Umuthi i-Gentamicin: imiyalo esetshenzisiwe

IGentamicin yi-ejenti elwa ne-antibacterial engokweqembu lama-aminoglycosides. Inemiphumela ehlukahlukene ye-bactericidal.

I-ATX

J01GB03 - Gentamicin

IGentamicin yi-ejenti elwa ne-antibacterial engokweqembu lama-aminoglycosides. Inemiphumela ehlukahlukene ye-bactericidal.

Khipha amafomu nokwakheka

Into esebenzayo i-glamicin sulfate. Kutholakala ngesimo se-powder noma isixazululo somjovo (imijovo kuma-ampoules), okokugcoba namaconsi wamehlo.

Amaphilisi

Ayitholakali ngendlela yepilisi.

Amaconsi

Sula uketshezi ngokusetshenziswa kwe-topical - amaconsi eso. I-1 ml iqukethe i-5 mg yesithako esisebenzayo. Ipakwe ngo-5 ml emabhodleleni e-dropper. Igcwele amaphakethe amakhadibhodi e-1 pc. kanye nemiyalo yokusetshenziswa.

Isixazululo

Uketshezi olucacile olungenamabala wokujova (lungalawulwa ngokuthambile kanye nange-intramuscularly). I-1 ml iqukethe ama-40 mg wento esebenzayo. Kufakwe ku-1 noma 2 ml ku-ampoules yengilazi. Ama-ampoule ayi-5 afakelwe emgqonyeni wamakhasethi, amaphakethe ama-1 noma ama-2 ekhakhini lamakhadibhodi kanye nommese opoule.

Sula uketshezi ngokusetshenziswa kwe-topical - amaconsi eso. I-1 ml iqukethe i-5 mg yesithako esisebenzayo.

Ku-1 ml yesisombululo seGentamicin iqukethe ama-40 mg ento esebenzayo. Kufakwe ku-1 noma 2 ml ku-ampoules yengilazi.

I-Gentamicin powder ingeyokusetshenziswa kwezilwane. I-1 g yesidakamizwa iqukethe i-100 mg yento esebenzayo.

Amafutha e-Gentamicin enzelwe ukusetshenziswa kwangaphandle. 1 g womkhiqizo uqukethe u-0,001 g wesithako esisebenzayo.

Powder

I-White noma i-ayisikhilimu powder, ehlanganiswe emasakeni we-foil lamoned e-1 kg. I-1 g yesidakamizwa iqukethe i-100 mg yento esebenzayo. Ine-aphoyintimenti yezilwane.

Amafutha

Ukusetshenziswa kwangaphandle. 1 g womkhiqizo uqukethe u-0,001 g wesithako esisebenzayo. Umkhiqizo ufakwe ezitsheni ze-15 ne-25 g, 1 pc. kanye nemiyalo amaphakethe ekhadibhodi.

Isenzo se-Pharmacological

Bactericidal antibiotic. Inemiphumela ehlukahlukene. Uyazwela kukho:

• i-aerobic gram-negative ezincane;
• i-aerobic gram-positive i-cocins ne-cocci.

Ukugcwala emzimbeni, kubhubhisa isithiyo esivikela - ulwelwesi lwe-cytoplasmic futhi kubangele ukufa kwamagciwane we-pathogenic.

IGentamicin iyi-bactericidal antibiotic. Inemiphumela ehlukahlukene.

I-Gentamicin, iqongelela emzimbeni, ibhubhisa isithiyo esivikelayo - ulwelwesi lwe-cytoplasmic futhi ibangele ukufa kwamagciwane we-pathogenic.

IGentamicin inokufakwa okuncane lapho ithathwa ngomlomo. Yabelwe ngabazali kuphela.

Ukugcotshwa okuphezulu kakhulu ku-plasma yegazi ngemuva kokuphathwa kwe-intramusky kunqunywa ngemuva kwemizuzu engama-30-90, ngemuva kokuphathwa kwe-intravenous, ngemuva kwemizuzu engu-15-30.

I-Gentamicin idlulwa ikakhulu yizinso. Ngomsebenzi ongasebenzi kahle wezinso, isikhathi se-excretion sincishisiwe.

IGentamicin isetshenziselwa izifo kubantu abadala nasezinganeni ezibangelwa yi-microflora ebucayi.

I-Pharmacokinetics

Inokukhipha okuphansi ngemuva kokusetshenziswa komlomo. Yabelwe ngabazali kuphela. Uma inj inj, igxila ngokuphelele. Ukugcotshwa okuphezulu kakhulu ku-plasma yegazi ngemuva kokuphathwa kwe-intramusky kunqunywa ngemuva kwemizuzu engama-30-90, ngemuva kokuphathwa kwe-intravenous, ngemuva kwemizuzu engu-15-30.

Akuhilelekile ezinqubweni ze-metabolic. Isikhathi sokususwa kwesigamu amahora angama-2-4. Kuhlangana esikhaleni se-lymphatic sendlebe yangaphakathi nezimbumbulu zezinso. Igcotshwa ikakhulu yizinso. Ngomsebenzi ongasebenzi kahle wezinso, isikhathi se-excretion sincishisiwe.

Isetshenziselwa ini?

Isetshenziselwa ukutheleleka kubantu abadala nasezinganeni okubangelwa yi-microflora ebucayi. Kunconywa ukwelashwa kwezinqubo zamagciwane:

• uhlelo lwe-bronchopulmonary;
• uhlelo lwezitho zofuzo;
• izinombolo kanye nezicubu ezithambile.

Kusetshenziswa ku-gynecology, ngezifo ezilimele futhi zishisa, imithombo yezindaba ye-otitis, i-pathologies yamagciwane asesiswini, kanye nokwelashwa kwezifo zamathambo namathuluzi wemisipha-ligamentous.

Contraindication

Ayinqunyelwe uma umlando uqukethe imininingwane mayelana nemibandela efana:

• ukungabekezelelani komuntu ngamunye ezingxenyeni zomuthi;
• i-nerve ye-nerve neuritis;
• ukwehluleka kwezinso.

Ayisebenzi ngesikhathi sokukhulelwa nokukhishwa komzimba. Akunconyelwe izinsana kuze kufike enyangeni eyi-1.

I-Gentamicin ayinqunyelwe uma umlando wolwazi ngezimo ezinjengokwehluleka kwezinso ukhona.

Umuthi awusetshenziswa ngesikhathi sokukhulelwa nangesikhathi sokuzala.

IGentamicin ayinconyelwe izinsana kuze kube yinyanga eyi-1 ubudala.

Umuthi usetshenziswa ngokuqapha iziguli ezihlobene nobudala (emva kweminyaka engama-60), nge-myasthenia gravis, i-botulism, isifo sikaParkinson kanye nokuphelelwa ngamandla komzimba.

Ngokunakekela

Ezigulini ezihlobene nobudala (ngemuva kweminyaka engama-60), nge-myasthenia gravis, i-botulism, isifo sikaParkinson kanye nokuphelelwa ngamandla komzimba.

Imithamo nokuphatha

Ama-regimens ajwayelekile ekwelashweni kwezinqubo ezingelula zokutheleleka kweziguli ezindala ngaphandle kwe-renal pathologies - nge-intramuscularly noma nge-intravenous, ama-3 mg ngegremu yomzimba njalo emahoreni angama-8 kuya kwayi-8. Ama-infusions we-Intravenous aphathwa ngokudonsa okweqile imizuzu engama-90-120 (umuthi uhlanjululwe ngo-50- 3400 ml we-sodium chloride solution noma ngo-5% dextrose solution.

Ngezindlela eziyinkimbinkimbi zesifo esithathelwanayo, umthamo wansuku zonke ngu-5 mg kilo nganye yesisindo somzimba, njalo emahoreni angama-6-8. Ngemuva kokuthuthuka, umthamo wehliselwa ku-3 mg / kg.

Uma kwenzeka izifo ezithathelwanayo futhi zingavuvukeli zomgudu womchamo, kunqunywa kanye kumthamo ka-120-160 g wezinsuku ezingama-7-10. Ukwelashwa kwe-gonorrhea - kanye ku-240-280 mg.

Ama-regimens ajwayelekile ekwelashweni kwezinqubo ezingelula zokutheleleka kweziguli ezindala ngaphandle kwe-renal pathologies - nge-intramuscularly noma nge-intravenous, ama-3 mg ngegremu yomzimba njalo emahoreni angama-8 kuya kwayi-8.

Ama-infusions we-Intravenous aphathwa ngokudonsa okweqile imizuzu engama-90-120 (umuthi uhlanjululwe ngo-50- 3400 ml we-sodium chloride solution noma ngo-5% dextrose solution.

Uma kwenzeka izifo ezithathelwanayo futhi zingavuvukeli zomgudu wokuchama, umuthi unqunywa kanye ngenani lika-120-160 g wezinsuku ezingama-7-10.

Kwi-pathologies enzima, imijovo inconywa emithanjeni ephansi, kepha ngokuvama okukhulu kokusebenzisa.

Ngokuthuthukiswa konyawo lwesifo sikashukela (usongo lokunqunywa), i-Gentamicin inqunywe ngokuhambisana neClindamycin.

Kwezifo ezithathelwanayo ezinganeni ezisanda kuzalwa ezisuka enyangeni eyi-1 bese kuthi izingane zifike eminyakeni emi-2 - 6 mg / kg kusetshenziswa njalo emahoreni ayi-8. Izingane ezivela eminyakeni emi-2 ubudala - ama-3-5 mg / kg kathathu ngosuku.

Kwi-pathologies enzima, imijovo inconywa emithanjeni ephansi, kepha ngokuvama okukhulu kokusebenzisa.

Kubantu abanomsebenzi we-renal okhubazekile - kwimithamo ye-1-1.7 mg / kg, yezinsana - 2-2.5 mg / kg.

Kungenzeka yini ukuthi uphuze umuthi onesifo sikashukela?

Ngokuthuthukiswa konyawo lwesifo sikashukela (usongo lokunqunywa), kubalwa ngokuhambisana ne-clindamycin.

Imiphumela emibi

Uma usebenzisa i-antibiotic, ukusabela okunganele komzimba kungenzeka, kuboniswa ngesimo:

• isicanucanu (kuze kufike ekuhlanzeni);
• Isiyezi
• ikhanda;
• ukozela
• ukuphazamiseka kwengqondo-ngokomzwelo;
• ukuthikamezwa kwezindlebe;
• isithulu esingenakuguqulwa;
• ukuxhumanisa okungalungile;
• i-hyperbilirubinemia;
• i-anemia
• i-leukopenia;
• i-granulocytopenia;
• i-thrombocytopenia;
• izimo ezethusayo;
• umsebenzi wezinso ongonakalisiwe;
• ukuvela komzimba esikhumbeni;
• ukuvuvukala.

Uma usebenzisa i-antibiotic, ukusabela okunganele komzimba kungenzeka, ngokwesibonelo, isiyezi, ikhanda, isicanucanu.

Njengomphumela oseceleni wokuthatha i-Gentamicin, i-anemia ne-leukopenia kungenzeka.

Ngokusetshenziswa isikhathi eside, umuthi uholela ekuthuthukisweni kwe-superinfection, yomlomo kanye ne-candidiasis yowesifazane.

Ngokusetshenziswa isikhathi eside, kuholela ekuthuthukisweni kwe-superinfection, yomlomo kanye ne-candidiasis yowesifazane.

Imiyalo ekhethekile

Lapho isifo sohudo isikhathi eside senzeka, kudinga ukubekwa eceleni kwe-pseudomembranous colitis.

Ekwelapheni i-pathologies yokutheleleka nokuvuvukala yohlelo lwe-genitourinary, kubalulekile ukusebenzisa amanani amaningi.

Ukuze uvimbele ukuthuthukiswa kokulimazeka kwezindlebe, izifundo ezisezingeni eliphakeme kufanele zenziwe njalo. Ngezinkomba ezidumazayo, umthamo we-antibiotic uyancishiswa noma ukhanseliwe.

Lapho unquma abantu abangaphezu kweminyaka engama-60 yobudala, ukulawulwa kwamazinga we-creatine kuyadingeka.

Lapho isifo sohudo isikhathi eside senzeka, kudinga ukubekwa eceleni kwe-pseudomembranous colitis.

Ekwelapheni i-pathologies yokutheleleka nokuvuvukala yohlelo lwe-genitourinary, kubalulekile ukusebenzisa amanani amaningi.

Ukuze uvimbele ukuthuthukiswa kokulimazeka kwezindlebe, izifundo ezisezingeni eliphakeme kufanele zenziwe njalo.

Lapho unquma abantu abangaphezu kweminyaka engama-60 yobudala, ukulawulwa kwamazinga we-creatine kuyadingeka.

Umthelela ekhonweni lokulawula izindlela

Kungaba nomthelela ongemuhle.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Akunconyelwe.

I-Gentamicin yezingane

Kusetshenziswa ekwelapheni izifo ezithathelwanayo nezokuvuvukala ezinganeni kusuka enyangeni eyi-1.

Sebenzisa ebudaleni

Ngokuqapha.

Ukweqisa

Ukudla ngokungalawulwa kwaleli gciwane le-antibacterial kungavusa ukwehla kokuqhutshwa kwenyama kwe-neuromuscular kuze kube yilapho ukuphefumula kuyeka.

I-Gentamicin ingaba nomthelela ongemuhle ekhonweni lokulawula izindlela.

Ukusetshenziswa kwe-Gentamicin ngesikhathi sokukhulelwa nokukhipha i-lactation akukhuthazwa.

Isidakamizwa sisetshenziswa ekwelapheni izifo ezithathelwanayo kanye nezifo ezinganeni kusuka enyangeni eyi-1.

Ukudla ngokungalawulwa kwaleli gciwane le-antibacterial kungavusa ukwehla kokuqhutshwa kwenyama kwe-neuromuscular kuze kube yilapho ukuphefumula kuyeka.

Dinga ukulaliswa esibhedlela ngokushesha.

Ukuxhumana nezinye izidakamizwa

Awukwazi ukungena kanye kanye neminye imithi (ngaphandle kwezixazululo ze-isotonic zokuphathwa kwe-intravenous).

Ithuthukisa izakhiwo zokuvuselela izicubu zezidakamizwa ezinjenge-curare. Yehlisa umphumela wemithi elwa ne-myasthenic.

Ngokusetshenziswa kanyekanye ne-diuretics noma i-Cisplatin kuthuthukisa i-nephrotoxicity yabo.

Ngokuhlanganiswa nama-antibhayabhithi, uchungechunge lwe-penicillin lonyusa izakhiwo zalo zokulwa namagciwane.

I-Gentamicin akufanele iphathwe kanyekanye neminye imithi (ngaphandle kwezixazululo ze-isotonic zokuphathwa kwe-intravenous).

Ngokusetshenziswa kanyekanye ne-diuretics noma i-Cisplatin kuthuthukisa i-nephrotoxicity yabo.

Ngokuhlanganiswa nama-antibhayabhithi, uchungechunge lwe-penicillin lonyusa izakhiwo zalo zokulwa namagciwane.

Kuhlanganiswa ne-indomethacin kwandisa amathuba okuba nemiphumela ebuhlungu.

Naphezu kohlu olukhulu lwama-analogues ahlelekile ale antibiotic, iGaramycin ingcono kunezinye izidakamizwa.

Kuhlanganiswa ne-indomethacin kwandisa amathuba okuba nemiphumela ebuhlungu.

Ama-Analog

Yize kunohlu olukhulu lwama-analog elesakhiwo saleli gciwane, azibonakalise angcono kunezinye izidakamizwa:

• Garamycin;
• Gentamicin Akos.

Imibandela yekhefu lekhemisi

Kutholakala nomuthi ngesi-Latin.

Intengo ye-Gentamicin

Izindleko zincike ohlotsheni lokukhipha umuthi. Izindleko eziphansi kumakhemisi aseRussia zivela kuma-ruble angama-35.

Izimo zokugcina zomuthi i-Gentamicin

Ebangeni lokushisa lifinyelela ku- + 25˚С. Gwema kude nezingane.

Isikhathi sokuphelelwa yisikhathi

Iminyaka emi-5

Ukubuyekezwa kodokotela neziguli mayelana neGentamicin

Minina T.V., Therapist, Novosibirsk.

I-Aminoglycoside chungechunge izidakamizwa ze-antibacterial ezinemiphumela ehlukahlukene. Inohlu olukhulu lwemiphumela emibi. Sebenzisa kuphela izizathu zezempilo njengoba kuyalelwe udokotela.

I-Kosyanov E.D., udokotela wamathambo, uKrasnoyarsk.

I-antibiotic enamandla. Isetshenziselwa ukwelapha izifo ezithathelwanayo kanye nokuvuvukala. I-Orthopedics imiselwe ukwelashwa nokuvinjwa kwezifo ezithathelwanayo ngemuva kwe-arthroplasty. Ine-contraindication nemikhawulo yokusebenzisa. Kufanele ichazwe ngudokotela.

UMarina, oneminyaka engama-36, idolobha laseTomsk.

Ingane yami yayine-conjunctivitis enzima. Udokotela wamehlo watusa leli thuluzi ngesimo samaconsi eso. Kusetshenziswe i-1 ukwehla kathathu ngosuku. Ukuthuthuka kwabonwa kakade ngosuku lwe-2 lokwelashwa. Ngemuva kwezinsuku ezi-5 zesifundo, izimpawu ezingemnandi zanyamalala ngokuphelele. Ithuluzi alishigi futhi liyasebenza. Ngigculisekile ngomphumela.