Ukuphazamiseka kokuhamba kwegazi lobuchopho, imiphumela elimazayo yobuthi kanye nokwehla kwezwi le-vascular kuholela ekubonakaleni kwezifo ezinzima ze-neurological, zenhliziyo nezinye. Ukuvimbela ukuthuthukiswa kwe-hypoxia nokufa kwamangqamuzana obuchopho, iziguli zinqunyelwe ama-antioxidants, ama-metabolic, ama-antihypoxants, ama-nootropics nezinye izidakamizwa ze-neurotropic.
Ngokuya ngendawo yesilonda, ekwelapheni izifo ze-ischemic kanye nama-pathologies wezinzwa, kusetshenziswa ama-ejenti anjengeMildronate neMexidol.
Izici ezijwayelekile zezidakamizwa
IMexidol neMildronate zibekelwe:
- ngcono imetabolism;
- kusebenze kokujikeleza kwegazi emithanjeni yengqondo;
- ukukhulisa ukumelana nokucindezelwa ngokomzimba nangokwengqondo.
Ekwelashweni kwezifo ze-ischemic kanye nama-pathologies we-neurological, kusetshenziswa iMildronate neMexidol.
Ezinye izinkomba zokusetshenziswa kwalezi zimali kungenxa yendlela yokusebenza kwezakhi ezisebenzayo.
I-Mexicoidol
Isithako esisebenzayo seMexidol yi-ethylmethylhydroxypyridine ancidi. Le nto itholakala ku-presinic acid, ehlanganisa izakhiwo zomvikeli we-membrane, i-antioxidant ne-metabolic stimulator.
Usawoti we-Succinic acid uvimbela i-peroxidation yamafutha acid, unciphisa isidingo se-oxygen kumaseli wobuchopho futhi wandise ukumelana kwawo ne-hypoxia. UMexidol wenza kusebenze umsebenzi wamandla we-mitochondria futhi uzinzisa izinga lamakhompiyutha we-macroergic (ATP, njll.).
UMexidol uvuselela ukwakheka kwe-asidi ye-nucleic acid kanye nokubuyiselwa kolwelwesi lweseli, kusebenze i-oxidation ye-glucose.
Umuthi uvuselela ukwakheka okungaphakathi kwe-nucleic acid kanye nokubuyiselwa kwama-membrane amaseli, kusebenze i-glucose oxidation futhi kuthuthukisa ukudluliswa kwe-synaptic phakathi kwezakhi zobuchopho. Umphumela onenzuzo kumapharamitha we-rheological wegazi kanye nezinga le-lipoprotein ephansi unganciphisa indawo yomonakalo ongaphenduki ku-ischemia futhi uvikele i-vasen stenosis ngokuzayo.
Ukusetshenziswa kweMexidol ukuhoxa kusiza ukwengeza isiguli ngokushesha futhi kunciphise izifiso zotshwala.
Inhloso yesidakamizwa ikhonjiswa kuma-pathologies alandelayo:
- i-encephalopathy ye-discirculatory, post-traumatic and other genesis, kufaka phakathi kuhambisana nokuhlaselwa okukhokhisayo;
- i-vegetative-vascular dystonia, asthenia;
- imiphumela yezingozi ze-cerebrovascular, TIA, ukulimala kobuchopho obuhlukumezanayo;
- ukonakala kwengqondo kwe-atherosulinotic etiology (ene-pathology emnene);
- IHD (njengengxenye yenkambo ebanzi);
- ukuphazamiseka kokukhathazeka nge-neurosis kanye nezifo ezinjenge-neurosis;
- ukudakwa ngezidambisi ze-antipsychotic, izimpawu zokuhoxa ekuthembekeni kotshwala (ngokubekelwa izimpawu zezimpawu zemisipha-yemithambo yegazi kanye ne-neurosis);
- ukucindezela, ukuzikhandla okusindayo ngokomzimba (ukumelana okwandayo kwe-hypoxia yokuxineka nokuvimbela ukuthuthukiswa kwezifo ze-systemic).
Umuthi uyatholakala ngesimo samathebulethi kanye nesisombululo sokufakwa.
Contraindication nokusetshenziswa kweMexidol yile:
- ukuzwela komuntu mathupha kokususwayo kwe-succinic acid;
- ukwehluleka okukhulu kokusebenza kwezinso nezinso;
- ukucaphuka
- ukukhulelwa
- iminyaka yezingane.
I-Mildronate
Into esebenzayo ye-Mildronate yi-meldonium. Umsebenzi oyinhloko wale ngxenye, kanye ne-analogue yayo yokwakheka (i-gamma-butyrobetaine), etholakala kuwo wonke amaseli omzimba womuntu, ukulinganisa ukuhlangana kwe-carnitine. Ngokuncipha kokukhiqizwa kwe-carnitine, ukuqina kokuthuthwa kwamafutha acid kumaseli kuyancipha, futhi umthombo omkhulu wamandla wezicubu zomzimba (i-ATP) uqala ukukhiqizwa ikakhulukazi ngenxa ye-glucose, i-oxidation yawo edinga umoya-mpilo omncane futhi ingashiyi inani elikhulu lemikhiqizo yokubola enobuthi.
Ukushintsha uhlobo lwezinqubo ze-metabolic kunciphisa isidingo se-oksijini yezicubu, ukunciphisa i-hypoxia, futhi kuvimbela ukulimala kwamaseli ngemikhiqizo enobuthi yokuphendula kwe-metabolic.
I-analogue yokwenziwa ye-gamma-butyrobetaine futhi inesakhiwo se-vasodilating (vasodilating), esisiza ukwenza ngcono ukujikeleza kwegazi, sinciphise ukwakheka kwezindawo ze-necrosis ngesikhathi sokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi. Ukusatshalaliswa kwegazi kabusha ngenxa yezindawo ze-ischemic kunciphisa ingozi yokuphazamiseka kwe-trophic, kunciphisa ukuqina kwesifo sezinhlungu, kukhulisa ukukhuthazela ngokomzimba kanye nokusebenza.
I-Mildronate inciphisa isidingo se-oxygen oxygen ngokunciphisa i-hypoxia futhi ivimbele ukulimala kweseli ezinobuthi.
Ukusetshenziswa kwe-meldonium kuyanconywa nezimpawu zokuhoxa: umuthi unciphisa izimpawu zokudakwa, umisa ukusebenza kokuphazamiseka kwesistimu yezinzwa ephakathi futhi kusize nezimpawu zokuhoxa ekwelashweni kotshwala obungamahlalakhona.
Izinkomba zokusetshenziswa kweMildronate yilezi zindlela ezilandelayo:
- izifo zenhliziyo ezi-coronary, ezihambisana nokuphefumula kobuhlungu besifuba;
- infarction myocardial;
- ukulimala kwe-dishormonal kwimisipha yenhliziyo nokuhluleka kwenhliziyo;
- ukuphazamiseka kokujikeleza kobuchopho (ukufakwa kwamakhaza, isimo sangaphambi kokushaywa unhlangothi);
- i-thrombosis yezinhlobo ezahlukahlukene;
- ukopha ezinhlamvini zamehlo kanye ne-retina, ukuphuma kwethambo lomgogodla oyinhloko namagatsha alo, i-retinopathy;
- i-encephalopathy ye-discirculatory, i-neuropathy nezinye izilonda zesifo sikashukela, inzuzo esheshayo yohlobo 2 lwesifo sikashukela;
- ukuhoxa kwesifo;
- umthamo wokusebenza ophansi;
- ukucindezelwa, ukuvivinya umzimba okukhulu.
Ucwaningo oluningi lukhombisa ukusebenza kahle kwe-Mildronate ekwelashweni okuyinkimbinkimbi kwesifo esingelapheki se-pulmonary sifo.
Ngokuya izinkomba, kusetshenziswe eyodwa yezindlela ezintathu zokukhipha umuthi:
- amaphilisi;
- isiraphu;
- Isixazululo se-parabulbar (intraocular) kanye nokuphathwa kwe-intravenous.
Ukuxhumana ngezindlela zokwelapha nge-Mildronate:
- ukuzwela komuntu ngamunye ezingxenyeni zomuthi;
- umfutho ophakeme we-intracranial (onama tumor kanye nokuphuma okudlayo kwe-venous);
- ukukhulelwa
- ukucaphuka
- iminyaka yezingane.
Nge-pathologies enzima yezinso nesibindi, ukwelashwa kufanele kwenziwe ngokuqapha.
Ukuqhathanisa kweMexidol neMildronate
IMildronate neMexidol zisetshenziselwa izinkomba ezifanayo futhi zinomphumela ofanayo we-antihypoxic, onquma ukusebenza kwawo ku-ischemia yezifunda zobuchopho. Ngaphandle kokufana, le mishanguzo ayinazo izakhi ezivamile futhi ihlukile ngendlela ehlukile yokusebenza.
Ukufana
Zombili lezi zidakamizwa zinciphisa isidingo se-oksijini yobuchopho namangqamuzana emisipha yenhliziyo ngokumisa ukusabela kwe-peroxide (esimweni seMexidol) noma ngokuvimbela ukuthuthwa kwamafutha acid (esimweni seMildronate). Lokhu kukuvumela ukuthi unciphise indawo ye-necrosis ekushayweni nasekushayweni yinhliziyo, kanye nokwandisa ukubekezelelana kwemithwalo esindayo.
Ukwenza ngcono ukujikeleza kwegazi ngesikhathi sokwelashwa ngeMexidol noma i-Mildronate kunomthelela omuhle ezigulini eziye zahlaselwa unhlangothi noma ezinezimpawu zokuhoxa.
Ukusebenzisana kwezidakamizwa kukhulisa umphumela wezokwelapha. Ngokushaywa yi-ischemic, izimpawu ze-vestibulo-ataxic disorder, i-arrhythmias, izimpawu zokuhoxa kanye nezinye i-pathologies, iMildronate neMexidol zingathathwa ngasikhathi sinye.
I-Mildronate ne-Mexicoidol zichazwe ngesikhathi sokukhulelwa nokuqunjelwa.
Uyini umehluko
Umehluko phakathi kwalezi zidakamizwa ezimbili ngezindlela ezihlukile nokucaciswa kokuchayeka. I-Mexicoidol ine-membrane-ukuzinza, i-nootropic, i-cerebroprotective, i-antioxidant ne-weakiolytic effect, futhi iMildronate inomphumela we-angio- ne-cardioprotective.
Ngokulashwa kweMexidol, ukutholakala kwe:
- umlomo owomile
- isicanucanu
- ukungahambi kahle komzimba;
- ukozela.
Imiphumela emibi ye-Mildronate yile:
- dyspepsia
- ukukhuphuka kwenhliziyo;
- ukuguqulwa kwengcindezi;
- ukungaphatheki kahle.
Ezimweni ezingavamile, ubuthakathaka, ukungezwani komzimba, kanye nokwanda kokugcwala kwama-eosinophils kuyabonakala.
Zombili lezi zidakamizwa zi-contraindified ebuntwaneni.
Yikuphi okushibhile
Izindleko zeMexidol zivela kuma-ruble angama-274 wamathebulethi angama-30 (umthamo - 125 mg) futhi kusuka kuma-ruble ayi-1423 ama-ampoules angama-20 we-5 ml (umthamo - 50 mg / ml).
Intengo ye-Mildronate iqala kusuka kuma-ruble angama-255 wamakhebuli angama-40 (umthamo - 250 mg) futhi isuka kuma-ruble angama-355 ama-ampoules ayi-10 ml (umthamo - 100 mg / ml).
Njengoba sinikezwe umthamo wokuncoma wokwelapha (400-800 mg / usuku weMexidol no-500-1000 mg / usuku lwe-Mildronate), ukwelashwa kwe-meldonium okunezinkomba ezifanayo kuzobiza kakhulu.
Okuhle: iMexidol noma iMildronate
I-Mexicoidol yisidakamizwa se-nootropic kanye ne-antioxidant, esivame ukubekelwa ukuphazamiseka kokuhlinzekwa kwegazi kwezicubu zobuchopho nezilonda zemithambo ye-atherosranceotic. I-Mildronate inomphumela omkhulu ezinqubweni ze-metabolic kumaseli nesimo sesistimu yenhliziyo.
Ukuzikhethela kwezimali kungukuphakanyiswa kukadokotela ohambele (udokotela wezifo zengqondo, isifo sezinzwa, udokotela oyi-narcologist). Lapho enquma umuthi, unaka izinkomba nomlando wesiguli.
Ukubuyekezwa kodokotela
Poroshnichenko A.I., udokotela wezifo zemizwa, uRyazan
I-Mexicoidol iyisidakamizwa esisebenzayo nesingabizi sokwenza umenzi wasekhaya, sinqunyelwe ama-pathologies amaningi wezinzwa. Ibekezelelwa kahle yiziguli futhi akuvamile ukuthi iphikise ukusabela okubi.
Ububi bomuthi ukuphumelela okuphansi kwefomu lawo lomlomo (amaphilisi). Ukuze uzuze ngokushesha lo mphumela, iMexidol kumele ithathwe ngokungena ngaphakathi noma emzimbeni.
UMayakov A.I., isazi sezinzwa, uKursk
I-Mildronate isusa ukubonakaliswa okujwayelekile kwe-asthenic, ifinyeze isikhathi sokuvuselela ubuthi obungapheli botshwala futhi isuse ukuphazamiseka kwe-trophic ku-peripheral nerve fibers ezifweni ezifana nesifo sikashukela. Umuthi unomphumela olinganiselayo we-antiarrhythmic futhi unciphisa ubude besikhathi semithi ethile yezidakamizwa ezinengqondo.
I-Minus Mildronate yimiphumela emibi (ubuthakathaka, ukungahambi kahle komzimba, ushintsho ekucindezelweni kwegazi), noma kunjalo, akuvamile.
Ngokubheka umthamo onconyiwe, ukwelashwa kwe-meldonium okunezinkomba ezifanayo kuzobiza kakhulu.
Ukubuyekezwa kweziguli mayelana neMexidol neMildronate
U-Ekaterina, oneminyaka engama-41, eMoscow
Ngemuva kokuhlinzwa emhlane (ukuxilongwa kuwumgogodla womgogodla wesibeletho), kwavela izinhlungu emathempelini nasemuva kwekhanda. Ngaphuza ama-painkiller izinsuku eziningana, kodwa nokho ngaphendukela kudokotela oyi-neurologist. Udokotela unikeze isifundo semijovo eyi-10 yeMexidol. Ngosuku 4, ngezwa ukuthuthuka kokuqala, ngosuku 6, izinhlungu zaphela ngokuphelele.
Ngemuva kokwelashwa, wabona ukuthi waqala ukulala kangcono, aphendula ngokuzithoba nangokweqile ekucindezelekeni nasezingxabanweni, futhi wagxila ngokushesha emsebenzini. Angibonanga imiphumela emibi, ngigculisekile ngomuthi.
UMaria, oneminyaka engama-33, uTomsk
Ngijove uMildronate izinsuku eziyishumi nginconywe udokotela. Ezinsukwini zokuqala, umphumela awubonakali, kepha ngemuva kwenkambo ephelele ingcindezi ibuyele kwesejwayelekile, umsindo osekhanda, ukuqwasha nokukhathala okungapheli wanyamalala. Manje senginamandla ngokwengeziwe emsebenzini futhi ngizinika isikhathi semisebenzi engiyithandayo.
Ukufakwa kuyinqubo engemnandi kangako, kepha umphumela wawo uyamangalisa.
