Umuthi obizwa ngokuthi yiGalvus wahlangana wenzelwa ukwelashwa kanye nokukhululeka kwezimpawu zesifo sikashukela sefomu elizimele le-insulin. Umuthi wanamuhla ususungule inani elikhulu lezidakamizwa ezahlukahlukene zamaqembu nezigaba ezahlukene.
Yiziphi izidakamizwa okufanele uzisebenzise nokuthi yini engcono ezigulini ezinalesi sifo ukuze zivimbele i-pathology futhi zenze imiphumela engemihle inqunywe ngudokotela oholayo ohola isifo sesiguli.
Umuthi wanamuhla usebenzisa amaqembu ahlukahlukene emithi ukuguqula amazinga kashukela futhi alondoloze izinqubo ze-metabolic emzimbeni.
Noma yimuphi umuthi kufanele unikezwe uchwepheshe wezokwelapha.
Kulokhu, ukuzelapha noma ushintsho kumuthi, umthamo wawo uvunyelwe ngokuphelele, ngoba ungadala imiphumela emibi.
Lapho ulwa nokuthuthukisa i-pathology, kufanele kukhunjulwe ukuthi ukuphuza imithi kufanele kuhambisane nokuqapha njalo kwamazinga kashukela wegazi.
Kuze kube manje, ukwelashwa kohlobo lwesifo sikashukela sohlobo 2 kungukusetshenziswa kwamaqembu alandelayo amadivayisi wezokwelapha:
- Izidakamizwa ezitholakala sulfonylurea. Umphumela we-pharmacological ukukhuthaza ukucasulwa kwe-insulin ye-insulin. I-Ammonyl ne-Diabeteson ezinye zezidakamizwa ezenziwe ngesisekelo se-sulfonylurea.
- Imikhiqizo yezokwelapha eqenjini le-Biguanide. Umphumela wazo uhlose ukunciphisa isidingo soku secretion se-insulin. Abamele abaphambili bemithi yalesi okusanhlamvu konke kungamalungiselelo nge-metformin hydrochloride (i-Glucofage) esemqoka esetshenziswayo.
- Imithi etholakala ku-thiazolidinol isiza ukwehlisa ushukela wegazi futhi ibe nomphumela omuhle ekuvumelaneni kwephrofayili ye-lipid. Izidakamizwa ezinje ezenzweni zazo zamakhemikhali ziyafana nama-Biguanides.
- I-Meglitinides ifaka isandla ekukhuphuleni i-insulin ngokwanda koshukela wegazi. Inzuzo enkulu yezidakamizwa ezinjengalezi ukuthi zikuvumela ukuthi wenze ushukela ojwayelekile abe noshukela ongathandeki.
- I-alfa glucosidase inhibitors. Umphumela omkhulu wemithi enjalo ihloselwe ukuvimbela ukumuncwa koshukela okuyinkimbinkimbi, njengomphumela wokuthi ushukela ungena egazini ngamanani amancane kakhulu.
- Ama -retretins.
- Imikhiqizo yezokwelapha ehlanganisiwe, efaka izakhi ezimbalwa eziphambili ezivela emaqenjini angenhla.
Umuthi okhethe ukwelashwa kufanele uphuzwe ngemithamo ekhonjiswe udokotela ohambelayo.
Ngaphezu kwalokho, isimo sesiguli, izinga lomsebenzi womzimba, kanye nesisindo somzimba kufanele kubhekwe.
Uyini umuthi we-hypoglycemic?
Umuthi okwenziwa nguGalvus wahlangana nomuthi we-hypoglycemic wokuphathwa ngomlomo. Izakhi eziphambili ezisebenzayo zomuthi yizinto ezimbili - i-vildagliptin ne-metformin hydrochloride
I-Vildagliptin imele isigaba sezinto ezishukumisayo zesisetshenziswa se-pancreas. Ingxenye isiza ukukhulisa ukuzwela kwamaseli we-beta ekungeneni ushukela omningi njengoba ayonakele. Kumele kuqashelwe ukuthi lapho into enjalo ithathwa ngumuntu onempilo, akukho shintsho ezingeni likashukela wegazi.
I-Metformin hydrochloride imele iqembu lesizukulwane sesithathu, elinomthelela ekuvinjelweni kwe-gluconeogeneis. Ukusetshenziswa kwezidakamizwa okusekwe kuzo kuvuselela i-glycolysis, okuholela ekuphuculeni kangcono ushukela ngamangqamuzana nezicubu zomzimba. Ngaphezu kwalokho kunokwehla kokufakwa kweglue amaseli wamathumbu. Inzuzo enkulu ye-metformin ukuthi akubangeli ukwehla okukhulu kwamazinga kashukela (ngaphansi kwamazinga ajwayelekile) futhi akuholeli ekuthuthukisweni kwe-hypoglycemia.
Ngaphezu kwalokho, ukwakheka kweGalvus kwahlangana kufaka phakathi okutholwayo okuhlukahlukene. Amathebhulethi anjalo avame ukubekelwa iziguli ezinesifo sikashukela i-mellitus, ngoba zithinta kahle i-lipid metabolism emzimbeni, futhi futhi zisize ukwehlisa inani le-cholesterol embi (ukukhuphula izinga lokuhle), i-triglycerides kanye ne-low density lipoproteins.
Umuthi unezinkomba ezilandelayo ezisetshenziswayo:
- njengendlela yokwelapha monotherapeutic yohlobo lwe-2 yesifo sikashukela, kuyilapho kudingeka ukuthi kudliwe ukudla okuphephile nokuzivocavoca okulinganiselayo,
- ukufaka ezinye izithako ezisebenzayo zeGalvus Met
- uma ukwelashwa kungasebenzi ngemuva kokudla izidakamizwa ngento eyodwa esebenzayo - i-metformin noma i-vildagliptin,
- ekwelashweni okuyinkimbinkimbi nge-insulin therapy noma kwe-sulfonylurea.
UGalvus wahlangana nemiyalo esetshenzisiwe ekhombisa ukuthi umuthi udonswa usushunqisiwe wesibeletho esincane ungene egazini. Ngakho-ke, umphumela wamathebulethi ubonwa kungakapheli isigamu sehora ngemuva kokuphathwa kwabo.
Umuthi osebenzayo usatshalaliswa ngokulinganayo kuwo wonke umzimba, emva kwalokho ukhishwe kanye nomchamo nendle.
Ingabe kunezinhlobo zama-ejenti we-hypoglycemic?
Kuze kube manje, imakethe yezokwelapha ifaka leyo mithi, uGalvus noGalvus bahlangana. Umehluko omkhulu weGalvusmet ukuthi ngokushesha iqukethe izingxenye ezimbili ezisebenzayo - i-metformin ne-vildagliptin.
Umkhiqizi wezidakamizwa zethebhulethi yinkampani yemithi yaseJalimane iNovartis Pharma Production GmbH. Ngaphezu kwalokho, emakhemisi ungathola imikhiqizo efanayo eyenziwe eSwitzerland.
Umuthi utholakala kuphela kwifomu lethebhulethi.
Ukuchazwa kwesidakamizwa emiyalweni esemthethweni kusho ukuthi i-INN Galvus yi-vildagliptin, INN Galvus yahlangana ne-vildagliptin metformin.
Ngaphambi kokuthatha u-Galvus wahlangana, kufanelekile ukunaka imithamo ekhona yalowo muthi:
- UGalvus wahlangana nethebhulethi engu-50 500 ebhalwe ngamacwecwe
- Ithebhulethi elibhalwe ngeGalvus Met 50 850
- UGalvus wahlangana namatafula angama-50 1000 egobolondweni.
Ngakho-ke, idijithi yokuqala ibonisa inani lamamayela wamamgmenti wengxenye esebenzayo ye-vildagliptin, elesibili libonisa izinga le-metformin hydrochloride.
Ngokuya ngokwakhiwa kwamatafula kanye nomthamo wawo, intengo yalo muthi isethiwe. Izindleko ezijwayelekile zeGalvus meth 50 mg / 500 mg cishe ziyi-ruble eziyinkulungwane nengxenye zamathebulethi angamashumi amathathu. Ngaphezu kwalokho, ungathenga isidakamizwa nezicucu ezingama-60 iphakethe ngalinye.
Imiyalo yokusebenzisa amaphilisi
Ukusetshenziswa nomuthi wesidakamizwa kufanele kwenziwe ngudokotela ohambelayo. Uchwepheshe wezokwelapha kuphela ozokwazi ukukhetha kahle umthamo womuthi we-hypoglycemic, ngokuya ngesimo se-pathology.
Lapho uthatha umuthi, udinga ukunaka inhlala-kahle futhi ubheke njalo amazinga kashukela egazini. Umthamo okhethwe kahle, njengomthetho, awunamphumela omubi emzimbeni wesiguli.
Ukusetshenziswa kwesidakamizwa kwenzeka ngomlomo, ngaphandle kokuhlafuna, kepha ngenani elikhulu loketshezi.
Ukuqeda ubungozi bokusabela okungekuhle, kunconywa ukuthi uthathe amaphilisi ngesikhathi sokudla. Kukangaki ngosuku lapho kudingeka khona ukuthatha i-hypoglycemic ejenti kunqunywa ngokuhlukile kwesiguli ngasinye.
Imiyalo yezokwelashwa maqondana nokwamukelwa imi kanje:
- Ukuqala kwenkambo yokwelapha kufanele kwenzeke kusetshenziswa umthamo omncane we-metformin hydrochloride. Kungakho kunconywa ukuthi uthathe umuthi uGalvus wahlangana no-50/500. Ngaphezu kwalokho, uchwepheshe wezokwelapha wenza isinqumo ngesidingo sokushintsha imithamo ethathiwe (phezulu).
- Ukushintshwa kwalesi sidakamizwa nokukhethwa komthamo kwenziwa ngesisekelo sezidakamizwa ezisetshenziswa ngaphambili ze-hypoglycemic.
- Ezigulini esezikhulile, umthamo womuthi ungancishiswa uma kukhona umsebenzi olulazayo.
Inkambo yokwelapha yokwelashwa kufanele ihambisane nokuqapha okuvamile elabhorethri yamazinga kashukela.
Contraindication nokusetshenziswa kwama-hypoglycemic agents
Njenganoma yikuphi ukulungiswa kwezokwelapha, u-Galvus uhlangane has a contraindication and decrease in use of use.
Umbuzo wokusetshenziswa kwesidakamizwa kufanele unqunywe kuphela kudokotela ohambelayo.
Kwenqatshelwe ukusebenzisa i-ejog ye-hypoglycemic ezimweni lapho kuboniswa khona izimo ezikhethekile ze-pathological noma zomzimba.
Contraindication ifaka okulandelayo:
- Izici zomuntu ngamunye zesiguli ngendlela yokungabekezeleleki karolong eyodwa noma eziningi zomuthi,
- ngokwakhiwa kwefomu elincike kushukela,
- ngaphambi nangemuva kokungenelela kokuhlinzwa, ukuhlolwa kokuxilonga kusetshenziswa amasu athile wesimanje,
- uma kukhona ukwephulwa kwezinqubo ze-metabolic emzimbeni ngendlela ye-acetonemia,
- ngesikhathi sokuphelelwa ngamandla komzimba, ngoba kunengozi yokusebenza kwethambo elingasebenzi kahle,
- ukwehluleka kwezinso okulimazayo noma okungamahlalakhona,
- izifo ezithathelwanayo ngamazinga akhula wentuthuko, isimo somkhuhlane,
- ukwehluleka kwesibindi
- izifo ezahlukahlukene zesibindi, kufaka phakathi i-hepatitis noma i-cirrhosis,
- ukwehluleka kwenhliziyo ngefomu eqinile noma engapheli, ngokuvela kwe-myocardial infarction,
- uma kunezinkinga zokuphefumula okungaholela ekwehlulekeni okunjalo,
- ukudakwa noma isimo sokudakwa komzimba,
- ukunamathela ekudleni okungalinganiseli noma ukubulawa yindlala (inani lamakhokhethi nsuku zonke amukelekile angaphansi kwenkulungwane),
- izingane ezingaphansi kweminyaka eyishumi nesishiyagalombili.
Ngesikhathi sokukhulelwa, kwenqatshelwe ukusebenzisa umuthi onjalo we-hypoglycemic, ngoba akukho lwazi olwanele mayelana nomphumela walo ekukhuleni kwengane. Ngaphezu kwalokho, akufanele uthathe umuthi ngenkathi uncelisa ibele.
Kuze kube manje, izifundo zobudokotela azange zenziwe ukuthola umphumela - ukuthi ngabe izinto ezisebenzayo zomuthi ziyadedelwa kanye nobisi lwebele.
Imiphumela emibi nemiphumela emibi engaba khona
Ukuphathwa ngokungafanele kwesidakamizwa se-hypoglycemic kungadala imiphumela emibi ehlukahlukene.
Amathuba wemiphumela emibi kufanele acatshangwe lapho kubalwa umthamo womuthi.
Imiphumela emibi enjalo iqala ukuvela engxenyeni yezitho ezahlukahlukene zangaphakathi kanye nezinhlelo zomzimba.
Okokuqala, umphumela wesidakamizwa ungasabela kabi:
- Amapheshana wesisu.
- Uhlelo lwezinzwa.
- Isibindi.
Ukuphendula okungalungile komzimba, ngokuphendula umuthi, kungenzeka ngesimo:
- Isicanucanu
- Ubuhlungu esiswini,
- ukuvela kwe-gastroesophageal Reflux, lesi simo sizibonakalisa lapho kukhululwa i-gastric acid emgodini ophansi,
- ziyaqhakaza futhi lenyuke flatulence,
- isifo sohudo
- ukuvuvukala kwepancreatic ngesimo se-pancreatitis eyingozi,
- ukwephulwa kokufakwa okujwayelekile kwamavithamini we-B,
- ukuvela kokunambitheka kwensimbi emgodini womlomo,
- ikhanda elibuhlungu noma isiyezi,
- ukubonakaliswa kokuqhaqhazela emilenzeni ephezulu,
- izinqubo zokuvuvukala esibindini eziphazamisa ukusebenza kwawo okujwayelekile,
- Ubuhlungu emalungeni nasemisipha
- ukuvuvukala kwesikhumba, ukubonakala kwamaqhubu phezu kwabo,
- ukukhuphuka kwenani le-uric acid, okungaholela ekwakhiweni kwe-lactic acidosis,
- imiphumela yokungezwani komzimba ehlukahlukene.
Uma isiguli sithatha umuthi ngemithamo ephakeme, isicanucanu, ukugabha, izinhlungu ezinzima emisipha, ukuqaqamba komzimba, noma ukwehla kwezinga likashukela ngaphansi kwamazinga amukelekile.
Uma kunesidingo, udokotela ohambelayo angancoma ukubuyisela lesi sidakamizwa ngemithi ye-analog (eshibhile noma ebiza kakhulu).
Ukuthatha umuthi onjalo, kufanele kubhekwe izici ezilandelayo:
- Amatafula ayenqatshelwe ukusebenzisa ngenkathi uphuza utshwala.
- Okungenani kanye njalo emavikini ambalwa, kwenziwa ucwaningo lokuxilonga ukuze kutholakale ukusebenza okuvamile kwesibindi nezinso.
- Imiphumela ehlukahlukene yesidakamizwa nezidakamizwa kwamanye amaqembu nezigaba ingaphawulwa. Kungakho udokotela ohambelayo kufanele aqaphele ukuthatha noma imuphi umuthi ukuze agweme ukubonakaliswa kwemiphumela emibi evela ekusebenzeni kwabo okuyinkimbinkimbi.
- Akunconyelwe ukwenza imisebenzi ehlukahlukene edinga ukunakwa okwengeziwe.
Ngaphezu kwalokho, ukusetshenziswa isikhathi eside kwalo muthi kungaholela ekuphazamisweni kwe-metabolic ohlelweni lwezinzwa. Ngenxa yalokho, i-anemia noma i-neuropathy ingakhula.
Yini ukubuyekezwa kwabathengi nochwepheshe bezokwelapha okufakazayo?
Mayelana nezidakamizwa i-Galvus ihlangane nazo. Njengomthetho, ezinhlangothini ezingezinhle zomuthi, abathengi babekela inani eliphakeme kakhulu lomuthi. Ngokuvamile, ukuhlanganiswa kwamatafula anomthamo omncane we-metformin kuyahlukahluka esifundeni sama-ruble ayinkulungwane nesigamu.
Kumele kwaziwe ukuthi iningi leziguli alinazikhalazo ngekhwalithi nokusebenza kahle komkhiqizo. Ngokombono wabo, umuthi uqala ukwenza ngokushesha futhi ulethe umphumela omuhle. Ngaphezu kwalokho, phakathi kwezici ezinhle zamaphilisi anjalo iqiniso lokuthi abanesifo sikashukela bangakwazi ukudla amaqembu athile wemikhiqizo ohlwini lwabenqatshelwe.
Ngokusho kodokotela, izindleko eziphakeme zomuthi ziyazithethelela. Ngaphezu kwalokho, iMetformin iyodwa (njengelungiselelo lethebhulethi) ayishibhile, futhi inani elikhulu lezimali liyadingeka ukukhiqizwa kanye nokwakheka kwe-vildaglipin.
Ochwepheshe bezokwelapha, ngokususelwa ekusebenzeni okuphezulu komuthi, babona ukuthi isilinganiso sekhwalithi yenani sisebangeni elijwayelekile. Ukuthatha umuthi kuhambisana nokuzinza kwamazinga kashukela, ukujwayelekile kwesisindo ngokweqile kanye nentuthuko ejwayelekile enhlalakahleni yesiguli.
Izidakamizwa ze-Hypoglycemic zichazwe kule vidiyo kule ndatshana.
