Uyisebenzisa kanjani i-drugtrtrtrtrtr GT?

IBlocktran GT isidakamizwa esivame ukubekelwa umfutho wegazi ophezulu. Isidingo esiphakeme salo muthi singenxa yomthamo olula kanye nezindleko eziphansi.

Igama Lezwe elingafanele

Igama elejwayelekile elejwayelekile lomuthi yiLosartan.

IBlocktran GT isidakamizwa esivame ukubekelwa umfutho wegazi ophezulu.

I-ATX

Ngokuyahlukaniswa kwezidakamizwa, i-ATX: C09DA01.

I-Losartan ihlanganiswe ne-diuretics.

Khipha amafomu nokwakheka

Umuthi ukhishwa ngesimo samaphilisi ayindilinga, ngalinye lawo liphekwe ngokuhlanganiswa okulula okubunjiwe. Umbala wegobolondo ungaba pink, kukhona umbala onsomi.

Ngokwakheka kwesidakamizwa, indima eyinhloko idlalwa izinto ezisebenzayo:

• i-losartan potassium;
• hydrochlorothiazide.

Uhlu lwezinto ezisizayo lubandakanya:

• i-microcrystalline cellulose;
• i-lactose monohydrate;
• isitashi samazambane;
• i-povidone;
• i-magnesium stearate;
• i-sodium starch glycolate;
• i-colloidal silicon dioxide.

Izinkimbinkimbi ze-losartan ne-hydrochlorothiazide zifaka isandla ekwehliseni umfutho wegazi.

Igobolondo yethebhulethi liqukethe lezi zinto ezilandelayo:

• polydextrose;
• i-hypromellose;
• i-talc;
• i-medium chain triglycerides;
• titanium dioxide;
• i-dextrin;
• udayi carmine obomvu wamanzi-encibilikayo (E120).

Isenzo se-Pharmacological

Inkimbinkimbi ye-losartan ne-hydrochlorothiazide inempahla ye-antihypertensive efakiwe. Ngenxa yalokhu, ukwehla kwengcindezi yegazi kwenzeka ngokwengeziwe kunangezikhathi lapho usebenzisa ingxenye ngayinye ngayinye. Ukuba khona komphumela we-diuretic kunomthelela ku:

• ukukhuthaza ukukhiqizwa kwe-aldosterone;
• umsebenzi owandayo we-plasma retin;
• ukunyuswa okukhulu kwe-angiotensin II;
• anciphise amazinga e-potassium we-serum.

Ngenxa yokuqukethwe kwe-losartan, lesi sidakamizwa singokwesigaba sabaphikisi be-angiotensin 2. Akuvimbeli i-kinase II (le enzyme inesibopho sokubhujiswa kwe-bradykinin).

Umuthi awubangeli ukuvinjwa kwamanye ama-hormone neziteshi ze-ion ezithinta ukusebenza kohlelo lwethambo nenhliziyo.

Umuthi osebenzayo uguqula izinqubo eziningana ohlelweni lokunikezela ngegazi ngasikhathi sinye:

• kwehlisa umfutho wegazi nokucindezela kokujikeleza kwe-pulmonary;
• kunciphisa ukuhlanganiswa kwe-norepinephrine ne-aldosterone ku-plasma yegazi;
• kwehlisa inani le-OPSS;
• inomphumela wokugaya;
• kunciphisa ukulayisha emuva;
• kusiza ukukhulisa ukubekezelelana kweziguli ezinokwehluleka kwenhliziyo okungapheli kokusebenza komzimba.

Kulokhu, umuthi awubangeli ukuvalwa kwamanye ama-hormone neziteshi ze-ion ezithinta ukusebenza kohlelo lwethambo nenhliziyo.

IHydrochlorothiazide inezici ze-antihypertensive ne-diuretic. Isenzo saso sihloselwe ukubuyisa ama-electrolyte aqukethe kuma-renal distal tubules. Ukwanda okungenzeka ekuqoqweni kwe-uric acid. Ngemuva kokuphathwa ngomlomo, ingxenye iqala ukusebenza ngemuva kwamahora ama-2. Ukusebenza ngobukhulu kutholakala ngemuva kwamahora ama-4. Isikhathi singashiyana kusuka emahoreni ayisithupha kuya kwayi-12.

I-Pharmacokinetics

Umphumela we-antihypertensive ngemuva kokuthola umthamo owodwa wesidakamizwa uphezulu ngemuva kwamahora ayi-6. Ngamahora angama-24 alandelayo, umphumela uyancipha kancane kancane. Ukucaciswa kwe-plasma yesidakamizwa kanye ne-metabolite yayo kungama-600 ml / min no-50 ml / min, ngokulandelana.

Ukukhishwa kwento esebenzayo kwenzeka ngokusebenzisa izinso namathumbu (kanye ne-bile).

Ukukhishwa kwento esebenzayo kwenzeka ngokusebenzisa izinso namathumbu (kanye ne-bile).

Izinkomba zokusetshenziswa

Umuthi unqunyelwe lokhu kutholwa okulandelayo:

1. Umfutho wegazi ophezulu we-Arterial. Umuthi lo usetshenziselwa izinjongo zokwelapha nezokuphrinta.
2. I-Hypertrophy ye-ventricle yangakwesobunxele. Umuthi uboniswa ukuvikela izifo zenhliziyo.

Contraindication

Kusetshenziswa umuthi ngaphandle kwemithi kadokotela. Kunezindlela eziningi zokwephulwa:

• hypersensitivity kwento eyodwa noma eziningana ekwakhiweni;
• iminyaka yezingane ifinyelela eminyakeni eyi-18 (umphumela wokuqalwa okusebenzayo emzimbeni wezingane awuzange ufundwe);
• ukuba khona kwe-glucose-galactose malabsorption syndrome, ukuntuleka kwe-lactase noma ukungabekezelelani kwe-lactose;
• isikhathi sokukhulelwa nesikhathi sokuncelisa;
• umlando onzima wesifo sesibindi, i-cholestasis;
• Isifo sika-Addison;
• ukomisa;
• i-hypotension enkulu ye-arterial;
• i-pathology yezinso (uma imvume ye-creatinine ingaphansi kwama-30 ml / min);
• i-anuria
• isichasiselo se-hypokalemia;
• hyperkalemia
• isifo sikashukela mellitus kunzima ukusilawula.

Awungeke usebenzise umuthi ngaphandle kwemithi kadokotela yokuqothuka kwe-arterial hypotension.

Awukwazi ukusebenzisa lesi sidakamizwa ngaphandle kwemithi kadokotela yesifo sika-Addison.

Akunakwenzeka ukusebenzisa umuthi ngaphandle kokuyalelwa ngudokotela ngama-pathologies wesibindi anamandla.

Ngokunakekela

Lapho kukhona ezinye izifo kunesidingo sokukhethwa komthamo ngokucophelela. Ngasikhathi sinye, udokotela ubhekwa njalo ngesimo sesiguli. Ngokuqapha, amaphilisi anqunywa kumacala alandelayo:

• i-stenosis (mitral ne-aortic);
• isikhathi sokululama ngemuva kokufakwa kwezinso;
• i-hypertrophic cardiomyopathy;
• ukuba khona kokwehluleka kwenhliziyo okukhulu;
• i-hyperaldosteronism eyinhloko;
• isifo se-cerebrovascular;
• i-angioedema.

Ungayithatha kanjani iBlocktran GT

Amacwecwe ayatholakala ekuphatheni ngomlomo. Ukudla akuphazamisi ama-pharmacokinetics, ngakho-ke, umuthi udliwa nganoma yisiphi isikhathi esikahle: ngaphambi kokudla, ngesikhathi sokudla, noma ngemuva kwalokho.

Umthamo ojwayelekile wansuku zonke ubhekwa njengethebhulethi eyi-1, ithathwe kanye. Imvamisa - Isikhathi esingu-1 ngosuku.

Kwezinye izimo, leli nani levolumu lingase lingalethi umphumela owuthandayo wokulashwa, khona-ke, ngaphansi kokuqondisa kukadokotela, kungenzeka ukwandisa umthamo kumathebhulethi amabili ngosuku. Leli nani kufanele lihlukaniswe ngemithamo emi-2. Imvamisa, iziguli ezinomfutho we-arterial hypertension zingena enkambweni enjalo yokwelashwa.

Ngoshukela

Ekwelashweni kweziguli ezinesifo sikashukela kufanele siqaphe njalo isimo sesiguli.

Ukusuka ohlelweni lwezinzwa nezitho zemizwa, ukukhathala okwandayo kungenzeka.

Imiphumela emibi yeBlocktran GT

Imiphumela emibi evela ekusetshenzisweni kwesidakamizwa ingahlobana nezinhlelo ezahlukene zomzimba. Ukubonakaliswa okubuthakathaka kwenzeka ezinsukwini zokuqala zokuthatha amaphilisi, ziyaqedwa kancane kancane.

Amapheshana wesisu

Ubukhulu bokuqunjelwa nobuhlungu esiswini. I-flatulence enokwenzeka, umlomo owomile, i-gastritis, i-sialadenitis, i-pancreatitis, i-hyponatremia.

Izitho zeHematopoietic

Ezinhlelweni zokujikeleza kanye nama-lymphatic, i-anemia ivame ukutholakala ezigulini. I-Leukopenia, i-agranulocytosis, i-thrombocytopenia, ne-aimura akuvamile ukwenzeka.

Isistimu yezinzwa ephakathi

Ukusuka ohlelweni lwezinzwa nezitho zemizwa, ukukhathala okwandayo, i-asthenia, isiyezi, ukuqwasha nekhanda kungenzeka.

Okungaphansi okuvame kakhulu, ukozela, ubuthakathaka, ukukhathazeka, i-peropheral neuropathy, ukukhubazeka kwenkumbulo, ukweqisa kwamalengiso, ukudangala, ukuphazamiseka ekunambithekeni, ukukhala kanye ne-tinnitus, i-conjunctivitis, nokulahlekelwa ukwazi.

Phakathi kwemiphumela emibi ejwayelekile ehlobene nohlelo lwe-urinal, ukubizwa kwezifo ze-urinary tract kubizwa.

Kusuka ohlelweni lomchamo

Eminye yemiphumela emibi ejwayelekile ehlobene nohlelo lwe-urinary ibizwa ngokuthi izifo ze-urinary tract, ukuncipha kwe-potency emadodeni, ukungasebenzi kahle kwe-renal, kanye nokuvela kokuchama kwe-peremptory. I-Hydrochlorothiazide kwezinye izimo ingadala i-glucosuria, i-interstitial nephritis.

Kusuka ohlelweni lokuphefumula

Ezinye iziguli zikhononda ngokuxinana kwamakhala, ukukhwehlela nezimpawu zezifo ezithinta ipheshana lokuphefumula elingaphezulu (phakathi kwabo i-sinusitis ne-pharyngitis). Ukubonakaliswa okunjalo kuvame ukuhambisana nomkhuhlane.

Okuncane kakhulu okuyi-rhinitis, i-bronchitis, ukuphefumula, i-pulmonary edema, i-pneumonitis.

Engxenyeni yesikhumba

Ukuthatha umuthi kungadala isikhumba esomile, i-photosensitivity, i-hyperemia, ukujuluka ngokweqile komzimba, i-necrolysis enobuthi, uhlobo lwesikhumba lwe-systemic lupus erythematosus.

Kusuka ohlelweni lwe-musculoskeletal

Ukuqunjelwa, ubuhlungu emuva, i-myalgia, izinhlungu emilenzeni nase esifubeni zivame ukutholwa. I-Arthralgia, i-fibromyalgia nesifo samathambo kubhekwa njengezibonakaliso ezingandile.

Kusuka ohlelweni lwe-musculoskeletal ngemuva kokuthatha umuthi, ukukhohliswa kwemizwa kuvame ukutholakala.

Kusuka ohlelweni lwezinhliziyo

Imiphumela emibi ngesikhathi sokwelashwa ingaba:

• ukukhuphuka kwenhliziyo;
• i-orthostatic hypotension;
• arrhythmia;
• angina pectoris;
• i-bradycardia;
• i-necrotizing vasculitis;
• Ubuhlungu enhliziyweni.

Allergies

I-Allergy ukusabela kwe-hypersensitivity engxenyeni ethile yomuthi. Ihambisana nokulunywa, i-urticaria, ukuqubuka, i-angioedema.

Umthelela ekhonweni lokulawula izindlela

Ngesikhathi sokulashwa ngomuthi, iziguli zingathola imiphumela emibi njengokuqina, ukuncipha kokuqina kanye nokuqina kokubona nesiyezi nokulahlekelwa ukwazi. Ngalesi sizathu, ukunakekelwa kufanele kuthathwe lapho ushayela futhi ubamba iqhaza emidlalweni eyingozi.

Imiyalo ekhethekile

IBlocktran inamandla okwandisa ukuqina kwe-serum creatinine ne-urea yegazi. Lezi zinguquko zivame ukwenzeka ezigulini ezitholakala ukuthi zinesifo sezinso noma imithambo yezinso.

I-Allergy ukusabela kwe-hypersensitivity engxenyeni ethile yomuthi.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Emithini, akukho datha ngomphumela walo muthi empilweni nakwisimo se-fetus. Kulokhu, lo muthi uthinta i-RAAS, okuthi embonweni kungaholela ekukhubazekeni okulimazayo nasekufeni kwengane lapho uthatha umuthi ku-2nd ne-3rd trimester yokukhulelwa.

Uma kudingekile ukusebenzisa lesi sidakamizwa ekwelapheni abesifazane abaphephayo, odokotela batusa ukuphazamisa ukuqunjelwa, ngoba ubisi lwebele luqukethe inani elincane le-losartan.

Ukuqokwa kweBlocktran GT izingane

Imininingwane yokusebenza kwomuthi ebuntwaneni ayitholakali. Ngalesi sizathu, izingane azinqunyelwe imishanguzo.

Sebenzisa ebudaleni

Njengomphumela wokuhlolwa kliniki, akubanga bikho ngozi lapho uthatha umthamo ojwayelekile womuthi. Ukuphakamisa umthamo akunconywa.

Ochwepheshe bayakwenqabela ukusetshenziswa kwalo muthi ngenkathi uncelisa ibele.

Isicelo sokusebenza kokulimala kwezinso

Kwezinye izimo, ukuthatha lo muthi kubangele ukungasebenzi kahle ezinso. Lokhu kuchazwa ukuvimbela kweRAAS, okwenzeka ngemuva kokuthatha iphilisi. Ama-pathologies anjalo ayesikhashana futhi amiswa ngemuva kokuqedwa kwezidakamizwa.

Ngokuqapha, umuthi kufanele unikezwe abantu abaphethwe yi-renal artery stenosis.

Isicelo sokusebenza kokulimala kwesibindi

Njengomphumela wezifundo zamakhemikhali, kuvezwe ukwanda okubukhali kwe-losartan egazini leziguli ezitholakale zinomdlavuza wesibindi. Ngalesi sizathu, umthamo wokusebenza kwesibindi ongasebenzi kahle uyancishiswa.

I-Overdose yeBlocktran GT

Ukweqisa umthamo obekwe udokotela kuvame ukuholela ekweqiseni komuthi. Kubonakala ngokubonakala komfutho wegazi ophansi, i-tachycardia, i-bradycardia. I-hydrochlorothiazide eyeqile ibangela i-hypochloremia, hypokalemia, hyponatremia. Mhlawumbe ukwanda kokuhlangana.

Njengomphumela wezifundo zamakhemikhali, kuvezwe ukwanda okubukhali kwe-losartan egazini leziguli ezitholakale zinomdlavuza wesibindi.

Ukuze kuzinze isimo sesiguli, odokotela basebenza nge-diuresis ephoqelelwe futhi basebenzise ukwelashwa okubonakalayo. Kulokhu, i-hemodialysis ayisebenzi.

Ukuxhumana nezinye izidakamizwa

I-Angiotensin II receptor antagonist kwezinye izimo ichazwa njengengxenye yokwelashwa okuyinkimbinkimbi. Kulokhu, i-losartan ye-izidakamizwa ixhumana ngokuhlukile nezinye izidakamizwa:

1. Ukuhlanganiswa ne-Aliskiren akunconywa ngenxa yengozi yokuthuthukisa ama-pathologies emsebenzini wezinso kanye ne-hypotension enzima.
2. Ngama-inhibitors e-ACE. Imvamisa kuba khona kwehluleka kwe-renal, syncope, hypotension noma hyperkalemia.
3. Ukusetshenziswa kanyekanye ngama-sympatholytics noma ama-antihypertgency agents kuholela ekuthuthukisweni okuhambisanayo kwesenzo sezidakamizwa.
4. Nge-diuretics esekela i-potassium, iziguli eziningi zithuthukisa amazinga aphezulu e-potassium emzimbeni.
5. Nge-fluconazole ne-rifampicin, umphumela we-losartan uyancishiswa.
6. Ngama-barbiturates nama-narcotic analgesics. Kukhona ingozi enkulu ye-orthostatic hypotension.
7. Nezidakamizwa ze-hypoglycemic. Ukulungiswa komthamo kuyadingeka, ngoba ukusebenza kwezidakamizwa kuncishisiwe.

Ukuhambisana notshwala

Ukuphuza amaphilisi akufiseleki kakhulu ukuhlanganisa nokusetshenziswa kotshwala. Izenzo ezinjalo zingaholela emiphumeleni emibi kakhulu. I-Hydrochlorothiazide ebakhona ethanol ingadala hypotension ye-orthostatic.

Ama-Analog

Umuthi unezichazi eziningana ezikhiqizwa yizinkampani zaseRussia nezangaphandle. Phakathi kwazo kukhona ama-generics nemithi enomphumela ofanayo:

• IVazotens H;
• ULorista N;
• Gizaar Forte;
• Presartan H;
• Simartan-N;
• E-Gizortan.

Phakathi kokufana kweBlocktran GT, iVazotens N.

Phakathi kokufana kweBlocktran GT ukwaba uLorista N.

Phakathi kokufana kweBlocktran GT, iGizaar Forte ihlukaniswa.

Imibandela yekhefu lekhemisi

Ungawuthenga umuthi ngomuthi kadokotela.

Ngingakwazi ukuthenga ngaphandle kadokotela

Imithi eqenjini le-angiotensin II receptor antagonists itholakala kuphela ngokubhaliwe.

Intengo yeBlocktran GT

Izindleko zomuthi zincike kumthamo wamathebulethi. Intengo elinganiselwa kumakhemisi eMoscow isuka kuma-ruble angama-220. iphakethe ngalinye (amaphilisi angama-30).

Izimo zokugcina zomuthi

Indawo yokugcina umuthi kufanele ibe yomile, ivikelwe elangeni eliqondile. Isimo sokushisa - hhayi ngaphezulu kuka- + 25 ° С.

Isikhathi sokuphelelwa yisikhathi

Ngokuya ngaphansi kwezimo zokugcina izidakamizwa, impilo yeshalofu yamathebulethi ifinyelela ezinyangeni ezingama-24 kusukela ngosuku lokukhishwa. Ngemuva kwalesi sikhathi, umuthi uvunyelwe ngokuphelele.

Umkhiqizi

Umuthi lo ukhiqizwa ngu-Pharmstandard-Leksredstva OJSC. Inkampani yemithi itholakala eKursk kuleli kheli: st. I-2nd Aggregate, 1a / 18.

Ukuhlolwa kweBlocktran GT

U-Alexander, oneminyaka engama-48 ubudala, uVolgograd

Umuthi lo waphuzwa njengengxenye yokwelashwa okuphelele ngemuva kokubhekana nenkinga yegazi. Ezinsukwini zokuqala, kwaqhamuka ikhanda nokukhathala okuncane. Udokotela weluleke ukuthi angavumi ukwamukela. Esontweni lesibili, imiphumela emibi yema. Inkambo yokuvuselela yayiphelele.

UTatyana, oneminyaka engama-39, Khabarovsk

Sekuphele iminyaka eminingi ngihlushwa umfutho wegazi ophakeme. Umuthi usebenza ngokushesha nangendlela efanele. Ngaphambi kwalapho, udokotela wabeka amanye amaphilisi, kepha awalethi mphumela.