I-cholesterol ephezulu ngalesi sikhathi sokuthuthuka komphakathi ingenye yezinkinga ezivame kakhulu esizukulwaneni esidala. Eminyakeni yamuva nje, ukuba khona kwe-cholesterol ephezulu kuyaqhubeka nokuqoshwa esizukulwaneni esincane.
Izizathu zokuvuselelwa kabusha kwe-pathology yenzeka kaningi kokucindezelwa kwengqondo okucindezelayo emzimbeni, ukwephula isiko lokudla, ukudla inani elikhulu lemikhiqizo engaba yingozi, futhi futhi kuholele nokuhlala lapho uhlala khona. Zonke lezi zinto zivusa ukuphazamiseka kwe-metabolic emzimbeni.
Ukuqeda isimo sokuphakama se-pathological, kuyadingeka ukuthi ukhethe umuthi omuhle futhi osebenzayo wokulungiswa okwelashwa kwe-cholesterol ku-plasma yegazi.
Ukwehlisa i-cholesterol ephezulu emzimbeni, odokotela bavame ukutusa ukusetshenziswa kwezidakamizwa eziseqenjini lama-statins.
Ethandwa kakhulu izidakamizwa ezimbili kuleli qembu - Krestor noma Roxer.
Le mishanguzo yehlisa i-lipid yenziwa ngumenzi ngesimo samathebulethi wokuphathwa komlomo.
Ukuze wenze ukwelashwa okusebenzayo, udinga ukuthola uRoxer noma i-Atorvastatin okungcono, ngaphezu kwalo mbuzo, iziguli nazo zinombuzo wokuthi yini engcono kuneRosucard noma iRoxer. Ukuvela kwale mibuzo kuhlobene nokuthandwa okuphezulu kwalezi zindlela zokwenza i-hypolipidemic therapy.
Ubunzima ekukhetheni umuthi ofanele ukuthi bonke banemiphumela efanayo emzimbeni wesiguli. Ngalesi sizathu, ngudokotela ohambelayo kuphela okwaziyo ukukhetha inketho efanele yezidakamizwa ngokuya ngemiphumela yokuhlolwa futhi anaka izici zomzimba womzimba wesiguli.
Izici zesidakamizwa Crestor
Isiphambano umuthi wangempela onezakhiwo ezokwehlisa i-lipid. Ukusetshenziswa kwesidakamizwa kunganciphisa ngempumelelo i-cholesterol ephelele, izinga lamandla aphansi we-lipoprotein kanye ne-triglycerides.
Umuthi umuthi wokuncintisana okhethiwe we-HMG-CoA reductase. Le enzyme ibhekele ukuguqulwa kwe-3-hydroxy-3-methylglutarylcoenzyme A to mevalonate, okuyisandulelo sotshwala be-polycyclic lipophilic.
Inkomba eyinhloko yokuvezwa kwezidakamizwa ama-hepatocytes wesibindi, lapho kwenziwa khona i-cholesterol ne-LDL catabolism.
Lapho usebenzisa umuthi, ukubonakala komphumela wokwelapha ubonwa ngesonto elilodwa ngemuva kokuqala kokuphatha.
Umphumela omkhulu utholakala ngokuphela kwenyanga yokwelashwa.
I-Excretion yeKrestor yenziwa ivela emzimbeni ngesimo esingaguquki njengengxenye yamalondolo. Cishe i-90% yengxenye esebenzayo yesidakamizwa ikhishwa ngamathumbu. I-10% eseleyo ikhishwa yizinso emchameni.
Isibonakaliso sokusetshenziswa komkhiqizo wokwelapha yile:
- ukuba khona kwesiguli se-hypercholesterolemia eyisisekelo ngokusho kukaFredrickson;
- isiguli sinomndeni i-homozygous hypercholesterolemia;
- ukutholwa kwe-hypertriglyceridemia enzima emzimbeni womuntu;
- ukusetshenziswa komuthi njengesici esinciphisa ukuqhubekela phambili kwe-atherosulinosis.
Lapho usebenzisa umuthi, okudingeka ukugcinwa kokudla okuqinile okwehlisa i-lipid.
Ukuxhumana kokusetshenziswa kweCrestor yilezi zimo ezilandelayo:
- Isifo sesibindi esigabeni esisebenzayo.
- Ukwephulwa kwezinso.
- I-Myopathy
- Ukwamukelwa njenge-ejenti yokwelapha ye-cyclosporine.
- Isikhathi sokukhulelwa nokuncelisa ibele.
- Hypersensitivity kuzakhi zomuthi.
Ngokuqapha, umuthi usetshenziselwa ukuhlukunyezwa kotshwala yisiguli futhi esimweni sokwelashwa asebekhulile, nesiguli esingaphezu kweminyaka engama-65.
I-overdose yesidakamizwa ingabangelwa uma ukuphathwa ngasikhathi sinye kwemithamo eminingana yansuku zonke.
Ayikho i-antidote ethile, futhi ukwelashwa kwenziwa uma kunesibonakaliso esidingekayo, okuhloswe ngakho ukugcina umsebenzi wezitho zomuntu ezibaluleke kakhulu.
Ukwakheka komuthi, indlela yokusebenzisa nomthamo
Isithako esikhulu esisebenzayo eCrestor yi-rosuvastatin. Le nto inomphumela okwehliswayo we-lipid. Ngaphezu kwalokho, ukwakheka kwamathebhulethi kunobubanzi obuhlukahlukene bezakhi zamakhemikhali ezidlala indima yokusiza.
Ukuthatha umuthi ngokuhambisana nemiyalo yokusebenzisa kungenziwa nganoma yisiphi isikhathi sosuku. Ithebhulethi ithathwa ngomlomo, ayihlafuneki futhi ihlanzwe ngenani elanele lamanzi. Isilinganiso sokuqala esinconyiwe somuthi ngu-5 mg. Uma kunesidingo, ukulungiswa kumthamo osetshenzisiwe kwenziwa ngenyanga ngemuva kokuqala kokwelashwa.
Lapho ukhetha umthamo wokuqala, umuntu kufanele aqondiswe yimiphumela yocwaningo lwesiguli kokuqukethwe kwe-cholesterol eseplasma yegazi. Ngaphezu kwalokho, lapho kuthathwa umthamo, kuyadingeka ukuhlola amandla wemiphumela emibi.
Lapho welapha iziguli zohlanga lwamaMongoloid, isilinganiso sokuqala somuthi esinconyiwe yi-5 mg.
Esimweni lapho isiguli sithambekele ekuthuthukisweni kwe-myopathy, khona-ke umthamo wokuqala womuthi uvunyelwe
Lapho usebenzisa umuthi, isiguli singathola imiphumela emibi ehlukahlukene.
Imvamisa, imiphumela emibi lapho usebenzisa i-Krestor ibonakaliswa uhlelo lwezinzwa oluphakathi, ipheshana lesisu, isikhumba, uhlelo lwe-musculoskeletal, kanye nohlelo lomchamo.
Ukufana kwezidakamizwa kungumuthi olandelayo:
- Mertenyl;
- Rosuvastatin SZ;
- URosart
- I-Tevastor
- IRosucard;
- I-Rosicore;
- Rosulip;
- I-Rustor;
- Roxer nabanye.
Izindleko zeKrestor nezimpawu zayo ziyahlukahluka ngokuya ngesifunda sezwe kanye nohlobo lomuthi oluthengwe umuntu ogulayo.
Eshibhile, kodwa ngasikhathi sinye ikhwalithi enhle ye-Crestor - Akort. Izindleko zalo muthi zingama-ruble angama-511.
Uma kuqhathaniswa nezindleko zomuthi woqobo ongama-ruble ayi-1,676, ungaphezulu kwezikhathi ezi-3.
Izici zesidakamizwa Roxer
I-Roxera isidakamizwa esinamandla se-hypolipidemic. Isithako esisebenzayo salo muthi yi-rosuvastatin.
Izinkomba zokusetshenziswa kwalo muthi wukuba khona kwesiguli se-hypercholesterolemia ngezindlela ezahlukahlukene - okuyizingqangi futhi ezixubekile.
I-Roxer nayo isetshenziswa ekwelapheni isifo esifana ne-atherosulinosis. Ukusetshenziswa kwomuthi kuvimbela ukukhula kwezifo ezimbi ezihambisana ne-cholesterol ephezulu ku-plasma yegazi.
Ozakwethu abajwayelekile kakhulu futhi abadumile kakhulu bakwaRoxer phakathi kweziguli izidakamizwa ezifana ne-Atoris neKrestor.
Kulezi zidakamizwa, i-compact main esebenzayo iyinto efanayo - rosuvastatin.
I-Roxera ingumuthi owakhiwa osokhemisi baseRussia.
I-Roxera iyatholakala ngesimo samathebulethi ahloselwe ukuphathwa ngomlomo.
Izibhebhe zomuthi zithathwa ngomlomo futhi zigezwa ngenani elanele lamanzi.
Imithamo Roxers esetshenziswa ekwelashweni iyafana nale esetshenziswa ekwelapheni kweCrestor.
Contraindication ukusetshenziselwa yilezi zimo ezilandelayo:
- I-Hypersensitivity engxenyeni eyinhloko noma amakhompiyutha asizayo.
- Isikhathi sokukhulelwa nesikhathi sokuncelisa.
- Iminyaka yesiguli ifinyelela eminyakeni eyi-18.
- Isiguli sinokubekezelelwa kwe-lactose kanye nokuntuleka emzimbeni we-lactase.
- I-Myopathy
- Ukwehluleka kwangempela nokwenziwa kwesibindi.
Endabeni yokusetshenziswa kwesidakamizwa, ukuthuthukiswa kwemiphumela emibi equkethe isiyezi kungenzeka; ikhanda; ukuqhuma kwesikhumba; ukuthuthukiswa kwe-jaundice; ukuthuthukiswa kwe-hepatitis; ukulahleka kwenkumbulo; Ubuhlungu esiswini; ukwenzeka kokuqunjelwa kanye nesifo sohudo; isicanucanu myopathy.
Ama-analog amakhulu weRoxers engxenyeni esebenzayo yile:
- URosulip.
- I-Rosucard.
- Crestor.
- I-Tevastor
- I-Mertenil.
- I-Akorta.
- I-Rustor.
Ama-analoggues alesi sidakamizwa, okuyiqembu lama-statins, yiZokor, Vazator, Lipona. I-Lipostat, i-Apextatin nezinye izindlela.
Umehluko omkhulu phakathi kukaCrestor noRoxer
Ukuze uphendule umbuzo wokuthi yisiphi isidakamizwa uKrestor noma uRoxer esingcono, kuyadingeka ukuthi ufunde umehluko omkhulu phakathi kwezidakamizwa.
Yomibili le mishanguzo ingeyeqembu elilodwa futhi inenhlanganisela efanayo esebenzayo, umehluko phakathi kwezidakamizwa ulele ekwakhiweni kwezakhi ezisizayo ezisetshenziswa emithini. Zombili lezi zidakamizwa zinciphisa kahle izinga lama-lipids emzimbeni wesiguli.
Lapho ukhetha umuthi, umehluko okhona phakathi kwemithi, okulandelayo:
- URoxer uyakwazi ukuqongelela umphumela wezokwelapha ngakho-ke amandla amahle akhonjiswa uma usebenzisa umuthi kuphela ekupheleni kwesonto lesibili lokuphatha. Isiphambano umuthi isenzo saso sishesha kakhulu, umphumela uyabonakala osukwini lwesi-5 somuthi.
- Lapho uthatha i-Krestor esigulini, ukukhula kwesifo sikashukela sohlobo 2 kungenzeka. Endabeni yokusetshenziswa kwomuthi wasekhaya, ukwephulwa okunecala okunjalo akubonwa.
- Umuthi osekhaya uyakwazi ukuvusa ukubonakala kwamaprotheni ekuhlolweni kwegazi elebhu, kanti i-analogue yakhe echaziwe ayibangeli ukwephulwa okunjalo.
- Isiphambano singasetshenziswa yiziguli ezingaphansi kweminyaka engu-18 ubudala, futhi umuthi wasekhaya uvunyelwe ukusetshenziswa kuze kube iminyaka eyi-18.
Lapho usebenzisa umuthi owodwa nowodwa, kudingeka ukudla okuqinile kwe-hypolipedymic nokulawula okwengeziwe komsebenzi wokusebenza kwesibindi.
Ngaphambi kokuthatha isinqumo mayelana nokukhethwa kwemithi, kunconywa ukubonisana nodokotela wakho futhi ujwayelane nokubuyekezwa kodokotela neziguli ngomunye nangomunye umuthi.
Ukubuyekezwa ngokusetshenziswa kwemithi engenisiwe kuvame ukushiywa kakhulu yiziguli ezine-atherosclerosis. Ngokusho kwabo, ukusetshenziswa kwalo muthi kukuvumela ukuthi unwebe isikhathi sokuxolelwa futhi wehlise inani lokuphindaphindeka okwenzeka, kanti ukusetshenziswa kwalesi sidakamizwa kwezinye izimo kugwema ukulaliswa esibhedlela.
Ngokusho kweziguli, ukusetshenziswa kwezidakamizwa ezifuywayo kuhlotshaniswa nokwenzeka kwemiphumela emibi ehlukahlukene esigulini. Umphumela onjalo emzimbeni wesiguli ubangela injongo engandile ye-analogue yasekhaya yeKrestor.
Uma kufanele ngithathe ama-statins uzotshela uchwepheshe kuvidiyo ekulesi sihloko.
