kodwa kukhona "kodwa" - kwesinye isikhathi ikhanda elikukhathazayo. "
Ingxenye esebenzayo ye-rosuvastatin itholakala kwezidakamizwa eziningi ezenziwa ngabakhiqizi abahlukahlukene. Izithonjana zifaka:
- I-Akorta;
- Crestor
- Mertenyl;
- URosart
- Ro-Statin;
- Rosistark;
- Rosuvastatin Canon;
- Roxer;
- I-Rustor.
Nge-hypersensitivity ngamanye ku-rosuvastatin, udokotela ukhetha i-analogue esebenzayo, i.e. i-ejenti equkethe enye into esebenzayo, kepha ikhiqiza umphumela ofanayo we-lipid. Ekhemisi ungathenga izidakamizwa ezifanayo:
- Atorvastatin.
- Atoris.
- UVasilip.
- I-Vero-simvastatin.
- I-Zokor.
- Simgal.
Into esemqoka ekwelashweni kwe-cholesterol ephezulu ukunamathela kuzo zonke izincomo zochwepheshe abakhona, landela indlela yokudla futhi uphile impilo esebenzayo. Ngakho-ke, kuzokwazi ukulawula ukugula futhi uvikele izinkinga ezihlukahlukene.
Umuthi i-Rosuvastatin SZ uchazwe ngokuningiliziwe kule vidiyo ekulesi sihloko.
