Imishanguzo eqenjini le-Biguanide isetshenziselwe ukwelashwa kwesifo sikashukela isikhathi eside - kusukela ngawo-1970. Omunye wabo umuthi uSiofor 500.
Enye yezinzuzo eziphambili ze-Biguanides iqiniso lokuthi azibangeli ukukhiqizwa okwengeziwe kwe-insulin ngamanyikwe. Umphumela wabo oyinhloko kungenxa yokuvinjwa kwe-gluconeogeneis.
Wonke ama-biguanides, kufaka phakathi uSiofor (isithombe), anento eyodwa esebenzayo - i-metformin hydrochloride, isici esiyingqayizivele sayo ukungabikho kwe-hypoglycemia. Kungumthelela omubi onjalo okhona emalungiselelo wokuphuma kwe-sulfonylurea.
Ungayithatha kanjani iSiofor 500 enesifo sikashukela futhi singasetshenziswa yini ukunciphisa isisindo?
Yini insiza yezokwelapha?
Ukwelashwa kwesifo sikashukela kuvame ukuqukethe ukwelashwa okuyinkimbinkimbi, okuthi nakanjani kuqukethe ukuthatha umuthi.
Umuthi uSiofor unqunywe njengomunye wezidakamizwa ezisebenzayo ezokwehlisa ushukela.
Isithako esikhulu esisebenzayo samathebhulethi yi-Into metformin hydrochloride, engagcini nje ngokuba nomphumela we-hypoglycemic, kodwa futhi nezinzuzo eziningi ezingenakuphikwa.
Izinkomba eziphambili zokusebenzisa umuthi:
- ngokwakhiwa kwe-mellitus engavikelekile nge-insulin njenge-monotherapy noma njengengxenye yokwelashwa okuyinkimbinkimbi
- sokuncipha kwesisindo kwabanesifo sikashukela uma ukugcinwa kokudla kokudla kungalethi umphumela ofanele
- njengethuluzi elengeziwe lokwelapha i-insulin.
Ukusebenza kahle kokusebenzisa lesi sidakamizwa kutholakala kuphela lapho umzimba uqhubeka nokukhiqiza i-insulin yawo noma i-hormone ihlangene.
Izinzuzo zomuthi yilezi ezilandelayo:
- Umuthi obekiwe uthinta ngqo ukwehla kokumelana ne-insulin. Ngaphezu kwalokho, lo mphumela ubonwa ngemuva kwesikhashana esifushane ngemuva kokuqala kwemithi. Umphumela wale nqubo ukwandisa izinga lokuzwela kwamangqamuzana nezicubu kuyi-hormone, okuholela ekusetshenzisweni okukhulu kweglucose.
- Njengoba ukulungiswa kwethebhulethi kufanele kuthathwe ngomlomo, kudonswa ngaphakathi kwezitho zepheshana emathunjini, okunciphisa ukudonswa kwe-glucose okuhlanganyele emathunjini, ngenxa yalokho kungagxili okubukhali ushukela wegazi. Ukwehla kwe-glucose kwenzeka kancane kancane futhi akuholeli ekwakhiweni kwe-hypoglycemia.
- Ukuvinjwa kwe-gluconeogenesis esibindini kwenzeka.
- Ngenxa yomuthi ophuziwe, ukwehla kwesifiso sokudla kuyabonakala. Ngakho-ke, isiguli siqala ukusebenzisa ukudla okuncane, okudingekayo ukuze sisimamise isisindo somzimba.
- Umphumela omuhle wesidakamizwa esezingeni elibi (encishisiwe) ne-cholesterol enhle. Njengomphumela wale nqubo, kukhona ukwehla kwe-dyslipidemia kanye nezinga le-triglycerides, low density lipoproteins.
Ngaphezu kwalokho, inqubo ye-lipid peroxidation iyacindezelwa, okufaka isandla ekukhuleni kwama-molecule wamahhala angama-radical.
Iziphi izinhlobo zokwenziwa kwethebhulethi ezikhona?
Umuthi uSiofor ukhiqizwa yinkampani yezokwelapha yaseJalimane iBerlin-Chemie AG.
Imiyalo yokusetshenziswa kwamanothi wezidakamizwa ukuthi umuthi unendlela eyodwa yokukhipha - ithebhulethi.
Imboni yezemithi ikwazile ukukhishwa kwalo muthi ezinhlotsheni ezahlukahlukene, ezinomthamo ohlukile wesakhiwo esikhulu esisebenzayo.
Kuze kube manje, imithamo elandelayo yesidakamizwa esinjalo ikhona:
- I-Siofor 500 - amaphilisi ahlanganisiwe aqukethe i-500 mg metformin hydrochloride.
- I-Siofor 850 - isidakamizwa esine-dosage ekhuphukayo. Isithako esisebenzayo ngu-850 mg kwithebhulethi eyodwa.
- I-Siofor 1000 - 1 gram yento esebenzayo iyingxenye yepilisi elilodwa.
Njengoba kusetshenziswa izingxenye ezengeziwe:
- ithebhulethi ngayinye ine-hypromellose, i-povidone, i-magnesium stearateꓼ
- igobolondo liqukethe i-hypromellose, titanium dioxide, macrogol 6000.
Ngokuya ekunciphiseni okudingekayo koshukela wegazi, uchwepheshe ukhetha umthamo wesiguli ngasinye.
Iithebhulethi zithengiswa emakhemisi asemadolobheni emaphaketheni amakhadibhodi wezingcezu eziyi-10, 30, 60 noma ezingama-120. Intengo yesidakamizwa incike kwinani lamathebulethi kanye nomthamo odingekayo. Njengomthetho, wokufakwa kwezingcezu ezingama-60, izindleko ziyahlukahluka kusuka kuma-ruble angama-240 kuya kwangama-300.
Izichasiso zalo muthi yilezo zemithi ezinesakhi esisebenzayo se-metformin - i-Glucofage, iFommetin, neGliformin.
Imiyalo yokusebenzisa amaphilisi
Ungayithatha kanjani iSiofor nokuthi inkambo yokwelashwa izohlala isikhathi esingakanani, uchwepheshe wezokwelapha unquma.
Amacwecwe ayi-Siofor 500 anezinkomba zawo zokusetshenziswa kanye nendlela efanele yokuphatha. Ukuqala kwenkambo yokwelapha yokwelashwa kufanele kube nomthamo omncane womuthi. Njengomthetho, lokhu kuyigremu eyodwa yento esebenzayo (amaphilisi amabili) ngosuku ngesikhathi sokudla main noma ngemuva kwayo.
Umuthi uthathwa ngomlomo, ugezwe ngamanzi amaningi amaminerali. Umthamo wansuku zonke kufanele uhlukaniswe ngemithamo emibili - ekuseni nakusihlwa. Le regimen kufanele ibonwe ngezinsuku ezintathu zokuqala zokwelashwa, emva kwalokho inani lamaphilisi landa.
Njengomthetho, kusukela osukwini lwesine kanye namaviki amabili alandelayo, umuthi uthathwa gramu eyodwa kathathu ngosuku. Ngemuva kwamasonto amabili, udokotela obonayo unquma umthamo odingekayo wokusebenzisa umuthi. Lokhu kungaba ukwehla kwemithi. Umthamo wokwelapha weSiofor uzonqunywa ngokuya ngemiphumela yokuhlolwa kanye nenani le-glucose egazini nomchamo.
Kuthatha isikhathi esingakanani ukuphuza amaphilisi emithanjeni enjalo, udokotela obonayo uyanquma. Njengomthetho, eyodwa noma amabili amagremu ento esebenzayo ngosuku anele ukugcina umphumela oyifunayo.
Uma isiguli ngasikhathi sinye sithatha inkambo yokwelashwa kwe-insulin (okungenani amayunithi angama-40 ngosuku), khona-ke isilinganiso sethamo lika-Siofor 500 sifana nalokhu okungenhla.
Kulokhu, kufanele ubheke ngokucophelela izinga likashukela egazini, kungadingeka ukuthi unciphise inani lemijovo ye-insulin efakiwe.
Kukuziphi izimo lapho kwenqatshelwe ukusebenzisa i-hypoglycemic agent?
Ngaphambi kokusebenzisa umuthi, kufanele ufunde ngokucophelela inani le-contraindication, ungadinga ukuthi ungene esikhundleni salokho.
Ama-analogues okungenzeka abe nokuphendula okuhluke ngokuphelele futhi abe nokubekezelela okujwayelekile.
ISiofor inezinombolo eziningi zemibango, lapho umuthi uvinjelwe.
Imikhawulo main lapho kunconywa kakhulu ukuthi ungasebenzisi iSiofor 500 ifaka:
- ifomu lesifo sikashukela esincike ku-insulin
- uma ngesikhathi sokukhula kwesifo sikashukela sohlobo lwesibili, i-pancreas iyamisa ngokuphelele imfihlo yayo ye-insulin
- ngesikhathi sesimo sekhokho noma isifo sikashukela
- ngokuboniswa kwe-ketoacidosisꓼ
- uma kunokulimazeka okukhulu kokusebenza kwezinso noma kwesibindiꓼ
- nge-myocardial infarction kanye nokwehluleka kwenhliziyoꓼ
- ukuthuthukiswa kwezinqubo ze-pathological emaphashini, okungahle kuholele ekuhlulekeni kokuphefumulaꓼ
- izifo ezithathelwanayo ezinzima ”
- ngaphambi nangemva kokuhlinzwa noma uma kukhona ukulimala kuqubuke
- Catabolic uthi womzimba, lokhu kungafaka izinqubo ezinokubola ezithuthukisiwe, njengasosomathumbu endologiesꓼ
- hypoxia stateꓼ
- ukuncika kotshwala, kufaka phakathi isimo esingamahlalakhona
- isimo se-lactic acidosisꓼ
- ngendlala ende noma ulandela ukudla okungalinganiseli okudla nsuku zonke amakhalori angaphansi kuka-1000
- ezinganeni ezingaphansi kweminyaka eyishumi nesishiyagalombili noma ngemuva kokufinyelela amamayela angamashumi ayisithupha nanhlanu
- uma kunokuzwela okwengeziwe kwento eyodwa noma eziningi eziyingxenye yomuthi.
Ngaphezu kwalokho, njengayo yonke eminye imithi, iSiofor 500 ayenqatshelwa ukuthatha isikhathi sokukhulelwa nangesikhathi sokuncelisa ibele, ngoba umuthi umthelela ongemuhle ukukhula kwengane.
Imiphumela emibi nemiphumela emibi engaba khona
Umuthi ongasebenzi kahle ungadala ukusabela okuhlukahlukene okungekuhle.
Kungakho kunqatshelwe ukuthatha umuthi kubantu abaphilile ukuze wehlise isisindo noma wephule izincomo zikadokotela oholayo.
Imiphumela emibi ingenzeka ngemithi eyeqile yemithi.
Imiphumela emibi yeSiofor 500 ingavela ezinhlelweni ezahlukahlukene zomzimba womuntu. Ukusabela okunjalo okubi kubonakalisa ngesimo se:
- Ukuqhakaza, izinhlungu, izinkinga zokugaya ukudla.
- Isifo sohudo.
- Isicanucanu, ukugabha kungenzeka futhi.
- Ukuncipha kwamazinga kashukela kungaholela ekudidekeni nasekuhlulekeni ukugxila.
- Ubuthakathaka obujwayelekile nokukhubazeka.
- Ukuntuleka kokuxhumana kokunyakaza.
- Ubuhlungu besifo sikashukela obukhulu.
Kuyaqabukela, i-megaloblastic anemia noma ukuthuthukiswa kokuvela komzimba kungenzeka.
Kufanele futhi kuphawulwe ukuthi ukusetshenziswa kanyekanye kweSiofor ngeCimeditin kwandisa ingozi ye-lactic acidosis. Udokotela ohambelayo kufanele aqaphele ukuthi imuphi umuthi odakelwa isiguli ukuze ugweme ukubonakaliswa kwemiphumela emibi evela ekusetshenzisweni okuhlangene.
Sebenzisa umuthi ukuze wenze ngokwejwayelekile isisindo esande ngokweqile
Umuthi usiza ukwehlisa isisindo sikashukela ndawonye nekhambi lokudla elinqunyelwe kanye nokuzivocavoca okulinganiselayo. Ukubuyekezwa okunjalo kuphawulwa abathengi abaningi bomkhiqizo.
Kumele kuqashelwe ukuthi ukusebenza kahle kwalo muthi kungenxa yokuthi kuyasiza ngempela ekulweni nabantu abakhuluphe ngokweqile abasheshe bakhiqize isifo sikashukela esingaxhomekeki ku-insulin. Ngeshwa, ukubuyekezwa okunjalo kuholele ekutheni ngisho nabesifazane abanempilo ngokuphelele abafuna ukuthola umzimba omncane baqala ukuphuza iSiofor 500.
Ngenxa yalokhu, ushukela wegazi labo uyehla, nemiphumela emibi ehlukahlukene nezimpawu ze-hypoglycemia ziqala ukuvela. Kungaleso sizathu, umuntu akufanele anqume ngokuzimela ekwelashweni kokukhuluphala ngaleli nokulungiswa kwethebhulethi.
Uma uSiofor 500 enqunywe udokotela ohambela isiguli esitholakala ukuthi unesifo sikashukela, umphumela omuhle ungadlula konke okulindelwe. Ngokukhuluphala kanye neshukela, umphumela wokunciphisa umzimba ungasukela kumakhilogremu amathathu kuya kwayishumi ngenyanga.
Isenzo sethebhulethi senzeka ngendlela enjalo emzimbeni wokuthi umuntu afise ukudla okumnandi - izinto zokubhaka eziphekiwe, amakhekhe noma amaswidi. Kungakho, ukudla kwansuku zonke kususwa ama-kilocalories angeziwe futhi isisindo siqala ukuncipha.
Izinzuzo eziyinhloko zokusebenzisa umuthi wethebhulethi ekulweni nesisindo ngokweqile ukubonakaliswa kwemiphumela elandelayo:
- okusheshayo, kepha okungenabuhlungu emzimbeni, ukunciphisa umzimba;
- ukwehla kwezinkanuko zokudla okunoshukela nokulimazayo (okunqatshelwe ngokuphelele kushukela);
- asikho isidingo sokulayisha kakhulu umzimba ngokuzikhandla ngokweqile ukuze ulahlekelwe ngamakhilogremu ambalwa, kwanele ukumane uholele indlela yokuphila esebenzayo futhi uhambe ngaphezulu;
- ngokomzwelo sisiza isiguli ukuba siguqukele ekudleni okufanele nasekudla okunempilo.
Lokhu okulandelayo kungabhekwa njengezinyathelo zokuthatha isidakamizwa:
- Kuyadingeka ukuqala inkambo yokwelashwa ngokunconywa kukadokotela oholayo nangaphansi kokulawulwa kwakhe.
- Kufanele kukhunjulwe ukuthi umuthi unomphumela wehlisela ushukela futhi uhloselwe abanesifo sikashukela.
- Qaphela okubonakaliswa kokusabela okungekuhle kusuka ezinhlakeni ezihlukene zomzimba. Kungakho-ke, umuthi kufanele uphuzwe kuphela kwimithamo enqunywe ngudokotela wezempiloꓼ
Ukuzilawula ngomuthi nokukhethwa komthamo lapho uthatha umuthi kungaholela emiphumeleni emibi nasekungasebenzi kahle kwezitho zangaphakathi.
Ungayisebenzisa kanjani iSiofor yabanesifo sikashukela izotshelwa uchwepheshe kule vidiyo ekulesi sihloko.
