I-Flemoklav Solutab iyindlela entsha encibilikayo yomuthi obonakele we-antibacterial. Ukuhlanganiswa kwe-amoxicillin ne-clavulanic acid kuyindlela esezingeni legolide ekwelapheni izinqubo zokuvuvukala zemvelaphi yamagciwane. Imiphumela ehlukahlukene ihlinzekwa yi-antibiotic eyinhloko ne-β-lactamase inhibitor (clavulanate). Kucwengisisiwe, ngokuya ocwaningweni lwakamuva, imithamo yezinto ezisungulwayo inciphisa ubungozi bemiphumela emibi.
Igama Lezwe elingafanele
Igama leqembu: Amoxicillin + clavulanic acid
Ath
I-J01CR02 Amoxicillin ehlanganiswe ne-beta-lactamase inhibitor
Khipha amafomu nokwakheka
I-Flemoklav Solutab 125 idalwe njengefomu elinyibilikayo ekuphathweni komlomo. Amathebulethi angagwinywa aphelele noma ahlanjululwe ngenani elincane lamanzi. Umthamo ophansi wezinto ezisebenzayo uvumela ukusetshenziswa komkhiqizo wezingane.
I-Flemoklav Solutab iyindlela entsha encibilikayo yomuthi obonakele we-antibacterial.
Ukwakheka kwethebhulethi elilodwa elinyibilikisiwe kufaka phakathi izinto:
- i-amooticillin (ngesimo se-trihidrate) - 145.7 mg, elihambelana ne-125 mg ye-antibiotic emsulwa;
- i-potasium clavulanate - 37.2 mg, okuthi ngokwe-clavulanic acid ingu-31.25 mg;
- ababukeli: i-microcrystalline cellulose, i-emulsifier, icrispovidone, i-vanilla, i-flavour, i-sweetener.
Amaphilisi e-Oblong asuka kumhlophe qwa ophuzi nge-inclusions ansundu, ngaphandle kwama-chamfers kanye namanothi, amakwa "421" kanye nelogo yomakhi.
I-Flemoklav itholakala kumithamo ka-250, 500 no-875 mg (amoxicillin), ekhonjiswa kumaphilisi ezinombolweni ezingama-422, 424 no-425 ngokulandelana.
Amathebhulethi anokuhlakazeka ahlanganiswa ngama-4 ama-pcs. kumaphakethe ama-blister, ama-blisters ama-5 emabhokisini amakhadibhodi anemiyalo yokutshala imali oyisebenzisayo ukuze isetshenziswe.
Isenzo se-Pharmacological
Ngokuphazamisa ukwakheka kodonga lwamagciwane, i-amoxicillin inegalelo ekufeni kwamagciwane. Iqondana nenqwaba yama-penicillin, ekuqaleni inesibalo esikhulu sokusebenza, futhi ukwakheka okuhlangene kuthuthukisa izakhiwo ze-antibacterial futhi kuvimbele ukuvela kwezingqinamba ezingazweli ngesikhathi sokwelapha.
I-Amoxicillin itholakala ubisi lwebele.
I-Clavulanic acid ivikela i-antibiotic emiphumeleni ye-beta-lactamases evezwa amanye amagciwane futhi ikwazi ukuvimba imiphumela ye-amoxicillin. Lokhu kunwebisa umthamo wesidakamizwa.
I-Flemoklav isebenza ngokulwa nama-microorganisms e-aerobic ne-anaerobic, kufaka phakathi i-gram-negative ne-gram-positive strains, kanye namagciwane agcina ama-enzymes wokuvikela - ama-lactamases.
I-Pharmacokinetics
Lezi zinto zombili zitholakala kakhulu ku-bioavava: ngenhla kwe-95% ye-amooticillin futhi cishe i-60% ye-clavulanate. Ukuqunjelwa endaweni yokugaya ukudla akuxhomekile ekugcwala kwesisu. Iqoqo eliphezulu le-amoxicillin esegazini litholakala ngokwesilinganiso emahoreni angama-1-2 nokuphathwa komlomo, okuhambisana namanani entengo we-clavulanic acid ku-plasma.
Umuthi wehlula umgoqo we-placental. I-Amoxicillin itholakala obisini lwebele, lwe-clavulanate, ayikho imininingwane enjalo. Zombili izinto zenziwa ngesibindi esibindini, ezikhishwa ikakhulu izinso. Isilinganiso sempilo-ecishe ifane futhi isukela emahoreni angu-1 kuye kwayi-2. I-Amoxicillin ne-clavulanate ziyakhishwa ngenkathi i-hemodialysis.
I-Amoxicillin ne-clavulanate ziyakhishwa ngenkathi i-hemodialysis.
Izinkomba zokusetshenziswa
Umuthi usetshenziswa nokuzwela okufakazelwe kwamagciwane amancane abangele lesi sifo, noma njenge-ejenti ebanzi yezifo ngezifo ezingachaziwe. Izinkomba zokusetshenziswa yilezi zimo ezilandelayo:
- ukutheleleka kwipheshana lokuphefumula elingaphezulu nelingezansi, kanye nezitho ze-ENT ngamafomu asezingeni eliphakeme nelingamahlalakhona;
- ukutheleleka kwesikhumba nezicubu ezithambile (kufaka phakathi izilonda ezihlanzekile, izilonda, amanxeba);
- ukulimala kwamagciwane ezinso nasegunjini lokuchama (kufaka phakathi i-cystitis, i-urethritis, i-pyelonephritis).
Ukuze uthole ukwelashwa kwezifo ze-gynecological, kanye nezilonda ezihlangene nezithambo, kudingeka imithamo ephezulu ye-amoxicillin. Ngakho-ke, umuthi ungabekwa ekuqoqweni kwe-500/25 noma i-875/2525, kusetshenziswa ifomu lethebhulethi elifanele.
Contraindication
Ungabeki umuthi ngokungabekezeleli kunoma iyiphi into ekwakhekeni nokuba khona kwe-hypersensitivity kuma-penicillin noma ama-cephalosporins emlandweni.
Okunye ukwephulwa:
- i-mononucleosis esithathelwanayo;
- i-lymphocytic leukemia;
- isibindi esihlobene ne-antibiotic noma ukungasebenzi kahle kwe-jaundice.
Ngokunakekela
Ngaphansi kokuqashwa njalo kwezokwelapha nangezinkomba eziqinile, ukwelashwa kwenziwa ngalezi zimo ezilandelayo:
- ukwehluleka kwesibindi;
- ukwehluleka okungapheli kwezinso;
- izifo zesistimu yokugaya.
UFlemoklav unqunywa ngokuqapha uma, ngemuva kokusebenzisa ama-penicillin, ukuthuthukiswa kwe-colitis kwaphawulwa.
Ungayithatha kanjani i-flemoklav solutab 125
Indlela yokunyibilika yokulungiselela okuyinkimbinkimbi ithathwa ngomlomo iphelele noma ifomu elihlanjululwe. Ukuze ulungiselele ukumiswa, kudingeka okungenani amanzi angama-30 ml, inani elilinganiselwe loluketshezi yingxenye yengilazi. Ithebhulethi iyavuselelwa kuze kuqedwe ngokuphelele futhi ukwakheka kudakwe ngokushesha ngemuva kokulungiswa.
I-antibiotic ayinqunyelwe ukungasebenzi kahle kwesibindi okuhlobene nemithi nezinye izifo zayo.
Zingaki izinsuku zokuphuza
Isikhathi sokwelashwa sinqunywa ngudokotela ngokuya ngokuqina kwesimo sesiguli, iminyaka, isisindo somzimba, izifo ezihambisanayo kanye nohlobo lokutheleleka. Inkambo evamile ihlala okungenani izinsuku ezi-5 futhi ingandiswa kuze kufike ezinsukwini ezingama-7-10. Umuthi awubekelwe isikhathi esingaphezu kwezinsuku eziyi-14.
Ngaphambi noma ngemuva kokudla
Ukusebenza kwazo zonke izingxenye zomuthi kuzimele kokudla. Ukuvimbela imiphumela emibi emgudwini wesisu, kunconywa ukuphuza ithebhulethi ngokudla.
Ngabe isifo sikashukela siyenzeka?
Umuthi awunazo izinto eziphikiswe ku-mellitus yesifo sikashukela futhi uvunyelwe ukusetshenziswa ngemuva kokubonisana nodokotela wakho.
Imiphumela emibi
Ngenxa yokwakheka okuhlanganisiwe nomthamo olungisiwe, umuthi ubekezelelwa kangcono kune-analogues yakhe eqenjini le-penicillin. Izehlakalo zokuphendula okungahambi kahle zingama-60% ngaphansi kwalapho i-amoxicillin emsulwa. Uma imithamo ebekwe udokotela ibonwa, imicimbi emibi ayivelakancane.
Umuthi awunazo izinto eziphikiswe ku-mellitus yesifo sikashukela futhi uvunyelwe ukusetshenziswa ngemuva kokubonisana nodokotela wakho.
Ukuphambana ngokweqile kwamagciwane, ukutheleleka ngefungal kungenzeka njengemiphumela emibi kuphela kusuka kumthamo omkhulu womuthi osetshenziswa ezifundweni ezinde.
Amapheshana wesisu
Kusukela epheshaneni lesisu, ukuvela kwenhliziyo, ukuhlanza, nobuhlungu besisu kungenzeka. Ngokulashwa isikhathi eside, ukuqunjelwa, ukuwohloka kwesibindi okwenza kubuye kwenzeke, ezimweni ezikhethekile, kubonakale izimpawu ze-pseudomembranous colitis (isifo sohudo esiphikelelayo).
Ushintsho emsebenzini wama-transaminases, ukwanda kwe-bilirubin kaningi akwenzeki kubantu besifazane nasezinganeni. Ukusabela okunjalo kulo muthi kuwuphawu lwamadoda, ikakhulukazi ngemuva kweminyaka engama-65. Ingozi yokulimazeka kwe-hepatic inyuka ngezifundo ezinde: ngaphezu kwamaviki ama-2.
Imiphumela emibi evela emgodini wesisu ingenzeka ngosuku lwe-4 lokuphuza umuthi, ngokushesha ngemuva kokwelashwa noma ngemuva kwamasonto ambalwa. Izinguquko ziyaphenduka.
Izitho zeHematopoietic
Ukusuka ezinhlelweni ze-lymphatic ne-hematopoietic, ukuphazamiseka kuphawulwa kaningi. Ukwandiswa kwesikhathi se-prothrombin kungokwesikhashana. Kwesinye isikhathi izinguquko ezinjalo ziyabonakala:
- i-leukopenia;
- i-thrombocytopenia;
- i-granulocytopenia;
- i-pancytopenia;
- i-anemia
Izinguquko kwifomula yegazi ziyaphenduka, futhi ngemuva kokuphothulwa kokwelashwa noma ukuhoxiswa kwezidakamizwa, izinkomba zibuyiselwa zodwa.
Isistimu yezinzwa ephakathi
I-Amoxicillin / clavulanic acid therapy ingahle ihambisane nekhanda. Isiyezi, ukwehluleka kuvame ukuvela njengezimpawu zokweqisa. Ukubonakala kwezimpawu ze-neurological akuvamile ukuba kuqashelwe: ukukhathazeka, ukuphazamiseka kokulala, ukuqina kwethonya noma ulaka.
Kusuka ohlelweni lomchamo
Ukungajabuli okuvela ezimweni ezingavamile (ukulunywa, ukusha, ukhipha) kukhombisa ukwephulwa ku-microflora yesitho sangasese. Ezimweni ezingazodwa, ukuthuthukiswa kwe-expressionomycosis, i-nephritis ye-interstitial kwaphawulwa.
Allergies
Ukuvela kokuqubuka kwesikhumba ekuqaleni kwenkambo yesifundo kungakhombisa ukungabekezeleleki kwezakhi. Akuvamile ukuthi umuthi uvuse izinhlobo ezahlukahlukene zesikhumba, i-erythema, iSteven-Johnson syndrome, i-vasculitis ye-allergic. Ubukhulu bokusabela kuncike kumthamo we-antibiotic othathwe kanye nesimo somzimba jikelele. Ezimweni ezinzima, ukuthuthukiswa kwe-edema ne-anaphylactic shock kungenzeka.
Imiyalo ekhethekile
Ukuhambisana notshwala
Ukusetshenziswa kwemithi elwa namagciwane kubangela umthwalo owengeziwe esibindini nasezinso. Ukusetshenziswa kanyekanye kwemikhiqizo equkethe utshwala kukhulisa umphumela onobuthi kwizitho kaningana. Kaningi, izinguquko ezingazelelwe zokucindezela, i-tachycardia, ukuqubuka okushisayo, isicanucanu kanye nokuhlanza kuyabonakala.
Ukusetshenziswa kanyekanye kwemikhiqizo equkethe utshwala kukhulisa umphumela onobuthi kwizitho kaningana.
I-Alcohol ne-amoxicillin bangabaphikisi. Isimo esidalwa ukusebenzisana kwabo kungaba sengozini empilweni.
Umthelela ekhonweni lokulawula izindlela
I-Amoxicillin ne-clavulanate ayithinti izinga lokuphendula nekhono lokulawula izindlela eziyinkimbinkimbi. Ukuqapha kufanele kuthathwe lapho ushayela imoto ngesikhathi sokwelashwa kulabo abaphuza umuthi okokuqala futhi ukusabela ngakunye komzimba akubhekwa.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Abukho ubufakazi bemitholampilo bemiphumela emibi enganeni lapho i-Flemoclav ibekelwa abesifazane abakhulelwe. Kunconywa ukuthi ugweme ukwelashwa ngama-antibiotic ku-trimester yokuqala. Kuma-trimesters e-2 ne-3, umuthi unqunywa ngemuva kokuhlola ukulimala kokuqashwa ngaphansi kokuqashwa njalo kwezokwelapha.
Ukudla i-amoxicillin obisini lwebele kungadala ukuqubuka komzimba, isisu, noma i-candidiasis ezinganeni ezisanda kuzalwa. Kulokhu, ukuncelisa kuyamiswa kuze kube sekupheleni kokwelashwa.
Ungayinikeza kanjani i-flemoklava solutab ezinganeni eziyi-125
Umthamo omncane we-amoxicillin ne-clavulanate kulesidakamizwa (ifomu elinyibilikisiwe) uyakuvumela ukuthi usetshenziselwe ukwelapha izingane. Umthamo wansuku zonke unqunywa udokotela ngokuya ngobunzima bokutheleleka kanye nesisindo somzimba wengane. Ukusuka ku-1 kuye ku-30 mg we-amooticillin uthathwa nge-1 kg yesisindo, inani elibaliwe lomuthi lincike eminyakeni yobudala.
Ezimweni ezinzima zesifo, udokotela angaliphinda kabili inani lempahla enqunyelwe. Umthamo omkhulu wansuku zonke wezingane ngu-15 mg we-clavulanate no-60 mg we-amoxicillin nge-1 kg yesisindo somzimba. Kungemva kokufika eminyakeni eyi-12 kuphela noma enesisindo esingaphezu kwama-40 kg lapho kuvunyelwe ukunquma izinhlobo zomuthi wabantu abadala.
Umthamo ekugugeni
Umuthi ohlanganisiwe ubekezelelwa kahle yiziguli esezikhulile. Ukulungiswa kwedosi kungadingeka kuphela uma kungasebenzi kahle izinso.
Isicelo sokusebenza kokulimala kwezinso
Ukulungiswa komthamo we-amoxicillin ohambisana ne-clavulanic acid ku-pathologies ye-renal kuyadingeka ngenxa yokuncipha kokukhipha izinto. Ngokuya ngezinga lokwehluleka kwezinso, kungancishiswa umthamo owodwa, kanti nesikhathi phakathi kwamathebulethi singandiswa.
Ukulungiswa kufanele kwenziwe yi-nephrologist ngokususelwa ekuhlolweni kwezinga lokuhlunga le-glomerular. Yehlisa inani lezinto zansuku zonke liqala uma ukufundwa kwemvume ye-creatine kwehla ngaphansi kwama-30 ml / min.
Sebenzisa umsebenzi wesibindi okhubazekile
Umuthi olwa namagciwane kufanele unikezwe ngokuqapha ezigulini ezinenkinga yokusebenza kwesibindi. Ukwelapha kungenzeka ngokuhlolwa kwelebhu njalo kwezinkomba.
Ukulungiswa komthamo we-amoxicillin ohambisana ne-clavulanic acid ku-pathologies ye-renal kuyadingeka ngenxa yokuncipha kokukhipha izinto.
Ukweqisa
Izimpawu zokuqala ze-overdose zingaba nemiphumela emibi emuthini. Isicanucanu, ukuhlanza, ukuhudula kuhambisana nokukhipha ukomisa. Uma kutholakala imiphumela emibi, kufanele uthintane nodokotela njalo.
Ukwelashwa okubonakalayo kwe-overdose kuqukethe ekuthatheni izimbotshana, ukuphinda wenze ibhalansi yama-electrolyte; ngokuphoxeka, i-Diazepam ivunyelwe. Ezimweni ezinzima, kunqunywa i-hemodialysis.
Ukuxhumana nezinye izidakamizwa
Ngokuphathwa kanyekanye kweFlemoclav nge-glucosamine, ama-laxatives kanye nama-antacid, ukufakwa kwe-antibacteria ethilini lokugaya ukudla kuyancipha; nge-Vitamin C - ishesha.
Okunye ukusebenzisana okufundwe:
- Ngama-antibiotic wesenzo se-bactericidal: aminoglycosides, cephalosporins, rifampicin, vancomycin ne-cycloserine - ukwanda kokusebenza kahle.
- Ngemithi ye-bacteriostatic: tetracyclines, sulfonamides, macrolides, lincosamides, chloramphenicol - antagonism.
- Ngama-anticoagulants angaqondile kuthuthukisa umphumela wawo. Kuyadingeka ukubheka njalo ukuhlangana kwegazi.
- Ngezinye izindlela zokuvimbela inzalo ngomlomo, ukusebenza kwazo kuyancipha. Kwandisa ubungozi bokuthi ukopha ngokweqile.
- I-Tubular secretion blockers (NSAIDs, phenylbutazone, diuretics, njll.) Ikhulisa i-amoxicillin.
Ukwelashwa okubonakalayo kwe-overdose kuqukethe ngokuthatha izidakamizwa.
Akunconyelwe ukunquma ngesikhathi esisodwa i-Flemoklav, i-Disulfiram, i-Allopurinol, i-Digoxin, efakwe ku-Amoxicillin.
Ama-Analog
Izimpawu zokusetshenziswa kwento esemqoka esebenzayo:
- Flemoxin Solutab;
- I-Amoxicillin;
- Augmentin;
- I-Amoxiclav;
- I-Ecoclave;
- Panclave.
Ama-analogues omuthi angaqukatha i-clavulanic acid noma i-amooticillin kuphela. Lapho ufakwa esikhundleni sezidakamizwa, naka ukwakheka nomthamo wengxenye ngayinye.
Izimo zeholide flemoklava solyutab 125 eziqhamuka ezitolo zezidakamizwa
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi olwa namagciwane usho izidakamizwa ezilungiselelwe. Amakhemisi amaningi azodinga ukuqokwa kodokotela ukuze athengiswe.
Intengo
Intengo kaFlemoklav Solutab kumthamo we-125 / 31.25 mg isezindaweni ezahlukahlukene zamakhemisi kusuka kuma-ruble angama-350 kuya kwangama-470.
Izimo zokugcina zomuthi
Ukushisa kwesitoreji - hhayi okuphakeme kuno- + 25 ° C. Gwema kude nezingane.
Isikhathi sokuphelelwa yisikhathi
Ngokubambelela ngokuqina kwephakeji, umuthi ugcina izakhiwo zawo iminyaka emi-3.
Umkhiqizi flemoklava solutab 125
I-Astellas Pharma Europe, Leiden, Netherlands
Ukubuyekezwa flemoklava solutab 125
U-Alina, oneminyaka engama-25, uPetrozavodsk:
UFlemoklav soluble uqokwe udokotela wezingane. Baqala nje ukuya enkulisa futhi bebegula njalo.Lapho i-bronchitis iqala, udokotela wabeka i-antibiotic. Isimo saba ngcono ngemuva kwezinsuku ezingama-5 zokwelashwa. Yize kwakwethusa kancane, yayingekho imiphumela emibi. Lapho sichithwa, kulula ukubanikeza isiphuzo samanzi, yize ukunambitheka kuhlala kungathandeki, kepha indodana yenqaba ngokuphelele amaphilisi.
UMarina, oneminyaka engama-35, u-Omsk:
Ngemuva komkhuhlane, indodana (eneminyaka eyi-7) yaqala ukuba nobuhlungu obukhulu bendlebe futhi izinga lokushisa lagxuma izinsukwana. I-ENT ikhombe abezindaba zesobunxele ze-otitis yabe isiyalela uFlemoklav Solutab no-Otipax behla ezindlebeni. Umuthi olwa namagciwane awubizi, kepha uyasiza ngokushesha. Ngemuva kwamaphilisi amabili, usevele walala ngokuthula. I-Otitis yelashwa ngesonto.
