I-Cefepime isidakamizwa esilwa ne-antibacterial esizosiza ukubhekana nanoma yikuphi ukutheleleka okungene emzimbeni futhi sekuyimbangela yokukhathazeka.
Igama Lezwe elingafanele
Igama ngesiLatini yiCefepime.
Ngokusho kwegama lokungadingeki kwezentengiso nasemazweni aphesheya, lo muthi ubizwa nge-cefepime.
I-Cefepime isidakamizwa esilwa ne-antibacterial esizosiza ukubhekana nanoma yikuphi ukutheleleka okungene emzimbeni futhi sekuyimbangela yokukhathazeka.
I-ATX
Ikhodi ye-ATX yiJ01DE01.
Khipha amafomu nokwakheka
Umuthi ngmpuphu esetshenziselwa ukujova intramuscular kanye nokuphathwa kwe-intravenous. Umuthi osebenzayo - i-cefepime hydrochloride - ukhona ngesilinganiso esingu-0.5 noma 1 g ngebhodlela ngalinye.
Isenzo se-Pharmacological
Umuthi ungowesizukulwane sesine sama-cephalosporin antibacterial agents.
Ama -organices alandelayo anokuzwela kwesidakamizwa:
- I-Staphylococcus epidermidis (i-epidermal staphylococcus);
- I-Streptococcus pneumoniae (pneumococcus);
- I-Klebsiella pneumoniae (wand kaFrindler's);
- I-Staphylococcus aureus (Staphylococcus aureus);
- I-Enterobacter cloacae;
- I-Pseudomonas aeruginosa (Pseudomonas aeruginosa);
- I-Escherichia coli (E. coli);
- I-Citrobacter diversus;
- Providencia stuartii;
- I-Enterobacter agglomerans;
- I-Streptococcus pyogene;
- I-Haemophilus influenzae (hemophilus bacillus).
Umuthi ngmpuphu esetshenziselwa ukujova intramuscular kanye nokuphathwa kwe-intravenous.
Amagciwane alandelayo abonakala ngokungazweli emithini:
- Clostridium Hardile;
- I-Xanthomonas maltophilia strains;
- I-Enterococcus faecalis;
- Ama-bacteriides fragilis;
- I-legionella spp.
I-Pharmacokinetics
Umuthi ubonakala ngokushesha ngaphakathi kweseli le-pathogenic futhi alivezi i-beta-lactamase.
Ukuhlanganiswa kwamaprotheni egazi azimele ekugxambeni kwe-plasma.
Izinkomba zokusetshenziswa
Umuthi ubekiwe uma isiguli sinezinkomba ezilandelayo:
- izifo ezithinta umchamo, kubandakanya lezo ezinezinkinga;
- uhlobo lwamagciwane we-meningitis (ebuntwaneni);
- inyumoniya
- ukutheleleka kwesikhumba;
- umkhuhlane we-neutropenic;
- izilonda ezithambile zezicubu;
- i-bronchitis nezinye izifo zohlelo lokuphefumula;
- i-gynecological pathologies, ngokwesibonelo, i-vaginitis.
Contraindication
Umuthi awukhuthazelwa abantu abane-hypersensitivity ukwakheka komuthi, kanye nezidakamizwa eziseqenjini lama-penicillin nama-cephalosporins.
Ngokunakekela
Ezigulini ezisengozini yokusabela komzimba kulo muthi, umuthi olwa namagciwane unqunywa ngokuqapha.
Ungayithatha kanjani isikhathi sokudla kwesikhashana
I-regimen yokwelashwa nemithamo incike esimweni sesiguli nomsebenzi wezinso, ngakho-ke umuthi ubekwa ngawodwana. Ukuze uthole ukwelashwa, babonana nodokotela futhi bathola izincomo.
Isikhathi sokwamukelwa sisukela ezinsukwini eziyi-7 kuye kwezingu-10.
Ezimweni ezimbi kakhulu, udokotela angakunquma isikhathi sokwelashwa esahlukile.
Ukuze uthole ukwelashwa, babonana nodokotela futhi bathola izincomo.
Ungazalela kanjani i-cefepim antibiotic
Emgudwini wokuphatha we-intramuscular, umuthi uyahlakazwa kuketshezi lomjovo lapho kukhona paraben noma phenylcarbinol. Ukusetshenziswa kwe-0,5% novocaine noma i-lidreyine engu-0.5-1% akunqunyelwe.
Ukusetshenziswa kwe-intravenous, umuthi uhlanjululwa kwisixazululo se-isotonic sodium chloride.
Ukuthatha umuthi wesifo sikashukela
Umuthi usetshenziswa ngokuya ngemiyalo esetshenziswayo. Ngesikhathi sokulashwa, kufanele kukhunjulwe ukuthi ngesikhathi sokuhlolwa kokuqukethwe ushukela kumchamo, imiphumela ingaba yimbi.
Ngesifo sikashukela, umuthi usetshenziswa ngokuya ngemiyalo yokusetshenziswa.
Imiphumela emibi
Ukulawulwa kwe-intramuscular of the antibiotic kungaholela emizweni ebuhlungu kanye nenqubo yokuvuvukala endaweni yomjovo.
Ngokufakwa kwe-intravenous, i-phlebitis kungenzeka - izilonda zezindonga ze-venous.
Amapheshana wesisu
Imiphumela emibi evela ohlelweni lokugaya ibonakaliswa ukubonakaliswa okulandelayo:
- ukuqunjelwa
- ushintsho lokunambitha;
- inqubo yokuvuvukala koloni, kufaka phakathi i-pseudomembranous colitis;
- isicanucanu
- dysbiosis;
- isifo sohudo
- Ubuhlungu esiswini.
Ukusebenzisa umuthi kungaholela kuhudo.
Izitho zeHematopoietic
Kunokwehla kwesilinganiso se-hemoglobin esegazini (anemia).
Isistimu yezinzwa ephakathi
Ezimweni eziningi, kuvela ikhanda. Ukuqunjelwa nesiyezi kuyinsakavukela.
Kusuka ohlelweni lokuphefumula
Imiphumela emibi ibonakala ngendlela yokukhwehlela.
Kusuka ohlelweni lwezitho zofuzo
Iningi leziguli elihlangabezane nezimpawu zangaphandle linezimpawu ezilandelayo:
- ama-candidiasis angacaciswanga;
- ukulunywa kwe-inguinal;
- kwabesifazane, ukuvuvukala mucosa wesitho sangasese sowesifazane;
- umsebenzi wezinso ongonakalisiwe.
Ngemuva kokuthatha, ukwehluleka kwezinso kungenzeka.
Kusuka ohlelweni lwezinhliziyo
Iziguli zigcine izimpawu ezifanayo:
- ukuphefumula
- ukuzindla kwenhliziyo.
Allergies
Kuvela izimpawu ezilandelayo:
- ukuqhuma kwesikhumba;
- ukusabela kwe-anaphylactic;
- umkhuhlane we-nettle.
Ngemuva kokuphuza umuthi, ukuqubuka kwesikhumba kungavela.
Imiyalo ekhethekile
Iziguli ekuqhubekeni okuqhubekayo kwe-peritoneal dialysis zandisa isikhathi esiphakathi kokuphathwa kwe-antibiotic. Kulokhu, umuthi uphathwa njalo emahoreni angama-48.
Umthelela ekhonweni lokulawula izindlela
Kunconywa ukwenqaba ukusebenzisa ezokuhamba kuze kube yilapho sekucaciswa impendulo yomzimba ekwelashweni. Uma kunemiphumela emibi ethinta kabi ukubekezelelwa kokunakwa (ikhanda, isiyezi), kufanele wenqabe ukushayela imoto.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi udlulela obisini lwebele, ngakho-ke, phakathi nesikhathi sokwelashwa, kuyadingeka ukudlulisa ingane kwizingxube zokwenziwa. Ngaphandle kwalokho, udinga ukuthola ithuluzi elifanelekile.
Ucwaningo olwenziwe ukutadisha umphumela womuthi emzimbeni womama nakwa-fetus alukenziwa. Ngenxa yalesi sizathu, akukho mininingwane ngokuphepha kokuphuza umuthi. Uma kudingekile ukwenza ukwelashwa, khona-ke kwenziwa kuphela ngemvume kadokotela nangaphansi kokulawulwa kwakhe.
Kunconywa ukwenqaba ukusebenzisa ezokuhamba kuze kube yilapho sekucaciswa impendulo yomzimba ekwelashweni.
Ukunquma Cefepime ezinganeni
I-antibacterial agent ayisetshenziselwa ukwelapha izingane ezingaphansi kwezinyanga ezimbili ubudala. Kwezinye izimo, i-antibiotic isetshenziswa ngemvume yongcweti.
Sebenzisa ebudaleni
Ezigulini esezikhulile, inani lemithi kumele lishintshwe, ngakho-ke, ukubonisana nodokotela kuyadingeka.
Isicelo sokusebenza kokulimala kwezinso
Uma kwenzeka wehluleka izinso, umthamo ubekiwe kucatshangelwa imvume ye-creatinine. Uma inkomba ingaphansi kwama-30 ml ngomzuzwana, lapho-ke udinga ukukhetha inani elifanele lama-antibiotic.
Sebenzisa umsebenzi wesibindi okhubazekile
Ukulungiswa komthamo akudingekile, noma kunjalo, isiguli kufanele siqashelwe ukulawula ukuhlangana komuthi egazini.
Ukweqisa
Ukweqa inani elivumelekile lomuthi kuholela ekubonisweni okufanayo:
- imibono;
- stupor;
- ukudideka kokwazi;
- ukusonta kwemisipha.
Ukweqa inani elamukelekayo lomuthi kuholela ekubonakalweni kwengqondo.
Ngaphezu kwalokho, izimpawu zemiphumela emibi zingaqina. Isiguli kufanele sifune ukwelashwa.
Ukuxhumana nezinye izidakamizwa
Akunconywa ukuhlanganisa ukuthatha i-antibiotic kanye nezidakamizwa ezilandelayo:
- i-aminoglycosides - ubungozi bokulimala kwe-vestibular ne-auditory Equipmentaratises; ukukhuphuka komthelela omubi ezinso;
- Isixazululo seMetronidazole;
- Imithi enezakhi ze-antimicrobial
Ukuhambisana notshwala
Umuthi awuhlanganiswa nemikhiqizo equkethe i-ethyl alcohol. Ukungawunaki lo mthetho kuholela emiphumeleni enobuthi esibindini nakwezinye izitho zomzimba.
Umuthi awuhlanganiswa nemikhiqizo equkethe i-ethyl alcohol.
Ama-Analog
Umphumela ofanayo unazo izindlela:
- I-Ceftriaxone isidakamizwa sesithathu se-cephalosporin. Umuthi olwa namagciwane uphumelela ngokuqhathaniswa ne-gram-negative ne-gram-positive microflora.
- UMaxipim yi-ejenti elwa namagciwane elwa ne-beta-lactamase.
- I-Movizar iyi-antibiotic yezizukulwane ezi-4 eyenzelwe ukusetshenziswa kwabazali.
- I-Cephalexin yisidakamizwa esikhishwa ngendlela yemiganu yokumiswa namatafula. Umuthi lo ufaka isandla ekubhujisweni kolwelwesi lwamagciwane, oluba yimbangela yokufa kwawo. Ayimelani nama-beta-lactamases.
- I-Maksicef yi-ejenti elwa namagciwane enobubanzi besenzo.
Imibandela yekhefu lekhemisi
Kukhululwa lapho kwethulwa iresiphi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ukuze uthenge umuthi, kuyadingeka ifomu lokuyalelwa.
Ukuze uthenge umuthi, kuyadingeka ifomu lokuyalelwa.
Intengo ye-cefepim
Ukuthengiswa kwalesi sidakamizwa kwenziwa ngentengo yama-ruble angama-98-226.
Izimo zokugcina zomuthi
Umuthi olwa namagciwane kufanele uvikeleke ekuchayweni kwelanga nokushisa okuphezulu. Isixazululo esilungiselelwe sivunyelwe ukugcinwa isikhathi esingaphezu kosuku lokushisa kwasekamelweni futhi isikhathi esingekho ngaphezu kwesonto 1 esiqandisini.
Isikhathi sokuphelelwa yisikhathi
Umuthi ufanele iminyaka emithathu.
Umkhiqizi
Ukukhishwa kwemali kwenziwa ngumkhankaso waseNdiya waseBrown Laboratories Limited.
Ubufakazi bodokotela neziguli mayelana neCefepime
UMaria Sergeevna, udokotela wezifo ezithathelwanayo
Ukusetshenziswa kwe-cefepime kufanele kwenzeke ngemvume kadokotela, njengoba umuthi unomphumela oqinile. Inzuzo yesidakamizwa ukuntuleka kokumelana nomuthi kumagciwane, ngakho-ke i-antibiotic iyasiza ezimweni lapho ezinye izidakamizwa zingasebenzi.
U-Inna, oneminyaka engama-38, uTyumen
Ukusetshenziswa kwesikhathi sokukhamba kwakudingeka lapho i-pneumonia yenzeka endodaneni, ngaleso sikhathi eyayinezinyanga ezi-5 ubudala. Phambilini kwakusetshenziswa amanye ama-antibiotic, kepha awasizanga, ngakho-ke anquma imijovo ngalo muthi. Inkambo yokwamukelwa yathatha isonto lonke. Ngemuva kokwelashwa, baya esibhedlela bayohlolwa. Imiphumela ikhombisile ukuthi ingane iphilile.
Anatoly, iminyaka engama-39, Syzran
Ngesikhathi sokuthuthukiswa kwe-pyelonephritis, imijovo ye-cefepim yachazwa. Isidakamizwa sasetshenziswa cishe izinsuku ezingama-5-7, kepha ukuthuthuka kokuphila kahle kwenzeka ngemuva komjovo wokuqala womuthi. Ngenxa yalokhu, ukutheleleka kunyamalale, akukho zinkinga. Ngemuva kokwelashwa, kube nezinkinga ngamathumbu, kepha ngosizo lweBifidumbacterin bakwazi ukwenza umsebenzi womzimba ube ngokwejwayelekile.
