I-Lorista neLorista N izidakamizwa ezisetshenziselwa ukwehlisa umfutho wegazi. Zingahle futhi zibekelwe umfutho wegazi ophakeme, oxazululwa yisifo senhliziyo nesifo sikashukela. Zenziwe eRussia. Ngendlela yokukhululwa kukhona amaphilisi, amafilimu ahlanganiswe.
Zisebenza kanjani izidakamizwa zeLorista neLorista N?
I-Lorista ingeyeqembu le-angiotensin II receptor antagonists.
I-Lorista ingeyeqembu le-angiotensin II receptor antagonists.
Into esebenzayo yesidakamizwa yi-potassium losartan. Umenzi unikeza imithamo emi-4:
- 12,5 mg;
- 25 mg;
- 50 mg;
- 100 mg
Le nto ikhetha ukuvimba ama-receptor e-AT1 ngaphandle kokuthinta ama-receptors amanye ama-hormone abandakanyeka kumthethonqubo wombuso wesistimu yemithambo yegazi. Ngenxa yalokhu, umuthi uvimbela ukwanda komfutho wegazi we-systolic ne-diastolic obangelwa ukumnika kwe-angiotensin:
- I-85% ngesikhathi sokuhlushwa kwe-plasma enkulu kakhulu ifinyelele ihora elilodwa ngemuva kokuthatha umthamo we-100 mg;
- Ama-26- 39% ngemuva kwamahora angama-24 kusukela esikhathini sokuphatha.
Ngaphezu kwe-hypertension ye-arterial, izinkomba zokusetshenziswa kwalesi sidakamizwa yilezi:
- ukwehluleka kwenhliziyo okungapheli (uma ukwelashwa nge-ACE inhibitors kungenzeki);
- isidingo sokunciphisa ukuqhubekela phambili kokwehluleka kwezinso ezigulini ezinesifo sikashukela sohlobo 2.
Ukuthatha le mishanguzo ye-hypertension kunganciphisa ukufa kwezifo zenhliziyo noma isifo sohlangothi phakathi kweziguli ezinezifo zenhliziyo, ikakhulukazi i-hypertrophy ye-ventricular kwesokunxele.
Ukwakheka kwesidakamizwa uLorista N kufaka phakathi:
- hydrochlorothiazide - 12,5 mg;
- potasium losartan - 50 mg.
Kuyisidakamizwa esihlanganisiwe se-antihypertensive.
Ukusetshenziswa okuhlangene kwalezi zingxenye kuholela kumphumela ophinyiselwe kakhulu kunokusebenzisa okuhlukile.
IHydrochlorothiazide ingeyeqembu le-thiazide diuretics, inomphumela olandelayo:
- kwandisa umsebenzi we-renin nokuqukethwe kwe-angiotesin II ku-plasma yegazi;
- kuvusa ukukhishwa kwe-aldosterone;
- kunciphisa ukubuyiselwa kabusha kwe-sodium kanye nenani le-potassium ku-serum yegazi.
Le nhlanganisela yezidakamizwa inikezela ukwehla okwanele komfutho wegazi, ngaphandle kokuthinta ukushaya kwenhliziyo.
Le nhlanganisela yezidakamizwa inikezela ukwehla okwanele komfutho wegazi, ngaphandle kokuthinta ukushaya kwenhliziyo.
Umphumela wokwelapha wethamo kwenzeka ngemuva kwamahora ama-2 ngemuva kokuphatha futhi uqhubeke amahora angama-24.
Imithi ebhekwe inenqwaba yemiphumela emibi, phakathi kwayo:
- ukuphazamiseka kohlelo lwezinzwa: ukuphazamiseka kokulala, ikhanda, ukukhubazeka kwememori, njll;
- ukuphazamiseka kwesigqi senhliziyo;
- umsebenzi wokuphazamiseka wezinso (kufaka phakathi ukwehluleka kwe-renal acute);
- ukuphazamiseka ekusebenzeni kwamanzi-electrolyte metabolism;
- ukukhuphuka kwe-cholesterol ye-serum nama-triglycerides;
- Izimpawu dyspeptic;
- ukubonakaliswa okuhlukahlukene kokungezwani komzimba;
- i-conjunctivitis kanye nokukhubazeka okubukwayo;
- ukuphefumula kokukhwehlela kanye namakhala;
- ukwephulwa komsebenzi wobulili.
Ngenxa yokuthi ukuthatha amakhambi aqukethe i-hydrochlorothiazide kungavusa ukungasebenzi kwezinso, kufanele kuhlanganiswe neMetformin ngokuqapha. Lokhu kungaholela ekukhuleni kwe-lactic acidosis.
Udinga ukwazi ukuthi le mishanguzo igqitshwa ezigulini ezingaphansi kweminyaka engu-18 ubudala, ngesikhathi sokukhulelwa nokukhulelwa, kanye nezifo ezilandelayo:
- hypotension;
- hyperkalemia
- ukomisa komzimba;
- malabsorption kashukela.
Izidakamizwa zithathwa ngomlomo 1 isikhathi / usuku, ngaphandle kokudla. Amathebulethi kufanele agezwe phansi ngamanzi amaningi. Inhlanganisela yalezi zidakamizwa nezinye izidakamizwa ze-antihypertensive ziyamukeleka. Ngokusetshenziswa ngasikhathi sinye, umphumela wokungezelela uyabonakala.
Ukuqhathanisa Izidakamizwa
Ngaphandle kwenombolo enkulu yezimpawu ezihlanganisa le mishanguzo, udokotela kuphela onganquma ukuthi uzokhetha muphi ukwelashwa, kuye ngezidingo zesiguli. Akwamukeleki ukuthi usebenzise umuthi owodwa usebenzise omunye ngokuzimela.
Ukufana
Le mishanguzo inezici ezijwayelekile ezilandelayo:
- umphumela otholakala ngokuthatha umuthi ukwehlisa umfutho wegazi;
- ukuba khona kwe-potassium e-losartan;
- indlela yokukhishwa kwezidakamizwa.
Uyini umehluko
Umehluko omkhulu phakathi kwezidakamizwa uyabonakala uma uqhathanisa izingoma. Itholakala phambi kweLorist N yento eyengeziwe esebenzayo. Leli qiniso liboniswa esimweni sesenzo somuthi (engeza umphumela wokugaya), nentengo yaso. Ngokubalulekile iqiniso lokuthi umuthi unikela ngemithamo emi-4.
I-Lorista N, ngokungafani neLorista, ayisetshenziselwa ukwelapha ukuhluleka kwenhliziyo futhi inciphise ukuthuthuka kokwehluleka kwezinso kwabanesifo sikashukela.
Yikuphi okushibhile
Inani lentengo lomuthi i-Lorista lincike ikakhulu kumthamo wento esebenzayo. Iwebhusayithi yekhemisi eyaziwayo yaseRussia inikela ngamathebhulethi angama-30 ngamanani alandelayo:
- 12,5 mg - ama-ruble angama-145.6;
- 25 mg - ama-ruble ayi-159;
- 50 mg - ama-ruble ayi-169;
- 100 mg - 302 rub.
Ngenkathi intengo yeLorista N ingama-ruble angama-265. Ukusuka kulokhu kungabonakala ukuthi ngomthamo olinganayo we-losartan potassium, amalungiselelo ahlanganisiwe azobiza ngaphezulu ngenxa yokuba khona kwento eyengeziwe esebenza lapho kuqakathekile.
Yikuphi okungcono - uLorista noma uLorista N
I-Lorista inezinzuzo eziningi ezingenakuphikwa kwifomu elihlanganisiwe:
- amandla okuhlinzeka nge-dosing eguqukayo yesidakamizwa;
- imiphumela emibi emincane ngenxa yesithako esisodwa esisebenzayo;
- izindleko eziphansi.
Kodwa-ke, lokhu akusho ukuthi ukukhetha kufanele nakanjani kunikezwe lolu hlobo lwomuthi. Uma impilo yesiguli idinga ukwelashwa okuhlanganiswa, ukuqokwa kukaLorista N kuzoba nesizathu ngokuphelele.
Ukubuyekezwa kodokotela ngeLorista noLorista N
U-Alexander, oneminyaka engama-38 ubudala, udokotela wezenhliziyo, eMoscow: "Ngibheka uLorista njengesidakamizwa sanamuhla, esifanele ukusetshenziswa kwehypertension ye-I and II degrees."
U-Elizaveta, 42, udokotela wezifo zenhliziyo, iNovosibirsk: "Ngicabanga ukuthi i-losartan potassium ayisebenzi ku-monotherapy. Ngihlala ngiyibeka njalo ngihlangana nabaphikisi be-calcium noma i-diuretics. Ekusebenzeni kwami, ngivame ukusebenzisa umuthi ohlanganisiwe weLorista N".
Ukubuyekezwa kweziguli
U-Azat, oneminyaka engu-54 ubudala, u-Ufa: "Bengiqala ukuthatha i-Lorista ekuseni inyanga yonke. Umphumela wokwelapha uhlala usuku lonke. Futhi ngakusasa ekuseni, ngaphambi kokuthatha iphilisi, ingcindezi isengaphansi kwemingcele eyamukelekayo."
UMarina, oneminyaka engama-50, uKazan: “Ngicabanga ukuthi uLorista N ungusizo olukhulu ukuthi i-hydrochlorothiazide ifakwe ekwakhekeni kwakhe, ngokususa ukuvuvukala kahle, ayikhulisi imvamisa yokuchama.”
UVladislav, oneminyaka engama-60, eSt.
