I-Liprimar iyisidakamizwa esisebenza masisha ukunciphisa i-cholesterol "embi" futhi inyuse "okuhle". Imithi ejwayelekile isiza ukuqina kwe-lipid metabolism futhi ivikele isifo senhliziyo.
Le ndatshana ichaza izici zesenzo se-lipid-yehlisa isidakamizwa i-Liprimar, imiyalo yayo yokusebenzisa, i-contraindication kanye nomonakalo ongaba khona, kanye nentengo, izidakamizwa ezifanayo nokubuyekezwa kweziguli.
Ukwakheka, ifomu lokukhulula nendlela yokusebenza
Amazwe amakhulu akhiqiza lo muthi yi-United States ne-Iceland.
Kubhekisa isizukulwane esisha sezidakamizwa ngenxa yokuba khona kwe-atorvastatin (Atorvastatin) kwisithako esisebenzayo.
Ngaphezu kwakho, i-Liprimar ifaka lonke uhla lwezakhi ezisizayo.
Iqhaza elisizayo ekwakhekeni kwamacwecwe lenziwa ngu:
- i-calcium carbonate;
- I-MCC;
- titanium dioxide;
- i-hypromellose;
- i-lactose monohydrate;
- i-croscarmellose sodium;
- i-hydroxypropyl cellulose;
- i-magnesium stearate;
- i-talc;
- i-polyethylene glycol;
- i-polysorbate 80;
- simethicone emulsion.
Umenzi ukhiqiza umuthi kuphela ngethebulethi ngomthamo we-10, 20, 40 no-80 mg wengxenye esebenzayo. Izithombe zokufakelwa eziyingqayizivele zingatholakala kwi-Intanethi.
I-Atorvastatin yehlisa ngempumelelo i-cholesterol, kufaka phakathi ukukhiqizwa kwayo yisibindi. Ngakho-ke, odokotela abaningi banquma lesi sidakamizwa ukuthola izakhi zofuzo noma i-hypercholesterolemia, ukuphazamiseka kwe-lipid metabolism, njll.
Ukusebenza kahle kwesidakamizwa ngesikhathi sokwelashwa kokuphazamiseka kwenhliziyo kuyaphawuleka, okunciphisa amathuba okuba neschemia noma umphumela obulalayo.
Ukuphathwa ngomlomo kwe-atorvastatin kunikeza ukumuncwa okuhle. Inani elikhulu lezinto ezisebenzayo liqashelwa emizuzwini eyi-120 ngemuva kokungena emzimbeni. Cishe ama-98% e-atorvastatin abopha amaprotheni egazi, futhi ukudla okungenayo cishe akunawo umthelela ku-bioavailability.
Njengomphumela wokusebenzisa i-Liprimar, kungenzeka ukwehlisa inani eliphelele le-cholesterol ngo-30-46%, kanye ne-low-density lipoproteins ngo-41-61%.
Lapho isithako esisebenzayo sesakhiwe, izinto ezisebenza emakhemikhali ziyakhiwa. Ukususwa kwawo emzimbeni kwenzeka nge-bile nomchamo.
Uhlu lwezinkomba kanye ne-contraindication
Phakathi kwezinkomba eziphambili zokusetshenziswa kweLiprimar, kuyadingeka ukuhlukanisa izinhlobo ezahlukahlukene ze-hyperlipidemia, hypercholesterolemia, hypertriglyceridemia kanye ne-dysbetalipoproteinemia.
Ochwepheshe bezenhliziyo baphinde banikeze nomuthi ukuvikela i-vascular pathologies ezimweni lapho iziguli zinezimpawu ezinzima ze-angina pectoris, unhlangothi, ukushaya kwenhliziyo, njll.
Ukufakwa kokufundiswa kuqukethe uhlu olucashile lwe-contraindication. Lokhu kufaka phakathi:
- hypersensitivity yomuntu ngamunye;
- izingane nentsha engaphansi kweminyaka engu-18 (ngenxa yokushoda kwedatha ekuphepheni kwemali yalesi sigaba seziguli);
- umsebenzi owandayo wama-transaminases ngaphezu kwezikhathi ezintathu;
- izifo zesibindi ezisebenzayo nokungasebenzi kahle kwe-hepatic.
Umuthi kufanele usetshenziswe ngokucophelela okukhulu kubantu abathatha utshwala noma abayimilutha yotshwala.
Kunconywe kakhulu ukuthi ungalandeli nje yonke imiyalo kadokotela, kepha futhi ufunde imiyalo ongayisebenzisa ngokwakho ukuze uqiniseke ukuthi akukho noma kukhona kwanoma yikuphi ukwephulwa.
Imiyalo yokusebenzisa umuthi
Ngaphambi kokuqala ukwelashwa ngalo muthi, isiguli sizama ukwehlisa ukugcwala kwe-cholesterol ngokulandela uhlelo lokudla lwe-hypocholesterol, ukuzivocavoca nokulungiswa kwesisindo.
Uma kungenzeki ngokuzimele ukwenza ngokwezifiso i-lipid metabolism, udokotela unquma i-Liprimar kwisiguli. Ukuphuza kwayo akuxhomekile esikhathini sosuku nokudla kokudla.
Umthamo womuthi uvela ku-10 mg uye kuma-80 mg kanye ngosuku. Ukukhethwa komthamo olungile kuya ngezici ezinjalo:
- I-cholesterol yegazi.
- Inhloso yokwelapha.
- Izici zomuntu ngamunye zesiguli.
Imvamisa, abantu abane-hypercholesterolemia eyisisekelo noma i-hyperlipidemia exubile idla ama-milligram angama-10 ngosuku. Umphumela wokwelapha wenzeka ngemuva kwezinsuku eziyi-14- 28.
Iziguli ezitholwa ne-homozygous womndeni hypercholesterolemia zithatha umthamo ophelele wama-80 mg ngosuku. Ngenxa yokwelashwa, ungangehlisa i- "cholesterol" embi "ngo-18-45%.
Ngokuqapha ngokweqile, i-Liprimar ibekelwe ukwehluleka kwesibindi. Uma isiguli sisebenzisa i-cyclosporine ngasikhathi sinye, khona-ke umthamo weLiprimar akufanele ube ngaphezu kwe-10 mg.
Uma kwenzeka umsebenzi wezinso ongasebenzi kahle noma lapho uguga, umphumela wokusebenzisa umuthi uhlala ungashintshiwe, ngakho-ke, awudingi ukulungiswa komthamo.
Amacwecwe kufanele agcinwe endaweni eyomile futhi emnyama lapho izingane zingafinyeleleki khona. Impilo yeshelf iyiminyaka emithathu.
Imiphumela engaphenduki engemihle
Njengoba ukubuyekezwa okuningi kodokotela neziguli kukhombisa, iLiprimar kuyaqabukela ibangele imiphumela emibi.
Kodwa-ke, amathuba okuthuthuka kwabo kumele kubhekwe.
Njengomthetho, "uhlangothi olusebenzayo" njengomphumela wokusebenzisa i-lipid-lowering agent liboniswa ngokulandelayo:
- Ukuphazamiseka kwe-CNS: ukungalali kahle ebusuku, i-migraine, i-asthenic syndrome;
- ukungahambi kahle komzimba: ukuqubuka kwesikhumba, i-urticaria, ukuqhuma kwe-bullous, ukushaqeka kwe-anaphylactic, i-erythema multiforme exudative, isifo sikaLyell;
- ukwephulwa komgudu wokugaya ukudla kanye nohlelo lokuphapha: isisu esibuhlungu, ukwanda kwegesi, uhudo, ukuqunjelwa, isicanucanu, ukugabha, ukuqina kwesibindi, ukuvuvukala kwamanyikwe, i-jaundice ne-anorexia;
- izinkinga ngohlelo lwe-hematopoietic: ukwehla kwenani lamapuleti (akuvamile);
- ukwephulwa kohlelo lwe-musculoskeletal: myositis, myalgia, myopathy, ubuhlungu emuva, i-arthralgia, rhabdomyolysis kanye nemisipha yokuqothuka;
- ukuphazamiseka kwe-metabolic: ukugcwala okukhulu kwe-serum creatine phosphokinase, hypo- ne-hyperglycemia;
- okunye ukusabela: ukungabi namandla, ubuhlungu besifuba, amandla anciphile okusebenza, ukuqina kwesisindo, i-tinnitus, ukuthuthukiswa kokuhluleka kwe-renal yesibili, i-alopecia, i-edema yodumo.
Amacala okweqa ngokweqile kwenzeka kakhulu, abonakaliswa ukwanda kwemiphumela emibi. Ezimweni ezinjalo, ukwelashwa okubonakalayo kwenziwa.
Ukuxhumana nezinye izidakamizwa
Udokotela kufanele azi ukuthi imiphi imishanguzo ngaphandle kweLiprimar isiguli esisebenzisayo. Lokhu kungenxa yokuthi le mithi inokuhambisana okuhlukile, kwesinye isikhathi okuholela ekuphendukeni okungathandeki komzimba.
Amathuba okukhula kwe-myopathy abangela ukusetshenziswa okufanayo kwe-cyclosporine, erythromycin, fibrate, clarithromycin, ama-antifungal agents, i-nicotinic acid enomuthi i-Liprimar.
Njengoba kushiwo ngaphambili, lapho uhlanganisa i-Liprimar ne-cyclosporine, umthamo wokuqala ungabi ngaphezu kwe-10 mg.
Umuthi osebenzayo, osebenzisana ne-erythromycin, i-diltiazem, i -cacithromycin kanye ne-isoenzyme ye-cytochrome CYP3A4, ukhulisa okuqukethwe kwayo egazini.
Uma isiguli sithatha i-Liprimar ngasikhathi sinye ngokuvimbela inzalo yomlomo, okubandakanya i-ethinyl estradiol ne-norethisterone, ne-digoxin, khona-ke ukugcwala kwalezi zidakamizwa emzimbeni kukhuphuka kakhulu.
Baholela ekwehleni kokuqukethwe kwe-atorvastatin ku-plasma yesidakamizwa esine-aluminium noma i-magnesium hydroxide, kanye ne-colestipol.
Izindleko zemithi kanye nama-analogues
Ungathenga umuthi kuphela ngemithi kadokotela.
Ungonga imali lapho u-oda umuthi online kwiwebhusayithi yomthengisi osemthethweni.
Ngokuvamile, i-Liprimar akuyona ikhambi elishibhile, yize linomphumela omude wokwelapha.
Izindleko ezimaphakathi zephakeji ezinamathebulethi angama-30 zivezwe ngezansi:
- 10 mg - ama-ruble angama-700;
- 20 mg - ama-ruble ayi-1000;
- 40 mg - ama-ruble ayi-1100;
- 80 mg - ama-ruble ayi-1220.
Uma kungenakwenzeka ukuthenga lesi sidakamizwa, udokotela angakhetha isichazamazwi esingabizi, i.e. i-ejenti equkethe isithako esifanayo esisebenzayo. Izivumelwano zeLirimar yilezi:
- Atorvastatin;
- Atoris;
- I-Vazator;
- INovostat;
- ITorvacard
- Tulip.
Ngenxa yobukhona be-contraindication noma ukusabela okuphambene, kuyadingeka ukufaka i-Liprimar nezinye izidakamizwa eziqukethe into ehlukile esebenzayo, kepha ibe nomphumela ofanayo wokulapha. Izifanekiso zomuthi zifaka:
- I-Akorta. Isithako esisebenzayo yi-rosuvastatin. Umenzi ukhiqiza amaphilisi kumthamo we-10 no-20 mg. Umuthi ushibhile uma uqhathaniswa neLiprimar: inani lentengo ephakeji (amaphilisi ayi-10 mg 30) angama-ruble ayi-510.
- I-Zokor. Ukuqanjwa kufaka phakathi i-ntho esetshenziswayo ye-simvastatin. Kukhiqizwa nemithamo emibili - 10 no-20 mg. Intengo iphakethe ngalinye (10 mg No. 28) ama-ruble angama-390.
- Crestor. Isidakamizwa esinciphisa i-lipid equkethe i-rosuvastatin. Kukhiqizwa ngemithamo efana ne-5, 10, 20 no-40 mg. Ngokwesilinganiso, izindleko zephakeji elilodwa (10 mg, No. 14) zingama-ruble ayi-970, ngakho-ke umuthi ubhekwa njengento ebizayo.
Emakethe yezokwelapha yaseRussia, umuntu angathola izithonjana ezifana neMertenil, Lipoprime, Ariescor, Rosart, Rosuvastatin, Rosistark, Roxer, njll.
Umbono weziguli mayelana nomuthi
Ngokuvamile, i-lipid-yehlisa i-liprimar isebenza kakhulu. Iziguli eziningi nodokotela baqinisekisa le mininingwane.
Umuthi uvame ukunikezwa iziguli ezinama-pathologies wezinhliziyo ezihlukahlukene. Ivimbela ukufakwa kwe-cholesterol "embi" ezindongeni zemithambo yegazi nokuthuthukiswa kwe-atherosclerosis.
Odokotela bathi ukuphumelela kokwelashwa kuncike ekudleni, ukuzivocavoca kanye nokulungiswa kwesisindo. Uma ulandela imiyalo kadokotela ngqo, unganciphisa i-LDL futhi ukhuphule i-HDL.
Ezinye iziguli zizama ukukhetha ngokuzimele umthamo womuthi, okuholela kulimaza imizimba yazo. Imiphumela emibi ejwayelekile yokuhlukumezeka ibulala kanye nokuncipha kwegazi.
Okuwukuphela kwento edabukisayo yesidakamizwa kungabizwa izindleko zayo ezinkulu. Akuzona zonke iziguli ezingakwazi ukukhokhela iLiprimar.
Izimo zichaziwe kuvidiyo ekulesi sihloko.
