I-Rosucard ingumuthi ovela eqenjini lama-statins, kunqunyelwe ukunciphisa inkomba ye-cholesterol "embi" ku-plasma yegazi.
Ngemuva kwamahora amahlanu uphuze lo muthi, ama-statin afinyelela isilinganiso segazi lawo. Ukusetshenziswa njalo kweRosucard akuyona umlutha. IStatin imunca esibindini, ngoba yilesi sitho somuntu esithile esikhiqiza i-cholesterol. Lapho, uthola i-biotransformation encane. Ngokukhishwa kwalesi sidakamizwa emzimbeni, i-10% yaso ikhishwa yizinso, kanti 90% esele ngamathumbu.
Umphumela wokuqala wokusetshenziswa kwomuthi ungabonakala ezinsukwini eziyisithupha ngemuva kokuqala kokwelashwa. Umphumela omuhle kakhulu ngemithi ejwayelekile ungatholwa ngosuku lweshumi nane lwenkambo yokwelashwa.
Ukwakheka komuthi, ifomu lokukhulula, inani
Isithako esisebenzayo somuthi yi-rosuvastatin. Phakathi kwezinto ezingeziwe, i-monohydrate-lactose, i-cellcose ye-microcrystalline, i-croscarmellose sodium ne-magnesium stearate ingaphawulwa.
I-Titanium dioxide, i-macrogol, i-oxide ebomvu, i-talc ne-hypromellose asetshenziselwa ukwakha igobolondo lezidakamizwa.
I-Rosucard itholakala ngale ndlela elandelayo: yiphilisi ye-oval ye-convex ene-notch. Ukufakwa komkhiqizi kungaqukatha inani elihlukile lamathebulethi (ama-10 ama-pcs, ama-30 ama-pcs, ama-60 ama-pcs kanye nama-90 ama-pcs) ngomthamo ongu-10, 20 no-40 mg.
Ngokuya ngomthamo nenani lamathebulethi, intengo yomuthi ingaba:
- ukupakishwa kwezingcezu ezingama-30 ngomthamo we-10 mg - kusuka kuma-ruble angama-550;
- ukupakishwa kwezingcezu ezingama-30 ngomthamo wama-20 mg - kusuka kuma-ruble ayi-850;
- ukufakwa kwezingcezu ezingama-60 ngomthamo we-10 mg - kusuka kuma-ruble ayi-1060;
- ukupakishwa kwezingcezu ezingama-90 ngomthamo we-10 mg - kusuka kuma-ruble ayi-1539.
Gcina umuthi endaweni engafinyeleleki ezinganeni, ngamazinga okushisa angaphezu kwe-25 degrees Celsius. Impilo yeshelfishi ayisekho izinyanga ezingama-24. Ngempilo yeshelufu ephelelwe isikhathi kuyenqatshelwa ukwamukela.
Lapho uthenga umuthi, kubalulekile ukwazi ukuthi ungowangempela, noma kunjalo waletha izinzuzo, hhayi ukulimaza umzimba. Ungayihlukanisa kanjani - ingabe kuyinkohliso noma cha? Ezimweni eziningi, imishanguzo ethandwa kakhulu futhi yezinkathi ifakiwe. Udinga ukuthenga amakhambi kuphela kumakhemisi futhi unake ukupakisha, amaphutha wopelomagama, ukusetshenziswa kwamafonti ahlukene, ukuphrinta okungekuhle kokuphrinta akwamukeleki.
Umkhiqizo woqobo uhlala unolwazi mayelana nomenzi, inombolo yokubhalisa, ibhakhodi nosuku lokuphelelwa.
Imiyalo yokusebenzisa umuthi
I-Rosucard ichazwa ezimweni lapho izindlela ezingezona izidakamizwa zokunciphisa i-cholesterol zingasasebenzi, okungukuthi ukusebenza ngokomzimba kanye nokunciphisa isisindo, noma zingenakusetshenziswa yisiguli. Umuthi usebenza kahle ngokuhambisana nokudla okulwa ne-lipid esimweni sokuqala noma esingumxube we-hypercholesterolemia, i-heterozygous hypercholesterolemia, isifo sokuqina kwemizwa ukuze unciphise izinga lokuthuthuka kwalesi sifo kanye nohlobo lwe-4 hypertriglyceridemia. I-Rosucard nayo ibekelwa ukuvimbela ukuhlaselwa yisifo senhliziyo, imivimbo, ngokubeka phambili i-angina pectoris nokwelashwa kwezinye izifo zenhliziyo.
Umuthi obekiwe kufanele ugezwe ngamanzi okuhlanzwa endaweni yokushisa yasekamelweni. Isikhathi sokuthatha iRosucad asithinti umphumela kusukela kuhlelo lokusebenza. Ngesikhathi sokulashwa, isiguli kufanele sinamathele ekudleni okokwehlisa okhethekile kwe-lipid, imenyu yansuku zonke kufanele iqukethe ukudla okunomthamo ophansi we-cholesterol "embi".
Isilinganiso nesikhathi ubude sokwelashwa sinqunywe ngudokotela oya kuye, kuye ngezinga le-cholesterol egazini le-plasma yesiguli esithile. Uma isimo singanakwa kakhulu, imvamisa thatha ithebhulethi engu-1 ngomthamo we-10 mg nsuku zonke. Uma kunesidingo, umthamo womuthi ungabuyekezwa futhi ukhuphuke.
Iziguli ezisengozini - nge-hypercholesterolemia esezingeni eliphezulu kanye nezinkinga ezinzima zokwehluleka kwenhliziyo, zibekelwa isilinganiso esiphezulu somuthi (amaphilisi amane), uma kuze kube ngu-20 mg nsuku zonke akuholeli kumphumela oyifunayo.
Izimo ezikhethekile zokusebenzisa ziyadingeka ezigulini ezine-hepatic pathologies, ezinezinkomba ezilinganisweni ze-Child-Pugh ezingafika kumaphuzu ayi-7, umthamo obekiwe awunakushintshwa. Uma kunendlela emnene yokuhluleka kwe-renal, khona-ke ukwelashwa kufanele kuqale ngo-5 g, olingana nohhafu wepilisi. Ngenkambo yesifo ejwayelekile, umthamo omkhulu awunakunqunywa.
Ngokwe-psychology enzima, i-Rosucard ayenqatshelwe ukusebenzisa, futhi ngokuthambekela kwe-myopathy, umthamo omkhulu akufanele unqunywe.
Imiphumela emibi nokuphikisana
Iphakethe ngalinye lesidakamizwa lihlinzekwa ngencwajana yokusetshenziswa komkhiqizo.
Yonke imiphumela emibi engenzeka ngokusetshenziswa kwesidakamizwa ichazwe emiyalweni yokusetshenziswa.
Ngaphezu kwalokho, imiyalo ikhombisa uhlu lokuphikisana okungenzeka.
Ukwelashwa kweRosucard kungahle kube nemiphumela emibi elandelayo:
- Isistimu ye-Lymphatic negazi: ezimweni ezingandile, kungadala i-thrombocytopenia.
- Uhlelo lwezinzwa: isiyezi kanye nekhanda kuthanda kakhulu, ezimweni ezingandile kakhulu kungadala ukuncipha noma ukulahleka kwememori, i-peropheral neuropathy. Kwesinye isikhathi kuba nokudangala, ukuqwasha, ukuphazamiseka kokulala kanye nobusuku obunzima.
- Uhlelo lokugaya: ukulwa esiswini, ukuqunjelwa kanye nausea. Ezimweni ezingavamile, i-pancreatitis, ukugabha, uhudo.
- Ama-ducts e-Bile, isibindi: ezimweni ezingavamile, ukwanda okwesikhashana emsebenzini we-ALT ne-AST, akuvamile kakhulu - i-jaundice ne-hepatitis.
- Izinso nepheshana lomchamo: i-proteinuria ijwayelekile, engancipha ngesikhathi sokwelashwa uma ingahlotshaniswa nokutheleleka kwe-urinary ipheshana nesifo sezinso; i-hematuria iyivelakancane kakhulu.
- Izicubu zemisipha nokuxhuma: ezimweni ezivame ukwenzeka, i-myalgia ingavela, incane kakhulu - i-rhabdomyolysis, myopathy; kuyaqabukela - i-tendopathy ne-arthralgia.
- Isikhumba nezicubu ezithambile: i-urticaria kanye nokulunywa kwesikhumba, ukuqubuka - hhayi kaningi. Ezimweni ezingavamile, iStevens-Johnson syndrome.
- Uhlelo lokuzala kanye nezindlala ezincelisayo: i-gynecomastia ezimweni ezingavamile.
Uma sikhuluma nge-contraindication, okokuqala-ke kufanele kuqashelwe ukungezwani komzimba kwizakhi zomuthi. Futhi, lesi sidakamizwa asikwazi ukusetshenziselwa ukwelashwa kwezinso nokuhluleka kwesibindi, i-myopathy, ukukhulelwa kanye nokwelashwa kweCyclosporin.
Izindlela zokuqapha kufanele ziyiswe eRosucard kubantu ngemuva kweminyaka yobudala engama-70. Okufanayo kusebenza kubantu abanezifo zemisipha kanye ne-hypothyroidism. Futhi, ukwelashwa okunama-statins ngeke kuhlanganiswe ne-fibrate.
Ezigulini ezikhubazekile ukubekezelela ushukela, ukusetshenziswa kweRosucard kungadala izimpawu zesifo sikashukela. Kulokhu, ngaphambi kokuqala isifundo, udokotela oholayo kuzodingeka aqhathanise ingozi engaba khona yokusebenzisa umuthi kanye nethonya lemiphumela elindelekile yokwelashwa.
Futhi, ukwelashwa kuzodingeka kwenzeke kuphela esibhedlela ngaphansi kokuqashwa kwabasebenzi bezokwelapha.
Ukweqisa izidakamizwa kanye nokulinganiselwa
Umenzi akabonisi izinyathelo ezikhethekile zokuqeda imiphumela yokuphuza ngokweqile komuthi. Ngokuvamile, impendulo ye-CPK nesibindi kufanele kugadwe.
Kubalulekile ukuthi iziguli zesifazane zazi ukuthi umuthi akufanele uphuzwe ngesikhathi sokukhulelwa nangesikhathi sokudla. Iziguli zeminyaka yokuzala zingathatha inkambo yeRosucard kuphela ngokuhlanganiswa nezindlela zokuvimbela inzalo. Uma ukutholakala kokukhulelwa kutholakala ngesikhathi sokwelashwa kwe-statin, umuthi kufanele uyekwe noma kufanele kubekwe obambele obungeyona ingozi.
Uma iRosuvastatin kufanele ibekelwe owesifazane ngesikhathi sokuncelisa, khona-ke ukuze ivikele ingane emiphumeleni emibi, kwenziwa isinqumo sokumisa ukukhulelwa. Futhi ngaphambi kokufika eminyakeni engu-18, ama-statin ngokuvamile anqatshelwe.
Iziguli ezine-cholesterol ephakeme ngenxa ye-nephrotic syndrome noma i-hypothyroidism kufanele zelashelwe lesi sifo esiyisisekelo ngaphambi kokuqala ukwelashwa kweRosucard.
Uma kuvela izimpawu ezinjengobuthakathaka bemisipha, kubuhlungu kanye nokukhubazeka, ikakhulukazi lezo ezihambisana nomkhuhlane kanye nokuqubuka okujwayelekile, kufanele uthintane nodokotela wakho ngokushesha.
I-Rosucard - ukufana kwezidakamizwa nezindleko zazo
Abanye babhekene nombuzo - ukusebenzisa iRosucard noma ingabe yiRosuvastatin? Yini esebenza kangcono? Eqinisweni, i-rosuvastatin iyinto esebenzayo yesidakamizwa. Lezi zidakamizwa zombili zingama-analog futhi zinokwakheka okufanayo kwamakhemikhali.
Ngenxa yokuthi iRosucard ivame ukubekelwa iziguli esezikhulile, futhi nezindleko zomuthi ziyathengwa hhayi wonke umuntu, umbuzo ophakamayo wokuba khona kwezifanekiselo ezingabizi zalolu hlobo lwama-statins, ngoba umehluko wezindleko ngezinye izikhathi ungaba mkhulu kakhulu.
Ngenhlanhla, kunezidakamizwa ezanele ezinento efanayo esebenzayo; izidakamizwa ezenziwe Russian ziyathengiswa. I-analogue engabizi kakhulu yeRosucard isidakamizwa saseRussia i-Atorvastatin, intengo yaso isebangeni lama-ruble ayi-130-600. Ukuqapha kufanele kuthathwe ngokudakwa okungapheli kanye ne-pancreatitis yotshwala. Imiphumela emibi ifaka i-urticaria, i-anorexia, ne-thrombocytopenia.
Futhi, iRosuvastatin-SZ izobiza kakhulu ngentengo, izindleko zayo isuka kuma-ruble angama-330 kuya kwangama-710. Umenzi wenkampani yasekhaya ebizwa ngeNorth Star. Le statin imiselwe izinhlobo ze-hypercholesterolemia 2a ne-2b. Musa ukuthatha izingane nentsha.
I-Atoris nayo ingabekelwa ukwehlisa i-cholesterol, lesi sidakamizwa esivela enkampanini iKrka sibiza kusuka kuma-ruble angama-360 kuye kwangama-1070, lapho sithengwa ekhemisi. ILiprimar, ekhiqizwa yiPfizer, nayo iyathandwa. Izindleko eziningi, ngaphakathi kwama-ruble ayi-740-1800.
I-Akorta, lo muthi uyatholakala kumthamo we-10 mg no-20 mg, izindleko zawo zivela kuma-ruble angama-500 kuye kwangama-860. Izinkomba zokusetshenziswa ziyefana neRosucard. Ibuye isetshenziswe njengezinyathelo zokuvimbela ezifweni zenhliziyo. Phakathi kwemiphumela emibi kufanele uphawule ikhanda, i-myalgia, i-pharyngitis kanye nenausea.
Phakathi kwezinye izifaniso kufanele siphawule i-Crestor, ikhiqizwa e-UK nasePuerto Rico. Izindleko ezijwayelekile ziqala kusuka kuma-ruble ayi-520. Umuthi uthengiswa ngendlela yamathebulethi efilimu. Kuyinto ethandwa kakhulu futhi inezibuyekezo ezinhle ezivela ezigulini.
ITorvacard, lo muthi ukhiqizwa yinkampani yaseCzech futhi ungumbambeli omuhle weRosucard. Intengo yayo isebangeni lama-ruble angama-300-1100, ngokuya ngenani lamathebulethi amaphakethe. Kuyenqatshelwa ukusetshenziswa ngabesifazane abakhulelwe nababolekayo, izingane nentsha eyeve eshumini nambili. Kufanele futhi isetshenziswe ngokucophelela kubantu abanenkinga yotshwala obungapheli, isifo se-metabolic ne-endocrine, isithuthwane, umlando wesifo sesibindi.
I-Tevastor ibuye ibe yi-analogue engabizi kakhulu, izindleko zivela kuma-ruble angama-350 wezingcezu ezingama-30 kuye kuma-ruble ayi-1,500 kumathebula ayi-90. Umphumela wesidakamizwa uyabonakala ngemuva kwesonto, umphumela omkhulu ungabonakala ngesonto lesine lesifundo futhi ngokusetshenziswa njalo lizogcinwa.
Isazi sevidiyo esikulesi sihloko sizokhuluma ngama-statin.
