I-LOZAREL - IMIYALO ESETSHENZISWAYO, INTENGO, UKUBUYEKEZWA KANYE NAMA-ANALOGUES

Send

I-Lozarel isidakamizwa esivimba ama-angiotensin ama-receptors 2. Ibekelwe iziguli ezinomfutho wegazi ophakeme, ukuhluleka kwenhliziyo nokuvikela izinso esikhathini eside kubantu abanesifo sikashukela. Inomphumela we-vasoconstrictor.

Igama Lezwe elingafanele

Igama elingafanele emhlabeni wonke nguLozarela - Losartan (Losartan).

I-Lozarel isidakamizwa esivimba ama-angiotensin 2 receptors.

I-ATX

Ikhodi ye-Lozarel ekuhlukanisweni kwe-ATX yi-C09DA01. Lo muthi wenzelwe ekwelapheni izifo zohlelo lwethambo nenhliziyo. Ithinta uhlelo lwe-renin-angiotensin. Kubhekiswa kuma-angiotensin II receptor antagonists ngokuhlanganiswa ne-diuretics.

Khipha amafomu nokwakheka

Kutholakala ebhokisini lekhadibhodi, lapho kukhona khona izinhlamvu ezi-3 zamathebulethi ayi-10. Okuqukethwe kwento esebenzayo kungama-50 mg ecezu ngalinye.

Umuthi uhloselwe ukwelashwa kwezifo zohlelo lwethambo nenhliziyo.

Isenzo se-Pharmacological

Kunqunywe ngudokotela ukufeza izinhloso ezilandelayo:

umfutho wegazi ophansi uma isiguli sinenkinga ye-hypertension;
ingcindezi ephansi ekujikelezeni kwe-pulmonary;
ukunciphisa i-proteinuria;
ukwenza lula umsebenzi wenhliziyo uma kukhona izifo (ukuhluleka kwenhliziyo);
Vikela izinso uma isiguli sinesifo sikashukela sohlobo 2.

Umuthi ubekelwe isiguli ukuze wehlise umfutho wegazi.

Ukwehluleka kwenhliziyo kuwuphawu lwezinkomba ezisetshenziswayo.

I-Lozarel izosiza ukuvikela izinso kuhlobo 2 lwesifo sikashukela.

I-Losartan isebenza emzimbeni womuntu, ivimba isenzo sento ebizwa ngokuthi yi-angiotensin II. Le nto ibangela ukuthi imikhumbi ihambisane, futhi futhi ibangele ukukhiqizwa kwenye into ebizwa nge-aldosterone. Kwenyusa inani lamanzi egazini. Ngokuvimbela isenzo se-angiotensin, i-losartan yehlisa umthwalo enhliziyweni bese yehlisa umfutho wegazi. Iphinde ibe nomphumela wokuvikela ezinso.

I-Pharmacokinetics

Lapho uthathwa ngomlomo, umunca ngokushesha. I-Bioavailability ingama-33%. Ifinyelela ekuhlushweni okuphezulu kakhulu ngehora. Ukwembulwa kwento esebenzayo kanye ne-metabolite yayo esebenzayo kudlula ezinsweni nasemathunjini. Akususwe yi-hemodialysis.

Lapho ithathwa ngomlomo, iLozrel imunca ngokushesha.

Izinkomba zokusetshenziswa

Kubekelwe iziguli ezihlushwa:

umfutho wegazi ophakeme
ukwehluleka kwenhliziyo;
Uhlobo 2 sikashukela.

Lesi sidakamizwa singabekwa njengomuthi owodwa, noma sihlanganiswe namanye amadivaysi ezokwelapha ukuthola izinzuzo eziphezulu zomzimba. Isibonelo, kukhona umuthi i-Lozarel Plus, futhi ufaka enye ingxenye - i-hydrochlorothiazide, i-diuretic. Le nhlanganisela ingabhekiswa kubantu abanomfutho wegazi ophakeme.

Ukuhlanganiswa kwe-Lozarel ne-Lozarel Plus kungahle kunikezwe abantu abanomfutho wegazi ophakeme.

Contraindication

Akwamukeleki ukuthi isetshenziswe yiziguli ezithi:

baphendule kabi ezingxenyeni zomuthi, bahlushwa ukungabekezelelani kwe-losartan;
ukhulelwe;
ukuncelisa;
ngaphansi kweminyaka eyi-18.

Ngokunakekela

Abantu abanezinso, izinso, noma izinkinga ze-stenosis kwinso elilodwa kufanele baqaphele kakhulu. Imininingwane engaphezulu ingatholakala kudokotela wakho. Qiniseka ukuthi ubika isimo sakho sempilo ngaphambi kokuqala ukwelashwa.

Ngesikhathi sokukhulelwa, ukuthatha amaphilisi akuvunyelwe ngokuphelele.

Isikhathi sokukhishwa kokwephula umthetho kusetshenziswa kwe-Lozarel.

Lesi sidakamizwa sinqatshelwe ezinganeni ezingaphansi kweminyaka engu-18.

Ungamthatha kanjani uLozarel

Funda imiyalo esetshenzisiwe. Landela yonke imiyalo oyinikezwe ngudokotela wakho. Ithebhulethi kufanele ihlanzwe phansi nengilazi yamanzi. Ukuthatha umuthi kwenziwa ngaphambi noma ngemuva kokudla.

Ngoshukela

Yonke imiyalo yokuthi ungasithatha kanjani lesi sidakamizwa sesifo sikashukela sohlobo 2 uzonikezwa ngudokotela wakho.

Imiphumela emibi ye-Lozarel

Ngokukhulu, imiphumela emibi ebalulekile ayibonwa noma ayinabungozi futhi idlula ngokushesha. Ukwanda okungenzeka kube khona emazingeni e-urea ne-nitrogen asele ku-plasma yegazi.

Amapheshana wesisu

Uhudo, ukuqunjelwa, ubuhlungu besisu, isicanucanu, ukugabha, futhi kuyaqabukela i-anorexia kungenzeka.

Izitho zeHematopoietic

Kunobungozi bokuthi une-anemia.

Izitho ze-Hematopoietic zingadala i-anemia njengemiphumela emibi.

Isistimu yezinzwa ephakathi

Kungahle kube nokubola, ikhanda, ukuphazamiseka kokulala, i-paresthesia.

Kusuka ohlelweni lwe-musculoskeletal

Kukhona ubungozi bokubonakaliswa kwe-myalgia, i-arthralgia.

Kusuka ohlelweni lokuphefumula

Umphumela omubi wohlelo lokuphefumula ukufushane komoya.

Engxenyeni yesikhumba

Ukubonakaliswa kokungafani komzimba: ukuqubuka, ukulunywa.

Kusuka ohlelweni lwezitho zofuzo

Umsebenzi wezinso ongasebenzi kahle, ukungabi namandla.

Kusuka ohlelweni lwezinhliziyo

Ukushiswa kwenhliziyo, ukushaya ngamandla, i-fibrillation ye-atrial, unhlangothi.

Allergies

I-Urticaria, ukulunywa, ukuqunjelwa, ukuqaphela kwezithombe kungabonakala.

Umthelela ekhonweni lokulawula izindlela

Akuthinti imisebenzi edinga ukunakwa okukhethekile.

Imiyalo ekhethekile

Qiniseka ukuthi utshela udokotela wakho ngazo zonke izindlela ozibonayo ngesikhathi sokwelashwa. Uma unomlando wanoma yiziphi izinkinga zempilo, bhala yonke imishanguzo oyiphuzayo, kufaka phakathi izidakamizwa ezingekho emthethweni kanye nezithasiselo ezahlukahlukene zokudla okunempilo.

Uma ukhohliwe ukuphuza umuthi, ngakho-ke ungakunxephezeli ngokuthatha umthamo ophindwe kabili ngosuku olulandelayo. Vakashela udokotela wakho njalo ukuze akwazi ukulandelela intuthuko yakho. Yenza ukuhlolwa kwegazi nge-potassium egazini (ukugwema ukwenzeka kwe-hyperkalemia), ukuqapha isimo sezinso.

Kungakhathalekile ukuthi iyiphi imithi oyithengayo (kungaba yi-aspirin noma i-ibuprofen), qiniseka ukuthi uthintana nochwepheshe, njengoba Kungenzeka ukuthi ukuhlangana kwezidakamizwa kwandise ubungozi bemiphumela emibi.

Namathela endleleni yokuphila udokotela wakho azokweluleka ngayo. Isibonelo, landela ukudla okunempilo, ungabhemi, zivivinya umzimba njalo.

Zama ukugwema ukudla okuqukethe i-potassium. Lapho welapha amazinyo, xwayisa ngokuthi uthatha i-losartan, njengoba ngokuhambisana nama-anesthetics, ingcindezi ingahle yehle kakhulu.

Kubantu abahlushwa ukugula kwenhliziyo okungapheli, umthamo wokuqala ngu-12,5 mg.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Awukwazi ukuthatha lesi sidakamizwa ngesikhathi sokukhulelwa nokuqunjelwa.

Ukuqokwa kwe-Lozarel ezinganeni

Kubekelwe iziguli kusuka eminyakeni eyi-18.

Sebenzisa ebudaleni

Olunye ushintsho ekwelashweni aluvamile ukudinga, kungadingeka ukuthi ulungise umthamo uneminyaka engaphezu kweminyaka engama-75.

Isicelo sokusebenza kokulimala kwezinso

Alukho ushintsho kwezokwelapha oludingekayo.

Sebenzisa umsebenzi wesibindi okhubazekile

Umthamo wokuqala uyancishiswa.

Uma kwenzeka ukungasebenzi kahle kwesibindi, umthamo wokuqala womuthi uyancipha.

Ukweqisa kweLoorel

Uma ngephutha uthatha amaphilisi amaningi we-Lozarel, thintana nodokotela wakho khona lapho. Umthamo omningi walesi sidakamizwa ungadala umfutho wegazi ophansi futhi ushintshe izinga lokushaya kwenhliziyo.

Ukuxhumana nezinye izidakamizwa

Ukusetshenziswa okuhlanganiswe kwalesi sidakamizwa nezinye izidakamizwa okwehlisa umfutho wegazi, noma izidakamizwa zokwelashwa okune-high-khatello (izidakamizwa ze-antihypertensive), noma izidakamizwa ezinganciphisa umfutho wegazi njengomphumela wecala, kungaholela ekunciphiseni okukhulu kwengcindezi.

Ukusetshenziswa okuhlangene kwalesi sidakamizwa nezinye izidakamizwa okwehlisa umfutho wegazi kungaholela ekwehleni kwengcindezi.

Lokhu kuzodala isiyezi noma ubuthakathaka, ikakhulukazi lapho usuka endaweni yokuhlala noma yokulala. Uma lokhu kwenzeka, khona-ke ungasuki kuze kube yilapho izimpawu ziphela. Uma uvame ukuzwa lo muzwa, ke uthintane nodokotela wakho ukuze alawule umthamo.

Umphumela wokwehlisa umfutho wegazi kusuka kulesi sidakamizwa ungaqhathaniswa nomphumela wokukhulisa umfutho wegazi kusuka kwezinye izidakamizwa. Lokhu kufaka phakathi: i-corticosteroids (dexamethasone, i-prednisone), ama-estrogens (amaphilisi okulawula ukuzala), izidakamizwa ezingezona ze-anti -idalidal (ibuprofen, diclofenac, indomethacin). Lokhu kungandisa ubungozi bezinkinga zezinso. Ama-painkiller kufanele agwenywe ngenkathi ethatha i-Lozarel uma izincomo ezinjalo zinikezwe ngudokotela.

Ama-painkiller kufanele agwenywe ngenkathi ethatha i-Lozarel uma izincomo ezinjalo zinikezwe ngudokotela.

Kuyadingeka ukuqapha okuqukethwe kwe-potassium esegazini uma usebenzisa ezinye izidakamizwa ezilandelayo:

i-aliskiren;
i-cyclosporine;
i-drospirenone;
i-epoetin;
i-heparin;
potassium indawo
usawoti we-potassium;
i-potassium-sparing diuretics;
izithasiselo ze-potassium;
i-tacrolimus;
trimethoprim.

I-Fluconazole ne-rifampicin inganciphisa umphumela we-losarel.

Umuthi ungakhulisa ukugcwala kwe-lithiamu egazini.

Lo muthi ungakhulisa ukugcwala kwe-lithiamu egazini. Endabeni ye-lithium, tshela udokotela wakho uma izimpawu zokudlula kwalesi sici emzimbeni zibonakala: ukulahleka kokudla, isisu, ukugabha, umbono ofiphele, ubuthakathaka bemisipha, ukuhlangana okungahambi kahle, ukozela, ukwethuka, ukungazinzi, i-tinnitus.

Ukuhambisana notshwala

Akunconyelwe. Amathuba emiphumela emibi, efana nesiyezi, ubuthakathaka obujwayelekile, ayanda.

Ama-Analog

Kumakhemisi aseRussia, ungathola izichasiselo ezilandelayo zalo muthi:

I-Lozap;
I-Losacor
I-Zisakar;
I-blocktran;
I-Cozaar.

Izici zokwelashwa kwe-hypertension nesidakamizwa i-Lozap

Ngokushesha ngezidakamizwa. Losartan

Imibandela yekhefu lekhemisi

Kuthengiswe ezigulini eziya kadokotela.

Ngingakwazi ukuthenga ngaphandle kadokotela

Uma ungenayo incwadi kadokotela, ngeke uwuthenge lo muthi.

Intengo ye-Lozarel

Izindleko ziyahlukahluka kusuka kuma-ruble angama-210 kuya kwangama-250.

Izimo zokugcina zomuthi

Gwema kude nezingane. Ukushisa kufinyelela ku- + 25 ° C, kude nemishini yokushisa kanye nomswakama ophezulu.

Ukushisa kufinyelela ku- + 25 ° C, kude nemishini yokushisa kanye nomswakama ophezulu.

Isikhathi sokuphelelwa yisikhathi

Iminyaka emi-2

Umkhiqizi

ISandoz, eSwitzerland.

Ukubuyekezwa ku-Lozarel

Ukubuyekezwa okuningi mayelana naleli thuluzi kuyinto enhle.

Odokotela

Izyumov S. V., udokotela wezokwelapha: "Ikulungele kahle ukwelashwa kwe-hypertension kwiziguli esezikhulile nezisencane. Angizange ngibe nemiphumela emibi lapho ngisebenza."

U-Butakov EV, udokotela ohlinzayo: "Usebenza ngobumnene nangamandla. Kubalulekile ukukhumbula umphumela ongahle wezidakamizwa."

Ukubuyekezwa kodokotela mayelana nomuthi we-Lozarel muhle kakhulu.

Iziguli

U-Avaleri, oneminyaka engama-38, uSamara: "Isikhathi esiningi ingcindezi inyuka ngenxa yokusebenza ngezinzwa, umngani wathi ngalesi sidakamizwa. Ngiqale ukusithatha, futhi kusukela lapho ingcindezi ibuyele kwesejwayelekile. Kepha ngaphambi kokuyisebenzisa, kufanele ubonane nodokotela."

UJulia, oneminyaka engama-49, uVladimir: "Intengo ekhangayo, kepha ingcindezi ayincishiswanga kakhulu. Noma kunjalo, ngibone umthelela omude uma ngiqhathaniswa nezinye izidakamizwa ezifanayo. Futhi ukuvuvukala ezingalweni nasemilenzeni kwehle."

Send