I-Metformin Canon ingelinye lama-ejenti adumile wesifo sokudambisa izifo aqukethe isakhi se-metformin hydrochloride. Umuthi ufakwa eqenjini lama-Biguanides wesizukulwane sesithathu.
Ukusetshenziswa kwayo kuyeluleka uma kwenzeka kungalawulwa kahle i-glycemia isebenzisa umsoco ofanele nokwelashwa kokuzivocavoca. Ikakhulu, umuthi usiza iziguli ezikhuluphele.
Kumele kukhunjulwe ukuthi umuthi ngamunye unezimpawu ezithile futhi ungaba nomthelela omubi emzimbeni. Ngakho-ke, ngaphambi kokusebenzisa noma yisiphi isidakamizwa, udinga ukubonana nochwepheshe futhi ufunde ngokucophelela imiyalo enamathiselwe.
Le ndatshana izosiza ukuthola izici zokusetshenziswa kweMetformin Canon, kanye nezifaniso zayo, imibono yabachwepheshe neziguli.
Izici ezijwayelekile zomuthi
Ukwakheka kwe-ejenti ye-antidiabetesic Metformin Canon kufaka i-metformin hydrochloride, into eyaziwayo emhlabeni enganciphisa amazinga kashukela kwabashukela.
Ngaphezu kwale ngxenye, ukulungiswa kuqukethe inani elincane le-sodium stearyl fumarate, isitashi, titanium dioxide, talc, macrogol nezinye izinto.
Umenzi we-ejog ye-hypoglycemic yinkampani yasekhaya ekhemisi iCanonfarm Production.
Le nkampani ikhiqiza umuthi ngohlobo lwezibhebhe (ezimhlophe, ze-biconvex) kumithamo ehlukahlukene:
- Metformin Canon 500 mg.
- Metformin Canon 850 mg.
- Metformin Canon 1000 mg.
Umuthi uvunyelwe ukuthathwa kusukela eminyakeni eyi-10, hhayi njenge-monotherapy kuphela, kepha futhi nokuhlanganiswa nemijovo ye-insulin. Lapho igxotshwa, i-metformin igxilwa emgodini wokugaya ukudla, futhi ukugxilwa kwayo okuphezulu kakhulu kutholakala cishe amahora angama-2-2,5 ngemuva kokungenwa. Isenzo se-hypoglycemic siqondiswa:
- ukuvimbela ukwakheka kwe-glucose kusuka kumakhemikhali anga-carbohydrate esibindini;
- ukwehlisa ukumuncwa kwe-glucose emgodini wokugaya ukudla;
- ukukhulisa ukuthikamezeka kwezicubu eziqondiwe kuma-hormone anciphisa ushukela;
- ukususa ushukela kusuka izicubu;
- ukukhuthaza i-grcoellis ye-intracellular;
- kusebenze kwe-glycogen synthase;
- ukuzinzisa i-lipid metabolism.
Ngaphezu kwalokho, umuthi unomphumela othile we-fibrinolytic. IMetformin Canon iyakwazi ukuqina futhi inciphise isisindo somzimba ngokweqile. Kuhlukile kumalungiselelo wokuphuma kwe-sulfonylurea ngoba akubangeli ukukhiqizwa okwengeziwe kwe-insulin futhi akuholeli ekwehleni ngokushesha kweshukela kubantu abanempilo.
Ingxenye esebenzayo isakazeka ngokushesha ngokwanele kwezicubu. Ingaqongelela esibindini, kwizindlala zamathe kanye nezinso.
I-Metformin cishe ayenziwa umzimba, ngakho-ke ichazwa yizinso ngendlela ecishe ingashintshiwe.
Imiyalo yokusebenzisa amaphilisi
Ngisho nangemva kokubonisana nodokotela wakho ngemuva kokuthenga umuthi, imiyalo yokusebenzisa kufanele ifundwe ngokucophelela. Uma unemibuzo nesiguli, kufanele ufune usizo lodokotela.
Amacwecwe anconywe ngokuqinile ukusebenzisa ngesikhathi sokudla noma ngemuva kwawo. Azihlafunwa, kepha zigwinywe ngengilazi yamanzi. Ukuchazwa kwalesi sidakamizwa kusho ukuthi umthamo wokuqala wabantu abadala yi-1000-1500 mg ngosuku. Kulokhu, kuyathandeka ukuhlukanisa umthamo kaningi ngosuku. Lesi sincomo singenxa yokuthi ngesikhathi sokuguqulwa komzimba esenzweni se-metformin, kuvela imiphumela emibi ethile, ehambisana kakhulu nenqubo yokugaya. Umuntu onesifo sikashukela angakhononda ngokuhlanza, isifo sohudo, ushintsho ekunambithekeni, ubuhlungu besisu nokuthopha. Kodwa-ke, ngemuva kwezinsuku eziyi-10-14, lokhu kusabela kuya ngokwabo.
Ngemuva kokuba umzimba usujwayele i-metformin, udokotela angakhuphula umthamo womenzeli we-hypoglycemic ngokususelwa ezingeni likashukela lesiguli. Umthamo wesondlo uthathwa njengowusukela ku-1500 kuya ku-2000 mg ngosuku. Isilinganiso esivumelekile sansuku zonke yi-3000 mg.
Uma isiguli sishintshela kuMetformin Canon namanye ama-antipyretic, kuzofanela siyeke ukuthatha lesi sikhathi. Lapho uhlanganisa umuthi ne-insulin therapy, kunconywa ekuqaleni kokwelashwa ukuthatha i-500 noma i-850 mg kabili kathathu ngosuku. I-Metformin 1000 mg ithathwa kanye ngosuku.
Izingane ezifike eminyakeni eyi-10 zingaqala ukwelashwa nge-500 mg yomuthi. Kungcono ukudla kusihlwa ngesikhathi sokudla. Ngemuva kwezinsuku eziyi-10-14, udokotela angakhulisa umthamo wansuku zonke ukuya ku-1000-1500 mg. Ingane ivunyelwe ukungathathi ngaphezu kwama-2000 mg ngosuku.
Abantu abadala abanesifo sikashukela kufanele banakwe ngokukhethekile. Imithamo kanye nesikhathi sokwelashwa kukhethwe udokotela ngokwahlukana. Ngaphezu kweminyaka engu-60, umuthi we-hypoglycemic ungaholela ekungasebenzi kahle kwezinso.
Kufanele kwaziwe ukuthi umkhiqizo awunakuthengwa ngaphandle kokuthola udokotela. Ukufakwa kweMetformin Canon kufanele kugcinwe kude nokukhanya kwelanga kanye nomswakama. Ukushisa kwesitoreji akufanele kudlule ama-25 degrees Celsius.
Ngemuva kosuku lokuphelelwa yisikhathi, okuyiminyaka emi-2, ukusetshenziswa kwezidakamizwa ezingama-antidiabetic akuvunyelwe.
Contraindication kanye nemiphumela emibi
I-Metformin Canon ayikwazi ukusetshenziswa nge-hypersensitivity kwisithako esisebenzayo kanye nabazitholelayo. Ngaphezu kwalokho, ayisetshenziswa ngesikhathi sokubeletha nokuncelisa ibele. Lokhu kuchazwa yiqiniso lokuthi umenzi akazange enze ucwaningo olwanele ukuthola umphumela we-metformin komama abakhulelwe nababambelelayo. Ngakho-ke, lapho uhlela ukukhulelwa, umuthi uyamiswa. Uma kunesidingo, ukusetshenziswa ngesikhathi sokuxhelwa kwenqatshelwe.
Ngokuphathelene nobudala beziguli, kunohlaka oluthile. Njengoba kushiwo ngaphambili, kwenqatshelwe ukuthatha lesi sidakamizwa izingane ezingaphansi kweminyaka eyi-10. Ngokucabanga kusengaphambili, iMetformin Canon kufanele isetshenziselwe iziguli ezineminyaka engaphezu kwengama-60, ikakhulukazi labo abasebenza kanzima.
Umyalo onamathiselwe ufaka ama-pathologies amaningi nezimo lapho kusetshenziswa khona umuthi we-hypoglycemic. Lokhu kufaka phakathi:
- Ukuthuthukiswa kwe-lactic acidosis.
- Ubuthi obunobuthi.
- Uphuzo oludakayo
- Ukudla okuphansi kilojoule, lapho bathatha khona ngaphansi kwama-kcal ayi-1000 ngosuku.
- Ukulimala okukhulu nokulimala.
- Ukuhlinzwa
- Ukwehluleka kwangempela
- Ukuthuthukiswa kwe-hypoxia.
- Izifo ezingelapheki futhi ezingalapheki ezingadala i-tishu hypoxia.
- Ukwehla komzimba ngenxa yokuhlanza, isifo sohudo, umkhuhlane, noma ukutheleleka ngamandla.
- Ukungasebenzi kwezinso.
- Ama-pathologies ashubile akhulisa ubungozi bokulimala kwe-renal function.
- Ukuthuthukiswa kwe-coma, i-precoma, noma i-ketoacidosis yesifo sikashukela.
- Ukusetshenziswa kwe-iodine equkethe i-ejenti yokuqhathanisa phakathi kwezifundo ze-radiological noma ze-radioisotope (ezinsukwini ezi-2 ngaphambi nangemva kwalokho).
Phakathi kwemiphumela emibi evame ukwenzeka ngenxa yokungalandeli imithetho yokuphuza imithi, singakwazi ukwahlukanisa:
- ukuphazamiseka kokugaya ukudla (ikakhulukazi okuhambisana nokuguqulwa komzimba ne-metformin);
- Ukuphazamiseka kwe-CNS - ushintsho ekunambithekeni (ukunambitheka kwensimbi emlonyeni);
- ukungasebenzi kwesibindi, ukuthuthukiswa kwe-hepatitis;
- ukusabela kwesikhumba - ubomvu, ukulunywa, ukuqunjelwa, i-erythema (akuvamile);
- i-lactic acidosis;
- ukumuncwa okungafanele i-Vitamin B9;
- ukuntuleka kwe-Vitamin B12.
Ngokweqile komuthi, kuba nesiyezi, kuvela ukuqwashisa, izinhlungu emisipha nasesiswini kwenzeka, izinga lokushisa lomzimba liyancipha, ukugaya, isici se-lactic acidosis, kuyaphazamiseka. Ezimweni ezibucayi, kungenzeka ukuthi ukhubazekile lube khona, lapho isiguli siphuthunyiswa esibhedlela ngokuphuthumayo.
Indlela ephumelela kakhulu yokususa i-lactate eyeqile yi-hemodialysis, futhi ukwelashwa okubonakalayo nakho kuyenziwa.
Okunye ukusebenzisana kwezidakamizwa
Njengoba wazi, ezinye izidakamizwa zingaba nomthelela oqondile esenzweni seMetformin Canon, sinciphise noma sandisa umphumela wazo we-hypoglycemic.
Imiyalo ithi inhlanganisela ebunjiwe ukusetshenziswa kwezinto ezihlukanisayo eziqukethe iodine.
Ngokuphikisana nesizinda sokwehluleka kwezinso ezigulini, kungaholela ekwakhiweni kwe-lactic acidosis. Akukalulekanga futhi ukuthi uhlanganise notshwala, i-loop diuretics namalungiselelo aqukethe i-ethanol ne-metformin.
Ukuqapha ngokukhethekile kuyadingeka ngezidakamizwa ezinganciphisa isenzo se-metformin futhi ziholele ku-hyperglycemia. Lokhu kufaka phakathi:
- UDanazole
- I-Chlorpromazine.
- Ama-antipsychotic.
- I-Glucocortecosteroids.
- Ama-agonist we-Beta2-adrenergic.
Ama-engiotensin-aguqula ama-enzyme inhibitors, imijovo ye-insulin, ama-salicylates, ama-acarbose kanye nokuphuma kwe-sulfonylureas kungandisa umphumela we-hypoglycemic we-metformin.
Kuyadingeka ukuthi unake ukuthi ngenkathi uthatha i-nifedipine ne-metformin, i-hypoglycemia ingahle ibe khona ku-mellitus yesifo sikashukela. Ukuvimbela ukukhula kokuhluleka kwe-renal, kubalulekile ukusebenzisa ama-NSAIDs ngokuqapha.
Kunoma yikuphi, lapho unquma ukusebenzisa noma yiziphi izidakamizwa, okokuqala, kubalulekile ukubonisana nodokotela wakho. Ukufihlwa kwama-pathologies kudokotela kungaholela emiphumeleni engenakuphikwa.
Ukubuyekezwa kwezindleko nezidakamizwa
Isiguli ngasinye sinikezwa ithuba lokuthenga lo muthi ekhemisi noma sigcwalise isicelo sokuthenga ngewebhusayithi esemthethweni yomkhiqizi.
Umthengi ongaba khona akagxili emiphumeleni yokwelapha yesidakamizwa, kodwa futhi nasezindleko zayo. Kufanele kwaziwe ukuthi iMetformin Canon inentengo ephansi.
Ngakho-ke, isiguli ngasinye singakwazi ukuthenga umuthi.
Izindleko zalo zincike ohlotsheni lokukhululwa nenombolo yamathebulethi amaphakethe:
- I-Metformin Canon 500 mg (amaphilisi angama-30) - kusuka kuma-ruble angama-94 kuye kwangama-110;
- I-Metformin Canon 850 mg (amaphilisi angama-30) - ama-radders angama-112 kuya kwayi-116;
- I-Metformin Canon 1000 mg (amaphilisi angama-30) - kusuka kuma-ruble ayi-117 kuye kwangama-165.
Phakathi kodokotela neziguli, ungathola imibono eminingi emihle ngokusetshenziswa kwalo muthi. Ngakho-ke, abanesifo sikashukela baphawula ukuthi iMetformin Canon iqinisa amazinga kashukela ngaphandle kokubangela i-hypoglycemia. Ukubuyekezwa futhi kukhombisa ukwehla kwesisindo kubantu abakhuluphele. Ngakho-ke, phakathi kwezinzuzo zomuthi kungabonakala ukusebenza ngempumelelo, ukukhululeka kokusebenzisa kanye nezindleko eziphansi.
Imiphumela emibi yomzimba eyenzeka ngokuphendula isenzo se-metformin - ukugaya okucashile kubhekwa njengecala elibi lokusetshenziswa kwalesi sidakamizwa. Kepha lapho uhlukanisa imithamo yansuku zonke kuma-doses ambalwa, izimpawu ezinjalo zincishiswa kakhulu.
Iningi leziguli ezithathe iMetformin Canon liphinda likhumbuze ukuthi ukwelashwa nomuthi wehliselwa ku “cha” uma ungalandeleli ekwelashweni kokudla, ungazibandakanyi kwezemidlalo futhi ungalawuli amazinga kashukela nsuku zonke.
Izidakamizwa ezifanayo
Kwesinye isikhathi ukusetshenziswa kwezidakamizwa kuba nzima ngezizathu ezahlukahlukene, noma ngabe kungukuphambana noma ukusabela okuphambene.
Ezimweni ezinjalo, wonke umthwalo ulele kudokotela, onquma ukuguqula umuthi. Kulokhu, kufanele acabangele izinga kashukela egazini lesiguli kanye nesimo sakhe sempilo esijwayelekile.
Izidakamizwa ezifanayo zinomphumela ofanayo wokwelapha, kepha ziyahluka ekubumbeni kwazo.
I-Metformin isidakamizwa esidumile esisetshenziselwa ukuguqula amazinga kashukela. Kulokhu, isetshenziswa njengengxenye esebenzayo yabaphatheli abaningi be-hypoglycemic.
Phakathi kokufana okwaziwayo kweMetformin Canon ukuhlukanisa:
- I-Gliformin iyisidakamizwa esisebenzayo sokulwa nesifo sikashukela esisetshenziselwa ukungasebenzi kwe-sulfonylureas. Ngenxa ye-metformin equkethwe, kuyasiza ukwehlisa isisindo kubantu abakhuluphele. Izindleko zayo ezimaphakathi zincike ohlotsheni lokukhululwa: ama-ruble angama-500 mg -106, ama-850 mg -186 nama-1000 mg - ama-ruble angama-368.
- IGlucophage kungenye ikhambi elingeqembu le-Biguanide. Itholakala ngesimo sesikhathi eside (i-Glucophage Long). Ibuye isetshenziselwe isifo sikashukela esincike ku-insulin. Intengo emaphakathi yephakethe elilodwa isuka ku-107 kuya kuma-ruble angama-315.
- I-Siofor 1000 ingumuthi osetshenziselwa ukuvimbela nokwelashwa kwesifo sikashukela kanye nokunciphisa umzimba. Ngokwesilinganiso, izindleko ziyahlukahluka kusuka kuma-ruble angama-246 kuya kwangama-420, ngakho-ke akunakubizwa nge-analogue eshibhile kakhulu.
- I-Metformin-Teva isidakamizwa esisetshenziselwa isifo sikashukela sohlobo 2, lapho ukudla nokuzilolonga kungasebenzi. NjengeMetformin Canon, iqinisa i-glycemia, i-lipid metabolism, kanye nesisindo somzimba wesineke. Izindleko ezijwayelekile zomuthi zivela kuma-ruble ayi-125 kuye kwangama-260.
Kukhona ezinye izidakamizwa eziningi ezinomphumela ofanayo kwi-Metformin Canon. Imininingwane egcwele ngabo ingatholakala kusetshenziswa i-Intanethi noma ngokubuza udokotela wakho.
I-Metformin Canon ingumuthi osebenza ngempumelelo wokulwa nesifo sikashukela. Ngokusebenzisa ngendlela efanele, ungasusa izimpawu ze- "sifo esimnandi" futhi uphile ngokugcwele nabantu abanempilo. Kodwa-ke, ngesikhathi sokusebenzisa umuthi, kufanele ulandele yonke imiyalo kadokotela, ukuze ungazilimazi.
Uchwepheshe ovela kuvidiyo ekulesi sihloko uzokhuluma ngeMetformin.
