Kunezidakamizwa eziningi eziklanyelwe ukwenza amazinga eglucose abe ngokwejwayelekile. I-Metformin noma i-Siofor, okuyinto engcono futhi ephumelela kakhudlwana? Umuntu onesifo sikashukela angahle abhekane nokukhetha ukuthi uzothenga muphi umuthi nokuthi umehluko uyini.
Kumele kwaziwe ukuthi amaphilisi iMetformin Teva, iGlucofage, iSiofor afakiwe eqenjini lezidakamizwa ze-greatuanide. Ngaphezu kwalokho, uma unaka ukwakheka komuthi, ungabona ukuthi isithako esikhulu esisebenzayo yinto efanayo.
I-metformin ye-izidakamizwa esebenzayo iyingxenye yemithi eminingi yokwehlisa ushukela. Ingxenye esebenzayo evela eqenjini le-Biguanides yesizukulwane sesithathu futhi isiza ukwehlisa amazinga kashukela egazi.
I-ejenti elwa nesifo sikashukela ivimbela inqubo ye-gluconeogenesis, ukuthutha kwama-elektroni kwamaketanga okuphefumula kwe-mitochondria. I-Glycolysis ivuselelwa, amangqamuzana aqala ukumunca kangcono ushukela, futhi ukumunca kwawo odongeni lwamathumbu kuyancipha.
Izinkomba zokusetshenziswa kwento yokwelapha?
Enye yezinzuzo zesakhi esisebenzayo ukuthi akubangeli ukwehla okubukhali kweglucose. Lokhu kungenxa yokuthi iMetformin akuyona into evuselelayo yokuqhekeka kwe-insulin ye-hormone.
Izinkomba eziphambili zokusetshenziswa kwezidakamizwa ezenziwa nge-metformin yilezi:
- ukuba khona kwe-metabolic syndrome noma ukubonakaliswa kokumelana ne-insulin;
- njengomthetho, lapho kukhona ukumelana ne-insulin, ukukhuluphala kukhula ngokushesha ezigulini, ngenxa yemiphumela ye-Metformin kanye nokugcinwa kokudla okukhethekile kokudla, ukunciphisa umzimba kancane kancane kungatholakala;
- uma kukhona ukwephulwa kokubekezelela ushukela;
- i-scleropolicystosis yama-ovari iba;
- i-mellitus encike kwisifo sikashukela njenge-monotherapy noma njengengxenye yokwelashwa okupheleleꓼ
- ifomu lokuncika kwesifo sikashukela ngokuhlangana nemijovo ye-insulin.
Lapho uqhathanisa amaphilisi asuselwa ku-metformin nezinye izidakamizwa ezokwehlisa ushukela, izinzuzo eziphambili ze-metformin kufanele zigqanyiswe:
- Umphumela wayo ekunciphiseni ukumelana ne-insulin esigulini. I-Metformin hydrochloride iyakwazi ukukhulisa ukuzwela kwamaseli nezicubu ku-glucose ekhiqizwa ama-pancreas.
- Ukuthatha lo muthi kuhambisana nokumunyiswa yizitho zepheshana lesisu. Ngakho-ke, ukwehla kancane kokufakwa kweglue esiswini kuyatholakala
- Isiza ukuvimbela i-gluconeogeneis yesibindi, inqubo ebizwa ngokuthi isinxephezelo sikashukela.
- Kuyasiza ukwehlisa isifiso sokudla, okubaluleke kakhulu kwabanesifo sikashukela ngokweqile.
- Kunomphumela omuhle ku-cholesterol, kunciphisa okubi futhi kukhula okuhle.
Inzuzo yezidakamizwa ezenziwa nge-metformin futhi iyasiza ukuthi inciphise inqubo ye-fat peroxidation.
Ukuphendula okungalungile kanye nokulimala okungenzeka kusuka ku-metformin
Ngaphandle kwesibalo sezakhiwo ezinhle ze-metformin hydrochloride, ukusetshenziswa kwayo okungafanele kungadala ukulimala okungalingani emzimbeni womuntu.
Kungakho abesifazane abanempilo enhle abafuna izindlela ezilula zokunciphisa umzimba kufanele bacabange ukuthi bangawuthatha yini umuthi onjalo?
Ithebhulethi nayo isetshenziswa ngenkani njengesidakamizwa sokwehla kwesisindo.
Ukuphendula okungalungile okuphezulu okungenzeka ngenxa yokuthatha i-metformin hydrochloride kufaka phakathi:
- ukuvela kwezinkinga ezahlukahlukene ngepheshana lesisu, ikakhulukazi izimpawu ezinjengokucanuzelelwa kwenhliziyo nokuhlanza, isifo sohudo, ukuqhakaza nobumnene besisu,
- umuthi ukhulisa ubungozi be-anorexia,
- ukuguqulwa kwemizwa yokunambitha kungenzeka, okubonakaliswa lapho kuvela imidwebo yensimbi engathandeki emgodini womlomo,
- ukwehla kwenani lamavithamini B, okuphoqa ukuthi ngaphezu kwalokho uthathe izidakamizwa ngezithasiselo zemithi,
- ukubonakaliswa kwe-anemia,
- nge-overdose ebalulekile, kungahle kube nengozi ye-hypoglycemia,
- Izinkinga zesikhumba, uma kuvela ukubonakala kokungezwani nomuthi ophuzwayo.
Kulokhu, i-Metformin, i-Siofor noma amanye ama-generator ahlelekile angadala ukukhula kwe-lactic acidosis uma ukuqoqwa okukhulu kwesamba sawo kwenzeka emzimbeni. Ukubonakaliswa okungalungile okunjalo kuvame ukuvela ngokusebenza kabi kwezinso.
Kumele kwaziwe ukuthi kwenqatshelwe ukuthatha izidakamizwa lapho kukhomba lezi zinto ezilandelayo:
- I-acidosis ngamafomu asebusweni noma angalapheki.
- Amantombazane ngesikhathi sokuzala ingane noma ukuncelisa.
- Iziguli zeminyaka yokuthatha umhlalaphansi, ikakhulukazi ngemuva kweminyaka engamashumi ayisithupha nanhlanu.
- Ukungabekezeleli kwengxenye yomuthi, ngoba ukuthuthukiswa kokungezwani komzimba okunamandla kungenzeka.
- Uma isiguli sitholakala sinehluleki senhliziyo.
- Nge-infraction yangaphambilini ye-myocardial.
- Uma kwenzeka i-hypoxia
- Ngesikhathi sokuphelelwa ngamanzi emzimbeni, okungadalwa futhi yi-pathologies ehlukahlukene yokutheleleka.
- Ukuzikhandla ngokweqile.
- Ukwehluleka kwesibindi.
Ngaphezu kwalokho, umphakeli we-hypoglycemic uthinta kabi i-mucosa yesisu.
Kuyenqatshelwa ukuthatha umuthi lapho ukhona izifo zezifo ze-gastrointestinal tract (ulcer).
Ingabe ukhona umehluko phakathi kwemithi?
Uyini umehluko phakathi kwezidakamizwa iMetformin, iGlatini, iSiofor yesifo sikashukela? Ingabe umuthi owodwa uhlukile komunye? Imvamisa iziguli ziphoqelelwa ukuba zikhethe: iGlucophage noma iSiofor, iGlucofage noma iMetformin, iSiofor noma iMetformin nokunye. Kumele kuqashelwe ukuthi umehluko omkhulu usegameni lomuthi kuphela.
Njengoba sekukhonjisiwe ngenhla, into eyi-Metformin hydrochloride isetshenziswa njengesithako esiyisisekelo esisebenzayo kulamadivayisi wezokwelapha. Ngakho-ke, umphumela wokuthatha lezi zidakamizwa kufanele ube ngokufanayo (lapho usebenzisa imithamo efanayo). In
Umehluko ungaba sezakhi ezingezekile, ezibuye ziyingxenye yokwenziwa kwethebhulethi. Lezi yizimbongi ezahlukahlukene. Uma uthenga, udinga ukunaka okuqukethwe kwabo - okuncane inani lezinto ezengeziwe, ezingcono. Ngaphezu kwalokho, udokotela ohambelayo angancoma ukuthatha umuthi othile, kuye ngezimpawu zomzimba wesiguli ngamunye.
Isibonelo, iSiofor 500 inale ndlela elandelayo:
- isakhi esiyinhloko yi-metformin hydrochloride,
- abathola - i-hypromellose, i-povidone, i-magnesium stearate, titanium dioxide, macrogol 6000.
Umuthi i-Glucophage (noma i-Glucophage ende) ekwakhiweni kwayo uqukethe izingxenye zamakhemikhali ezilandelayo:
- into esebenzayo - metformin hydrochloride,
- njengoba kusetshenziswa izakhi ezengeziwe, i-hypromellose, i-povidone, i-magnesium stearate.
Ngakho-ke, uma kukhona ukukhetha phakathi kweSiofor noma iGlucophage yesifo sikashukela sohlobo 2, inketho yesibili, enezakhi ezimbalwa, ilungele kangcono ukwakheka kwamakhemikhali.
Lapho ukhetha umuthi, umuntu kufanele futhi acabangele into efana nezindleko zomuthi. Imvamisa, ama-analogu aphesheya anentengo ephakeme kaningana kunemithi yethu yasekhaya. Njengoba umkhuba ukhombisa, umphumela wokwamukela kwabo awufani. Kuze kube manje, amaphilisi e-Metformin ayindlela ebhajethi kakhulu phakathi kwamadivayisi ezokwelapha aqukethe i-metformin hydrochloride.
Uma isifo sikashukela singabaza okuthile futhi singazi ukuthi singakwazi yini ukubuyisela umuthi owodwa kwesinye, kufanele uthintane nodokotela wakho. Uchwepheshe wezokwelapha uzokwazi ukuchaza umehluko phakathi kwamadivayisi ezokwelapha analogous, futhi achaze nokuthi kungani umuthi onjalo ulungele umuntu othize.
I-Glucophage noma iSiofor - njengoba kukhonjisiwe ngemiyalo esetshenzisiwe?
Imithi ye-Glucophage ne-Siofor ayiziphawu zesakhiwo.
Ngakho-ke, umphumela wohlelo lwabo lokusebenza kufanele uboniswe ngokulinganayo.
Kwesinye isikhathi udokotela ofikayo unikeza isiguli sakhe uhlu lwamaphilisi e-analog nethuba lokuthenga elinye laso.
Uma kwenzeka kunesimo esinjalo, kufanele kucatshangelwe izici ezilandelayo:
- Umuthi kufanele ube ushibhile.
- Uma kunokwenzeka, ube nezakhi ezimbalwa ezingeziwe.
- Ukwehluka kungenzeka kube kuhlu lwe-contraindication nemiphumela emibi.
Ukuze uqhathanise, kungcono ukusebenzisa imiyalo esemthethweni yokusetshenziswa kwemithi, bese ukhetha ukuthi yisiphi isidakamizwa esifanelekile.
IMetformin, iGlucofage 850 yehlukile kuSiofor ezimeni ezinjalo:
- IGlucophage 850 inenombolo enkulu yokuphendula okungahambi kahle. Kungakho, okunye ukubuyekezwa kwabathengi kukhombisa ukuthi umuthi awuzilingani.
- Ukuqhathanisa kukhombisa ukuba khona kwenani elikhulu le-contraindication namacala lapho kungenakwenzeka ukuthatha iSiofor (ngokungafani neGlucofage eneMetformin).
- Intengo yeGlucofage iphakeme kancane, kulolu daba uSiofor ungcono.
Kumele kuqashelwe ukuthi uma uchwepheshe wezokwelapha enquma ukuphathwa kwamathebhulethi okuvezwa isikhathi eside, izindleko zomuthi zanda kakhulu. Isibonelo, i-Glucofage ende izobiza cishe ama-ruble angamakhulu amathathu ngesilinganiso esincane.
Umbono wochwepheshe bezokwelapha ngukuthi izidakamizwa ezinjengalezi zinciphisa ushukela wegazi ophakeme, zenze kube nzima ukubonakaliswa kokumelana ne-insulin kwi-hormone futhi kusize ukwenziwa ngokwejwayelekile i-cholesterol enhle. Amathebulethi angashintshwa, ngenxa yokuthi isiguli singamkhetha inketho enhle kakhulu.
Yikuphi ama-hypoglycemic agents asebenza kakhulu achazwe kuvidiyo kule sihloko.
