Ungayisebenzisa kanjani i-Liprimar yezidakamizwa?

Izifo zesifo senhliziyo ziphakathi kwezimbangela ezivame kakhulu zokufa eRussia nasemhlabeni jikelele. Ngaphansi kwale mibandela, ukuvimbela izifo zenhliziyo kubalulekile. Ezokwelapha zinikezela ngezindlela eziningi zokukhetha izidakamizwa okuhloswe ngazo ukuqeda ama-pathologies kule ndawo. Enye yazo umuthi i-Liprimar.

I-ATX

Ikhodi ye-ATX yesidakamizwa yi-C10AA05. Into esebenzayo yi-atorvastatin (iqembu lama-statins).

I-Liprimar, isidakamizwa esusa izifo zohlelo lokuthinta kwenhliziyo futhi isebenze ukuvikela kuzo.

Khipha amafomu nokwakheka

Ukwakheka kwamacwecwe kuyizinto ezisebenzayo nezingxenye ezisizayo.

I-Atorvastatin, emelelwa usawoti we-calcium, isebenza njengento esebenzayo. Inani laso kwithebhulethi ngayinye kuya ngesilinganiso semithi (kusuka ku-10 mg kuye ku-80 mg).

Ukuqanjwa okwakusizayo kuyimicimbi eminingi. Kufaka:

• i-lactose monohydrate;
• i-calcium carbonate;
• i-croscarmellose sodium;
• I-MCC;
• i-hydroxypropyl cellulose;
• i-polysorbate 80;
• i-magnesium stearate;
• I-Opadra imhlophe.

Umuthi ukhiqizwa ngefomu lethebhulethi, noma kunjalo, ungaba nemithamo eminingana. Izibhebhe zimhlophe futhi zinobuso obulinganayo, zimbozwe ngegobolondo elimhlophe elibushelelezi ngaphezulu. Ngokuphatha okulula, ungakhetha amaphilisi ngomthamo wento esebenzayo 10, 20, 40 noma 80 mg.

Ngokuphatha okulula, ungakhetha amaphilisi weLiprimar ngomthamo we-10, 20, 40 noma 80 mg wento esebenzayo.

Ukupakishwa komuthi - imishanguzo kufakwe kuyo amaphilisi ayi-7 noma ayi-10. Isixha sekhadibhodi singaba nama-2, 5, 8 noma ama-10.

Isenzo se-Pharmacological

Umuthi unezakhiwo ze-hypocholesterolemic ne-lipid-lowering.

Isithako esikhulu samathebhulethi yi-atorvastatin, ethathwa njenge-inhibitor ekhethiwe yokuncintisana ye-HMG-CoA reductase. Le nto ihilelekile kulawulo lokushintshwa kwe-HMG-CoA ibe ngeyedlule. Amathebulethi akhulisa inani lama-LDL receptors.

Ngaphansi kwethonya le-atorvastatin, izinguquko ezilandelayo zenzeka emzimbeni:

• egazini, inani lama-lipoproteins aphansi kakhulu liyancipha;
• ukugcwala kokuqina kwe-lipoproteins ephezulu;
• okuqukethwe kwe-triglycerides ne-apolipoprotein B kuyancipha.

I-Pharmacokinetics

Ngemuva kokuphathwa ngomlomo, ukumuncwa ngokushesha kwento esebenzayo kwenzeka. Ukuhlushwa okuphezulu egazini kufinyelelwa ngemuva kwamahora we-1.5-2 ngemuva kokuthi umuthi ungene. I-bioavailability yento ephezulu - cishe i-95-98%.

Ngaphansi kwesenzo sezinto eziphambili ezisebenzayo i-Liprimar, ukugcwala kwama-lipoprotein aphezulu kwabantu egazini kuyanda.

Ukuhlanganiswa kwamaprotheni egazi nakho kusezingeni eliphakeme (cishe i-98%).

I-Atorvastatin kanye nama-metabolites ayo adalulwa ikakhulu ngesibindi. Isikhathi sokuqeda okungamahora angama-28.

Izinkomba zokusetshenziswa

Kunezizathu eziningana zokuthi kungani udokotela angakunikeza lo muthi.

Iziguli ezine-hypercholesterolemia:

1. Ukuphelelisa ekudleni. Umuthi usiza ukufeza umphumela oyifunayo uma kwenzeka wehluleka ukudla. Ukuxilongwa kungahlanganisa okulandelayo: i-hypercholesterolemia eyinhloko, uhlobo lwe-heterozygous noma uhlobo oluxubile lwesifo. Kulokhu, ukwehla kwe-LDL-C, cholesterol, ne-triglycerides kutholakala.
2. Njengokwengezwa kokwelashwa okwehlisa i-lipid noma lapho kungenakwenzeka ukusebenzisa ezinye izindlela zokwelapha. Le ndlela iyasebenza e-homozygous hypercholesterolemia yomndeni.

Ngokuvimbela izifo zohlelo lwethambo nenhliziyo kubekiwe:

1. Iziguli ezisengcupheni yokuthuthuka kwe-pathology ye-inhliziyo eyinhloko.
2. Ukugwema ukuhlaselwa yisifo senhliziyo, imivimbo ye-myocardial kanye nokuthuthukiswa kwezimo ezisesimweni esine-angina pectoris. Kulokhu, umuthi ubekelwe iziguli ezinesifo senhliziyo nezinye izifo zenhliziyo.

Contraindication

Umuthi unezinto eziningi eziphikisana. Lokhu kufaka:

• ukungabekezelelani ngakunye kwezithako ezithile kusukela ekubunjweni kwamacwecwe;
• ukukhulelwa nesikhathi sokuncelisa (uma lo muthi unqunyiwe, ukuncelisa ibele kuyanconywa ukuthi kuphazanyiswe);
• ukungabekezelelani kwe-lactose, ukusilela kwe-lactase (ukuzalwa kabusha);
• i-glucose-galactose malabsorption;
• ama-pathologies wesibindi aqatha, kufaka phakathi umsebenzi ophakeme wama-hepatic transaminases;
• izingane ezingaphansi kweminyaka eyi-18 (okuhlukile kuwukuxilongwa kwe-heterozygous hypercholesterolemia yomndeni, lapho umuthi unqunyelwe izingane ezineminyaka eyi-10).

I-Liprimar ayinqunyelwe ama-pathologies wesibindi ezinzima.

Ungayithatha kanjani iLiprimar

Amacwecwe enzelwe ukuphathwa ngomlomo. Kulokhu, umuthi kufanele ugezwe kakhulu ngamanzi. Ukudla akuthinti ijubane nokuphelele kokufakwa kwento esebenzayo, ngakho-ke amaphilisi angadliwa nganoma isiphi isikhathi sosuku olwandulela noma ngemuva kokudla.

I-Atorvastanin kufanele ichazwe ezimweni lapho isidlo esikhethekile, ukuzivocavoca nezinye izinhlobo zokwelashwa kungalethi umphumela oyifunayo.

Ithebhulethi ithathwa isikhathi esingu-1 ngosuku, ngenkathi umthamo ungahluka kusuka ku-10 mg uye kuma-80 mg. Umthamo omkhulu wansuku zonke umthamo we-80 mg we-atorvastatin. Esigulini ngasinye, umthamo ophelele ukhethwa ngamunye ngokuya ngokuxilongwa nezinye izinhlobo zokwelashwa.

Kwezinye izimo, ukwelashwa kwe-atorvastatin nokwenyuka kancane kancane komthamo wansuku zonke kunconywa. Ngaphezu kwalokho, ukwanda okulandelanayo ngakunye kudinga ukubhekwa kwesimo sesiguli (ukwakheka kwegazi, ukusebenza kwesibindi nokusebenza kwezinso).

Ngoshukela

Ngokwemiphumela yocwaningo, i-HMG-CoA reductase inhibitors kwezinye izimo ikhulisa ukugcwala kwe-glucose ku-plasma yegazi. Iziguli ezisengozini yokuba nesifo sikashukela zingakhulisa i-hyperglycemia.

Ngasikhathi sinye, odokotela baphawula ukuthi imvamisa yamacala anjalo incane, futhi izinzuzo zokwelashwa kweLiprimar zidlula izingozi ezingaba khona. Ngakho-ke, iziguli ezinesifo sikashukela futhi ezisengozini kufanele zisebenzise lo muthi ngaphansi kokuqondisa kukadokotela. Zidinga ukulungiswa komthamo nokuhlolwa kwegazi okujwayelekile.

Iziguli ezinesifo sikashukela zithatha i-Liprimar ngaphansi kokuqondisa udokotela. Benza ukulungiswa komthamo nokuhlolwa kwegazi okujwayelekile.

Kungenzeka yini uhlukanise ngesigamu

Ithebhulethi ayinconywa ukuba ihlukaniswe phakathi. Lokhu kungachazwa ngokuba khona kwegobolondo, okuvimbela ukuqothuka ngaphambi kwesikhathi kwento esebenzayo.

Isici esibalulekile ukutholakala kwamathebulethi ngemithamo ehlukene. Lokhu kwenza kube lula ukukhetha inketho efanele ngaphandle kwesidingo sokwehlukanisa.

Imiphumela emibi

Imiphumela emibi ekuthatheni ingathinta amasistimu e-organ ehlukahlukene Ukubonakaliswa okuncane kwezimpawu kungenzeka ezinsukwini zokuqala zokwelashwa. Akusona njalo isikhathi sokuhoxiswa kwezidakamizwa. Ngezimpawu ezinzima, umuthi uyakhanselwa bese, uma kungenzeka, uthathelwe omunye.

1. Kusukela ohlangothini lohlelo lwe-musculoskeletal, izinhlungu zivame ukwenzeka emalungeni, e-arthralgia nase-myalgia, kubuhlungu emuva, ukuvuvukala kwamalunga, ubuthakathaka bemisipha.
2. Imiphumela emibi evela ezithweni zezinzwa inokwenzeka. Iziguli ziphawula ukubukeka kwesihenqo ngaphambi kwamehlo, i-tinnitus, ukwephula imizwa yokunambitha.
3. Mhlawumbe ukuthuthukiswa kwe-hyperglycemia ne-hypoglycemia.
4. Kuchazwa amacala ahlukanisiwe okubonakala kokungabi namandla.

Amapheshana wesisu

Ezinye iziguli zibika i-dyspepsia, isicanucanu, ukuthopha kanye nokuqunjelwa. Ukutholakala okujwayelekile kutholakala ebuhlungu be-epigastric, i-belching, izikhathi zokuhlanza, ne-pancreatitis.

Izitho zeHematopoietic

Amacala amaningana we-thrombocytopenia achazwe.

Isistimu yezinzwa ephakathi

Imiphumela emibi ejwayelekile evela ohlelweni lwezinzwa oluphakathi ikhanda kanye nokuphazamiseka kokulala. Isiyezi, i-hypesthesia, i-paresthesia ivela ngandlela thize. Kukhona izinkomba ze-peripheral neuropathy kanye nokukhubazeka kwememori.

Kusuka ohlelweni lomchamo

Mhlawumbe ukuthuthukiswa kokuhluleka kwe-renal, i-edema yangaphandle.

Kusuka ohlelweni lokuphefumula

Umphimbo obuhlungu kanye ne-nosebleeds kungenzeka. Kuchazwe izigameko eziningana zesifo samaphaphu ezihlangene.

Allergies

Ukusabela kokungezwani nomuthi kuwuphawu lwe-hypersensitivity engxenyeni eyodwa noma ngaphezulu ekwakhiweni. Izimo ezinjalo zivame ukuhambisana ne-urticaria, ukuqhuma kwe-bullous, i-anaphylaxis, i-erythema multiforme exudative noma i-necyololosis enobuthi.

Lapho usebenzisa i-Liprimar kusuka ohlangothini lohlelo lwe-musculoskeletal, izinhlungu zivame ukwenzeka emalungeni, ukuvuvukala kwamalunga.

Ngesikhathi sokulashwa ngeLiprimar, imiphumela emibi ejwayelekile iba yikhanda nokuphazamiseka kokulala.

Ngokuphikisana nesizinda sokuthatha i-Liprimar, i-urticaria ingahle ivele.

Imiyalo ekhethekile

Ukuvimbela izinkinga, umuthi kufanele unikezwe ngokucophelela ama-pathologies wezinso nesibindi. Ezigulini esezikhulile, uma kungekho bungozi, ukulungiswa kwamthamo akudingeki.

Ukuhambisana notshwala

Ukusetshenziswa okuhlanganisiwe kwesidakamizwa notshwala akunconywa ngokuphelele. Ngaphezu kwalokho, abantu abasebenzisa kabi utshwala bancishiswa ngokuthatha i-atorvastatin. Lokhu kuchazwa ngumsebenzi owandayo we-hepatic transaminases. Ezimweni ezimbi kakhulu, kunengozi yokufa.

Umthelela ekhonweni lokulawula izindlela

Lesi sidakamizwa asilithinti ngokuqondile inani lokuphendula. Kulokhu, imiphumela emibi efana nesiyezi, i-tinnitus ne-acuity ebonakalayo kungenzeka ngesikhathi sokwelashwa. Ngalesi sizathu, odokotela batusa ukuthi ushayele ngokucophelela.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Abesifazane ababekelwe amaphilisi ngesikhathi sokukhulelwa nokuncelisa.

Kunquma uLiprimar ezinganeni

Umuthi lo uphethwe umthetho kuze kube iminyaka engu-18, ngoba kunedatha enganele ekusetshenzisweni kwalesi sidakamizwa ekwelapheni izingane. Okuhlukile ukuthi iziguli zitholakala nge-heterozygous hypercholesterolemia yomndeni. Ezimweni ezinjalo, umuthi ungasetjenziselwa ukwelapha izingane ezisukela eminyakeni eyi-10. Ukwelashwa kwenzeka ngaphansi kokuqashwa kukadokotela.

Ukweqisa

Umthamo omkhulu ovunyelwe nsuku zonke ngu-80 mg we-atorvastatin. Uma weqa umthamo onconyiwe, ukwanda kwemiphumela emibi kwenzeka. Akukho ukwelashwa okuthile kulokhu, ngenxa yalokho kunconywa ukwelashwa okubonakalayo. Iziguli zinqunyelwe ukulawula komsebenzi we-KFK nokuhlolwa kwesibindi okusebenzayo. IHemodialysis ayisebenzi ngenxa yokubopha okusebenzayo kwezidakamizwa kumaprotheni egazi.

Ukuxhumana nezinye izidakamizwa

Umuthi uvame ukusetshenziswa njengengxenye yokwelashwa okuyinkimbinkimbi, ngakho-ke ukuhambisana kwezidakamizwa kuyiphuzu elibalulekile.

Inhlanganisela ayinconywa

Ubungozi be-myopathy bukhuphuka kakhulu ngokusetshenziswa kanyekanye ngama-fibrate, i-cyclosporine, i-nicotinic acid, i-ezetrol, izidakamizwa ze-antifungal kanye ne -cacithromycin.

Ngokunakekela

Ukuphathwa okuhlangene kwe-diltiazem, i-erythromycin, i-isoenzyme ye-cytochrome CYP3A4, i -cacithromycin ingakhulisa ukuqina kwesidakamizwa ku-plasma yegazi.

I-Atorvastatin inganciphisa ukugcwala kwezidakamizwa ezifana ne-colestipol, i-aluminium hydroxide ne-magnesium hydroxide.

I-Atorvastatin yandisa ukugxila egazini lezidakamizwa ezilandelayo: ethinyl estadiol, digoxin, norethisterone.

Kuzo zonke lezi zimo, ukulungiswa komthamo kuyadingeka.

Umkhiqizi

Lesi sidakamizwa senziwa ngabakwaPfizer Pharmaceuticals ElElSi.

Ama-Analoggs aseLiprimar

Izidakamizwa ezilandelayo zingafakwa kuhlu lwezimpawu zesakhiwo somuthi:

• I-Ator;
• Atoris;
• I-Anvistat;
• Umbono;
• I-Atomax;
• INovostat;
• I-Atocord
• I-Torvazin;
• Lipona
• I-Lipronorm;
• Tulip;
• Crestor
• ITorvacard
• Lipoford.

I-Tulip iyi-analogue yeLiprimar.

Imibandela yekhefu lekhemisi

Amalungiselelo aleli qembu lezidakamizwa athengiswa emakhemisi ngomuthi kadokotela.

Ngingakwazi ukuthenga ngaphandle kadokotela

Awungeke uthenge amaphilisi ngaphandle kadokotela.

Intengo

Amanani ayahluka ngokuya ngesilinganiso kanye nenani lamathebulethi:

• Amaphilisi we-10 mg (ama-pcs ayi-100) - cishe ama-ruble ayi-1600;
• Amaphilisi we-20 mg (ama-100 ama-pcs.) - ama-ruble angaba ngu-2500 .;
• I-40 mg amaphilisi (ama-30 ama-pcs.) - ama-ruble angaba ngu-1100 .;
• Amaphilisi we-80 mg (ama-30 ama-pcs.) - ama-ruble angaba ngu-1200.

Amalungiselelo aleli qembu lezidakamizwa athengiswa emakhemisi ngomuthi kadokotela.

Izimo zesitoreji seLiprimar

Gcina amathebhulethi endaweni engenakufinyeleleka ezinganeni at lokushisa lika + 15 ... + 25 ° C.

Isikhathi sokuphelelwa yisikhathi

Isikhathi sokugcina - iminyaka emi-3.

Ukubuyekezwa ku-Liprimar

U-Eugene, udokotela wenhliziyo, isipiliyoni sezokwelapha iminyaka eyi-11, eMoscow

Imvamisa ngibeka lo muthi ezigulini ezinesifo senhliziyo futhi sinciphise ubungozi bezinkinga zenhliziyo. Lesi sidakamizwa senze izifundo eziningi ezifakazelwe ngokomtholampilo, kunobufakazi bokusebenza kwaso. Enye yezinzuzo zokuyisebenzisa ukubekezelela kwayo okuhle, imiphumela emibi ayivelakancane. Okubi izindleko eziphakeme zokwelashwa ngokusetshenziswa kwesikhathi eside.

ULydia, oneminyaka engama-56, uYaroslavl

Unenkinga yokuhlaselwa yisifo senhliziyo, okwathi emva kwalokho udokotela wamisela amaphilisi akhethekile ukuvimbela ukuqanjwa kabusha. Amathebulethi abiza kakhulu. Ngiphuza i-1 ithebhulethi kanye ngosuku, njengoba kusho udokotela. Ngingakwazi ukwahlulela ukusebenza kahle okwamanje, kepha akukho miphumela.

UVitaliy, oneminyaka engama-42, uP Pskov

Kwatholakala ukuthi ngine-cholesterol ephezulu. Ngiqhubeke nokudla isikhathi eside, kepha angikwazanga ukwehlisa izinkomba. Ngemuva kwesheke elilandelayo, la mapilisi anqunywa. Ngiqale ukwamukela. Umuthi ulungele, ngoba udinga ukuwuphuza kanye ngosuku. Ekuseni ngithathe iphilisi ngaya emsebenzini. Okusanda kuhlolwa futhi, i-cholesterol yehle kancane.