I-Metformin umuthi onikezwa kadokotela osetshenziselwa ukwehlisa ushukela wegazi ngohlobo 2 sikashukela. Lesi sidakamizwa sinezinye izinzuzo eziningi. Isibonelo, isetshenziselwa ukulahleka kwesisindo futhi ezinye izifundo ziqinisekisa ukusebenza kwayo ekwelashweni kweziguli ezinomdlavuza.
Igama Lezwe elingafanele
Igama elijwayelekile lalesi sidakamizwa nguMetformin (Metformin).
I-Metformin umuthi onikezwa kadokotela osetshenziselwa ukwehlisa ushukela wegazi ngohlobo 2 sikashukela.
I-ATX
Ikhodi yi-A10BA02. Umuthi uthinta umgudu wokugaya ukudla kanye nemetabolism, kuyindlela yokwelashwa kwesifo sikashukela. Kuthiwa izidakamizwa ze-hypoglycemic, ngaphandle kwe-insulin. Biguanide.
Khipha amafomu nokwakheka
IMetformin Long Canon ithengiswa ezibhebheni. Ukwakheka kufaka i-500/8/10/2000/2000 mg ye-metformin.
Isenzo se-Pharmacological
I-Metformin inezici ezahlukahlukene ezivumela ukusetshenziswa kwayo ekwelapheni izifo ezithile.
Ukwelashwa nokuvimbela isifo sikashukela sohlobo 2
I-Metformin yehlisa izinga le-glycemia, ngaleyo ndlela ivikele izitho zomzimba kusuka kumonakalo ongapheli, ongadala ukungasebenzi kwazo noma ukungasebenzi kahle isikhashana. Lesi sidakamizwa sisebenza ngokuthonya kwaso ku-AMPK, esenza ukuthi i-glucose ivele egazini iye emisipha. I-Metformin inyusa i-AMPK, evumela izicubu ukuba zisebenzise ushukela omningi, okunciphisa ukugcwala koshukela egazini.
Ngaphezu kwalokho, i-metformin inganciphisa ushukela wegazi ngokuvimba ukukhiqizwa kwayo (gluconeogeneis).
Ukwanda kokuzwela kwe-insulin
Ukumelana ne-insulin kuyisici esidala ukwanda kohlobo lwesifo sikashukela sohlobo 2, kodwa futhi kubhekwe ku-polycystic ovary syndrome kanye nomthelela ongemuhle wokwelashwa kwe-HIV.
Umuthi ukhulisa umuzwa we-insulin futhi uthola imiphumela yokuphikisana ne-insulin kubantu abanesifo sikashukela.
Izimpawu Zokulwa I-PCOS
I-Polycystic Ovary Syndrome (PCOS) ingukuphazamiseka kwe-hormonal okuvame ukwanda ukukhuluphala kanye ne-insulin. I-Metformin ivimbela ukweqa kwe-ovulation, ukungahambi kahle kokuya esikhathini kanye ne-insulin ethe xaxa emzimbeni. Kwandisa amathuba okukhulelwa okuphumelelayo futhi kunciphisa ubungozi bokuphuphuma kwezisu. Yehlisa amathuba okuba nesifo sikashukela sokukhulelwa kanye nokuvuvukala okuhambisana ne-polycystic ovary syndrome.
I-Metformin yandisa amathuba okukhulelwa okuphumelelayo futhi yehlise nengozi yokuphuphuma kwezisu.
Kungavimbela umdlavuza noma kusetshenziswe ekwelapheni kwayo
IMetformin yayeka ukukhula nokukhula kwezinhlobo ezithile zomdlavuza ezigulini ezingaphezu kuka-300,000 ezinesifo sikashukela sohlobo 2.
Ukuhlaziywa kwe-meta kuveze ukwehliswa okungu-60% kumdlavuza womdlavuza wesibindi (i-intrahepatic cholangiocarcinoma) kubantu abanesifo sikashukela ababemiselwe i-metformin. Ucwaningo lukhombisa ukuncipha kwamathuba okuba nomdlavuza we-pancreatic kanye webele, umdlavuza we-colorectal kanye namaphaphu ngo-50-85%.
Yini umehluko phakathi kwe-Amoxiclav neFlemoxin Solutab?
Ingabe i-kiwi ilusizo kuma-diabetes? Funda kabanzi esihlokweni.
Imiyalo yokusebenzisa i-Detralex 1000.
Kuvikela inhliziyo
Imvamisa, esinye sezici eziyingozi zokuthola isifo senhliziyo ukungalingani kushukela wegazi.
Ucwaningo lweziguli ezingama-645,000 ezinesifo sikashukela luveze ikhono le-metformin lokunciphisa ukuphazamiseka kwenhliziyo (i-atrial fibrillation).
Kwehlisa cholesterol
I-Metformin yehlisa i-cholesterol “embi”, i-lipoproteins ephansi (i-LDL).
Isiza ekunciphiseni isisindo
Ocwaningweni lapho abesifazane abaseminyakeni ephakathi abanamazinga aphezulu e-insulin maqondana noshukela wegazi nesisindo somzimba kwathathwa, kwatholakala ukuthi i-metformin iyasiza ukunciphisa umzimba.
Kokunye isifundo, i-metformin yehlise inkomba yomzimba ezigulini eziyi-19 ezinegciwane lesandulela ngculaza ngokusatshalaliswa okungafanele kwamafutha omzimba (lipodystrophy).
Kwangathi kungaphatha ukungasebenzi kahle kwe-erectile emadodeni
Ucwaningo oluningi luye lwabonisa ukuthi i-metformin inganciphisa ukungasebenzi kahle kwe-erectile emadodeni anenkinga yokukhuluphala, ukumelana ne-insulin, noma isifo sikashukela.
Ingavikela ekulimaleni okubangelwa yi-gentamicin
I-Gentamicin Umuthi olwa namagciwane obangela ukulimala kwezinso nasezinhlwini zokuzwa. I-Metformin ingavikela ekulahlekelweni kwezindlebe okubangelwa ukuchayeka ku-glamicin.
Ukwelashwa kwezifo zesibindi ezingelona utshwala
I-NAFLD yisifo esingamahlalakhona esijwayelekile lapho amaconsi aqwabelana khona ngokomqondo esibindini, kepha lokhu akuhlobene nokuphuzwa kotshwala. I-Metformin yehlisa ukuthambekela kokuqongelela amaconsi amafutha.
I-Pharmacokinetics
Kufakwe ngokwanele emgodini wesisu ngemuva kokuphathwa ngomlomo. I-Bioavailability ifinyelela ku-60%. Ku-plasma, okuqukethwe okuphezulu kubonwa ngemuva kwamahora we-2,5.
Kuthuliswa izinso zingashintshiwe.
Izinkomba zokusetshenziswa
Kusetshenziswa iziguli ezinomdlavuza wesifo sikashukela sohlobo 2 (ikakhulukazi ephumelela abantu abakhuluphele) njenge-monotherapy uma kungekho miphumela ebonakalayo evela ekudleni okufanele nasekuzivocavoca. Kubhalwe futhi ngokuhlanganiswa nezidakamizwa ezinomphumela we-hypoglycemic, noma nge-insulin.
Contraindication
It is contraindicated ezigulini ezimweni ezilandelayo:
- hypersensitivity kwento esebenzayo;
- ukulimazeka kwezinso;
- I-metabolic ye-metabolic engamahlalakhona, kufaka phakathi i-ketoaciadiasis yesifo sikashukela (ene-coma noma engenawo), infarction ye-myocardial acute;
- umsebenzi we-renal noma we-hepatic;
- i-lactic acidosis;
- izifo ezingaba nomthelela ekuqubukeni kwe-tishu hypoxia;
- ukukhulelwa, isikhathi sokuncelisa ibele;
- iminyaka engu-18.
Ngokunakekela
Umuthi unikezwa ngokuqapha ezigulini esezikhulile ezisebenza kanzima.
Ungayithatha kanjani iMetformin 1000
Ithathwe ngomlomo. Umthamo ngosuku unqunywa udokotela ohambelayo.
Ngaphambi noma ngemuva kokudla
Lesi sidakamizwa sithathwa ngesikhathi sokudla noma ngokushesha ngemuva kokudla.
Ngoshukela
Kwesinye isikhathi isetshenziswa ihlanganiswe ne-insulin. Imiyalo enemininingwane inikezwa udokotela ohambelayo.
Ukwehla kwesisindo
Kukholelwa ukuthi lesi sidakamizwa singasiza ngokunciphisa umzimba. Kodwa-ke, ngaphambi kokusebenzisa, izeluleko zochwepheshe ziyadingeka.
Imiphumela emibi yeMetformin 1000
Imiphumela emibi engaba khona:
- i-lactic acidosis, okuholela ebuhlungwini bemisipha, ukukhathala, ukubanda, isiyezi, ukozela;
- ukunambitheka kwensimbi emlonyeni;
- ukwehlisa umfutho wegazi;
- i-hypoglycemia;
- ukulahleka kwesifiso.
Amapheshana wesisu
Kungadala i-nausea, ukugabha, i-anorexia, isifo sohudo, ukomisa kwezinso, ukuthopha.
Ngasohlangothini lwe-metabolism
Akuvamile ukuthi kubangele i-lactic acidosis.
Engxenyeni yesikhumba
Ukuvela kokuqubuka, isikhumba.
Uhlelo lwe-Endocrine
Kukhona kungenzeka kwe-hypoglycemia.
Allergies
Imiphumela yokungezwani komzimba kungenzeka.
Umthelela ekhonweni lokulawula izindlela
Uma kuphela lesi sidakamizwa sithathwa, khona-ke awukho umphumela. Uma usebenzisa izidakamizwa ze-antidiabetes, kunconywa ukuthi ugweme imisebenzi edinga ukunakwa okwengeziwe.
Imiyalo ekhethekile
Umuthi awunakusetshenziswa ezinsukwini ezi-2 ngaphambi kokuhlinzwa kanye namahora angama-48 ngemuva kwawo (inqobo nje uma isiguli sisebenza ngokujwayelekile izinso).
Kunconywa ukuthi kwenziwe izivivinyo njalo ukulawula isifo sikashukela.
Ngaphambi kokusebenzisa, kufanelekile ukufunda imiyalo yokusebenzisa.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukusetshenziswa ngesikhathi sokukhulelwa akwamukeleki. Ngesikhathi sokulashwa, ukuncelisa ibele kufanele kumiswe.
Ukunquma iMetformin ezinganeni ezi-1000
Umuthi ubekelwe iziguli ezisukela eminyakeni engu-18 ubudala.
Sebenzisa ebudaleni
Lapho unquma iziguli esezikhulile, kudingeka ukuthi kuqashelwe isimo sezempilo esengeziwe.
Isicelo sokusebenza kokulimala kwezinso
Akunconyelwe.
Sebenzisa umsebenzi wesibindi okhubazekile
Akunconyelwe.
I-overdose yeMetformin 1000
Uma kwenzeka kweqa ngokweqile, ukubonakaliswa kwemiphumela emibi kuyanda.
Uma weqa umthamo, thintana nodokotela ngokushesha.
Ukuxhumana nezinye izidakamizwa
Kuhlanganiswe ne-iodine-aqukethe ama-radiopaque agents ahlanganisiwe.
Lapho kuhlanganiswa ne-danazol, chlorpromazine, glucocorticosteroids, diuretics, injektha ye-beta2-adrenergic agonist, ukuqapha nokubheka kaningi ushukela wegazi kuyadingeka.
Kuphikisiwe ukuhlanganisa i-metformin nezidakamizwa eziqukethe iodine i-radiopaque.
Uma kusetshenziswa izidakamizwa ze-antidiabetic, ukubonakaliswa kwe-hypoglycemia kungenzeka.
Bheka ukuthi zihambisana yini nazo zonke izidakamizwa owaphuza ngenkathi welashwa nge-metformin.
Ukuhambisana notshwala
Akufanele kuhlanganiswe notshwala, njengoba amathuba okuba i-lactic acidosis inyuke.
Ama-Analog
Uma ufisa, ama-analogues alandelayo angasetshenziswa esikhundleni seMetformin:
- Siofor;
- I-Glycometer;
- Metformin Richter;
- Metformin-Teva;
- I-Diaformin;
- IGlucophage;
- Insufor nabanye
Imibandela yekhefu lekhemisi
Ukuthengiswa kwesidakamizwa iMetformin 1000 (ngesiLatini - Metforminum) kungukuya kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
E-Russia, ukuthengiswa kwezidakamizwa ezihlinzekiwe uma ungekho umuthi akunqunyelwe.
Intengo yeMetformin 1000
Izindleko zalesi sidakamizwa emakhemisi aseRussia ziyehlukahluka ukusuka ku-190 kuya kuma-ruble angama-250.
Izimo zokugcina zomuthi
Kunconywa ukugcina lo muthi endaweni yokushisa engeqi ku-+ 25 ° C endaweni emnyama neyomile engatholakali ezinganeni.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
I-LLC "Isikhungo Sokusabalalisa se-Nycomed" (iRussia, iMoscow).
Ukubuyekezwa mayelana neMetformin 1000
Ochwepheshe bavumela leli thuluzi ukwelashwa kwezifo ezahlukahlukene.
Odokotela
UBobkov E.V., udokotela ojwayelekile, oneminyaka engama-45, u-Ufa: "Umuthi osungulwe kahle osetshenziselwa ukwelapha isifo sikashukela sohlobo 2."
UDanilov S.P., udokotela ojwayelekile, oneminyaka engama-34, uKazan: "Kuyo yonke le minyaka, kuye kwaboniswa ukuthi kusebenza ngokweqile. Kuyasiza ukufeza umphumela omuhle ngesikhathi esifushane."
Iziguli
UDmitry, oneminyaka engu-43 ubudala, uVladivostok: "Nginesifo sikashukela sohlobo 2. Ngiphuza lo muthi kanye nemijovo ye-insulin isikhathi esingangonyaka. Yehlisa ushukela wegazi."
UVladimir, oneminyaka engama-39, e-Ekaterinburg: "Ngathatha isikhathi eside i-Glibenclamide, kodwa ngokuhamba kwesikhathi kwaqokwa iMetformin. Idluliswa kamnandi, noshukela wegazi wami ubuyela esimeni esejwayelekile, isimo sami saba sihle."
Ukulahlekelwa isisindo
USvetlana, oneminyaka engama-37, uRostov-on-Don: "Ngithengile lesi sidakamizwa ezelulekweni zikadokotela wezempilo. Angizwanga ngamphumela omuhle."
UValeria, oneminyaka engama-33, e-Orenburg: "Kusukela ebuntwaneni, wayethambekele kakhulu ngokudonsa kanzima. Udokotela owayekhona lapho eluleka uMetformin. Ngemuva kwenyanga, wayeka ukuyithatha, ngoba yayinesiyezi futhi inenkani."
