I-Lorista 12.5 umuthi wokwelapha othambisa inhliziyo wehlisa umfutho wegazi, kungakhathalekile ubulili nobudala beziguli. Isebenza ngokusebenzisa i-blockade ye-oligopeptide hormone angiotensin, ebangela i-vasoconstriction.
Igama Lezwe elingafanele
Losartan.
I-ATX
Ikhodi ye-ATX yi-C09CA01.
I-Lorista 12.5 umuthi wokwelapha othambisa inhliziyo wehlisa umfutho wegazi, kungakhathalekile ubulili nobudala beziguli.
Khipha amafomu nokwakheka
Ikhiqizwa ngesimo samathebulethi efakwe kumafilimu aqukethe izinto ezisebenzayo nezinosizo ekwakhiweni kwawo.
Iphakheji ingaqukatha amaphilisi angama-30, 60 noma ama-90 kuzinhlavu zezingcezu eziyi-10. Kukhona umthamo we-12,5 mg, 25 mg, 50 mg no-100 mg.
I-Lorista 12.5 iqukethe u-12.5 mg wento esebenzayo.
Isithako esisebenzayo yi-potassium losartan.
Ukutholwa kwayo kwe-lactose yokucindezela okuqondile kufakelwa i-starches, i-enterosorbent, i-thickener, njll. Ukuqanjwa kufaka nezingxenye zokuhlanganiswa kwefilimu komkhiqizo.
Isenzo se-Pharmacological
I-Losartan yisiphikisi se-angiotensin 2. Ivimbela ama-receptors aleli hormone ikakhulukazi emithanjeni yegazi yenhliziyo, izinso nezindlala ze-adrenal, ngaleyo ndlela kudaleke umphumela we-hypotensive.
Yehlisa ukumelana okuphelele emikhunjini eyiphutha, ingcindezi ekujikelezeni kwe-pulmonary; inomphumela wokugaya, ukwandisa ukumelana nokusebenza ngokomzimba ekwehlulekeni kwenhliziyo.
Ezigulini ezinomfutho we-arterial hypertension, i-losartan emithanjeni enconywayo ayithinti inani lokuzila ukudla kwe-triglycerides, i-cholesterol concentration, ushukela weglue.
Umuthi uyatholakala ngesimo samathebulethi egobolondo lamafilimu, aqukethe ukwakheka kwawo ngokusebenzayo nababekhona.
I-Pharmacokinetics
Ukuqunjelwa kwento esebenzayo kwenzeka ngokushesha futhi ngemuva kwemizuzu engama-60-70 ukugxila kwayo okuphezulu kakhulu kuyi-plasma yegazi kanye nokwehla kwe-angiotensin sekutholakele kakade. Sisakazeka ngokubopha amaprotheni e-plasma egazi. Iguqulwa esibindini i-carboxylic acid.
I-Excretion yenzeka kungakapheli amahora angama-6-9 ngokusebenzisa izinso ngomchamo nangaphakathi kwamathumbu nge-bile.
Okusizayo
Lokhu kungumuthi osebenzayo wokwelapha okuhlanganisiwe kwe-arterial hypertension kanye nokuhluleka kwenhliziyo.
Kuqokwe emacaleni alandelayo:
- umfutho ophakeme we-arterial hypertension lapho usumdala;
- ekwelapheni isifo sezinso ezigulini zabantu abadala abane-hypertension ye-arterial futhi thayipha i-2 mellitus yesifo sikashukela ene-proteinuria;
- uhlobo olungapheli lokuhluleka kwenhliziyo, lapho kungenakwenzeka ukusebenzisa ama-ejenti athile ngenxa yokungabekezelelani;
- ukuvimbela ukuhlaselwa umfutho wegazi ophakeme futhi kwaqinisekiswa nge-hypertrophy engakwesobunxele.
Kukuphi ingcindezi okufanele uyithathe
Kunqunywa lapho umfutho wegazi wanda, kungakhathalekile iminyaka yobudala, ngaphandle kwezingane ezingaphansi kweminyaka engu-6.
Contraindication
Ukuphulwa okuqondile yilezi:
- umfutho wegazi ophansi;
- ukusabela okungekuhle entweni esebenzayo noma kwezinye izinto zomuthi;
- iminyaka efinyelela eminyakeni eyi-6;
- ukukhuphuka kwe-potassium yegazi ezigulini;
- ukumuncwa kweglue;
- ukungabekezelelani kwe-lactose;
- ukomisa;
- isikhathi sokukhulelwa nokuncelisa ibele.
Ngokunakekela
Ukunakwa ikakhulukazi kufanele kukhokhwe lapho kunqunywa imishanguzo ezinganeni nakwentsha engaphansi kweminyaka engu-18 ngenxa yolwazi oluphansi lwethonya emzimbeni wezingane nokukhula kwayo.
Ngokucophelela nangaphansi kokuqondiswa kwabasebenzi bezokwelapha, imali ithathwa ngenkathi kuncipha imithambo ye-renal, ngemuva kokufakelwa kwezinso, ngesikhathi sinciphisa i-aorta noma i-mitral valve, ukuqina kodonga lwe-ventricle yesinxele noma kwesokudla yenhliziyo, umsebenzi we-renal ophazamisekile ekwehlulekeni kwenhliziyo, isifo senhliziyo somoya, isifo se-cerebrovascular, ukukhiqizwa okwandayo kwe-aldosterone, ukuthatha imithamo ephezulu yemithi ye-diuretic.
Ungamthatha kanjani uLorista 12.5
Thatha ngomlomo kanye ngosuku, ungagxili ekudleni kokudla (ngaphambi, ngemuva, ngesikhathi sokudla).
Ukuphatha okungenzeka ngokuhlangana nezinye izidakamizwa ze-antihypertensive.
Ngomfutho wegazi ophakeme, i-50 mg kuqala inqunyelwe, bese kuthi, ngokusho kwezinye iziguli, umthamo unyuke ufike ku-100 mg ngosuku.
Kwezifo zesibindi, ngokuya ngobukhali bazo nangezifundo, inani lomuthi kwesinye isikhathi liyancishiswa liye kuma-25 mg ngosuku.
Ekwehlulekeni kwenhliziyo okungamahlalakhona, ekuqaleni unikeze u-12,5 mg ngosuku, bese ukhuphuka kancane kancane uye ku-150 mg ngosuku, isikhathi ngasinye ukhulisa umthamo kabili ngokuphumula kwesonto. Ukuqokwa kohlelo lokuphatha olunjalo kunconyelwa kuhlangene nama-diuretics nama-glycosides enhliziyo.
Thatha ngomlomo kanye ngosuku, ungagxili ekudleni kokudla (ngaphambi, ngemuva, ngesikhathi sokudla).
Ngoshukela
Uma isiguli sinesifo sikashukela se-mellitus sedigri yesibili esine-protein yokuchama emgodleni, ukuvimbela isidingo sokudayela kanye nomphumela obulalayo, umthamo wokuqala wokwelapha uyoba ngokwesilinganiso kube ngu-50 mg ngokukhuphuka ngokuzayo okufika ku-100 mg ngosuku, kuye ngomthelela wokwehlisa umfutho wegazi. Ukwemukelwa nge-insulin nezidakamizwa okwehlisa izinga likashukela (glitazone, njll). Kuvunyelwe ukuthatha ama-diuretics nezinye izidakamizwa ze-antihypertensive.
Imiphumela emibi
Inani elincane lemiphumela emibi likhona emuthini, kepha kunezimo ezithile zokusabela okunganele zomzimba ezivela ezithweni nasezinhlotsheni ezahlukahlukene. Ngakho-ke, uhlelo lwenhliziyo lungasabela ngokushaya kwenhliziyo okushesha, i-arrhythmias yenhliziyo, njll.
Ukuxineka kwe-nasal, ukuvuvukala kwe-larynx ne-bronchi, imvuthuluka, ubuhlungu emuva, izinyawo nemisipha, kanye nokwephulwa kwemali esele kwe-electrolyte. Kepha imvamisa, ukusabela kubuthakathaka futhi kudlula ngokushesha kangangokuba ukuguqula umthamo noma ukuguqulwa kwezidakamizwa akudingeki.
Amapheshana wesisu
Isistimu yokugaya ukudla ingaphendula ubukhona be-losartan ngesicanucanu, izitulo ezikhungathekile, i-dyspepsia kanye nobuhlungu besisu.
Izitho zeHematopoietic
Kuyaqabukela, kepha kungahle kube nokubonakaliswa ngohlobo lwe-anemia ne-Shenlein-Genoch's aimura.
Isistimu yezinzwa ephakathi
Uhlangothi lwesistimu yezinzwa ephakathi nendawo lungaba nemiphumela emibi efana nesiyezi, ubuthakathaka obujwayelekile, ikhanda, ukukhathala, ukuphazamiseka kokulala.
Allergies
Amacala asezindaweni ezithile yokusabela kwe-anaphylactic kanye nemikhuba yendawo yonke eye yabhalwa.
Umthelela ekhonweni lokulawula izindlela
Lapho ulawula izindlela futhi ngenkathi ushayela, kudingeka ukuqapha, ngoba isiyezi nokuqwasha kungenzeka. Ukusabela okunjalo kufana nezigaba zokuqala zokwelashwa noma ngethamo elikhulu.
Imiyalo ekhethekile
Iziguli ezake zathola i-edema engahambi kahle, isifo sesibindi noma sezinso kufanele zithole ukwelashwa nomuthi kuphela ngaphansi kokuhlolwa udokotela nangezizathu zempilo.
Umuthi akufanele usetshenziswe yiziguli ndawonye nemithi equkethe i-aliskiren noma i-aliskiren yesifo sikashukela.
Sebenzisa ebudaleni
Eminyakeni yokuguga, umthamo awufani nalowo usetshenziswa yintsha.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngesikhathi sokuzala nokuncelisa, umuthi awubekiwe, futhi uma kukhulelwa kumiswa, kukhanselwa masinyane, ngoba kunobungozi engxenyeni ye-fetus (hypoplasia yamaphaphu nesigaxa, ukuguqulwa kwesimo samathambo, ukuqina kwesiqalo se-fetus, njll.). Umphumela wokutholwa okusha komuthi owethulwe obisini lwebele awuzange ufundwe, ngakho-ke, akufanele usetshenziswe ngenxa yokungacabangi kokusabela komzimba wengane.
Ngesikhathi sokuncelisa, umuthi awunqunyelwe.
Ukuqokwa kweLorista izingane eziyi-12,5
Izingane ezingaphansi kweminyaka eyisithupha azinqunyelwe. Eminyakeni yobudala aze afike eminyakeni eyi-18, ukusetshenziswa akunconyiwe futhi kungenzeka kuphela lapho kungekho okunye okutholakalayo, ngoba akukho zifundo zokuzijwayeza ukusebenzisa izingane ngezidakamizwa ezine-losartan ekwakhiweni.
Ukweqisa
Esimweni lapho kuthathwa umthamo onamandla ngokweqile, i-arterial hypotension kanye ne-pelohac arrhythmias, ekhishwa ngesisekelo sezimpawu.
Ukuxhumana nezinye izidakamizwa
Ihambisana kahle ne-hydrochlorothiazide, digoxin, warfarin, cimetidine, phenobarbital nabanye. Izidakamizwa ze-potassium-sparing diuretic namalungiselelo e-potassium (Triamteren, Amiloride, njll.) Zingavusa ukwanda kwale nto egazini. Ukuhlanganiswa nezidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala kunganciphisa umphumela wesidakamizwa esichaziwe.
Ama-diuretics ama-Thiazive ahlanganiswe ne-losartan aholela ekwehleni okungalawulwa kwengcindezi emithanjeni yemithambo yegazi.
Ukwamkelwa nezinye izidakamizwa ze-antihypertensive kunganciphisa umfutho wegazi ngokungadingekile.
Imithi enomphumela ku-RAAS (i-Captopril, Lisinopril, njll.) Ingaphazamisa ukusebenza kwe-renal futhi ikhulise okuqukethwe kwe-urea ne-creatinine ngokuya ngamapharamitha welebhu.
Ukuhambisana notshwala
Ukuvimbela imiphumela engafuneki ohlelweni senhliziyo ngeke ihlanganiswe neziphuzo eziqukethe utshwala. Ukusetshenziswa ngasikhathi sinye kungaholela ekwehlekeni okukhulu komfutho wegazi, ukwephulwa kwemisebenzi yesisu, isibindi kanye nezinso.
Ama-Analog
- I-Angizar (India).
- IGizaar (USA).
- ICardomin-Sanovel (Turkey).
- I-Losartan (Israel).
- I-Lozarel (Switzerland).
- ULorista ND (Slovenia).
- I-Lozap plus (Czech Republic).
- U-Erinorm (Serbia).
Izimo zeholide uLorista 12.5 ovela ekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela
Akuhanjiswa ngaphandle kwemithi kadokotela.
Intengo yeLorista 12.5
Intengo iyahlukahluka kuye ngomkhiqizi, inani lamathebulethi kuphakethe nendawo ethengiswayo. Uhla lwamanani - kusuka kuma-ruble ayi-180 kuye kwangama-160 ngephakeji ngalinye.
Izimo zokugcina zomuthi
Endaweni eyomile, emnyama ngamazinga okushisa angekho ngaphezu kwe-30ºะก. Gcina kude nezingane nasezilwaneni.
Isikhathi sokuphelelwa yisikhathi
Gcina isikhathi esingekho ngaphezulu kweminyaka emi-2 kusuka ngosuku lokukhiqizwa.
Umkhiqizi uLorista 12.5
Ikhiqizwa eSlovenia yinkampani yezokwelapha iJSC Krka, dd, iNovo mesto. E-Russia, ukukhiqizwa kwenziwa yi-KRKA-RUS LLC edolobheni lase-Istra, eSifundeni SaseMoscow.
Ukubuyekezwa kweLorista 12.5
Izazi zezenhliziyo
U-Arina Ivanovna, udokotela wezifo zenhliziyo, u-Omsk
Lapho uthatha lo muthi, kubalulekile ukucubungula konke ukuphambana kanye nama-nuances wokuwaphuza. Kuyadingeka ngokucophelela ukuqasha abantu abanenkinga yezinso ukusebenza, ngokungabekezeleli ingxenye eyinhloko, enesifo senhliziyo, ukukhulelwa kanye nokuncelisa ibele. Kubalulekile ukuxwayisa ukuthi ngaphambi kokuphela kwenkambo yokudonsa kubalulekile ukugwema utshwala isikhathi sonke sokwelashwa ngokubanjwa kwezinsuku ezingama-5-7 ngemuva kokuphela kokuthatha amaphilisi ukuze into leyo iqedwe emzimbeni.
UPavel Anatolyevich, udokotela wezifo zenhliziyo, uSamara
Kusetshenziswa ikakhulukazi ngokuhlanganiswa nezinye izidakamizwa, futhi njengoba ukwenza imali kungakhombisi ukusebenza okuhle. Ikhwalithi ebalulekile ngicabanga ikhono lokuvikela izinso ezigulini ezinesifo sikashukela sohlobo 2 esine-proteinuria. Intengo inesilinganiso, okwenza umuthi ubize cishe cishe wonke amaqembu eziguli.
Ukungathandeki yi-embryotoxicity ephezulu, okwenza kungakwazi ukuyisebenzisa ngesikhathi sokukhulelwa.
U-Alexey Stepanovich, udokotela wezifo zenhliziyo, uNorilsk
Ngokusho kokubuyekezwa kweziguli, kubekezelelwa kahle, ingcindezi incipha kancane nangobumnene, ilungele bobabili abantu abasha nabadala.
Ngabona imiphumela emibi kanye kuphela - owesilisa oneminyaka engama-49 waqala ukuzwa isiyezi, ngenxa yalokho wangakwazi ukushayela imoto. Kulokhu, umuthi ubuyiselwe esikhundleni.
Iziguli
U-Andrey, oneminyaka engama-30 ubudala, uKursk
Uphuze amaphilisi njengoba kuchaziwe ngudokotela wezenhliziyo. Umthamo wokuqala wawungu-50 mg, bese ukhuphuka kancane kancane waba ngu-150 mg. Isebenza kahle, bekungekho miphumela emibi. Futhi intengo ayiphezulu kakhulu.
U-Olga, oneminyaka engama-25, u-Aktyubinsk
Inikezwe umama ukuvikela izinso, ngoba unesifo sikashukela esine-proteinuria. Ngokusho kokubonwa, umama uzizwe engcono: ingcindezi izinzile. Futhi ukwahlulela ngokuhlaziya, inani lamaprotheni kumchamo lehlile. Umuthi uhambe kahle impela futhi akukho miphumela emibi yokuwuthatha yabonwa.
