I-Rosucard isho ama-statins anciphisa ngempumelelo ukugcwala kwe-cholesterol egazini. Igama elingelona elenziwa ngomuthi elisezingeni eliphezulu yiRosuvastatin (Rosuvastatin).
Umuthi uthathwa ngenkuthalo ekwelapheni i-hypercholesterolemia, ukuvimbela ukwakheka kwezigcawu ze-atherosulinotic kanye ne-pathologies ye-inhliziyo. Udokotela unquma umthamo womuthi ngokubheka kobunzima besifo kanye nezimpawu zesiguli ngasinye.
I-athikili iqukethe imininingwane eyisisekelo mayelana neRosucard (10.20.40 mg), intengo yayo, ukubuyekezwa kweziguli nama-analogues.
Uhlobo nokwakheka kwalo muthi
I-Rosucard ithathwa njengesidakamizwa esinomphumela ophansi we-lipid. Ingxenye esebenzayo ivimbela ukwenziwa kwe-HMG-CoA reductase. Ngenxa yale enzyme, i-HMG-CoA iguqulwa iguqulwe i-mevalonic acid, okuyisandulelo se-cholesterol.
Inkampani yezemithi yaseCzech iZentiva yethula lesi sidakamizwa. I-Rosucard ikhiqizwa kwifomu lethebhulethi elenzelwe ifilimu ukuze isetshenziswe ngomlomo. Ithebhulethi inombala opinki okhanyayo, umphezulu we-convex kuzinhlangothi zombili kanye nobume obude.
Ingxenye esebenzayo yesidakamizwa yi-rosuvastatin. Ithebhulethi eyi-1 yeRosucard ingaqukatha 10, 20 noma 40 mg wento esebenzayo. Ngaphezu kwalokhu, lesi sidakamizwa sifaka izakhi ezisizayo, okungukuthi:
- i-crosscarmellose sodium;
- i-microcrystalline cellulose;
- i-lactose monohydrate;
- i-magnesium stearate.
Ifilimu liqukethe izinto ezifana ne-talc, i-macrogol 6000, i-oxide ebomvu, i-hypromellose ne-titanium dioxide.
Iqhubu elilodwa liqukethe amaphilisi ayi-10. Ukupakishwa kukhiqizwa eyodwa, ezintathu noma eziyisishiyagalolunye iziqu. Ukufakwa kweRosucard kuhlale kuphelezelwa iphetshana lokufaka ukuze kusetshenziswe amaphilisi.
Indlela yokusebenza yesakhi esiyinhloko
Isenzo se-rosuvastatin sihlose ukukhulisa izinga lama-LDL receptors kumaseli we-parenchyma yesibindi (hepatocytes). Ukwanda kwenani labo kufaka phakathi ukwanda kokuthathwa kanye nokucekelwa phansi kwe-LDL, ukwehla ekukhiqizweni kwe-VLDL nokuqukethwe okuphelele kwe-cholesterol "embi".
Umphumela wehlise i-lipid weRosucard incike ngqo kumthamo othathwe. Ngemuva kwesonto elilodwa lokuthatha umuthi, ukwehla kwezinga le-cholesterol kuyabonakala, ngemuva kwamaviki ama-2% ama-90% womthelela omkhulu kakhulu wokwelapha utholakala. Ngeviki lesi-4, kuqiniswa ukuzinza kokuqina kwe-cholesterol ezingeni elamukelekayo kuyabonakala.
Umuthi usiza ukukhulisa amazinga we-HDL, okungewona ama-atherogenic futhi awafakwa ngohlobo lwama-plaque nokukhula odongeni lwemithambo yegazi.
Ukudla nsuku zonke kwe-rosuvastatin akuguquki imingcele ye-pharmacokinetic. Umuthi uxhumana namaprotheni egazi (okungenani abopha i-albhamuin), ukumuncwa kwenzeka ngesibindi. Ingxenye ingawela i-placenta.
Cishe ama-90% e-rosuvastatin akhishwa emzimbeni ngamathumbu, amanye aphumele ezinso. I-pharmacokinetics yesakhi esisebenzayo ayixhomekile ebulini nakubudala.
Izinkomba kanye ne-contraindication ukuze zisetshenziswe
Udokotela unquma iRosucard uma ukutholakala kwesiguli kuhlotshaniswa ne-cholesterol ekhulayo.
Ukuzelapha kungavunyelwe ngokuphelele.
Kunama-pathologies amaningi lapho ukwehluleka khona kwe-lipid metabolism kwenzeka.
Ukusetshenziswa kwamathebulethi kusebenza ku:
- I-hypercholesterolemia eyisisekelo noma exubile.
- Ukwelashwa okuyinkimbinkimbi kwe-hypertriglyceridemia.
- I-hypercholesterolemia ye-Familiaal (ifa).
- Yehlisa ukuthuthukiswa kwe-atherosclerosis (engeza ekudleni).
- Ukuvimbela ama-pathologies wezinhliziyo ngokumelene nesizinda se-atherosulinosis (izinhlungu zenhliziyo, umfutho wegazi ophakeme, unhlangothi kanye nokuhlaselwa yisifo senhliziyo).
Ukusetshenziswa kwesidakamizwa esinomuthi we-10 no-20 mg ku-contraindised ku:
- ukuba khona kokuzwela komuntu ngamunye kwizakhi;
- ukuthwala ingane noma ukuncelisa;
- engafiki eminyakeni eyi-18;
- ukuthuthukiswa kwe-myopathy (isifo se-neuromuscular);
- ukwelashwa okuyinkimbinkimbi nge-cyclosporine;
- umsebenzi owengeziwe we-enzyme ye-CPK izikhathi ezingaphezu kwezihlanu;
- ukwenqaba kowesifazane ukuvimbela inzalo okwanele;
- ukwehluleka kwesibindi nokungasebenzi kahle kwezitho zomzimba;
- ukuphathwa okuyinkimbinkimbi kwe-HIV proteinase blockers.
Kukhona nohlu lwe-contraindication sici somthamo we-40 mg:
- Ukuthambekela kokuzizwa kwe-myopathy.
- Ukudakwa okungapheli kanye nokudakwa.
- Ukwehluleka kwangempela kwesimo esidaluliwe.
- I-Myelotoxicity ngenkathi uthatha ama-blockers we-HMG-CoA reductase kanye nama-fiber
- Ukungasebenzi kahle kwe-yegilo.
- Ukusetshenziswa okuhlanganisiwe kwama-fibrate.
- Ama-pathologies ahlukahlukene aholela ekwandeni kokuhlushwa kwe-rosuvastatin egazini.
Akunconywa futhi ukusebenzisa umthamo ka-40 mg ngabamele bohlanga lwamaMongoloid ngenxa yokuba khona kwezimpawu zomuntu ngamunye.
Imiyalo yokusebenzisa umuthi
Amacwecwe awadingi ukulunywa noma ukuhlafunwa, agwinywa ngamanzi. Ukuthatha umuthi akuxhomekile esikhathini sosuku noma ekudleni kokudla.
Ngaphambi kokunquma iRosucard, udokotela uncoma ngokuqinile ukuthi isiguli sinamathele ekudleni okuhlose ukunciphisa inani lekholesteroli elichithwayo.
Isilinganiso sokuqala somuthi nsuku zonke singamaphilisi angu-0.5-1 (5-10 mg). Ngemuva kwamaviki amane, umthamo ungakhuphuka ngudokotela. Ukwanda komthamo wansuku zonke kuya ku-40 mg kungenzeka kuphela uma kwenzeka cholesterol ephezulu kakhulu kanye nethuba eliphezulu lezinkinga zesifo senhliziyo, lapho umthamo wansuku zonke we-20 mg ungasebenzi.
Ithebula elingezansi libonisa izici zokusetshenziswa kweRosucard kubantu bohlanga lwamaMongoloid, kanye ne-pathologies yohlelo lwe-biliary kanye ne-neuromuscular disorder.
| Ukugula / isimo | Izici zokuphuza amaphilisi |
| Ukwehluleka kwesibindi | Uma lidlula amaphuzu ayi-7, kuyadingeka ukulungisa umthamo womuthi. |
| Ukwehluleka kwangempela | Umthamo ngu-5-10 mg ngosuku. Ngokwesilinganiso esiphakathi, i-40 mg ngosuku akufanele idliwe, ngokuntula okukhulu, i-rosuvastatin inqatshelwe ngokuphelele. |
| Ukuthambekela kwe-myopathy | Iziguli zivunyelwe ukuthatha u-10-20 mg wesidakamizwa. Umthamo we-40 mg ubhalwe ngokuqondile kulokhu okubunjiweyo. |
| Umjaho wamaMongoloid | Isimo somuthi sansuku zonke yi-5-10 mg. Ukungezelela umthamo kwenqatshelwe ngokuphelele. |
Impilo yeshelf iyizinyanga ezingama-24, ngemuva kwalesi sikhathi, ukuphuza umuthi akuvunyelwe ngokuphelele. Ukupakisha kugcinwa kude nezingane ezincane ekushiseni kwama-25 ° C.
Ukuphendula okungalungile kanye ne-overdose ngokweqile
Imiphumela emibi ingenzeka ngenkathi uphuza umuthi.
Uma kwenzeka ukusabela okubi, isiguli kufanele siyeke ukusebenzisa iRosucard futhi sithinte uchwepheshe wezokunakekelwa kwempilo.
Imiphumela emibi ixhomeke ngqo kumthamo womuthi, ngakho-ke, uvame ukubonwa kakhulu ngenxa yokuphathwa kwamathebulethi omthamo ka-40 mg.
Umyalo uqukethe imininingwane elandelayo ngezehlakalo ezingezinhle:
- Isifo se-dyspeptic - ukuhlaselwa isicanucanu nokuhlanza, izinhlungu esifundeni se-epigastric, kwesinye isikhathi ukuthuthukiswa kwe-pancreatitis kanye ne-hepatitis.
- Ukuphendula kwezakhi zofuzo - i-proteinuria (ukuba khona kwamaprotheni kumchamo), i-hematuria (ukuba khona kwegazi kumchamo).
- Ukubonakaliswa kwe-allergic - ukulunywa, ukuqubuka esikhunjeni, i-urticaria.
- Ukuphazamiseka kwemisipha yemisipha - ubuhlungu bemisipha, ukuvuvukala kwemisipha, ukubhujiswa kwamangqamuzana emisipha.
- Ukungasebenzi kahle kwe-CNS - i-migraine ngezikhathi ezithile, ukukhathala, ukulala okungekuhle kanye nobusuku obunzima, ukudangala.
- Ukwephulwa kwezitho zokuzala - ukukhula kwezinduna ezincelisayo kwabesilisa.
- Isikhumba kanye nokushintshwa kwezicubu ezithinta isikhumba yiStevens-Johnson syndrome (noma i-necrotic dermatitis).
- Ukuphazamiseka ohlelweni lwe-endocrine - ukuthuthukiswa kohlobo lwesifo sikashukela esinga-insulin.
- Ukwehluleka kokuphefumula - ukukhwehlela owomile kanye nokuphefumula.
Njengoba i-pharmacokinetics yesithako esisebenzayo ayixhomekekile kumthamo, i-overdose ayikhuli. Kwesinye isikhathi kuyenzeka ukwandise izimpawu zokuphendula okungahambi kahle.
Ukwelashwa kufaka izindlela ezifana nokuqunjelwa esiswini, ukusetshenziswa kwama-sorbents kanye nokuqedwa kwezimpawu.
Ukuhambisana nezinye izidakamizwa
Ukuhambisana kweRosucard nemithi ethile kungaholela ekwehleni noma okuphambene nalokho kukhulisa ukusebenza kwento esebenzayo, kanye nokwenzeka kwemiphumela emibi.
Ukuze azivikele emiphumeleni emibi, isiguli kufanele sazise udokotela ngazo zonke izifo ezihlangene nemithi ethathiwe.
Okulandelayo itafula eliqukethe uhlu lwezidakamizwa okuphathwa kwalo kanyekanye kukhulisa noma kwehlise umphumela wokwelapha weRosucard.
| Ngcono umphumela | Yehlisa umphumela |
| I-cyclosporin (i-immunosuppressant enamandla). I-Nicotinic acid Ama-protease inhibitors e-HIV. Izindlela Zokuvimbela inzalo. I-Gemfibrozil namanye ama-fibrate. | I-Erythromycin (i-antibiotic evela kusigaba se-macrolide). Ama-antacid, kufaka phakathi i-aluminium ne-magnesium hydroxide. |
Kunemininingwane yokuthi ngokusetshenziswa okuyinkimbinkimbi kweRosucard ne-Warfarin nabanye abaphikisana no-Vitamin K, ukwehla kwe-INR kungenzeka.
Ngesikhathi sokuhlolwa kwezesayensi, akubanga khona ukusabela okukhulu kwamakhemikhali phakathi kwezingxenye zeRosucard neKetoconazole, iFluconazole, i-Itraconazole, iDigoxin, i-Ezetimibe.
Kwenqatshelwe ukuthatha isidakamizwa notshwala ngasikhathi sinye. Ukugwema utshwala nokubhema kusiza ukwehlisa i-cholesterol ibe sezingeni elamukelekayo.
Izindleko nombono wesineke
Njengoba iRosucard ingumuthi ongenisiwe, izindleko zayo ziphakeme impela. Naphezu kokusebenza kahle kwalo muthi, intengo yawo isalokhu iyisihibe esikhulu.
Ngokwesilinganiso, iRosucard 10 mg (amaphilisi angama-30) angathengwa ngamanani ama-ruble angama-595, ama-20 mg ama-ruble ayi-875, ama-40 mg ama-ruble ayi-1155. Ukuze ulondoloze imali yakho, ungabeka i-oda online kuwebhusayithi yommeli osemthethweni.
Iningi leziguli libona umphumela omuhle wokwelapha ngokuthatha umuthi. Izinzuzo eziphambili ifomu lomthamo olula kanye nesidingo sokusebenzisa isikhathi esisodwa kuphela ngosuku.
Kodwa-ke, ukubuyekezwa okungalungile kweziguli kungatholakala nakwi-Intanethi.
Ochwepheshe bezokwelapha kanye nabezenhliziyo bahlobanisa ukusabela okunamandla okungekuhle nemithamo emikhulu yomuthi. Yilokho udokotela N.S. akushoyo Ama-Yakimets:
"Ngihlolile ukusebenza kwalesi sidakamizwa esijwayelekile - kuqinisa kahle imetabolism ye-lipid kuzinqubo ezingezona ezomdabu kanye nokungasebenzi kahle, ngokwemvelo kuyindleko, ngokuqhathaniswa nesichazamazwi Krestor. Kunemiphumela emibi, kepha akuvamile kakhulu, ngoba nginquma u-5-10 mg wokuxilonga ukuphazamiseka okuncane."
Izithonjana nezifanekiswane zomuthi
Ezimweni lapho isiguli senqatshelwe ukuthatha iRosucard ngenxa ye-contraindication noma imiphumela emibi, udokotela ukhetha obambele osebenzayo.
Emakethe yemithi ungathola izithonjana eziningi zomuthi, eziqukethe into efanayo. Phakathi kwazo kukhona:
- Rosuvastatin;
- Crestor
- Rosistark;
- I-Tevastor
- I-Akorta;
- Roxer;
- URosart
- Mertenyl;
- URosulip.
Kukhona nama-analogs ahlukile kokuqukethwe kwento esebenzayo, kepha afakiwe eqenjini lama-statins:
- I-Zokor.
- Atoris.
- UVasilip
I-Zokor. Kufaka i-simvastatin yesithako esisebenzayo, esivimbela i-HMG-CoA reductase. Kwenziwa yizinkampani ezenza amakhemikhali e-USA naseNetherlands. Izindleko ezijwayelekile zokupakishwa (Cha. 28 10mg) ngama-ruble angama-385.
Atoris. Lesi i-analogue eshibhile yeRosucard, ngoba inani lokupakishwa (Cha. 30 10mg) ngama-ruble angama-330. Umuthi osebenzayo yi-atorvastatin, ekhulisa umsebenzi we-LDL receptors etholakala esibindini nasezicubu ezengeziwe.
UVasilip. Umuthi uqukethe i-simvastatin ku-dosage ye-10.20 no-40 milligrams. Inezinkomba ezifanayo kanye ne-contraindication njengeRosucard. Umuthi ungathengwa ngama-ruble angama-250 kuphela (Cha. 28 10mg).
Mayelana nezidakamizwa ezisuselwa ku-rosuvastatin zichazwe kuvidiyo kule ndatshana.
