I-Moflaxia 400 - amaphilisi ane-antibacterial isenzo, aqukethe ama-400 mg we-moxifloxacin. Isakhiwo esisebenzayo siyasebenza ngokuchasana ne-aerobes yegramu ne-gram-positive. Ochwepheshe bezokwelapha banquma i-antibiotic yokuthuthukiswa kwezinqubo ezithathelwanayo, ezihambisana nokuvuvukala okunzima. Ngesikhathi sokulashwa, kubalulekile ukulandela ngokuqinile izincomo zikadokotela nemiyalo yokuyisebenzisa.
Igama Lezwe elingafanele
Moxifloxacin.
I-Moflaxia 400 - amaphilisi ane-antibacterial isenzo, aqukethe ama-400 mg we-moxifloxacin.
I-ATX
J01MA14.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo samathebulethi aqukethe ama-400 mg wekhompiyutha esebenzayo - moxifloxacin hydrochloride. Ukwenza ngcono ukumuncwa, into esebenzayo ihlanganiswe nezinto ezengeziwe:
- i-magnesium stearate;
- i-microcrystalline cellulose;
- crodarmellose sodium.
Umbala wefomu lezidakamizwa upinki omnyama, ngenxa yokuqukethwe kudayi obomvu. Izibhebhe zihlanganiswa ne-titanium dioxide, macrogol ne-hypromellose. Amayunithi omuthi usezinhlakeni zamakhadibhodi zezingcezu ezi-5, 10, eziyi-15 ezinhlwini.
Umphumela we-bactericidal kungenxa yokuvinjwa komsebenzi we-enzymatic wezakhi zangaphakathi ezibandakanyekile ekuphindaphindweni nasekubhalweni kwezinto zofuzo.
Isenzo se-Pharmacological
Indlela yokusebenza ye-bactericidal yesenzo kungenxa yokuvinjwa kwe-topoisomerase II ne-IV, i-protein metabolism kanye nokuvinjwa komsebenzi we-enzymatic wezakhi zangaphakathi ezibandakanyekile ekuphindaphindweni nasekubhalweni kwezinto zofuzo. Njengomphumela wokuthola umphumela wokwelapha, amandla odonga lweseli ayancipha. Uhlobo lwe-pathogenic lufa ngenxa yokwephulwa kwengcindezi ye-osmotic.
I-Pharmacokinetics
Lapho sithathwa, i-ejenti yomlomo iqala ukudonswa ngokushesha ngaphakathi odongeni lwamathumbu, ukusuka lapho iguqukela egazini. Ngomthamo owodwa we-400 mg, ukuqina kwe-serum ephezulu kunqunyelwe ngaphakathi kwemizuzu engama-30-240 ngemuva kokufaka isicelo. I-Bioavailability ingama-91%. Egazini, ukuxhumana namaprotheni e-plasma kufinyelela ku-45%.
Umuthi ngokuhlanganiswa kwe-albhamuin uqala ukusakazeka ngezicubu nakamanzi. Ukuqunjelwa okuphezulu kwe-moxifloxacin kubonwa ku-alveoli yamaphaphu, i-bronchi, i-epanelium ye-cutaneous, endaweni yenqubo yokuvuvukala. Lapho udlula kuma-hepatocytes, i-compact esebenzayo isebenza ngaphansi kwe-biotransformation ngokwakhiwa kwama-glucuronides nama-sulfates angenawo umsebenzi we-antimicrobial.
Ukuqedwa kwesigamu sempilo kuthatha amahora ayi-12. Umuthi olwa ne-antibacterial udlulwa ngendlela yokuqala ye-moxifloxacin nomchamo ngo-15%, onamanyala asesimweni semetabolites ngo-25%.
Lapho sithathwa, i-ejenti yomlomo iqala ukudonswa ngokushesha ngaphakathi odongeni lwamathumbu, ukusuka lapho iguqukela egazini.
Izinkomba zokusetshenziswa
Ochwepheshe bezokwelapha banganquma iMoflaxia lapho kunezinqubo ezithathelwanayo ezicasulwa ama-microorganisms we-pathogenic azwela i-moxifloxacin:
- ukuvuvukala okukhulu kwezono;
- i-bacterial bronchitis;
- inyumoniya etholwe ngumphakathi;
- ukulimala kokutheleleka esikhunjeni nezicubu ezithambile, izifo eziyindida eziyinkimbinkimbi noma ezingasho lula (unyawo lwesifo sikashukela);
- izifo zokuvuvukala zezitho zangasese zowesifazane;
- ukutheleleka kwe-intra-isisu;
- I-stomatitis, i-prostatitis, i-cystitis eyingozi;
- izinqubo zokutheleleka nokuvuvukala emgodleni we-pelvic, hhayi ezihambisana nokwakhiwa kwezinkinga.
Contraindication
Ekwenzeni umtholampilo, i-Moflaxia ayinqunyelwe ukuthi:
- ukuba khona kwezinqubo ze-pathological of tendons eziye zathuthukiswa ngenxa yokwelashwa ngama-quinolones;
- yandisa isikhathi esiphakathi kwamazinyo e-Q-T kwikhadinali;
- ukuphazamiseka kubhalansi-wamanzi we-electrolyte;
- ukuzwela kokuzwela komzimba kuma-antibiotics we-fluoroquinolones noma ezintweni ezihlangene zeMohlaxia;
- ama-pathologies we-vascular ezinzima;
- umsebenzi owengeziwe we-hepatic aminotransferases.
Umuthi awuvunyelwe ukusetshenziswa ngabesifazane abakhulelwe nababambisayo.
Ngokunakekela
Kuyadingeka ukuthatha umuthi ngaphansi kokuqashwa okuqinile kwezokwelapha phambi kwale mibandela elandelayo:
- inqubo ye-pathological yesistimu yezinzwa ephakathi, engavusa ukuthuthukiswa kwemisipha yokuqothuka;
- ukuphazamiseka kwengqondo, ukukhuphuka kokukhathazeka, ukwesaba;
- izifo zesisu esiswini;
- ukuphazamiseka kwesigqi senhliziyo;
- isifo senhliziyo;
- ukonakala kwamafutha noma i-cirrhosis yesibindi;
- ukuntuleka kwe-glucose-6-phosphate dehydrogenase;
- myasthenia gravis.
Akunconyelwe ukuthatha umuthi ngokuhambisana nezidakamizwa ezinciphisa ukugcwala kwama-ion e-potassium ku-plasma.
Ungayithatha kanjani iMoflaxia 400
I-antibiotic yenzelwe ukusetshenziswa komlomo. Umthamo wansuku zonke onconywayo wokusetshenziswa okukodwa ngu-400 mg, kungakhathalekile isikhathi sokudla. Isikhathi sokwelashwa okubulala amagciwane sinqunywa ngudokotela oholayo, oqondiswa ubucayi benqubo yamagciwane, indawo akuyo nemininingwane yomtholampilo yesiguli:
- ubude besikhathi sokwelashwa kwe-pneumonia etholakala emphakathini ngokusebenzisa ama-intravenous antibiotic alandelwa nguMoglaxia 400 ngamaviki angama-1-2;
- ku-sinusitis eyingozi - isonto eli-1;
- i-lesion esithathelanayo yesikhumba, eqhubeka ngaphandle kwezinkinga, idinga ukwelashwa kungakapheli izinsuku eziyi-7;
- ukuvuvukala kwesikhumba nezicubu ezithambile kubhekelwa ekwelashweni kwesinyathelo okuhlala izinsuku ezingama-7-21;
- i-bacterial Bronchitis engapheli esigabeni esibuhlungu iphathwa izinsuku ezingama-5- 10;
- ukutheleleka kwezitho zesisu kufanele kuphathwe izinsuku ezingama-5 kuya kwezingu-14 lapho kukhona ubunzima;
- ukwelashwa kwezitho zomzimba wesibeletho kuthatha amasonto ama-2.
Isikhathi esiphezulu sokwelashwa kwe-antimicrobial izinsuku ezingama-21. Akunconywa ukwedlula inkambo yokwelashwa enconyiwe. Kubalulekile ukukhumbula ukuthi ama-microorganisms we-pathogenic angakhulisa ukumelana ne-fluoroquinolone, ngenxa yokuthi umphumela wokwelapha uzobe ungekho.
Ukuthatha umuthi wesifo sikashukela
Umuthi olwa ne-antibacterial awuthinti ibhalansi ye-glycemic emzimbeni kanye nemiphumela yezidakamizwa ze-hypoglycemic. Ngaso leso sikhathi, i-moxifloxacin ayephuli ukusebenza kwe-hormonal yamaseli we-pancreatic beta, futhi ngenxa yalokho, ukulungiswa komthamo owengeziwe kubantu abanesifo sikashukela sohlobo 1 noma 2 akudingekile.
Imiphumela emibi ye-Moflaxia 400
Imiphumela emibi iba nokusetshenziswa okungafanele kwesidakamizwa se-antibacterial noma ngokuhlukumeza.
Amapheshana wesisu
Ukuphazamiseka emgudwini wokugaya ukudla kungahambisana nobuhlungu, isicanucanu, i-dysphagia, isifo sohudo kanye nokuphazamiseka kokunambitheka, ukuthuthukiswa kwe-pseudomembranous colitis. Lesi sakamuva sivela ngemuva kwesizinda sohudo isikhathi eside nokungcola kwegazi okungenzeka. Lapho uqinisekisa ukutholwa, kufanele uyeke ukuthatha i-antibiotic.
Ngenxa yokuvinjelwa kwezitho ezakha igazi, inani lamangqamuzana egazi abomvu, amaseli amhlophe egazi namaplatelethi ku-serum yegazi ayancipha.
Izitho zeHematopoietic
Ngenxa yokuvinjelwa kwezitho ezakha igazi, inani lamangqamuzana egazi abomvu, amaseli amhlophe egazi namaplatelethi ku-serum yegazi ayancipha.
Isistimu yezinzwa ephakathi
Ukwephulwa kohlelo lwezinzwa kuvezwa njenge:
- ukuphazamiseka kokulala (ukuqwasha);
- ukuthuthumela
- ukuphazamiseka kwemoto kahle;
- isimo sokudangala;
- ukudideka nokulahlekelwa ukwazi;
- izicubu zomsipha;
- Isiyezi
- usizi emikhawulweni ephansi;
- ukulahleka kokulawulwa okungokomzwelo.
Ukusuka ekusebenziseni umuthi, ukuphazamiseka kokulala (ukuqwasha) kuyabonakala.
Umphumela wecala lomuthi isimo esidabukisayo.
Ukusuka ekusebenziseni umuthi kungaba ukulahlekelwa ukwazi.
Kusukela ekusetshenzisweni kwalo muthi, ukuphazamiseka kohlelo lwezinzwa kuvezwa ngesimo sokuncipha kwemisipha.
Kusuka ohlelweni lomchamo
Kwezinye izimo, ukugcinwa komchamo kungenzeka.
Kusuka ohlelweni lokuphefumula
Ngomzimba ophakeme, i-dyspnea ingahle ikhule.
Engxenyeni yesikhumba nezicubu ezingaphansi
Ukuvela kwemiphumela emibi esikhunjeni kubonakaliswa ukuthuthukiswa kokulunywa, ukuvela kwamaqhubu, i-erythema.
Engxenyeni ye-metabolism kanye nokudla okunempilo
Lapho kudlula izivivinyo zelebhu, ukwehla kwesikhathi se-prothrombin kanye nokwanda komsebenzi we-amylase kungenzeka.
Kusuka ohlelweni lwezinhliziyo
Kwezinye izimo, i-tachycardia ende ingaqalwa.
Umphumela omubi wokusetshenziswa kwe-Moflaxia 400 ovela ohlelweni lwezinhliziyo ungaba yi-tachycardia yokuphefumula.
Uhlelo lwe-Endocrine
Kungenzeka ukukhuphuka kokujuluka.
Kusuka ezicutshini zemisipha
Isiguli singazizwa izinhlungu emhlane, emajoyineni, nasemisipha.
Allergies
Uma kunokuphambuka kokuqala, kunethuba lokuthuthuka kwe-anaphylactic noma ukusabela kwesikhumba.
Umthelela ekhonweni lokulawula izindlela
I-antibiotic ayithinti amandla okushayela imoto noma izindlela eziyinkimbinkimbi, ngakho-ke, ngesikhathi sokwelashwa kwe-antimicrobial, ukushayela noma ukuhlanganyela kweminye imisebenzi edinga ukunakwa okwengeziwe futhi izinga lokuphendula okuphezulu kusuka esigulini livunyelwe.
Imiyalo ekhethekile
Kuyadingeka ukusebenzisa i-moxifloxacin ngokuqapha ezigulini ezinesithuthwane, isikhathi esandisiwe se-QT ku-electrocardiogram, kanye nokwehluleka kwesibindi.
Ngesikhathi sokulashwa kwezidakamizwa nge-fluoroquinolones, kunengozi yokuqalwa kwenqubo yokuvuvukala kumakhonsathi ngokuqhuma okwalandelayo kwezicubu. Amathuba we-tenosynovitis akhuphuka kubantu abaneminyaka engaphezu kwengu-65 ubudala futhi elashwa ngokufana nama-glucocorticosteroids. Lapho kuvela izimpawu zokuqala zobuhlungu noma izimpawu zokuvuvukala, kufanele uyeke ukuthatha uMoxlaxia. Kunconywa ukunciphisa ukusebenza komzimba, ikakhulukazi umthwalo osemilenzeni ngenqubo ye-pathological.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi awubekelwe abesifazane abakhulelwe, ngoba kunengozi yokungena kwe-moxifloxacin ngomgoqo we-placental. Into esebenzayo iyakwazi ukuphazamisa ibhukumaka lesitho esiyinhloko kwinqubo yokukhula kombungu.
Ngesikhathi sokulashwa, kuyadingeka ukuthi udlulise ingane ekudla okungenamsoco.
Ukunquma uMoflaxia ezinganeni ezingama-400
Ngaphambi kweminyaka yobudala eyi-18, ukuthatha umuthi akuvunyelwe.
Sebenzisa ebudaleni
Abantu abadala basethubeni lokuhlakulela ukuvuvukala kuma-tendon kanye nama-ligaments, kulandelwe ukuqhuma.
Isicelo sokusebenza kokulimala kwezinso
Iziguli ezinokusebenza okungalungile kwe-renal azidingi ukulungisa umthamo.
Sebenzisa umsebenzi wesibindi okhubazekile
Iziguli ezinenkinga yesibindi sokusebenza azidingi ukulungisa uhlobo lomthamo.
I-overdose ye-Moflaxia 400
Ngesikhathi sokufunda kuqala, kwakungekho zimpawu zokweqisa lapho uthatha i-1200 mg yomuthi kanye noma ama-600 mg nsuku zonke izinsuku eziyishumi. Ngokuya ngezimpawu ngazinye, ukuthuthukiswa kwemiphumela emibi noma ukwanda kwazo kungenzeka.
Esimweni sokulaliswa esibhedlela, izindlela zokwelapha zizohlose ukuqeda isithombe esibonisa uphawu lwe-overdose. Ikhabhoni esebenzayo iyanconywa ukuvimbela ukutholwa okwengeziwe kwe-antibacterial.
Ukuqeda isithombe esibonisa ukuthi une-overdose, kunconywa ukuthatha namalahle ocushiwe.
Ukuxhumana nezinye izidakamizwa
Kukhona ukungahambelani kwemithi nokusetshenziswa okufanayo kwe-moxifloxacin ngale mithi elandelayo:
- izidakamizwa ze-antiarrhythmic IA nesigaba III;
- ama-antihistamines;
- ama-antibiotic, isixazululo se-erythromycin sokuphathwa kwe-intravenous, antimalarials, Sparfloxacin;
- IVincomycin;
- izidakamizwa ze-antipsychotic;
- Umehluko;
- antidepressants;
- I-Cisapride.
Ama-antacid, izithasiselo zokudla ezine-multivitamin ne-mineral complex, i-magnesium ne-iron amalungiselelo, imishanguzo yegciwane lengculazi inganciphisa ukumuncwa kwe-moxifloxacin. Kulokhu, umphumela we-antibacterial ubuthaka. Ngokutholwa okujwayelekile kwe-moxifloxacin, kuyadingeka ukuthatha le mishanguzo ngemuva kwamahora ama-4 noma amahora ama-4 ngemuva kokusebenzisa umuthi olwa namagciwane.
I-Warfarin kanye nezinye izidakamizwa zokwelapha eziguqula ukuguquguquka kwegazi aziguquli izinhlaka zemithi ye-moxifloxacin.
Ngokusetshenziswa okufanayo kwama-anticoagulants, amacala okunyuka kokusebenza kwezidakamizwa aqoshwe. Ingozi yokwanda kwesenzo se-anticoagulant inyuka phambi kwenqubo enkulu yokuvuvukala, isiguli singathandi. Abantu asebekhulile bathambekele kakhulu ekulweni nezifo zokugoba. Ngakho-ke, ngokuphathwa kanyekanye kwe-moxifloxacin nge-anticoagulants engaqondile, kubalulekile ukulungisa uhlobo lokulinganisa lwamuva.
I-Moxifloxacin iyakwazi ukukhuphula inani leplasma eliphezulu le-digoxin ngama-30%. Kodwa-ke, lokhu akuyona inkomba yomtholampilo, ngoba ukwanda kwezinga lezinto ezisebenzayo akukuthinti isimo esivamile sesiguli.
Ukusebenza kwekhabhoni kuvimbela ukufakwa kwe-molaxia esetshenzisiwe ngo-80-90%, ngaleyo ndlela kunciphise ukusebenza kwe-bioavailability komuthi olwa namagciwane.
Ukuhambisana notshwala
Ngesikhathi sokulashwa, kwenqatshelwe ukuphuza utshwala maqondana nokwanda amathuba okuhluleka kwesibindi. I-Ethanol yenza buthaka umphumela wezokwelapha kwi-microflora yamagciwane, ikhulisa isimo sezinzwa eziphakathi nendawo nezinsizakalo zokujikeleza kwegazi.
Ukuthengiswa kwamahhala kwezidakamizwa kukhawulelwe ngenxa yengozi enkulu yesifo se-dysbiosis samathumbu ngokusetshenziswa okungalungile kwesidakamizwa.
Ama-Analog
I-Moflaxia ithathelwa indawo yenye yezidakamizwa ezilandelayo:
- I-Alvelon;
- Moxifloxacin Canon;
- I-Megaflox;
- UMaxiflox;
- I-Rotomox.
Imibandela yekhefu lekhemisi
Umuthi uyathengiswa ngomuthi onikezwe wona.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ukuthengiswa kwamahhala kwezidakamizwa kukhawulelwe ngenxa yengozi enkulu yesifo se-dysbiosis samathumbu ngokusetshenziswa okungalungile kwesidakamizwa.
Inani lentengo ye-Moflaxia 400
Izindleko ezijwayelekile zomuthi olwa namagciwane zingama-ruble angama-350.
Izimo zokugcina zomuthi
Kunconywa ukuvikela amaphilisi kusuka ekuchayweni yimisebe ye-ultraviolet. Ngesikhathi sokulondolozwa, kuyadingeka ukugcina umbuso wokushisa + 8 ... + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
I-JSC "Krka, dd, iNovo mesto", iSlovenia.
Ukubuyekezwa kwe-Moflaxia 400
UValentin Kalashnikov, oneminyaka engama-39, eMoscow
Bathola i-bacterial bilneal pneumonia futhi bangeniswa esibhedlela. Kwakunesonto esibhedlela, phakathi nesikhathi lapho uMoflaxia enqunywe khona nethamo elengeziwe leDoxycycline. Naphezu kohlu lwe-contraindication kanye nokuphendula okungathandeki, umzimba wawubekezelela kahle umuthi. Ngabona ukuthuthuka ngosuku lokuqala: izinga lokushisa, elalizinza ku-+ 38 ° C, lehle laya emazingeni ajwayelekile.
UGalina Antonova, oneminyaka engama-27, u-Arkhangelsk
Kwadingeka ngiphuze imishanguzo ehlukahlukene, eminye yayo engeyona. Uthole i-Moflaxia kwizincomo ze-otolaryngologist ene-skepticism. Kodwa i-sinusitis kwakumelwe ilashwe. Ukwesaba akuzange kumenze umzimba, ngoba akubanga khona ukusabela komzimba noma eminye imiphumela emibi. Ngosuku lwesibili lokwelashwa ngezidakamizwa, isimo saba ngcono. Kwaba lula ukuphefumula, ukuvuvukala kwaqala ukudlula. Ngathatha ithebhulethi engu-1 ngosuku.
