Izinkinga zesifo sikashukela zifaka ukulimala kodonga lwe-vascular kanye nokukhula kwe-micro- and macroangiopathy. Lapho zisakazekela emithanjeni yobuchopho, i-diephalopathy yesifo sikashukela iba.
Kuhlukaniswa njengesibonakaliso se-polyneuropathy ephakathi. Lo mqondo ubandakanya ukubonakaliswa okuningi kusuka kwekhanda nesiyezi ukuya emsebenzini wezengqondo ongasebenzi kahle.
Isifo sokuwohloka kwemithambo sivela ngemuva kwesizinda sokulimala komzimba kanye ne-lipid metabolism, ukungondleki kwengqondo, i-hypoxia. Lokhu kuholela ekuqongeleleni imikhiqizo enobuthi, enomthelela ekuwohlokeni kwemisebenzi yobuchopho ephakeme.
Izimbangela zokulimala kobuchopho kushukela
Amangqamuzana obuchopho azwela kakhulu ekushintshashintsheni kweglucose yegazi. Kubo, ungumthombo wamandla oyinhloko. Ngakho-ke, kwisifo sikashukela i-mellitus, kungakhathalekile ukuthi hlobo luni, izinguquko ziba khona emithanjeni nasezitheni zobuchopho uqobo.
Izimpawu zokuphazamiseka kwemithamboza ziqhubeka njengoba isifo sikashukela siqhubeka, ukugula isikhathi eside kulapho kuthinta khona izinqubo zokucabanga. Futhi kuncike ekunxephezelweni sikashukela kanye nokuba khona kokushintshashintsha okungazelelwe kwamazinga kashukela.
Uhlobo lwesibili sikashukela luhambisana nemetabolism ebambezelekile, ukuncipha kwama-lipoprotein aphezulu kanye nokwenyuka kwe-cholesterol. Ngokwesifo sikashukela sohlobo 2, iziguli zinamafutha amaningi futhi zinomfutho wegazi ophakeme kakhulu kunhlobo lokuqala.
Isifo sokuwohloka kwemizwa sihambisana nohlobo lwesibili sikashukela kaningi kakhulu ngoba iminyaka yeziguli ivame ukuholela ekunciphiseni kokuqina kwemithambo, kanye nezilonda ze-atherosulinotic kanye ne-thrombosis kuzo.
Ngaphezu kwalokho, kubantu asebekhulile, ama-vein arterial anastomoses mancane amathuba okuba kwakheke ukujikeleza kwegazi endaweni yezicubu zobuchopho ezilimele. Izici eziholela ekuwohlokeni komqondo ku-mellitus yesifo sikashukela yilezi:
- Ukuncipha kwekhono lomzimba lokuqothula amaprotheni e-amyloid ngokuntuleka kwe-insulin noma ukumelana ne-insulin.
- Ukubhujiswa kodonga lwe-vascular yi-hyperglycemia.
- Ukulimala kwe-lipid metabolism, okucasulayo ukubekwa kwe-cholesterol emikhunjini
- Ukuhlaselwa kwe-hypoglycemia okuholela ekufeni kwamangqamuzana obuchopho.
Ososayensi abaphenye ubudlelwano obuphakathi kwesifo sikashukela ne-Alzheimer's bathole ukuthi ingozi yokulahlekelwa inkumbulo kushukela ikhuphuka kabili uma iqhathaniswa ne-carbohydrate metabolism. Umqondo owodwa wobudlelwano phakathi kwalezi zifo ukufana kwamaprotheni e-amyloid emaphashini nasengqondweni.
Kulesi sifo se-Alzheimer's, i-amyloid protein deposits iyisizathu sokulahleka kwekhono lokusungula ukuxhumana phakathi kwama-neurons obuchopho. Lokhu kudala izimpawu ezinjengokwehla kwenkumbulo nobuhlakani kule pathology. Ngomonakalo kumaseli we-beta akhiqiza i-insulin, ukunqwabelana kwe-amyloid kutholakala kwezicubu ze-pancreatic.
Njengoba isifo sokuwohloka kwemithambo sandisa ukubonakaliswa kwalesi sifo, kubhekwa njengesici sobungozi esibaluleke kakhulu sesibili ekwakhiweni kwalesi sifo esachazwa yi-Alzheimer.
I-hypoxia yezicubu eziholelwayo iholela ekuqalisweni kwama-enzymes adonsela phansi umsebenzi wobuchopho.
Izimpawu Zokuncipha Kwesifo Sikashukela Sengqondo
Iqembu lezimpawu ezihlobene nokubonakaliswa kokuwohloka komqondo lifaka izinkinga ngokukhumbula, ukucabanga, ukuxazulula izinkinga zansuku zonke nezenhlalo. Kubandakanya nezinkinga zokukhuluma ezingahambisani nezindawo ezibalulekile ze-necrosis noma izinqubo zesimila ebuchosheni.
Ezigulini ezihlushwa uhlobo lwesibili sikashukela, lokhu kubonakaliswa kuyaqhubeka, ngoba kuhlotshaniswa nokuphazamiseka okuningana ekunikezelweni kwegazi kuya ebuchosheni. Ukuguga kungakhulisa ukwehla kokuqonda nokucabanga.
Izimpawu zokuwohloka komqondo kwisifo sikashukela i-mellitus zivame ukwanda kancane kancane, zithuthuke kakhulu nge-hyperglycemia. Ekuqaleni, iziguli zithola ubunzima bezikhumbule nokugxila. Ngemuva kwalokho kwephula amandla okucabanga okunengqondo nokusungulwa kobudlelwano be-causal.
Ngokukhula kwesifo, izimpawu ezilandelayo ziyaqina:
- Ukuqonda komhlaba wangaphandle kanye nokuholwa ngesikhathi, indawo iyancishiswa.
- Izimo zomuntu zishintsha - i-egoism nokungabi nandaba kwabanye kukhula.
- Balahlekelwe amandla okusebenza ngokuzimela.
- Iziguli azikwazi ukuqonda imininingwane emisha, izinkumbulo zesikhathi esidlule zinikeza okusha.
- Bayayeka ukuqaphela izihlobo nabangane abaseduze.
- Amakhono wasendlini nawobungcweti, amakhono okufunda nokubala alahlekile.
- Isilulumagama siyancipha, izinkulumo ezingenamqondo ziyavela.
Esigabeni esandisiwe, ukuwohloka komzimba kungabonakala njenge-delirium and hallucinations, iziguli ziye zincike ngokuphelele kwabangaphandle, ngoba azikwazi ukwenza imisebenzi elula yasendlini futhi zibheke nezindlela zokuhlanzeka eziyisisekelo.
Ukwelashwa kokuwohloka komqondo kwisifo sikashukela
Enye yezinto ezembula ukuhlangana kwesifo i-Alzheimer's nesifo sikashukela ukutholakala komphumela we-antidiabetesic therapy ukubambezela ukuwohloka komqondo.
Ngakho-ke, ukunikezwa kwemithi okufika ngesikhathi kwemithi ukwehlisa ushukela futhi kufinyelele emazingeni eglue glucose, kanye ne-cholesterol ephansi kanye nomfutho wegazi, kungabambezela ukuthuthukiswa kokuwohloka komqondo ku-mellitus yesifo sikashukela.
Ngokulashwa okufanele, kufaka phakathi ukuguqukela ekwelashweni kwe-insulin kwesifo sikashukela sohlobo 2, kukhona ukuncipha okuqhubekayo kwamapharamitha we-neuropsychological. Ngaphezu kwalokho, iziqephu ze-hypoglycemia ziyingozi ezigulini ezine-pathology yemithambo yengqondo yobuchopho, ngoba zilimaza ukusebenza kwengqondo.
Ukulahleka kwenkumbulo kushukela sikashukela kuphathwa nangama-neuroprotectors, anconyelwe ukusetshenziswa ezifundweni:
- Ceraxon.
- Cerebrolysin.
- Glycine.
- ICortexin.
- I-Semax
Ngaphezu kwalokho, kungalungiswa amavithamini we-B - i-Neurorubin, iMilgamm.
Esithombeni somtholampilo sokuwohloka komqondo, ukuphathwa okuqhubekayo kwezidakamizwa ukwenza ngcono inkumbulo nokubona kukhonjisiwe. Lokhu kufaka: i-donepezil (Alpezil, Almer, Donerum, Paliksid-Richter), galantamine (Nivalin, Reminyl), Rivastigmin, memantine (Abiksa, Meme, Remanto, Demax).
Izindlela zokuvimbela zifaka ukulandela ukudla okubandakanya izinhlanzi, ukudla kwasolwandle, uwoyela womnqumo nemifino emisha, ukuthosa, ikakhulukazi i-turmeric. Ngasikhathi sinye, ngaphezu kwemikhawulo yendabuko yokudla okumnandi, ufulawa namafutha, kunconyelwa ukunciphisa ukusetshenziswa kwenyama nemikhiqizo yobisi.
Ukusebenza ngokomzimba okuphoqelekile, izinga lokunqunywa ngokuya ngesimo sokuqala sesiguli, kanye nokuqeqeshwa kwenkumbulo ngendlela yomdlalo we-chess, amasheke, ukuxazulula amagama asemaphazili, iphazili, ukufunda izinganekwane.
Ukulala okugcwele nokumelana kwengqondo nokucindezelwa nakho kubalulekile. Ukwenza lokhu, iziguli zingancoma izivivinyo zokuphefumula nezikhathi zokuphumula. Ividiyo ekulesi sihloko iqhubeka nengqikithi yezinkinga zesifo sikashukela.
