Umuthi Heinemox: imiyalo esetshenzisiwe

Amathebhulethi e-Heinemox angaqeda ukuvuvukala okubangelwa umsebenzi wama-anaerobic, ama-acid alwa nama-bacteria kanye nama-atypical bacteria. Ukugwema ukusabela okungekuhle, umuthi kufanele uvumelane nodokotela oholayo.

Igama Lezwe elingafanele

I-Moxifloxacin (moxifloxacin).

I-ATX

J01MA14.

Umuthi we-antimicrobial uthengiswa ngohlobo lwezibhebhe ze-400 mg ze-moxifloxacin.

Khipha amafomu nokwakheka

Umuthi we-antimicrobial uthengiswa ngohlobo lwezibhebhe ze-400 mg ze-moxifloxacin (isakhi esisebenzayo).

Ezinye izinto ezakhiwe:

• i-anhydrous colloidal silicon dioxide;
• i-croscarmellose sodium;
• i-cellulose microcrystals;
• i-magnesium stearate;
• i-talcum powder ecolisisiwe;
• i-sodium lauryl sulfate;
• Ama-macrogol ayi-3000;
• soya lecithin;
• i-oxide ebomvu yensimbi;
• I-White Opadry 85G58977.

Isenzo se-Pharmacological

Umuthi ungowenombolo yama-fluoroquinolones futhi unomphumela we-bactericidal. Isebenza ngokumelene nama-anaerobes amaningi, ama-bacterium atypical, amelana ne-acid (kufaka phakathi i-gram-negative kanye ne-gram-positive gerins).

Izinto ezakha isisekelo samathebhulethi zivimbela ama-enzyme e-DNA amagciwane, zivimbela ukukhula kwawo kanye nekhono lokuzala. Umsebenzi wokwelapha we-moxifloxacin uncike ngqo ekugxileni kokufakwa kwezithako ezithweni zezicubu neplasma yegazi.

Phakathi kwezindlela zochungechunge lwe-fluoroquinolone, ukusabela kokuphikisana nokuqoshwa kwaqoshwa. Kepha ama-anaerobes amaningi kanye namagciwane anamandla egram awavikelekile kwamanye ama-fluoroquinolones azwela kakhulu imiphumela ye-moxifloxacin.

Izinto ezakha isisekelo samathebhulethi zivimbela ama-enzyme e-DNA amagciwane, zivimbela ukukhula kwawo kanye nekhono lokuzala.

I-Pharmacokinetics

I-Moxifloxacin imunca iphelele futhi ngesikhathi esifushane. I-Cmax ithayipha ngemizuzu engama-30-240. I-bioavailability ye-MS ifinyelela kuma-90%. Izinga lezinto ezikhuphukayo libonwa kulwelwesi lwama-mucous bronchial mucuses, sinuses nezicubu zezitho zesisu. Igcotshwa kanye nezindunduma kanye nomchamo. Ukulinganiselwa kwengxenye yempilo kungamahora ayi-12.

Izinkomba zokusetshenziswa

Izindlela ezilandelayo zokuvuvukala nezifo ezithukutheliswa yizinambuzane ziwuthaka umuthi:

• i-pneumonia etholwe ngumphakathi icasulwe yi-Streptococcus anginosus kanye ne-Streptococcus milleri;
• isiteji esibuhlungu sesimo esingamahlalakhona se-bronchitis;
• i-sinusitis (i-acute), icasulwa ngamagciwane we-pathogenic;
• izifo ezithathelwanayo zangaphakathi kwamathumbu (kufaka phakathi izifo ze-polymicrobial);
• ukutheleleka kwesikhumba nezilonda ezithambile zezicubu;
• Izifo zokuvuvukala kwe-pelvic, kubandakanya i-endometritis ne-salpingitis.

I-Heinemox imiselwe izifo zokuvuvukala zezitho zangasese.

Ngokutheleleka kwesikhumba, i-Heinemox inqunyelwe.

I-Thrombomagum ayinqunyelwe ukukhinyabeza kohlelo lokuphefumula.

Ukuthatha umuthi kubekelwe i-pneumonia.

Nge-sinusitis, kuyisiko ukunquma i-Heinemox.

Contraindication

Umuthi awusetshenziselwa lezi zinto ezilandelayo:

• ukungezwani komzimba soya kanye / noma amantongomane;
• hypersensitivity to moxifloxacin;
• Ukulimala kwezicubu ze-Tendon ngemuva kokwelashwa kwe-quinolone;
• ukuhlanganiswa kwama-antihistamines okwandisa isikhathi sokuphumula se-QT (Terfenadine, Astemizole), nezidakamizwa ezilwa ne-antibacterial (Halofantrine);
• iziguli ezinenkinga enkulu yesibindi nezinso;
• iminyaka emincane.

I-ejenti elwa namagciwane ibekelwa ngokucophelela izifo zesistimu yezinzwa, ihambisana nokuququdwa, ingqondo, imiphumela yokuqina, kanye ne-hepatic cirrhosis kanye nokuhlangana nemithi enciphisa izinga le-potassium emzimbeni.

Uma isiguli simelana ne-soy, ukuphuza umuthi akuvunyelwe.

Ukulimala kwezicubu ze-tendon ngemuva kokwelashwa kwe-quinolone kuwukuphikisana nokuphuza umuthi.

Ngefomu emnene yokuhluleka kwezinso nezinso, umuthi kufanele uthathwe ngokuqapha.

Ubudala obuncane - ukuphikisana nokusetshenziswa kwesidakamizwa Heinemoks.

Ungayithatha kanjani i-Heinemox

Izibhebhe ze-antimicrobial kufanele zithathwe ngomlomo zizonke, zigezwe ngamanzi. Kungcono ukwenza lokhu ngemuva kokudla.

Imithamo emaphakathi

• i-pneumonia (izinhlobonhlobo ezitholwe ngumphakathi): izidakamizwa zithathwa ku-400 mg; ukwelashwa kuhlala kusuka kumaviki awu-1 kuya kwayi-2;
• i-bronchitis (ene-exacerbation): inani lansuku zonke lezidakamizwa - 400 mg; isikhathi sokwamukelwa siyizinsuku ezingama-5- 10;
• i-sinusitis yemvelaphi yamagciwane: 400 mg wezidakamizwa enqunywe ngosuku; isikhathi sokwelashwa - isonto eli-1;
• izifo zesikhumba / subcutaneous: umthamo - 400 mg; Isikhathi sokwelashwa sisuka kumaviki awu-1 kuye kwayi-3;
• ama-pathologies we-intra-abdominal pathologies: umthamo - 400 mg; isikhathi sokwelashwa - kusuka ezinsukwini ezi-5 kuye kwezingu-14;
• izilonda zokuvuvukala (ezingalukhuni), zenziwe endaweni yezitho zomzimba wesibeletho: isilinganiso sansuku zonke - 400 mg; Isikhathi sokwamukelwa singamaviki ama-2.

Izibhebhe ze-antimicrobial kufanele zithathwe ngomlomo zizonke, zigezwe ngamanzi.

Ngoshukela

Lapho uphuza umuthi, abanesifo sikashukela badinga ukuqapha njalo ukugcwala kweglucose egazini.

Imiphumela emibi ye-Heinemox

Kusuka ezicutshini zemisipha

• i-myalgia;
• i-arthralgia;
• ukwanda kwezicubu zomzimba;
• izicubu zomsipha;
• ubuthakathaka
• isifo samathambo;
• ukwanda kwe-myasthenia gravis;
• ukulimala kwe-tendon.

Amapheshana wesisu

• isisu esibuhlungu;
• isicanucanu
• isifo sohudo
• ukuthopha;
• ukwehla kwesifiso sokudla;
• i-stomatitis
• dysphagia;
• i-colitis (ifomu le-pseudomembranous);
• gastroenteritis.

Ngesikhathi sokuphatha umuthi, kungenzeka kuqubuke imisipha.

Ubuhlungu esiswini bungumphumela ongemuhle wesidakamizwa uStrombomag.

Ngesikhathi sokulashwa nge-Heinemox, ukwehla kwesifiso sokudla kungenzeka.

Umuthi ungadala uhudo.

Ngenkathi uthatha i-thrombomag, isicanucanu nokuhlanza kungenzeka.

Izitho zeHematopoietic

• ukukhuphuka kwe-INR / ukunwetshwa kwe-PV;
• ushintsho ekuhlushwa kwe-thromboplastin;
• i-leukopenia;
• neutropenia;
• i-thrombocythemia;
• i-thrombocytopenia;
• i-anemia

Isistimu yezinzwa ephakathi

• Isiyezi
• i-dysesthesia / paresthesia;
• ukonakala ekunambithekeni;
• ukudideka;
• ukuqwasha
• Ukudana
• vertigo;
• ukukhathala
• ukozela
• izehlakalo zemvelo;
• Izinkinga ngomsebenzi wokukhuluma;
• hypnothesia.

Ngenkathi uthatha umuthi, ukuvela kobuthakathaka obujwayelekile kungenzeka.

Ukuba nesiyezi okuqhubekayo kungumphumela wokuthatha i-Aspirin.

I-Insomnia ingenye yemiphumela emibi yesidakamizwa.

I-Heinemox ingadala ukozela.

Kusuka ohlelweni lwezinhliziyo

• ukwelulwa kokuphumula kwe-QT kubantu abahlushwa i-hypokalemia;
• ukukhuphuka / ukuncipha komfutho wegazi;
• i-ventricular tachyarrhythmia;
• izinhlobo ezingacaciswanga ze-arrhythmia;
• ukungasebenzi kwenhliziyo.

Ngasohlangothini lwe-metabolism

• i-hyperuricemia
• ukukhuphuka kwezinga le-bilirubin;
• i-hyperglycemia;
• i-hyperlipidemia

Allergies

• i-eosinophilia;
• ukusabela kwe-anaphylactic;
• ukuqhuma
• I-edema kaQuincke;
• ukuvuvukala kwe-laryngeal (okusongela impilo).

Izinkinga zokuzwa kanye ne-dyspnea kwesinye isikhathi kungavela.

Ngesikhathi sokulashwa nge-Heinemox, ukubonakaliswa kokungasebenzi kahle kwenhliziyo kungenzeka.

Umthelela ekhonweni lokulawula izindlela

Izindlela ezivela esigabeni se-fluoroquinolones zingaholela ekushintsheni komsebenzi we-psychomotor lapho zithathwa, ngakho-ke ngalesi sikhathi kungcono ukuyeka ukushayela neminye imisebenzi engaba yingozi.

Imiyalo ekhethekile

Ngesikhathi sokuphathwa kwezidakamizwa, kwaqoshwa amacala ambalwa okuvela kwezilonda zesikhumba esiyinkunzi (i-epidermal tocr necrolysis, isifo seStevens-Johnson). Isiguli kufanele saziswe kusengaphambili ukuthi uma kwenzeka kuvela imiphumela emibi, kufanele uthintane nodokotela ngokushesha.

Kuyinto engathandeki ukusebenzisa umuthi ekwelapheni izifo ezithathelwanayo ezibangelwa amagciwane alwa nemithi egayimayo.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ochwepheshe bayakwenqabela ukusetshenziswa kwalesi sidakamizwa ngesikhathi sokuncelisa ibele nokukhulelwa.

Ochwepheshe bayakwenqabela ukusetshenziswa kwalo muthi ngenkathi uncelisa ibele.

Sebenzisa ebudaleni

Ezigulini ezinjalo, ukuzwela umuthi kukhuphuka kakhulu, ngakho-ke umthamo kufanele ukhethwe kucatshangelwa isimo sabo sempilo.

Isabelo sezingane

Akabelwe kuze kube iminyaka eyi-18.

Sebenzisa umsebenzi wesibindi okhubazekile

Kubhekwe ngokucophelela ezinkingeni ngomzimba.

I-overdose ye-Heinemox

Kulokhu, kuyadingeka ukunaka isithombe somtholampilo. Ukwelashwa ngokweqile - okusekela, okusekelwe ekuqapheleni usebenzisa i-ECG. Ukuphathwa ngomlomo kwe-carbon ocushiwe kuvimbela imiphumela eyeqisayo ye-moxifloxacin.

Ukuphathwa ngomlomo kwe-carbon ocushiwe kuvimbela imiphumela eyeqisayo ye-moxifloxacin.

Ukuxhumana nezinye izidakamizwa

Ngokusetshenziswa kanyekanye ngama-antacid, ama-multivitamini kanye nezakhi zamaminerali, ukumunca kuyancipha futhi izinga leplasma le-moxifloxacin lehla.

Ngokusetshenziswa kanyekanye kwezidakamizwa namanye ama-fluoroquinolones, kunobungozi bokubonakala kwezithombe.

I-Ranitidine isiza ukunciphisa ukumuncwa kwe-moxifloxacin.

Ukuhambisana notshwala

Umenzi akamnikeli imininingwane mayelana nenhlanganisela enjalo.

I-Avelox iyi-analogue yesidakamizwa i-Heinemox.

Intela yesidakamizwa i-Heinemox - iMaxiflox.

Esikhundleni seHeinemox, i-Vigamox kwesinye isikhathi inqunywa.

I-Rotomox kwesinye isikhathi iyachazwa esikhundleni seHeinemox.

Ama-Analog

• I-Avelox;
• UMaxiflox;
• I-Vigamox;
• Moksimak;
• Moxigram;
• I-Aquamax;
• I-Alvelon MF;
• I-Ultramox;
• Simoflox;
• I-Rotomox;
• I-Plevilox;
• Moflaxia.

Imibandela yekhefu lekhemisi

Amaphilisi Wokunikezwa

Intengo

300-380 rub. ngepakethi enguNombolo 10 (amaphilisi ayi-10, efakwe kumafilimu).

Izimo zokugcina zomuthi

Umuthi kufanele ube sendaweni ekude nezingane ezingamazinga okushisa esegumbini angaphansi kuka- + 25 ° C.

Isikhathi sokuphelelwa yisikhathi

Iminyaka emi-5

Umkhiqizi

I-Highglans Laboratories HTP. I-LTD (India).

Ukubuyekezwa

U-Olga Shapovalova, oneminyaka engama-39, u-Irkutsk

Ngihlala ngidla lo muthi lapho i-bronchitis yami iba mubi. Isebenza ngobumnene futhi ayibizi. Bengihlala ngisebenzisa omunye umuthi, kepha kulokhu akukho engingakwenza.

UVictor Koklyushnikov, oneminyaka engama-45, uVladimir

Welashwa ngamaphilisi e-sinusitis, ngoba avimbela ukusebenza kwamagciwane angena gram kanye nama-gram-negative. Waya emsebenzini kungakapheli amasonto ayi-1.5 ngemuva kokuqala kokwelashwa. Izinkomba zemitholampilo zibuyele kokujwayelekile, isimo sathuthuka.