I-Rinsulin NPH, njengoba ingahlulelwa ngegama layo, yenzelwe ukulwa nesifo sikashukela. Inikezwe abantu abadala nezingane.
Igama Lezwe elingafanele
Isulin insulin.
I-Rinsulin NPH, njengoba ingahlulelwa ngegama layo, yenzelwe ukulwa nesifo sikashukela.
I-ATX
A10AC01.
Khipha amafomu nokwakheka
Ukwenziwa kwalesi sidakamizwa kwenziwa ngesimo sokumiswa kokuphathwa kobuhlakani. I-100 IU ku-1 ml - lokhu okuqukethwe kokuqukethwe okusebenzayo kulungiselelo, okumelwe yi-insulin yabantu.
Isenzo se-Pharmacological
Umuthi osebenzayo utholakala ngendlela ye-DNA ephindaphindwayo. Kubhekiswa kuma-insulins ubude besikhathi sokusebenza. Uma ubheka ukwakheka kwe-insulin receptor tata, ivuselela izinqubo ngaphakathi kweseli lomzimba womuntu, okubandakanya ukukhiqizwa kwama-enzymes amakhulu.
Ukwenziwa kwalesi sidakamizwa kwenziwa ngesimo sokumiswa kokuphathwa kobuhlakani.
Izinga le-glucose egazini ngesikhathi sokwelashwa liyancipha ngenxa yokuthi ukuhanjiswa kwalo kwangaphakathi kuyanda, izinga lokukhiqizwa kwalo ngesibindi liyancipha.
Umuthi uqala ukusebenza cishe amahora angama-1.5 ngemuva kokuphathwa kwawo ngokunqenqemeni. Umphumela omkhulu kakhulu ungabonakala ngemuva kwamahora we-4-12. Ukuvezwa okukhulu kuyenziwa phakathi nosuku.
I-Pharmacokinetics
Ukuthi i-insulin ifakwa kahle kangakanani nokuthi ingawuthinta kahle kangakanani umzimba wesiguli kuya ngezinto eziningi. Lesi yisayithi lomjovo (ithanga, isisu noma amabhuzu), umthamo nokuhlakazwa kwento esebenzayo ekwelashweni. Ukusatshalaliswa kwezicubu zomzimba kubonakaliswa ngokungalingani. I-Excretion ingena ezinso zeziguli.
Izinkomba zokusetshenziswa
Umuthi usetshenziswa ekwelapheni i-mellitus yesifo sikashukela sohlobo lokuqala nolwesibili. Uhlobo lwesibili sikashukela ngosizo lwaleli thuluzi lungalashwa ngesikhathi sokukhulelwa.
Contraindication
Ukwelashwa ngezidakamizwa akunakwenzeka uma umuntu ene-hypoglycemia noma ekhuphuka i-insulin.
Ungayithatha kanjani i-Rinsulin NPH
Ngoshukela
Umthamo oqondile wesiguli ngasinye kufanele ukhethwe ngamunye futhi kususelwa kuzinga le-glucose esegazini.
Umthamo ojwayelekile usebangeni le-0.5-1 IU nge-1 kg yesisindo somuntu.
Esikhathini esiningi, umuthi ujojwa ngokungabonakali ungene ethangeni.
Ungawuphathi umuthi umuthi. Izinga lokushisa lesisombululo sokuphatha kufanele lisondele ekushiseni kwegumbi.
Esikhathini esiningi, umuthi ujojwa ngokungabonakali ungene ethangeni. Ukufakwa kungafakwa ngaphambili kwe-peritoneum, ihlombe noma iqhubu. Kubalulekile ukuthi ushintshe ukwenziwa kwasendaweni kokulawulwa kwezidakamizwa, ongavimba ngayo ukuthuthukiswa kwe-lipodystrophy. Udokotela kufanele aqaphele ikakhulukazi lapho efaka umjovo ukuze angalimazi umkhumbi. Uma isiguli sizokwenza inqubo ngokwayo, kufanele siqale saqeqeshwa kulokhu futhi sazi nemiyalo.
Ngaphambi kokubeka umjovo, udinga ukugoqa i-cartridge phakathi kwezandla cishe izikhathi eziyi-10, uyibambe ngokuqondile. Kubalulekile ukukwenza lokhu kuze kube yilapho i-insulin ithatha uhlobo lwento engasebenzi kahle, efana nobisi.
Lapho usebenzisa i-cartridge, izincomo zomenzi maqondana nokufakwa kwayo esibayeni sesirinji nokufakwa kwenaliti kumele kubhekwe. Ngemuva kokuthi umjovo usuhanjisiwe, udinga ukukhulula inaliti nge-cap yangaphandle uyilahle. Lokhu kuzoqinisekisa izimo ezifanele zokungasebenzi kahle, ukugwema ukuvikeleka kwenaliti nokungena komoya kuwo. Ngemuva kwalokho, udinga ukufaka i-cap kwisibambo.
Umuthi ozosetshenziswa ungagcinwa endaweni yokushisa yasekamelweni izinsuku ezingeqile kwezingama-28.
Imiphumela emibi
Ngokuphendula kwendawo, i-hyperemia, ukulunywa nokuvuvukala endaweni yomjovo, isici se-lipodystrophy esinokwethulwa njalo kwasendaweni efanayo siyaphawulwa.
Imvamisa kuba khona kokunye okubangelwa wumphumela kumzimba we-carbohydrate metabolism. Zifanekiselwa isiyezi, ukuncipha kokubonakalayo okunciphile, ubuthakathaka, ukubanda, ukuthuthumela nokukhuphuka kokujuluka, isikhumba esimpunga, indlala kanye ne-paresthesias.
Kokubonakaliswa kwe-allergic, ukwethuka kwe-anaphylactic kanye nokuqhuma esikhunjeni yizimpawu ezinokwenzeka. Ngeziqephu zokulahlekelwa ukwazi, i-hypoglycemia, nezinye izimpawu eziseceleni, isidingo esiphuthumayo sokufuna usizo lodokotela. Udokotela uzokwazi ukuguqula izindlela zokwelashwa futhi athathe izinyathelo ezifanele.
Umthelela ekhonweni lokulawula izindlela
Leli khono lingaba yingozi, ngoba uhlelo lwezinzwa oluyindlala luvame ukuhlupheka.
Imiyalo ekhethekile
Iziguli esezikhulile zingadinga ushintsho lomthamo. Kwenzeka okufanayo nasezigulini ezinokulimala kwe-renal kanye ne-hepatic function.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukwelashwa ngomuthi ngesikhathi sokukhulelwa kungenzeka, ngenxa yokuthi i-insulin ayikwazi ukungena ekuvinjelweni ngumama okubamba inyongo. Isidingo se-insulin sincipha ku-trimester yokuqala futhi sikhula kwesibili nesithathu.
Ngesikhathi sokubeletha nangemva kokubeletha, isidingo sokwelashwa okunjalo singehliswa. Ngesikhathi sokuqunjelwa, ukwelashwa kungenziwa, kepha kungadingeka ukunciphisa umthamo we-insulin otholwe ngowesifazane.
Ukwelashwa ngomuthi ngesikhathi sokukhulelwa kungenzeka, ngenxa yokuthi i-insulin ayikwazi ukungena ekuvinjelweni ngumama okubamba inyongo.
Ukuhambisana notshwala
Kuyadingeka ukuyeka ukusetshenziswa kotshwala ekwelashweni kwe-pathology.
Ukweqisa
Ukudlula umthamo kusongela i-hypoglycemia. Isiguli singasusa i-overdose emnene ngokwayo ngokudla ushukela noma ukudla okunokuqukethwe okuphezulu kwengxenye ye-carbohydrate. Ngenxa yalesi sizathu, iziguli ezine-pathology kudingeka zibe nojusi, amakhukhi noma amaswidi nazo. Ezimweni ezimbi kakhulu, ukuphatha okufakwayo kwekhambi le-dextrose nge-40% kuyadingeka. I-Glucagon nayo ingahanjiswa ngokungahambanga kahle, ngaphakathi noma ngaphakathi.
Ukuvimbela ukuphindeka kwezimpawu ngemuva kokuqina kwesimo somzimba, udinga ukudla ukudla okugcwele ama-carbohydrate.
Ukuxhumana nezinye izidakamizwa
Imithi efana ne-fenfluramine, i-tetracyclines, i-ketoconazole, i-sulfonamides nabanye abanye bayakwazi ukwandisa umphumela wesidakamizwa.
I-Heparin, i-loop diuretics, ukuvimbela inzalo ngomlomo nama-estrogenic, i-nicotine ingawenza buthaka umphumela.
Ama-Analog
Biosulin N, Protafan.
Imibandela Yokuphumula Ye-Rinsulin RPH
Ngingakwazi ukuthenga ngaphandle kadokotela
Kuphela ngomuthi kadokotela.
Intengo ye-Rinsulin NPH
Intengo ephansi ngama-ruble ayi-1000 (i-Russia).
Izimo zokugcina zomuthi
Izinga lokushisa kufanele lisuke ku-+2 liye ku- + 8 ° C.
I-Rinsulin NPH ingathengwa kuphela ngemithi kadokotela.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emi-2
Umakhi weRinsulin NPH
I-National Biotechnologies OJSC, 142279, Russia, Isifunda saseMoscow, iSerpukhov District.
Ukubuyekezwa mayelana neRinsulin NPH
Odokotela
A.D. I-Koltygina, i-endocrinologist, u-Ulyanovsk: "Nginikeza umuthi kaningi, ngoba iziguli zivame ukusibekezelela kahle. Okulula ukuthi ukwazi ukuzelapha ekhaya, okujabulisa iziguli. Ithuluzi likhombisa imiphumela emihle ekwelashweni kwesifo sikashukela" .
E.O. UKarimulina, udokotela ojwayelekile, uNovy Urengoy: "Umuthi usiza ukwehlisa ukugcwala kwe-glucose egazini, okuqinisekiswa iminyaka eminingi yokusebenza komtholampilo."
IHeparin ingawenza buthaka umphumela wesidakamizwa i-Rinsulin NPH.
Iziguli
UVioletta, oneminyaka engama-38, uKrasnoyarsk: "Ngelashwa lesi sidakamizwa ngesifo sikashukela. Ngingasho ukuthi kwasiza futhi akubanga namiphumela emibi. Ngicabanga ukuthi le yinzuzo enkulu yokusebenzisa noma yimuphi umuthi. Bekulula futhi ukuthi imijovo ingenziwa ekhaya. Ngijabule kakhulu ngempatho. "
URustam, oneminyaka engama-48 ubudala, u-Omsk: "Ngisebenzise lo muthi ezinyangeni ezimbalwa ezedlule. Ngeke ngasho ukuthi sengeluleme ngokuphelele, umzabalazo useyaphambili, kepha i-pathology isiqala ukuhlehla. Ngizizwa ngingcono kakhulu. Ngibonga kakhulu kudokotela ngokukunikeza umuthi onjalo osebenzayo. Ngingaluleka "kuzo zonke iziguli ezithole ukuphazamiseka okukhulu komzimba ngendlela yesifo sikashukela. Kubalulekile ukuthi udokotela abhekele ukwelashwa ngaso sonke isikhathi futhi aqaphe isiguli, lokhu kuzosiza ukufeza umphumela omuhle kakhulu wezokwelapha."
U-Arina, oneminyaka engama-28, u-Obninsk: "Yize esemncane, wabhekana nesifo sikashukela. Umuthi wasiza ekulweni nalo."
