I-Sofamet umuthi osetshenziselwa ukwelapha isifo sikashukela ezigulini. Ukuzilolonga kukhombisa ukuthi kunika imiphumela esheshayo efanelekile ngokuqokwa onekhono.
Igama Lezwe elingafanele
I-Metformin.
I-Sofamet umuthi osetshenziselwa ukwelapha isifo sikashukela ezigulini.
I-ATX
A10BA02.
Khipha amafomu nokwakheka
Ithuluzi likhiqizwa ngendlela yamathebulethi. Ku-1 pc iqukethe i-850 mg ye-metformin hydrochloride. Amathebulethi amhlophe ahlanganiswa, awanawo iphunga. Esiphaketheni samathebhulethi ayi-10 eqhweni.
Isenzo se-Pharmacological
Lo menzeli we-hypoglycemic wokuphathwa komlomo ungokwesigaba sama-Biguanides. Indlela yokusebenza ukuthi umuthi uvimbela i-gluconeogenesis, i-oxidation enamafutha kanye nokwakhiwa kwamahhala wamafutha acid.
Umuzwa wokutholwa kwama-receptors we-peripheral to kuongezeka kwe-insulin, ngenxa yokuthi amaseli aqala ukususa ushukela.
Ukukhiqizwa kwe-glycogen emzimbeni kuyashukunyiswa. IGlucose idonswa amathumbu kancane. Inani lama-triglycerides liyancipha. Isisindo sesiguli ngenkathi sithatha umuthi singawa sobabili futhi sihlale sizinzile.
I-Pharmacokinetics
Ukuchofoza ohlelweni lokugaya ukudla kungachazwa njengokungapheleli futhi okuhamba kancane. Ukuhlushwa kwe-plasma ephezulu kakhulu kufinyelelwa emahoreni angama-2,5 ngemuva kokuthatha umuthi. I-bioavailability yesidakamizwa ngu-50-60%. Ukumunca ngokugcwele kuyancipha uma isiguli siphuza amaphilisi ngokudla.
Ukumunca ngokugcwele kuyancipha uma isiguli siphuza amaphilisi ngokudla.
Ukusatshalaliswa kwezicubu zomzimba kuyashesha. Ukuhlanganiswa namaprotheni e-plasma kungachazwa njengokuncane. Ukuqunjelwa kwenzeka ezindlebeni zamathe, izinso nesibindi. I-Excretion yenziwa ngezinso, futhi ayiguquki. Nge-pathology yomsebenzi wezinso, ukubalwa kwento esebenzayo kungenzeka.
Izinkomba zokusetshenziswa
Inhloso yokuthi umuthi uzoba ofanele uma isiguli sinesifo sikashukela sohlobo 2 (esingathembekile kwe-insulin). Lokhu kusebenza ikakhulukazi uma, ngaphambi kokuchaza umuthi, ukwenziwa okujwayelekile kokudla kanye nokwethulwa komsebenzi womzimba kungalethi imiphumela efanele. Kunqunyelwe, kufaka phakathi iziguli ezinokukhuluphala.
Inhloso yokuthi umuthi uzoba ofanele uma isiguli sinesifo sikashukela sohlobo 2.
Contraindication
Umuthi akufanele uphathwe uma isiguli sinezinkinga kulezi zimo ezilandelayo:
- Izifo ezingama-acute nezingamahlalakhona, okuthi, njengoba zithuthuka, zingavusa izicubu ze-izicubu esigulini (ukuhluleka kwenhliziyo nokuphefumula, ukumamatheka kwe-myocardial);
- i-metabolic acidosis;
- ukukhula kokuthile kokuthile okusebenzayo;
- ukwethuka kwe-hypoglycemic;
- izinqubo ezinzima zokutheleleka emzimbeni;
- ukuncipha komzimba.
Ungayithatha kanjani iSofamet?
Uhlobo lomthamo luyahlukahluka ngokuya ngesimo sesiguli.
Ngoshukela
Ukwemukela kufanele kwenzeke ngesikhathi sokudla noma ngemuva kokudla. Umthamo wokuqala wabantu abadala ungama-500 mg izikhathi ezingama-1-3 ngosuku. Kuvunyelwe ukuthatha izikhathi ezingama-850 mg izikhathi eziyi-1-2 ngosuku.
Ngemuva kwezinsuku eziyi-10-15 zokuthatha umuthi ungashintshwa ngudokotela ngokusekelwe kushukela wegazi.
Kwezinye izimo, udokotela unquma ukunquma ukwelashwa okuhlanganisa ne-insulin.
Imiphumela emibi Sofameta
Phakathi kwemiphumela engemihle engahle ivele: i-lactic acidosis (kulokhu, udinga ukuyeka ukwelashwa), isicanucanu kanye nokungajabuli esiswini, ukuhanjiswa yisisu nokuthopha, kanye ne-hepatitis kanye nokushintshwa kwemingcele yesibindi.
Njengomphumela wecala ongavamile, i-malabsorption ye-Vitamin B12 ingaqala ukukhula. Ukuphendula ngemuva kokuthatha umuthi kuyefana kubantu abadala nasezinganeni.
Umthelela ekhonweni lokulawula izindlela
Umuthi awunamphumela ekugxambeni kweziguli ngenxa yokuthi imiphumela emibi evela ohlelweni lwezinzwa oluyinhloko ayibhekwa.
Imiyalo ekhethekile
Ithuluzi alinikezi ukubonakala kwe-hypoglycemia.
Isabelo sezingane
Ezinganeni, umuthi ubekwa ngemuva kokufika eminyakeni eyi-10. Umthamo wokuqala ungaba ngu-500 noma 850 mg 1 isikhathi ngosuku. Enye indlela ingaba ngu-500 mg kabili ngosuku. Umthamo ophelele ovunyelwe kungaba 2 g ngosuku.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Njengoba into esebenzayo ikwazi ukudlula kumgoqo we-placental, ukusetshenziswa kwayo ngesikhathi sokukhulelwa kungenzeka kuphela njengezinyathelo sokugcina. Isithako esisebenzayo singafaka nobisi lukamama. Lokhu kusho ukuthi ngesikhathi sokuzala, umuthi ungcono ukungabeki.
Njengoba into esebenzayo ikwazi ukudlula kumgoqo we-placental, ukusetshenziswa kwayo ngesikhathi sokukhulelwa kungenzeka kuphela njengezinyathelo sokugcina.
Isicelo sokusebenza kokulimala kwezinso
Ukulimazeka okukhulu kwezinso kuwukuphikisana nokuqokwa komuthi.
Sebenzisa umsebenzi wesibindi okhubazekile
Izimpawu ezibalulekile ze-hepatic yisona sizathu sokunqunyelwa kokunqunywa.
Ukweqisa kwe-Sofamet
Ngokuthatha ngokweqile umuthi emzimbeni, ukuthuthukiswa kwe-lactic acidosis enomphumela obulalayo kungenzeka. Kuyadingeka ukususa umuthi emzimbeni usebenzisa i-hemodialysis.
Izimpawu ezibalulekile ze-hepatic yisona sizathu sokunqunyelwa kokunqunywa.
Ukuxhumana nezinye izidakamizwa
I-Nifedipine inyusa ukumunca kanye nokugxilisa okuphezulu ku-plasma yegazi ye-metformin.
Ngokusetshenziswa kanyekanye kwezindlela zokuvimbela inzalo zama-hormonal, ama-Danazole kanye ne-nicotinic acid exuatives nomuthi, ukwehla kokusebenza kwomuthi kungenzeka.
Lapho uphuza ne-insulin, i-MAO inhibitors, ama-salicylates, umphumela wemithi ungakhuphuka.
Ukuhambisana notshwala
Inhlanganisela yomuthi notshwala ikhulisa ubungozi be-lactic acidosis.
Ama-Analog
Ungabuyisela isidakamizwa ngezidakamizwa ezifana neGlucofage, Metospanin, Siafor.
Imibandela yekhefu lekhemisi
Umuthi wethulwa kunoma yisiphi isikhungo samakhemisi.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Ukuphumula kuvunyelwe kuphela ngomuthi kadokotela.
Intengo yeSofamet
Izindleko zethuluzi ziqala kusuka kuma-ruble ayi-150.
Izimo zokugcina zomuthi
Gcina endaweni emnyama emazingeni okushisa angadluli + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
SOPHARMA. IFetetin iyi-analogue yokukhiqizwa kweRussia.
Ukubuyekezwa ku-Sofamet
A.D. I-Shelestova, i-endocrinologist, i-Lipetsk: "Umuthi ukhombisa imiphumela emihle ekwelashweni kwesifo sikashukela sohlobo 2. Lokhu kungenxa yokuthi inqubo yokusebenza ihlose ukunciphisa inani le-glucose egazini. Ngakho-ke, umphumela ungatholakala emavikini ama-2 okwelashwa, afanele iziguli. Kubalulekile ukuthi ubheke ukuthi ngemuva kokwelashwa, uzodinga ukuhola impilo enempilo futhi ugcine umzimba uphelele. "
I-S.R. I-Reshetova, i-endocrinologist, i-Orsk: "Umenzeli wemithi uvumela ukuthi kutholakale usizo oluhle ekwelashweni kwesifo sikashukela sesigaba 2. Ngesikhathi sokwelashwa, kubalulekile ukubheka isimo sesiguli, ngoba ezimweni eziningi ukulungiswa kwamthamo kufanele kwenziwe ngemuva kwesonto lokwelashwa. "Uma lokhu kwenzeka, isiguli sizokwazi ukusiza nge-hemodialysis."
U-Elvira, oneminyaka engama-34, uLipetsk: "Kwavela ukuthi kufanele ngilaphe isifo sikashukela. Lesi sifo asisihle, sibangela usizi oluningi. Ukwelashwa kuhambisane nalesi sidakamizwa. Angibonanga imiphumela emibi, kepha ukuthuthuka okukhulu akubanga isikhathi eside ukuza. Ngingayichaza njengengcono kakhulu. Ngakho-ke, ngiyayincoma ezigulini ezinesifo sikashukela. Umuthi ungasiza esikhathini esifushane futhi unciphise izimpawu ezishiwo ngalesi sifo. "
U-Igor, oneminyaka engama-23, u-Anapa: "Yize ngisemncane, bekumele ngiphathe isifo esibucayi njengesifo sikashukela. Ngifuna ukuqaphela ngaso leso sikhathi ukuthi ukwelashwa bekungagcini ngokuphuza ukuthatha umuthi. Bekumele ngishintshe indlela engiphila ngayo, ngiguqule engikudlayo futhi ngihlanganise nemidlalo kanye nenqubo yami yansuku zonke. Ukuzivocavoca umzimba.Isidakamizwa sisize ukwehlisa izimpawu ze-pathology, ezaziphazamisa impilo ejwayelekile. Angizange ngiqaphele noma yimiphi imiphumela emibi, ngangizizwa ngijwayelekile ngaphandle kwezimpawu ezijwayelekile zesifo. Ngingawuncoma lo muthi ukuze ngilinganise izinga le-glu eskers. "
U-Antonina, oneminyaka engama-42, uPetrokrepost: "Isifo sikashukela sivele ngenxa yokuxineka kakhulu. Ukuze kubuye kudalulwe izimpawu zokugula, udokotela ovumayo udonsa ngamaphilisi ukuthi wehlise ushukela wegazi. Ngabona imiphumela ngemuva kwezinsuku ezimbalwa. Akubanga khona mpendulo imbi lapho udla lomuthi" .
