Ukulungiselela kwe-Enzymatic, noma, ngamanye amagama, ama-enzyme, kuneniche ebalulekile embonini yamakhemikhali. Le yimithi engekho isiguli esinezifo zamapheshana emathunjini engenza ngaphandle kwayo, ukusetshenziswa kwama-enzyme akunqunyelwe kubantu abaphilile ngokuphelele.
Amalungiselelo angama-enzymatic avela ezitshalweni nasezilwaneni. Izilwane zisebenza ngokushesha nangendlela ephumelelayo; izitshalo zilungele ukudliwa okude. Le mishanguzo itholakala ngezindlela ezimbili eziphambili - amaphilisi kanye namaphilisi.
Abamele amaphilisi yiMezim, Pancreatin. Futhi izindlela ezikumakhompiyutha yiPangrol, uCreon, iPanzinorm.
Kunesimangalo sokuthi amakhompiyutha asebenza kangcono ngoba ama-enzyme awenzekile esiswini. Amafomu abekwe etafuleni anomthelela wokwelapha, kepha buthakathaka kakhulu.
Ama-enzyme atholakalayo kulungiselelo anezakhiwo ezilandelayo:
- umsebenzi we-amylolytic - amandla wesidakamizwa ukutshabalalisa ama-carbohydrate;
- umsebenzi we-proteinolytic - ukubhujiswa kwezakhi zamaprotheni;
- umsebenzi we-lipolytic - ukwephulwa kwamafutha.
Amandla okudiliza izinto ezithile kunqunywa yiqembu lama-enzyme afakiwe kulo muthi. Futhi, njengesengezo, ngivame ukusebenzisa i-bile, esiza ngaphezu kwalokho ukudiliza amafutha kepha, ngeshwa, le ngxenye inezimpawu eziningi eziphikisayo. Ngakho-ke, ngaphambi kokuthatha amalungiselelo e-enzymatic nge-bile, udinga ukubonana nochwepheshe.
Ukusetshenziswa kwePangrol kungabikho kwezifo zokugaya
Kubantu abaphilile, ama-enzyme angaba izidakamizwa ezisiza ukubuyisela ukugaya ngemuva kweholide eliningi.
Ngaphezu kwalokho, amathuluzi anjalo anomthelela ekwenzeni ngcono ukubukeka komuntu.
Ukusetshenziswa kwama-enzyme kuvumela umuntu onenkinga yokuphazamiseka emathunjini esiswini ukuthi enze ngokwejwayelekile ukusebenza kwawo futhi anciphise umthwalo ezithweni ezifana nesibindi namanyikwe.
Yiziphi izimpawu zokushoda kwe-enzymatic?
Ukuntuleka kwe-Enzymatic kubonakaliswa ngu:
- Uma ukuguga kwesikhumba kubonwa ngokuwohloka kwesimo saso, ukubonakala kwemibimbi yokuqala, isikhumba esimpunga.
- Ukwanda kokulahleka kwezinwele, izipikili ezi-brittle - konke lokhu kungaba imbangela yokuntuleka kwama-enzyme, ngenxa yalokho ukutholwa kwezinto ezidingekayo ukuze kulondolozwe ukubukeka okunempilo kuphazamiseka.
- Ukudumazeka emgodini wesisu kungukuqunjelwa ngezikhathi ezithile noma isifo sohudo, okuvusa ukudla okugaywe ngokungafanele.
- Ukuwohloka komzimba okwehlisiwe futhi, ngenxa yalokho, kuvame ukuvela komkhuhlane.
- Ukuphazamiseka emkhakheni we-hormonal, ukungasebenzi kahle kwe-gland yegland kanye nengxenye yama-pancreas.
Ngakho-ke, kuba sobala ukuthi inani elinganele lama-enzyme liholela ekuthweni okungalungisiwe kwezinto ezisemqoka zokwakheka komzimba - amaprotheni, amafutha kanye ne-carbohydrate, kanye nokufakwa okungafanele kwamaminerali, amavithamini kanye nezinto zokulandela umkhondo. Ukulungisa lesi simo, kufanele ushintshe indlela yokuphila. Kufanele ulandele ukudla okuqinile futhi uzame ukugcina umsebenzi olinganiselayo womzimba.
Ukufinyelela umphumela ongcono futhi osheshayo, ukusetshenziswa kwamalungiselelo we-enzymatic kungenzeka.
IPangrol - kuyini?
Elinye lamalungiselelo enzyme anamandla futhi aphumelelayo yiPangrol. Itholakala kumithamo eminingana: amayunithi ayizinkulungwane eziyishumi, izinkulungwane ezingama-20 no-25. Inhloso yomthamo othile kuncike kumthamo odingekayo wansuku zonke, futhi kuyehluka ngenani lemithamo ngosuku.
IPangrol yinkimbinkimbi yama-enzyme emvelaphi yezilwane - i-lyophilized powder (pancreatin) evela kumanyikwe ingulube. Izinga lomsebenzi wesidakamizwa libangelwa ikakhulukazi isenzo sengxenyana ye-lipolytic, khona-ke ingxenyana ye-proteinolytic. Izinga lokuqhekeka kwama-carbohydrate liphansi impela futhi linqunywa ikakhulukazi njengengxenye ebalulekile yokwelashwa kwe-cystic fibrosis.
Umuthi unomphumela cishe kuwo wonke ukugaya, ngoba i-trypsin ekwakhiweni kwayo inamandla, ngaphezu kokuhlukanisa amaprotheni, ukuvimbela ukucasha kwe-pancreatic futhi kunciphise izinhlungu. Lezi zici zomuthi zilungele kakhulu ekwelapheni i-pancreatitis.
I-Pangrol iyatholakala kumakhompiyutha aqukethe amaphilisi amancane ngaphakathi. Lapho i-capsule ingena esiswini, iyancibilika ngaphansi kwesenzo se-acid bese ikhipha amatafula amancanyana amancane egobolondo lawo alwa nama-asidi. Ukusatshalaliswa okufanayo kwengxenye esebenzayo yamacwecwe kuhlu lokudla kwenzeka.
Uma ingena endaweni ye-alkaline noma engathathi hlangothi ye-duodenum - lokhu kunomthelela kusebenze kwama-enzyme.
Izinkomba Pangrol
Isibonakaliso esiyinhloko sokuqokwa kwePangrol ukungapheleli komsebenzi we-exocrine pancreatic, ovame ukuhlinzeka umzimba ngama-enzyme. Imbangela yokwephulwa okunjalo kungaba:
- i-pancreatitis engapheli;
- i-pancreatectomy;
- gastrectomy;
- i-pancreatitis yotshwala;
- i-cystic fibrosis;
- ukuphazamiseka kwe-duct ye-pancreas noma i-bile duct ejwayelekile nge-calculus noma isimila;
- i-pancreatitis eyingozi, lapho isiguli sidluliselwa kokudla okungenamsoco.
IPangrol nayo ibekelwa ezinye izimo ezingeyona ingozi:
- ukuthopha;
- isifo sohudo esingatheleleki;
- lapho udla ngokweqile noma udla ukudla okusindayo;
- lapho uphuza utshwala;
- ngendlela yokuphila engasebenzi noma ukungasebenzi isikhathi eside;
- phambi kwezinkinga ezisebenzelweni ezihlafunwayo.
Phezu kwazo zonke lezi zinkomba, uPangrol unqunywe ngaphambi kokwenza izifundo ezinomsizi ukuze asibone kahle isithombe ngokunciphisa ukuvuvukala.
Imiyalo yokusebenzisa umuthi
Umuthi uphathwa ngomlomo. Ama-Capsule awakwazi ukuhlafunwa, ngoba ama-enzyme angalimaza ulwelwesi lwe-mucous lomgodi womlomo. Phuza umuthi ngenani elikhulu loketshezi. Uma ukugwinya kuphazamiseka noma ngesikhathi sokudla usebenzisa uphenyo, ungavula isembozo bese uqeda amatafula amancane emanzini noma ekudleni okuwuketshezi. Le ngxube ayikwazi ukugcinwa, udinga ukuyisebenzisa ngokushesha.
Umthamo wesidakamizwa uqokwa ngamunye. Imithamo ejwayelekile yiPangrol 10000 - ikhafi elilodwa izikhathi ezingama-2-3 ngosuku ngaphambi kokudla. I-Pangrol eyizinkulungwane ezingama-20 no-25 isetshenziswa i-capsule eyodwa noma amabili ngosuku. Udokotela uguqula umthamo, uma kunesidingo, uwukhulise. Umthamo omkhulu wansuku zonke wabantu abadala nezingane ngaphezu kweminyaka eyi-12 amayunithi ayizinkulungwane eziyikhulu.
Ngama-cystic fibrosis, izingane ezingaphansi kweminyaka engu-4 ubudala zinquma iPangrol kumthamo wamayunithi ayi-1000 ngekhilogremu yesisindo ngasinye, kuthi emva kwama-4x - 500 amayunithi ngekhilogremu ngayinye.
Njengoba umuthi ungangenwa egazini, kepha usebenza endaweni yangasese epheshaneni lesisu, futhi ayinayo imiphumela emibi ehlelekile, njenge-hepatotoxicity, nephrotoxicity. Eminye yemiphumela engemihle ekhona yile:
- ukumbiwa okwandisiwe kwe-uric acid ngomchamo, maqondana nalokhu kunesidingo sokulawula ukwakheka kwe-calculi;
- unciphisa esifundeni se-ileocecal ezinganeni ezine-cystic fibrosis futhi zidla imithamo ephezulu yePangrol. Le nkinga igcwele ukuthuthukiswa kokuphazamiseka kwamathumbu, ngakho-ke, idinga ukulawulwa okuqinile;
- ukuphazamiseka kwengqondo ngesimo sokucanuzelelwa kwenhliziyo, ukuhlanza, ukuqunjelwa, isifo sohudo, ukuthopha;
- ukungahambi kahle komzimba - ukuqubuka, ukulunywa, i-urticaria, ukuqunjelwa, i-bronchospasm.
Umuthi usetshenziselwa ukwelapha izingane futhi ungasetshenziswa kwabesifazane abakhulelwe njengoba kuchazwe udokotela uma inzuzo elindelwe kunina idlula ubungozi obukhona enganeni. Umuthi ungasetshenziswa ngesikhathi sokuqunjelwa.
Ukuphikisana nokusetshenziswa kwePangrol kungukuzwela kweprotheni yengulube, ikakhulukazi uma kunomlando wokungezwani nenyama yengulube.
IPangrol inamandla okunciphisa ukumuncwa kwe-folic acid, ngakho-ke ukusetshenziswa kwayo okuhlangene nezidakamizwa eziqukethe akunamsebenzi. Futhi ngisho nangaphezulu - ngokusetshenziswa isikhathi eside kwePangrol, ukuntuleka kwe-folic acid kungenzeka, kugcwele inkinga enjalo njenge-anemia. Kulokhu, eminye imizila eyengeziwe yokuphuza i-folic acid iyadingeka.
I-Pangrol isetshenziswa kaningi ekwelashweni okuyinkimbinkimbi kwezifo zokugaya, ngenxa yalokho, ihlala ihlanganiswa nezidakamizwa ze-antiulcer ezisehlisa i-acidity, ngokwesibonelo, ngesikhathi sokwelashwa kwe-pancreatitis. Kuhlanganiswe nama-sorbents ubuthi bokudla.
IPangrol ibekelwa kanye namagciwane lapho kunesidingo ukwelapha ukutheleleka kwamathumbu.
Ukwenziwa kwesidakamizwa iPangrol
I-patent yesidakamizwa ingeyophawu lwentengiso yase-Italy, kepha ikhiqiza umuthi futhi inayo ukulawula kwayo kokugcina iJalimane. Ngakho-ke, isidakamizwa sePangrol singeniswa futhi sikude eshibhile. Yini engathatha isikhundla sePangrol futhi ingabiza malini?
I-analogue enganciphisi i-Pangrol ekusebenzeni kahle, kodwa enezindleko eziphindwe izikhathi ezimbili - yiCreon. Ezinye ezinye ezimbili - iMezim Forte nePancreatinum 8000. Intengo ye-pancreatinum incane. Kepha, ngokuya ngezibuyekezo, lo muthi futhi unomphumela omuhle ohlelweni lokugaya ukudla. I-pancreatin ingahle ibhekane ne-pancreatitis engapheli, kepha izosiza ukuqeda ukungakhululeki kokudla ngokweqile.
Ngemuva kokuhlaziya amalungiselelo e-enzymatic kanye nesilinganiso sentengo yazo kuya kwikhwalithi, kungaphethwa ngokuthi ukusetshenziswa kwamalungiselelo okwenziwe nge-capsule kusasebenza kakhulu, ngoba iningi lama-enzymes lihlala lisebenza ngemuva kokudlula esiswini. Kubalulekile futhi ukucubungula umthamo ngamunye.
Kuyiqiniso, njengoba kubonakala emiyalweni yokusetshenziswa, ama-enzyme awanemiphumela emibi eminingi, kepha kungcono ukuthi udokotela anqume umthamo, kucatshangelwa izici zesiguli ngasinye. Uma ama-enzyme edingekayo ekuvuseleleni izimpawu noma ukugaya isikhathi esisodwa ngemuva kwedili, ungasebenzisa futhi amalungiselelo wethebhulethi, anenani lentengo elithe xaxa.
Udokotela ukhuluma ngokwelashwa kwe-pancreatitis kuvidiyo kule ndatshana.
