I-Thioctacid ilungiselelo le-alpha-lipoic (thioctic) acid, ebonakala ngomphumela onamandla we-antioxidant ngenxa yokubopha kwama-radicals wamahhala, futhi futhi inezici ze-hepatoprotector, ezibamba iqhaza kulawulo lwezinqubo ze-metabolic namandla ezinga lamaselula.
Umuthi ubhalisiwe futhi usetshenziselwa ukwelapha ngempumelelo i-neuropathy kanye nokukhubazeka kwemizwa okubangelwa yile ndlela yokusebenza kwezidakwa notshwala.
I-Thioctacid ibhekane nezilingo ezibucayi zomtholampilo zamazwe omhlaba nezeningi, okufakazela ukusebenza kwayo nokuphepha.
Ikhiqizwa eJalimane, futhi into esebenzayo (i-alpha lipoic acid ngokwayo) ithengwa e-Italy.
Izici ze-Thioctacid
Ekhemisi ungathenga lo mkhiqizo ngesimo samaphilisi i-BV (ukukhishwa okusheshayo) noma isixazululo. Ukuze uqinisekise ukuthathwa okuhle kakhulu futhi uqede ukulahleka kwento, izakhiwo ezikhishwa ngokushesha zilungele izakhiwo ze-thioctic acid. I-Acid iyakhishwa futhi igxishwe masinyane esiswini, bese iqala ukukhishwa masinyane. I-Thioctic acid ayiqoqeki futhi isuswa ngokuphelele emzimbeni, njengoba isetshenziswa ngenkuthalo ekubuyiselweni nasekuvikelweni kwamaseli.
I-Thioctacid itholakala ngesimo samathebulethi kuphela wokukhishwa okusheshayo, ngoba ifomu elijwayelekile libonakaliswa yi-digestibility ephansi nokungalindeleki kwemiphumela yokwelashwa.
Umuthi uthathwa ngethebhulethi elingu-1 isikhathi ngosuku ngosuku esiswini esingenalutho imizuzu engama-20 kuya kwengama-30 ngaphambi kokudla - nganoma yisiphi isikhathi sosuku. Isixazululo singahanjiswa ngaphandle kwe-dilution, kepha imvamisa ifakwa kusawoti bese iphathwa kancane, hhayi ngokushesha kunemizuzu eyi-12, ngakho-ke le nqubo yenziwa esibhedlela.
Into esemqoka yokusebenza kwesidakamizwa yi-alpha-lipoic (thioctic) acid enenani le-600 mg kwithebhulethi ngayinye kanye ne-ampoule ngayinye yesisombululo.
Njengengxenye eselekelelayo, ikhambi liqukethe i-trometamol namanzi angcolile wokujova futhi ayinayo i-ethylene diamine, i-propylene glycols ne-macrogol.
Amathebulethi abonakala ngokuqukethwe okuncane kwabafaki, aqukethe i-lactose, isitashi, i-cellulose, i-castor oil, ejwayele izidakamizwa ezishibhile ze-thioctic acid.
Izindlela zokusebenzisa
I-asidi ye-thiocic acid esebenzayo ibamba iqhaza ku-metabolism eyenziwa ku-mitochondria - izinhlaka zamaseli ezibhekele ukwakhiwa kwe-universal energy ntho ye-adenosine triphosphoric acid (ATP) kusuka kumafutha kanye nama-carbohydrate. I-ATP iyadingeka ukuze wonke amaseli athole amandla. Uma into yamandla inganele, khona-ke iseli alikwazi ukusebenza kahle. Ngenxa yalokhu, ukungasebenzi kahle okuhlukahlukene emsebenzini wezitho, izicubu nezinhlelo zawo wonke amalungu omzimba kuyakhula.
I-Thiocic acid iyi-antioxidant enamandla ye-endo native, esondele kakhulu ku-Vitamin B ngokuya ngendlela yokusebenza kwayo.
Ku-mellitus yesifo sikashukela, umlutha wotshwala kanye nezinye izindlela zemithambo yegazi, imithambo yegazi emincane ivame ukuvaleka futhi iqhutshwe kahle.
Imicu yama-nerve, etholakala ekujukeni kwezicubu, izwa ukushoda kwezakhi ezibalulekile kanye ne-ATP, ebanga izifo. Zibonakaliswa ukwephulwa kokuzwela okujwayelekile kanye nokuqhutshwa kwemoto.
Ngaso leso sikhathi, isiguli sizwa ukungakhululeki endaweni lapho kudlula khona izinzwa ezithintekile. Imizwa engathandeki ifaka phakathi:
- Ukuphazamiseka kwesistimu ye-peripheral yezinzwa (ukuzizwa, ukulunywa, umuzwa ovuthayo emilenzeni, umuzwa wokukhasa)
- ukuphazamiseka kohlelo lwezinzwa lwe-autonomic (i-dyskinesia yesisu, ukuphazamiseka kohlelo lwenhliziyo, ukungasebenzi komzimba, ukungasebenzi komchamo, ukujuluka, isikhumba esomile nabanye)
Ukuqeda lezi zimpawu, ukubuyisela ukondleka kwamaselula, isidakamizwa i-Thioctacid BV siyadingeka. Le substrate ihlangabezana ngokugcwele nezidingo zamangqamuzana ngenxa yokuthi kwakhiwa ngokwanele i-ATP e-mitochondria.
I-Thioctic acid ngokwayo ivame ukukhiqizwa kuwo wonke amaseli emzimbeni ngokunembile ngoba iyadingeka. Ngokuncipha kwenombolo yayo, ukwephulwa okuhlukahlukene kuvela.
Umuthi uqeda ukuntuleka kokudla okunempilo nezimpawu ezingemnandi ze-neuropathy yesifo sikashukela. Ngaphezu kwalokho, umuthi ubonakala ngezenzo:
- antioxidant. Njenge-antioxidant, isiza ukuvikela amaseli wezinhlelo nezitho zomzimba ekulimaleni ngama-radicals wamahhala, akhiwa ngesikhathi sokubhujiswa kwazo zonke izinto zangaphandle ezingena emzimbeni. Kungaba izinhlayiya zothuli, usawoti wezinsimbi ezisindayo namagciwane atholakalayo;
- antitoxic. Umuthi usiza ukuqeda ukubonakaliswa kokudakwa ngenxa yokuqothulwa okusheshayo kanye nokungathathi hlangothi kwezinto ezinoshevu emzimbeni;
- njenge-insulin. Kusemandleni emuthi ukwehlisa ukuhla ushukela egazini ngokwandisa ukusetshenziswa kwawo ngamaseli. Ngakho-ke, lesi sidakamizwa sijwayelekile i-glycemia ezigulini ezinesifo sikashukela, sithuthukisa impilo yaso jikelele futhi sisebenza njenge-insulin yazo;
- ukufaka isandla ekunciphiseni isisindo (yenza iphango ibe ngokweqile, iphule fat, ikhuphule umsebenzi jikelele futhi ithuthukise inhlala-kahle);
- i-hepatoprotective;
- anticholesterolemic;
- ukwehliswa kwe-lipid.
Kubalulekile ukukhumbula ukuthi kuyadingeka ukuthobela yonke imiyalo kadokotela ekwelapheni lesi sifo esiyisisekelo - isifo sikashukela.
Izinkomba zokusetshenziswa kwe-Thioctacid (BV)
Njengoba sekushiwo, umuthi uboniswa ukuqeda i-neuropathy ne-polyneuropathy ekuthembekeni kotshwala kanye nesifo sikashukela (njengoba kuqinisekisiwe ukubuyekezwa kodokotela neziguli zabo).
Amathebhulethi e-Thioctacid kufanele athathwe isisu esisodwa esingenalutho imizuzu engama-30 ngaphambi kokudla. Umuthi udliwa uphelele (ngaphandle kokuhlafuna) bese ugeza ngamanzi.
Isikhathi sokwelashwa sizonqunywa ngudokotela oholayo esimweni ngasinye. Ubukhulu bezokwelapha buzoya ngoku:
- ubukhulu besifo;
- izinga lapho izimpawu zakhe zinyamalala;
- isimo esivamile sesiguli.
Kunconywa inkambo ende yokwelashwa, ngoba into ingokwemvelo emzimbeni futhi ayinqwabelani. Eqinisweni, lokhu ukwelashwa okuthatha indawo. Ngakho-ke, inkambo ephansi iyizinyanga ezi-3 (kukhona iphakethe lamathebulethi ayi-100, awukhetheke kakhulu ngokomnotho). Kunezifundo zokuphatha okuqhubekayo iminyaka engu-4, ekhombise ukubekezelela nokuphepha okuhle komuthi. Iziguli eziningi zizithatha njalo, ngoba umphumela olimazayo wesifo kwizicubu zemizwa uyagcinwa futhi nomzimba uhlala udinga lokhu.
Ngenkambiso eqinile yesifo kanye nezimpawu eziveziwe ze-neuropathy, abanesifo sikashukela bakhonjiswa ukuthi bathathe i-Thioctacid ngembobo yamasonto ama-2-4. Kungemva nje kwalokhu kushintshela ekusebenziseni kwesondlo kwe-Thioctacid isikhathi eside ku-600 mg ngosuku.
Isicelo se-Thioctacid T
Isixazululo somuthi i-Thioctacid T (600 mg) kwezokwelapha sisetshenziselwa ukuphathwa okuqondile kwe-intravenous. Umuthi lo u-photosensitive, ngakho-ke ama-ampoules amnyama ngombala, kanti ibhodlela elinesixazululo limbozwe ucwecwe. I-intravenous drip kancane. Dose 600 mg (1 ampoule) ngosuku. Ngokuyalelwa ngudokotela, kungenzeka ukuthi andise umthamo ngokuya ngesimo sesiguli.
Uma i-neuropathy enesifo sikashukela ilukhuni, khona-ke umuthi uphathwa ngaphakathi kwamasonto amabili kuya kwayi-4.
Esimweni lapho isiguli singakwazi ukuthola i-droplet ye-Thioctacid 600 T esimweni sesibhedlela, uma kunesidingo, singathathelwa indawo ukusetshenziswa kwamathebhulethi e-Thioctacid BV endaweni yomthamo olinganayo, ngoba anikeza isilinganiso esanele sokwelapha sento esebenzayo emzimbeni.
Ngokwezindinganiso zokwelashwa zoMnyango Wezempilo waseRussia Federation, i-thioctic acid iboniswa i-hepatitis, radiculopathies, njll.
Imithetho yokwenziwa nokugcinwa komuthi
Uma udokotela enikeze ukumfaka kwe-intravenous, khona-ke isiguli kufanele sazi ukuthi lonke ivolumu yansuku zonke kufanele liphathwe ngesikhathi. Uma kunesidingo, faka i-600 mg yento kufanele ihlanjululwe ku-saline (ungakwazi ngisho nangesilinganiso esincane). Ukufakwa njalo kuqhutshwa kancane kancane ngesilinganiso esingadluli ku-1.7 ml ngemizuzwana engama-60 - kuya ngevolumu kasawoti (250 ml we-saline kuphathwa imizuzu engama-30 kuya kwayi-40 ukugwema i-heestasis). Ukubuyekezwa kusho ukuthi irejimeni enjalo yabanesifo sikashukela iphelele.
Uma ufuna ukujova umuthi ngokuqondile ngaphakathi, ngakho-ke kuleli cala, ukugxilwa kuthathwa ngqo ku-ampoule ku-syringe futhi iphampu yesirinji yokufaka isixhunywe kuyo, evumela umjovo onembile kunayo yonke. Ukwethulwa emthanjeni kufanele kube kancane futhi kungapheli imizuzu eyi-12.
Ngenxa yokuthi isixazululo esilungiselelwe seThioctacid sizwela kakhulu ukukhanya, silungiswa ngokushesha ngaphambi kokusetshenziswa. Ampoules anento nawo asuswa kuphela ngaphambi kokusetshenziswa. Ukuvimbela imiphumela emibi yokukhanya, isitsha esinesixazululo esiphelile kufanele simbozwe ngokucophelela nge-foil.
Ingagcinwa kuleli fomu isikhathi esingekho ngaphezulu kwamahora ayi-6 kusuka ngosuku lokulungiswa.
Amacala wokuphendula ngokweqile nokubi
Uma i-overdose yenzekile ngezizathu ezahlukahlukene, khona-ke izimpawu zayo kuzoba:
- ukuphefumula kwenhliziyo;
- ukuqunjelwa;
- ikhanda.
Lapho uthatha imali enkulu yokudakwa, i-Thiox BV ibonakaliswa ukucindezelwa kokwazi nokuphazamiseka kwengqondo. Ngemuva kwalokho i-lactic acidosis nokubanjwa okukholisayo sekuvele.
I-antidote ethile esebenzayo ayikho. Uma kukhona okukukhathazayo ngokudakwa, kubalulekile ukuxhumana nesikhungo sezokwelapha ngokushesha ngohlobo lwezindlela zokwelapha zokuhlanza umzimba.
