I-Diameride yi-ejenti ye-hypoglycemic uhlobo lweziguli ezi-2 zesifo sikashukela ezithatha ukwehlisa ushukela wegazi wazo. Ukwelashwa nalesi sidakamizwa kwenzeka ngaphansi kokuqashwa njalo kwezokwelapha.
Igama Lezwe elingafanele
Igama elingafanele emhlabeni jikelele lalesi sidakamizwa yi-glimepiride. Kusho ikhambi elisebenzayo lezidakamizwa. Lokhu kungokwesizukulwane sesithathu sulfonylurea.
I-Diamerid isidakamizwa esisetshenziswa ukwehlisa ushukela wegazi.
I-ATX
Ikhodi yezidakamizwa ngokuya nge-ATX (i-anatomical, yezokwelapha kanye nokuhlukaniswa kwamakhemikhali) yi-A10BB12. Okusho ukuthi, lo muthi uyithuluzi elithinta umgudu wokugaya ukudla kanye nemetabolism, yakhelwe ukuqeda isifo sikashukela, uthathwa njengento ye-hypoglycemic, i-sulfonylurea (glimepiride).
Khipha amafomu nokwakheka
Umuthi uyatholakala ezibhebheni. Ukuma kwamatafula kuyindilinda eyisicaba enembozo. Umbala uncike kunani lezithako ezisebenzayo kwithebhulethi; lingaba liphuzi noma lipinki.
Amathebulethi aqukethe i-1, 2, 3 mg noma i-4 mg yesithako esisebenzayo esisebenzayo.
Ababekhona yilezi: lactose monohydrate, magnesium stearate, povidone, microcrystalline cellulose, poloxamer, croscarmellose sodium, udayi.
Iphakethe elilodwa liqukethe amabhulashi ama-3, ngalinye li-10 ama-pcs.
Isenzo se-Pharmacological
Lesi sidakamizwa sinomphumela we-hypoglycemic. Isenzo somuthi sincike ekuvuseleleni ukukhiqizwa kwe-insulin ngamaseli we-beta wesikebhe se-pangerreat of Langerhans, kanye nokwandisa ukuzwela kwezithako ezitholela i-hormone nokwandisa inani lamaprotheni we-glucose transporter egazini. Esebenza ngezicubu ze-pancreatic, isidakamizwa sibangela ukudonswa kwaso kanye nokuvulwa kweziteshi ezincike ku-calcium, ngenxa yokuthi kwenzeka kanjani ukusebenza kwamaseli.
Yehlisa inani le-gluconeogenesis esibindini ngenxa yokuvinjwa kwama-enzyme asemqoka, ngaleyo ndlela iba nomphumela we-hypoglycemic.
Umuthi unomthelela ekuhlanganiseni kweplatelet, kuyinciphisa. Ivimbela i-cycloo oxygenase, evimba i-oxidation ye-arachidonic acid, inomphumela we-antioxidant, wehlisa izinga le-lipid peroxidation.
I-Pharmacokinetics
Ngokusetshenziswa njalo, ku-4 mg ngosuku, umthamo omkhulu womuthi osegazini uqashelwa emahoreni angama-2-3 ngemuva kokuphathwa. Kufika kuma-99% ento ebophele amaprotheni e-serum.
Isigamu sempilo singamahora angama-5-8, into ikhishwa ngendlela efakiwe, ayiqoqeki emzimbeni. Idlula kwi-placenta bese idlulela ebisini lwebele.
Izinkomba zokusetshenziswa
Thayipha i-2 mellitus yesifo sikashukela, uma ukwelashwa ngokudla okune-carb okuphansi kanye nokuzivocavoca umzimba okujwayelekile kunganikeli umphumela oyifunayo.
Contraindication
Ukwemukelwa akunconywa kumacala alandelayo:
- thayipha i-1 isifo sikashukela;
- Isifo sikashukela nobungozi bokukhula kwayo;
- izimo ze-hypoglycemic ezidalwa yizizathu ezahlukahlukene;
- ukubalwa kweseli emhlophe ephansi;
- ukungasebenzi kahle kwesibindi;
- ukungasebenzi kahle kwezinso, ukusebenzisa imishini yokufaka yezinso;
- ukukhulelwa
- ukuncelisa;
- izingane ezingaphansi kweminyaka engu-18;
- i-malabsorption syndrome kanye nokwephulwa kokugaya kwe-lactose.
Ungayithatha kanjani i-diamerid?
Lapho uthatha umuthi, udokotela kumele aqaphe njalo amazinga eglucose egazini. Uchwepheshe unquma ukuhlangana kweglucose egazini, okufanele kube ngemuva kokuthatha umuthi. Kusetshenziswa umthamo omncane kakhulu, ongatholwa ngawo umphumela odingekayo.
Umuthi uyatholakala ezibhebheni. Ukuma kwamatafula kuyindilinda eyisicaba enembozo.
Ngoshukela
Umthamo wokuqala ngu-1 mg ngosuku. Ngokuphumula kwamasonto angu-1-2, udokotela unyusa umthamo, ukhetha okudingekile. Wena ngokwakho ngeke, ngaphandle kokubonana nodokotela, uqale uthathe umuthi noma ushintshe umthamo obekiwe, ngoba yi-ejenti enamandla yokwelapha, ukusetshenziswa okungalungile okuzoba nemiphumela emibi.
Ngoshukela olawulwa kahle, umthamo wezidakamizwa ngosuku ngu-1-4 mg, ukugxila okuphezulu akuvamisile ukusetshenziswa ngenxa yokuthi kusebenza kuphela kwinani elincane labantu.
Ngemuva kokuthatha umuthi, akufanele weqe ukudla, okufanele kube mnene. Ukwelashwa yinde.
I-Diameride iyanconywa ngohlobo lwe-2 yesifo sikashukela, uma ukwelashwa ngokudla okune-carb ephansi kanye nokuzivocavoca umzimba okujwayelekile kunganikeli umphumela oyifunayo.
Imiphumela emibi ye-diamerid
Lo muthi unomsebenzi omuhle kakhulu, ngakho-ke une-contraindication eminingi.
Engxenyeni yezitho zombono
Kungahle kube khona ukusebenza kwamehlo okungahambi kahle: ukungaboni okwesikhashana noma ukubona okungalunganga kusitho esisodwa noma kuzo zombili izitho. Izimpawu ezinjalo zingavela ekuqaleni kokwelashwa ngenxa yezinguquko emazingeni kashukela.
Amapheshana wesisu
Isicanucanu, ukugabha, uhudo, ubuhlungu besisu. Ukwephula okungenzeka kwesibindi: i-hepatitis, jaundice, cholestasis.
Izitho zeHematopoietic
Kwehlisiwe ukubalwa kweplatelet, amaseli amhlophe egazi namaseli abomvu egazi, i-anemia.
Imiphumela emibi ye-diamerid: ukwehla kwenani lamapuleti, amangqamuzana amhlophe egazi namaseli abomvu egazi, i-anemia.
Ngasohlangothini lwe-metabolism
I-hypoglycemia yesikhathi eside, ehambisana nokucanuzelelwa inhliziyo, ikhanda, ukuhlushwa okulimazayo. isifiso sokudla, ukulamba okungapheli, ukunganaki.
Allergies
Imiphumela yokungezwani komzimba: ukulunywa, ubomvu, ukuqubuka. Ezimweni ezingavamile, ukwethuka kwe-anaphylactic kungahle kube khona.
Umthelela ekhonweni lokulawula izindlela
Umuthi uthinta ikhono lokulawula izindlela ezisetshenziswayo ngenxa yokuqalwa kwe-hypoglycemia, ehambisana nokwehla kokuxineka, ukukhathala okungapheli kanye nokudangala. Amandla okwenza umsebenzi odinga ukunakwa njalo ukunakwa, kufaka phakathi ukushayela izimoto, ancishisiwe.
Imiyalo ekhethekile
Uma uthatha, kuyadingeka ukuthi ubhekele izimfanelo zomuthi.
Ungaqala ukuthatha umuthi noma ushintshe umthamo obekiwe ngokwakho, ngaphandle kokubonana nodokotela.
Sebenzisa ebudaleni
Ebudaleni, umuntu uvame ukungakwazi ukuxhumana ngokukhululekile nodokotela wakhe, ngenxa yokuthi udokotela angakwazi ukuthola isimo sesiguli ngemuva kokuthatha umuthi futhi alungise umthamo, othinta kabi ukusebenza kahle kokulashwa nesimo sesiguli. Ngakho-ke, isiguli kufanele ngaso sonke isikhathi sazise udokotela ngazo zonke izinguquko zombuso, siqaphele ukuthi lokhu kubalulekile okokuqala kuye ngokwakhe.
Isabelo sezingane
Ezinganeni ezingaphansi kweminyaka engu-18 ubudala, lesi sidakamizwa siyaphulwa.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngesikhathi sokukhulelwa ngenkathi uncelisa ibele, umuthi uyaphulwa ngenxa yokuthi uyakwazi ukungena esibambekweni se-placental futhi ucashile ubisi lwebele, olungalimaza umzimba wengane obuthaka. Ngakho-ke, owesifazane othathe lesi sidakamizwa ngaphambi kokukhulelwa udluliselwa ekwelashweni kwe-insulin.
Ngesikhathi sokukhulelwa ngenkathi uncelisa ibele, umuthi uyaphulwa
I-overdose ye-diamerid
Uma kwenzeka kwe-overdose, i-hypoglycemia ibonwa, ehambisana nekhanda, umuzwa wobuthakathaka, ukukhuphuka kokujuluka, i-tachycardia, umuzwa wokwesaba nokukhathazeka. Uma lezi zimpawu zenzeka, udinga ukuthatha i-carbohydrate esheshayo, isibonelo, udle ucezu kashukela. Uma kwenzeka okweqa ngokweqile komuthi, kubalulekile ukugeza isisu noma ukuhlanza. Kuze kube kutholakala isimo esizinzile, isiguli kufanele sibe ngaphansi kokuqashwa ngudokotela, ukuze kuthi uma kwenzeka ukwehla okuphindaphindiwe kwe-glucose, udokotela akwazi ukunikeza usizo.
Ukuxhumana nezinye izidakamizwa
Lapho usebenzisa umuthi nezinye izidakamizwa, kungenzeka ukwenza buthaka noma uqinise isenzo sawo, kanye noshintsho olwenziwe kwenye into, ngakho-ke kubalulekile ukwazisa udokotela ngemithi esetshenzisiwe. Isibonelo:
- Ngokuphathwa kanyekanye kwe-glimepiride ne-insulin, amanye ama-hypoglycemic agents, ama-coumarin derivatives, glucocorticoids, metformin, ama-hormone ocansi, ama-angiotensin-aguqula ama-enzyme inhibitors, i-fluoxetine, njll, i-hypoglycemia enobunzima ingakhula.
- I-Glimepiride ingavimba noma ithuthukise umphumela wokutholakala kwe-coumarin - ama-anticoagulant agents.
- Ama-Barbiturates, ama-laxatives, i-T3, T4, i-glucagon ingawenza buthaka umphumela wezidakamizwa, anciphise ukusebenza ngempumelelo kokwelashwa.
- Ama-blockers e-H2 histamine receptor angaguqula imiphumela ye-glimepiride.
Ngokuphathwa kanyekanye kwe-glimepiride ne-insulin, amanye ama-hypoglycemic agents, ukuthuthukiswa kwe-hypoglycemia enzima kungenzeka.
Ukuhambisana notshwala
Umthamo owodwa wotshwala noma ukusetshenziswa kwawo njalo kungawushintsha umsebenzi wesidakamizwa, uwandise noma usinciphise.
Ama-Analog
Ama-analogues ngama-ejenti aqukethe i-glimepiride njengento esebenzayo. Lezi izidakamizwa ezifana:
- Amaril. Lona umuthi waseJalimane, ithebhulethi ngayinye equkethe umthamo we-1, 2, 3 noma 4 mg. Ukukhiqiza: EJalimane.
- I-Glimepiride Canon, Itholakala kumthamo we-2 noma 4 mg. Ukukhiqiza: iRussia.
- I-Glimepiride Teva. Kutholakala ngemithamo ye-1, 2 noma 3 mg. Ukukhiqiza: ECroatia.
I-Diabeteson isidakamizwa se-hypoglycemic, inomphumela ofanayo we-hypoglycemic, kepha into yayo esebenzayo isusuloplulurea yesizukulwane sesibili.
I-Amaryl iyi-analogue yeDiamerid. Lona umuthi waseJalimane, ithebhulethi ngayinye equkethe umthamo we-1, 2, 3 noma 4 mg.
Imibandela yekhefu lekhemisi
Umuthi ungathengwa kunoma iyiphi ikhemisi e-Russian Federation.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Umuthi usatshalaliswa kuphela ngomuthi obhaliwe.
Intengo yedayamidi
Izindleko ezimaphakathi zomuthi zivela kuma-ruble angama-202 kuya kwangama-347. Intengo incike ekhemisi nedolobha. Izindleko zama-analogues zincike ezweni lokukhiqiza.
Izimo zokugcina zomuthi
Umuthi kufanele ugcinwe endaweni emnyama, okushisa okungadluli ku-25 ° C, kungatholakali ezinganeni.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emi-2
Umkhiqizi
Ikhiqizwa yi-Chemical and Pharmaceutical Plant AKRIKHIN AO, etholakala eRussia.
Isitshalo samakhemikhali nezemithi i-AKRIKHIN AO.
Ukubuyekezwa kweDiamerida
Ngaphambi kokusebenzisa umuthi, udinga ukujwayelana nokubuyekezwa ngakho.
Odokotela
I-Starichenko V. K: "Lo muthi uyithuluzi eliphumelelayo lokususa isifo sikashukela sohlobo lwe-2. Kuvunyelwe ukuwusebenzisa nge-insulin noma njenge-monotherapy. Udokotela kuphela ongayinikeza futhi ayishintshe imithamo."
UVasilieva O. S.: "Umuthi wehlisela izinga likashukela egazini, uvikele imiphumela emibi yesifo sikashukela. Uchwepheshe kuphela okufanele abhale lo makhambi bese enquma uhlobo lokwelashwa."
Iziguli
UGalina: "Amazinga kashukela egazini akhuphuke ngokumangazayo, kwafakwa umuthi nge-glimepiride esebenzayo. Amathebulethi ayakhululeka, agwinya kahle, aphuza nsuku zonke ngaphambi kokudla kwasekuseni. I-glucose evamile ingejwayelekile, izimpawu ezingemnandi zesifo sikashukela sezinyamalele."
UNatasha: "Umama unesifo sikashukela, elinye ikhambi alisizanga, udokotela ubeke lo muthi, wathi lokho kuvuselela ukukhiqizwa kwe-insulin futhi kuthuthukisa nokuzwela kwamangqamuzana kuyo. Ushukela uvamile, kuthatha cishe unyaka."
