IManinil 5 isidakamizwa se-hypoglycemic esetshenziselwa ukwelapha isifo sikashukela.
Igama Lezwe elingafanele
I-Glibenclamide.
IManinil 5 isidakamizwa se-hypoglycemic esetshenziselwa ukwelapha isifo sikashukela.
I-ATX
A10VB01 - Glibenclamide.
Khipha amafomu nokwakheka
Flat, amaphilisi cylindrical egobolondweni. Umbala wegobolondo upinki. Isithako esiyisisekelo esisebenzayo yi-glibenclamide, eyethulwa lapho kulungiswa ngesimo esenziwe ngemiksi. Ukuqanjwa kwahlanganiswa ne-talc, i-gelatin, i-lactose monohydrate, isitashi samazambane, i-magnesium stearate, udayi obomvu.
Isenzo se-Pharmacological
IGlibenclamide yehlisa izinga lokucasulwa kwamaseli e-beta ngoshukela, ongena emzimbeni ngokudla, ngaleyo ndlela ivuselela ama-pancreas ukukhiqiza i-insulin eyanele.
Umuthi ukhulisa ukuzwela kwe-insulin, ukusheshisa ukubopha kwe-hormone ukukhomba amaseli. Imbangela ukukhishwa okusheshayo kwe-insulin ekhiqizwayo. Inqanda inqubo ye-lipolysis kwezicubu ze-adipose.
I-Pharmacokinetics
Umphumela wokwelapha uthatha usuku, umuthi uqala ukusebenza ngemuva kwamahora 1.5-2 ngemuva kwesicelo. Izakhi zithakwa ngokushesha futhi emzimbeni ngokuphelele. Ukuhlushwa okuphezulu egazini kutholakala ngemuva kwamahora we-2-2,5. Amaphesenti okubopha kumaprotheni egazi angama-98%.
Umuthi oyinhloko wesidakamizwa uthola inqubo ye-metabolic ezicutshini zesibindi, ngenxa yalokho kwakhiwa ama-metabolites amabili angasebenzi. Enye yazo ikhishwa ngomchamo, enye ine-nele.
Ukuqedwa kwesigamu sempilo kuthatha amahora angama-7, futhi kubantu abanezifo zegazi kuthatha isikhathi eside.
Izinkomba zokusetshenziswa
Kunqunyelwe ekwelashweni kohlobo 2 lwe-insulin ethembele kushukela. Ukuphuza umuthi kuyadingeka lapho kungenzeki ukuthi kujwayeleke ukugxilisa ushukela ngokudla kanye nokuzivocavoca umzimba. Ekwelashweni kwesifo sikashukela, umuthi unqunyelwe ekwelashweni okuhlanganiswa namanye ama-hypoglycemic agents, ngaphezu kwama-glinides kanye ne-sulfonylureas.
Umuthi unqunyelwe ekwelapheni uhlobo 2 lwesifo sikashukela esincike ku-insulin.
Contraindication
Ukwemukelwa kwe-ejenti ye-hypoglycemic akunakwenzeka kuzimo ezinjalo:
- Uhlobo 1 isifo sikashukela;
- i-precoma, ikhesa;
- ukuphazamiseka kwe-metabolic okubolile;
- isikhathi sokululama ngemuva kokususwa kwe-yegilo yegilo;
- i-carbohydrate metabolised ebunjiwe ebangelwa izifo ezithathelwanayo;
- gastric paresis;
- i-leukopenia;
- ukwephulwa kwenqubo yokungenisa ukudla;
- hypoglycemia
Kuvinjelwe ngokuphelele ukuthatha phambi kokungabekezelelani komuntu ngamunye ezingxenyeni ezithile zomuthi.
Ngokunakekela
Ukuphulwa okuhlobene yilezi:
- umkhuhlane;
- ukuphazamiseka kwe-gland yegilo;
- i-pituitary hypofunction;
- ukusetshenziswa ngokweqile futhi njalo kotshwala, wonke amabanga obunzima bokuncika kotshwala.
Kulezi zimo, umuthi unqunyelwe izinkomba ezikhethekile kuphela, lapho amanye ama-hypoglycemic agents engakwazi ukunikeza umphumela ofanele wokwelapha. Ngokuqapha ngokweqile, umuthi ubekelwe abantu abangaphezu kweminyaka engama-65. Ezigulini esezikhulile, kunamathuba aphezulu we-hypoglycemia.
Ungayithatha kanjani iManinil 5?
Inkambo yokwelashwa iqala ngomthamo omncane noma ojwayelekile, okumele wenyuswe kancane kancane. Umthamo wokuqala ngu-2,5 mg noma we-5 mg (isigamu noma i-tablet ephelele), thatha isikhathi esingu-1 ngosuku. Umthamo ukhuphuka ngeviki eli-1 uze ulethwe ezincomweni zokwelapha.
Uma udokotela enquma amaphilisi ama-2, kufanele aphuzwe isikhathi esisodwa ngosuku. Uma kunesidingo, thatha ezibhebheni ezi-3 noma ngaphezulu ngosuku, umthamo kufanele uhlukaniswe ngemithamo eminingana ngokusho kohlelo - iningi lomuthi ekuseni, kancane kusihlwa.
Ngoshukela
Ekhambweni elilula lesifo sikashukela sohlobo 2, umthamo wansuku zonke ngu-2,5 mg. Inkambo enzima yesifo ingu-15 mg / ngosuku. Amacwecwe adakiwe 1 isikhathi. Uma kuthathwa umthamo we-15 mg, uhlukaniswe ngemithamo emi-2 ngosuku. Izibhebhe zidakwe ziphelele ngaphandle kokuhlafuna.
Umuthi uthathwa imizuzu engama-30 ngaphambi kokudla okukhulu.
Umuthi uthathwa imizuzu engama-30 ngaphambi kokudla okukhulu. Uma amandla agqamile avela ekusebenziseni i-hypoglycemic agent engekho izinyanga eziyi-1-1,5, umuthi kumele ushintshwe.
Imiphumela emibi yeManinil 5
Imvamisa kuba khona kokusabela okufana nokungajabuli - isicanucanu, ubuhlungu besisu, isisu, ukuqaqamba ekhanda, umkhuhlane. Akuvamile: kunciphise ukubonwa kwe-acuity, ukungasebenzi kahle kwesibindi.
Amapheshana wesisu
Isicanucanu, ukungagabuki kaningi, ukuzwa isisu esigcwele nokusinda okukuyo. Ubuhlungu besisu, ukuvalwa njalo, isifo sohudo, ukunambitheka kwensimbi emgodini womlomo. Ukuba khona kwalesi sifo kungadingi ukuyekwa komuthi.
Izitho zeHematopoietic
Isibonakaliso secala esingajwayelekile: i-thrombocytopenia, i-pancytopenia. Amacala angajwayelekile: i-leukopenia, agranulocytosis, i-erythropenia, i-hemolytic anemia.
Isistimu yezinzwa ephakathi
Ubuhlungu bekhanda nesiyezi, ukuqwasha, ukudangala. Ukuthuthuka kwama-automatisms asendulo kungukusonteka ngokuzithandela, ukwenza ukunyakaza okungalawuliwe, umpetha, ukuqina kwemisipha kanye nokwehla kokuzithiba.
Ngasohlangothini lwe-metabolism
Umuzwa oqhubekayo wendlala, ukozela nokukhathala, ukujuluka ngokweqile, ukuhlangana kahle kokunyakaza, ukuphazamiseka kokukhuluma, i-parresis, ukukhubazeka komzimba, ukushesha kwesisindo.
Kusuka emasosheni omzimba
Akuvamile: ukulunywa kwesikhumba, ukubonakala kwe-urticaria. Akuvamile kakhulu: umkhuhlane, i-jaundice, ukuthuthukiswa kokuqhaqhazeka kwe-anaphylactic, ukubukeka kwe-vasculitis, arthralgia.
Allergies
Umkhuhlane, ukuqubuka kwesikhumba, i-vasculitis yemvelo yokwaliwa.
Umthelela ekhonweni lokulawula izindlela
Kubangela imiphumela emibi yesikhashana evela kwa-NS, kungaholela ekunciphiseni kokuxineka futhi kwehlise ijubane lokuphendula. Njengoba kunikezwe ubungozi obukhona, kunconywa ukwenqaba ukushayela izimoto nokusebenza ngezinqubo eziyinkimbinkimbi zesikhathi sokwelashwa.
Imiyalo ekhethekile
Ukuyekelela isikhathi eside ekudleni ukudla, ukuntuleka kwama-carbohydrate ekudleni, ukusebenza ngokweqile komzimba kungaholela ekwakhiweni kwe-hypoglycemia. Masking of izimpawu ze-hypoglycemia kuyabonakala ngenkathi uthatha lo muthi nezidakamizwa ezithinta uhlelo lwangaphakathi lwezinzwa.
Ukwenqaba kusukela ekuphathweni ngomlomo kweManinil 5 ngokushintshwa kwe-insulin kuyadingeka ngemuva kokuhlinzwa, lapho kukhona izilonda zesikhumba ezinwebekile, amanxeba, ukushiswa, izifo ezithathelwanayo ezihambisana nombuso onamandla kakhulu.
Sebenzisa ebudaleni
Ukunakekelwa okubalulekile kufanele kuthathwe nomthamo ngamunye okhethiwe ngenxa yobungozi obukhulu be-hypoglycemia.
Ukuqokwa kukaManinila izingane ezi-5
Izifundo zemitholampilo ezifundweni zezingane azenziwanga. Ngokunikezwa ubungozi obungahle bube khona, umuthi awubekiwe kuze kube iminyaka eyi-18.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
I-Contraindified ngenxa yezingozi eziphezulu zokuthola ukusabela okungafuneki nezinkinga.
Isicelo sokusebenza kokulimala kwezinso
Kunqunyelwe umthamo wokugcina omncane.
Sebenzisa umsebenzi wesibindi okhubazekile
Umthamo omncane wokwelapha uvunyelwe.
I-Overdose yeManinil 5
Ukusetshenziswa okukodwa komthamo ophakeme wesidakamizwa kuholela ekubonakaleni kwezimpawu kakhulu ze-hypoglycemia, ukuphazamiseka kwemizwa, ukuhlanekezela kokuqonda. Ukudakwa kakhulu kubangela ukulahlekelwa ukuzithiba, i-hypoglycemic coma.
Ukwelashwa ngokweqile - ukuthathwa kokuphuthumayo kokudla okumnandi noma kwamanzi, ucezu kashukela ocolisisiwe. Uma isiguli siphelelwa yimizwa - ukuphathwa okuphathelene nekhambi le-glucose. Ekudakwiseni kakhulu, kudingeka ukunakekelwa okujulile.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa okuhambisana ne-ACE inhibitors, ama-anabolics, umuthi wokutholwa kwe-coumarin, ama-tetracyclines akhulisa umphumela wokwelashwa womenzeli we-hypoglycemic.
Izindlela zokuvimbela inzalo, izidakamizwa ze-hormonal, ama-barbiturates anciphisa umphumela we-hypoglycemic.
Ihambisana ne-Acarbose, insulin, Metformin.
Ukuhambisana notshwala
Ukuphuza utshwala akunakwa. I-Ethanol yomabili iphansi futhi inyusa umphumela wesidakamizwa.
Ama-Analog
Izidakamizwa ezinomphumela ofanayo we-hypoglycemic: Gliclada, Glian, Glimax, Glimed, Reklid, Perinel.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela?
Ukuthengiswa kwencwadi kadokotela
Intengo yeManinil 5
Izindleko ziqala kusuka kuma-ruble ayi-120. Ibhodlela ngalinye noma iphakheji elinamabhulashi anamathebhulethi ayi-120.
Izimo zokugcina zomuthi
Ekushiseni kwegumbi.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
Berlin-Chemie AG, eJalimane.
Ukubuyekezwa ku-Maninil 5
Odokotela
USvetlana, oneminyaka engama-50 ubudala, iMoscow, i-endocrinologist: "Lesi sidakamizwa sakwamanye amazwe ngentengo engabizi siyithuluzi elihle kakhulu lokwelashwa okusekela uhlobo lwe-2 mellitus yesifo sikashukela. Kuyaqabukela kudala ukubonakaliswa okungekuhle, kepha lapho kusetshenziswa, ukudla kanye nokuzivocavoca okulinganiselayo kuyadingeka."
USergey, oneminyaka engama-41 ubudala, udokotela obulala izidakamizwa, u-Odessa: "Umuthi we-hypoglycemic ungenye yezidakamizwa ezihamba phambili kuleli qembu lezokwelapha. Alinawo umlutha, libekezelelwa kahle yiziguli futhi lingasetshenziswa njenge-prophylaxis ekuxolelweni."
Isifo sikashukela
UKsenia, 52, uBarnaul: "Amathebulethi akwaManinil asizile ngokushesha. Lapho ushukela uqala ukukhuphuka ngokushesha, umuthi wehlise ukugcwala kwe-glucose amahlandla ama-2 ngesikhathi esifushane. Angibanga nemiphumela emibi."
UGennady, oneminyaka engama-42 ubudala, uMinsk: "Isikhathi eside bengifuna umuthi ongasiza ngokushesha ukwehlisa ushukela. Ngikwazile ukuthola la maphilisi.Asebenza kahle. Into esemqoka ukuwasebenzisa ngokucophelela ukuze kungabikho buthakathaka (hypoglycemia) ngemiphumela emibi, ngibe nekhanda nje nobuthakathaka obuncane. "
UMarianna, oneminyaka engama-32, u-Irkutsk: "Izinkomba zesifo sikashukela zehle kabili ezinsukwini ezimbalwa ngemuva kokufaka isicelo seManinil 5. Impilo iyonke yathuthuka kakhulu. Ngithatha lesi sidakamizwa ngenza isifundo, bese ngiqala ikhefu. Ngakwazi ukuzuza ukuxolelwa ezifundweni eziningi ezinje."
