Ukusetshenziswa kwama-protease inhibitors ekwelapheni ama-pancreas

Nge-pancreatitis, kusebenze ama-proteinases kuholela ekulimazeni kwesitho nokukhula kwezindawo ze-necrotic.

Ukuvimbela izinqubo ezinjalo ze-pathological, uchwepheshe unquma i-Contrical, Trasilol, Gordoks noma i-Antagozan. Ukusetshenziswa kwalezi zidakamizwa ukuphathwa kwe-intravenous kubalulekile ngosuku lokuqala lwe-pancreatitis e-acute.

Izinhlobo ze-Pancreatic Enzymes

Umsebenzi oyinhloko wama-pancreas ukwenza imisebenzi ye-endocrine (yangaphakathi) ne-exocrine (yangaphandle). Umsebenzi we-Endocrine uqukethe ukukhiqizwa kwama-hormone - i-insulin, esehlisa ushukela, ne-glucagon, okunomthelela ekubekweni phansi koshukela esibindini.

Umsebenzi we-pocrreas ukukhiqizwa kwama-enzymes akhethekile (ama-enzymes) wokugaya ukudla. Kufanele zihlukaniswe ngamaqembu amaningana - ama-enzyme e-lipolytic, ama-amylolytic nama-protein. Ake sibheke ngemininingwane eminingi ingxenye ngayinye.

Ama-enzyme e-Lipolytic. Leli qembu linecala lokwephulwa kwamafutha kuma-fatty acid kanye ne-glycerol. I-Prolipase iyi-enzyme engasebenzi ye-lipase yokuthi, lapho ingena kwi-duodenum, ihlangana ne-colipase.

Ukwenza kusebenze i-Lipase kwenzeka ngenani elanele losawoti we-bile ne-trypsin. Ukwephulwa kwezakhi ze-lipolytic kwenziwa emahoreni angama-7-14. Ama-Renal glomeruli anesibopho sokuhlunga kwawo: akhuthaza ukumuncwa kwe-lipase esakhiweni sezicubu, ngakho-ke izinhlayiya zezingxenye ze-lipolytic azitholakali kumchamo. Izinto ezifana ne-lipase nazo zikhiqizwa isibindi, amaphaphu namathumbu.

Ama-enzyme e-Amylolytic. Kunezinhlobo eziningi - i-alpha, i-beta ne-gamma amylase. Leli qembu lama-enzyme libizwa nangokuthi isitashi. Ngenqubo yokugaya, i-alpha-amylase kuphela ebandakanyekayo.

Kukhiqizwa futhi ngamanani amancane yizindlala zamathe, ikakhulukazi lapho kuhlafunwa ukudla. Ngakho-ke, sizwa ukunambitheka okumnandi ngenkathi kuthungatha ukudla okuqukethe isitashi - ilayisi noma amazambane abunjiwe. Ngenxa ye-amylase, inqubo yokutholwa kwesitashi namanye ama-carbohydrate ayinkimbinkimbi iba lula.

Ama-enzyme ama-Proteolytic. Umsebenzi oyisihluthulelo waleli qembu ukuqhekeka kwamaprotheni. Ama-enzyme ama-Proteolytic aba nomthelela ekuqhekekeni kwama-amino acid abophayo aqukethe kuma-peptides namaprotheni. Kunezinhlobo ezimbili ezihlukile ze-proteinase ku-pancreatic juice:

1. I-Peptidase, noma i-exopeptidase, ebhekele i-hydrolysis yamakhemikhali angaphandle ama-peptides.
2. I-Proteinase, noma i-endopeptidase, ephula imithambo yangaphakathi yama-peptides.

Ngakho-ke, i-lipase, i-amylase ne-proteinase yakha ujusi we-pancreatic, okuthi, lapho ungena ngaphakathi kwe-duodenum, uphule ama-molecule wokudla abe yinkimbinkimbi elula.

Izimbangela nezimpawu ze-pancreatitis

Kumuntu ophile kahle, ukusebenza kwe-enzymes ze-pancreatic kwenzeka kwi-duodenum.

Uma ukusebenza kwe-amylase, i-proteinase ne-lipase kuqala kumanyikwe uqobo, singakhuluma ngokwehluleka kwesitho.

I-pancreatitis iqondwa njengeyinkimbinkimbi yama-syndromes nezifo ezihambisana nokwenza kusebenze kwama-enzyme egazini, okuholela enqubweni “yokuzigaya”. Ngenxa yalokho, abangeni kwi-duodenum, futhi ukugaya kuyaphazamiseka.

Kunezizathu eziningi eziholela kwinqubo enjalo ye-pathological:

• ukuphuza njalo
• ukwehluleka ukulandela ukudla okulinganiselayo;
• ukusetshenziswa ngokweqile kokudla okuthosiwe nokunamafutha;
• ukudla ukudla okunomsoco kakhulu ngemuva kokudla okuqinile noma ukuzila ukudla;
• ukudla okungalawulwa kwemithi ethile;
• ukulimala kwesistimu yokugaya;
• i-pathology yesimo esithathelwanayo.

Ngokusebenza kwama-enzymes kuma-pancreas, ukuvuvukala kwenzeka: kuyanda ngosayizi, bese kuvela izindawo ze-necrotic. Inqubo enjalo ayinakuba yi-asymptomatic, ngaphezu kwalokho, kukhona ukuphulwa kwepheshana lesisu.

Ngokushoda kwama-enzymes we-pancreatic ku-duodenum kanye nokuvuvukala kwamanyikwe, kuboniswa izimpawu ezilandelayo:

1. Ubuhlungu ku-hypochondrium yesobunxele, imvamisa yesimo se-shingles.
2. Ukwehliswa okuphawulekayo kokukhubazeka, i-malaise ejwayelekile nobuthakathaka
3. I-dyspeptic disorder - ukuqhakaza, isicanucanu noma ukugabha, ukuntuleka kwesifiso sokudla, ukuthambisa okhubazekile.

Izimpawu zesifo zingahluka ngokuya ngokuntuleka kwe-enzyme ethile:

• Ukushoda kwe-Amylase kuholela kuhudo, ukusweleka kwamavithamini, ukulahleka kwesisindo okubukhali. Amangqamuzana aba uketshezi, izinhlayiya zokudla ezingatholakali zitholakala kuwo.
• Inani elinganele le-lipase elibhidliza amafutha libangela i-steatorrhea - ukukhuphuka kwenani lamafutha esihlalweni. Ngama-pancreatitis, ukunyakaza kwamathumbu kuba ophuzi noma owolintshi, ukuhlanganiswa kwe-mucus kuyabonakala kubo.
• Ngokushoda kwe-proteinase, kutholakala imicu yamaprotheni engagundisiwe ezithombeni. Isimpawu esibonakalayo ukuthuthukiswa kwe-anemia.

Uma umuntu ezibona izimpawu ezinjalo, kufanele afune usizo lwezokwelapha ngokushesha okukhulu. Udokotela uzonikeza isigaba sokuhlolwa nokwelashwa okwanele.

Natural Pancreatic Enzyme Inhibitors

Umzimba ukhiqiza hhayi kuphela izinto ze-enzymatic ezinegalelo ekuwohlokeni kwamangqamuzana ayinkimbinkimbi, kodwa futhi nezivikeli zokuqhekeka kwepancreatic, i.e. izakhi ezivimba ukukhiqizwa ngokweqile kwejusi le-pancreatic.

Ama-enzyme blockers afaka i-pancreatic polypeptide (PPP), i-YY peptide, somatostatin, i-pancreatic glucagon, i-pancreastatin ne-neuropeptides.

Iziqhingi zaseLangerhans, ikakhulukazi ezitholakala emsileni we-pancreas, zikhiqiza i-hormone ekhethekile, i-PPP, evimbela ukukhiqizwa kwamanzi okuyi-pancreatic, ama-enzyme nama-bicarbonates. Iphinde ivimbele ukukhiqizwa kwe-acetylcholine.

Ukuqashwa kwe-PPP kuyanda ezimweni ezinjalo:

1. ngokudla okungqondo noma ukudla ukudla;
2. ngemuva kokuthokozelwa kwethambo lobufazi;
3. nge-acidization ye-duodenum;
4. lapho kuvezwa i-gastrin kanye ne-gastrin-pulling peptide;
5. lapho udalulwa i-secretin, cholecystokinin ne-VIP.

I-distal ileum nekholoni kukhipha i-YY peptide ngokushesha nje kwamafutha angena emgodini wokugaya ukudla. Le peptide isiza ekunciphiseni ukuthambeka kwendlala emiphumeleni ye-cholecystokinin neye-secinin.

Amaseli we-pancreatic D nolwelwesi lwe-mucous lomgudu wokugaya ukudla kukhiqiza i-somatostatin. Le hormone ivimbela ukwenziwa kwama-enzyme nama-bicarbonates. Uhlelo lwezinzwa lwe-autonomic luba nengxenye ekwenziweni kwe-somatostatin, lapho nje amafutha nama-amino acid evela ekudleni.

Amanye ama-inhibitors e-pancreatic amelelwa ngama-hormone anjalo:

• I-pancreatic glucagon, emisa ukukhiqizwa koketshezi, ama-bicarbonates nama-enzyme.
• I-Pancreatin, evimbela ukukhishwa kwe-acetylcholine. Ikhiqizwa emaphethelweni we-vagus nerve.
• I-Neuropeptides, equkethe i-calcitonin-information peptide (ivuselela somatostatin) ne-enkephalins (inciphisa ukukhiqizwa kwe-acetylcholine).

Ngezinqubo ezonakalisayo e-gland, ukukhululeka kwe-pancreatic enzyme inhibitors kungaphazamiseka, ngakho-ke, kumele kuthathwe imithi.

Izimiso zokwelashwa kwe-pancreatitis

Izakhi ezimbili ezibalulekile zokwelashwa okusebenzayo kwalesi sifo ukudla nokudla. Uhlobo lokwelashwa luthuthukiswa ngokuhlukile ngokuya ngobunzima besifo kanye nomonakalo wamanyikwe.

Ukudla okuyisipesheli kwe-pancreatitis kususelwa kwinombolo yokudla 5 ngokwe-Pevzner. Iqeda ukusetshenziswa ngokweqile kwe-carbohydrate nokudla okunamafutha, futhi ihlose nokudla ukudla kwamaprotheni.

Ngokuqala kwe-pancreatitis engapheli, kunqunywa izinsuku ezingama-3-4 zokuzila ukudla. Ngalesi sikhathi, kufanele wenqabe ngokuphelele ukudla nokuphuza amanzi afudumele we-alkaline, ngokwesibonelo, iBorjomi.

Ngemuva kokubulawa yindlala nge-pancreatitis, ukudla okusindayo kwethulwa ekudleni okungeke umthwalo umthwalo wokugaya ukudla. Iziguli ezine-pancreatitis zivunyelwe ukusebenzisa:

• izinhlobo zokudla zenyama nezinhlanzi;
• isobho lemifino kanye nomhluzi owazondayo;
• isinkwa izolo namabhisikidi;
• imikhiqizo yobisi yesikhumba;
• izithelo ezintsha, amakhambi nemifino;
• okusanhlamvu okuphekwe emanzini noma ngobisi lwe-skim;
• amaqanda ngamanani angenamkhawulo;
• umhluzi we-rosehip, uju noma ujamu (umkhawulo).

Ngokuvuvukala kwamanyikwe, kubalulekile ukwenqaba ukudla okuqinisa inqubo yokugaya ukudla:

1. Imikhiqizo ye-chocolate, namakhekhe, amakhukhi.
2. Isinkwa esisha.
3. Ukudla okuthosiwe.
4. Ukulondolozwa, ukubhema inyama nokhukhamba.
5. Inyama enamafutha nenhlanzi.
6. Imikhiqizo yobisi enamafutha.
7. Iziphuzo ze-Carbonated.
8. Izinongo.
9. Umhluzi ocebile.
10. Kunamaqanda amaningi.
11. Itiye elinamandla nekhofi.
12. Amasoseji.
13. Izimbali namatamatisi.

Ngokukhuphuka kwe-pancreatitis engapheli, kubalulekile ukunamathela ekuphumuleni kombhede.

Imithi yokwelashwa kwamanyikwe ibandakanya ukusetshenziswa kwe:

• ama-enzyme inhibitors ukunciphisa ukusebenza kwe-pancreatic proteinases (proteinases);
• ama-antibacterial agents ukugwema izinqubo zokuvuvukala zesisu sesisu, ukuvuvukala okuhlanzekile kwe-omsa bursa, ukuthuthukiswa kwe-pancreatic necrosis kanye nokubola kwe-cellulitis cellulose yesikhala ngemuva kwe-peritoneum;
• Ama-H2 blockers ukunciphisa ukukhiqizwa kwe-hydrochloric acid;
• ama-antacid ukwenza i-hydrochloric acid ibe sethangeni;
• ama-antispasmodics wokukhishwa kwemisipha ebushelelezi ehambisana nomsebenzi we-sphincter ongasebenzi kahle ku-pancreatic duct;
• izidakamizwa ze-anticholinergic ukuvimba izinqubo ezingezinhle ku-ganglia kanye ne-cortex ye-cerebral;

Ngaphezu kwalokho, ama-enzymatic agents asetshenziselwa ukwenza ngcono inqubo yokugaya ukudla kanye nokuqeda ukuphazamiseka kwe-dyspeptic.

Imithi ephumelelayo

Ngosuku lokuqala lokwanda kwefomu elingamahlalakhona, ukusetshenziswa kwama-proteinase inhibitors ekwelapheni i-pancreatitis kufanelekile. Le mishanguzo iqeda imbangela yokubonakala kwe-infurrate yokuvuvukala nokusakazwa kwezindawo ze-necrotic.

Imithi itholakala kwi-pulmonary parenchyma namanyikwe ezinkomeni.

Ngezansi kunezidakamizwa ezisebenza kahle kakhulu, umthamo wazo unqunywa ngudokotela oholayo. Azitholakali ngesimo samathebhulethi, kepha ngesimo sokugxilisisa noma i-lyophilisate sokufakwa.

Ukwelashwa kwe-pancreatitis ene-inhibitors enokuphathwa kwe-intravenous kwenziwa kuphela endaweni yesikhundla. Ngaphezu kwalokho, umhlengikazi nodokotela kufanele basibhekele ngokucophelela isimo sesiguli. Ukudla No. 5 kufanele futhi kubhekwe ngokuqinile, okuthi, kuhlangene nokwelashwa kwezidakamizwa, okuzoqinisekisa ukululama okuphumelelayo kwesiguli ngaphandle kwezinkinga.

Ungayiphatha kanjani i-pancreatitis ezochazwa ngochwepheshe kule vidiyo ekulesi sihloko.