IFommetin isidakamizwa esisebenzayo se-metformin hydrochloride. Umthamo: 0.5 g; I-0.85 g noma i-1 g. Analogs: IGlatini, iMetadiene, iNovava Met, iNovoFormin, iSiofor, iSofamet.
Izinto ezisizayo: i-croscarmellose sodium; i-povidone ephakathi yesisindo (i-polyvinylpyrrolidone), i-magnesium stearate embonini yezemithi.
Ifomu lokukhishwa: amaphilisi amhlophe ayindilinga ajikelezayo amhlophe ane-facet nengozi (umthamo we-0.5 g) kanye namacwecwe amhlophe we-biconvex amhlophe onobungozi ohlangothini olulodwa (umthamo we-0.85 g no-1.0 g).
Izimpawu ze-Pharmacological
IFethethine inciphisa ukumuncwa kwe-glucose esiswini, kuvimbela inqubo ye-gluconeogenesis esibindini, ithuthukisa ukuphuma kweglucose, ikhulisa ukuzwela kwezicubu kumalungiselelo e-insulin.
Kulokhu, i-formetin
- Akuthinti ukukhiqizwa kwe-insulin ngamaseli e-beta akhiwe kumanyikwe.
- Akuvusi ukuthuthuka kwesimo se-hypoglycemic.
- Yehlisa inani lamazinga aphansi we-lipoprotein kanye ne-triglycerides egazini.
- Yehlisa ukhuluphele, izinza isisindo esijwayelekile.
- Inomphumela we-fibrinolytic ngenxa yokucindezelwa kwe-activism izicubu ze-plasminogen.
I-Formaline, ngemuva kokuphathwa ngomlomo, imunwa kancane kancane iphuma esiswini se-gastrointestinal. Inani lempahla etholakala ngemuva kokusebenzisa idosi ejwayelekile licishe libe ngama-60%.
Iqoqo eliphakeme lomuthi osegazini livela amahora angama-2,5 ngemuva kokusetshenziswa kwangaphakathi.
IFomuethine cishe ayihlanganisi namaprotheni e-plasma; bunqwabelana esibindini, izinso, izicubu zomzimba, izindlala zamathe; okucasulwa izinso kwifomu elingafanele. Ukuphila kwengxenye kwento ngamahora 1.5 - 4.5.
Nakani! Uma isiguli siphazamise umsebenzi wezinso, ukuhlangana komuthi emzimbeni kungenzeka.
Izinkomba zokusetshenziswa
Umuthi ubekelwe uhlobo 2 lwesifo sikashukela, lapho ukwelashwa kungadalanga imiphumela emihle (ezigulini ezinokukhuluphala), konke lokhu kukhonjiswa yimiyalo yomuthi.
Umthamo wesidakamizwa unqunywe ngudokotela uqobo esigulini ngasinye. Umehluko kumthamo ubangelwa ukugcwala kweglucose egazini. Izibhebhe zeFomuethine kufanele zithathwe ngesikhathi noma ngokushesha lapho isiguli sithathe ukudla, ngaphandle kokuhlafuna futhi siphuze inani elikhulu lamanzi.
Esigabeni sokuqala sokwelashwa, umthamo kufanele ube ngu-0.85g. Isikhathi esingu-1 ngosuku noma i-0.5g. Izikhathi ezi-1-2 ngosuku. Khuphula kancane kancane isilinganiso ku-3g. ngosuku.
Kubalulekile! Ezigulini esezikhulile, inkambiso yansuku zonke akufanele idlule i-1g. Ngenxa yengozi enkulu ye-lactic acidosis, enama-metabolic ezinzima e-metabolic, umthamo kufanele uncishiswe.
Izincomo ezikhethekile zokusetshenziswa
Imiyalo: ngesikhathi sokwelashwa, udinga ukusebenzisa ukulawula okusebenzayo kokusebenza kwezintso. Kanye emva kwezinyanga eziyisithupha nangokwakhiwa kwe-myalgia, kuyadingeka ukuthola inani le-lactate ku-plasma.
I-formmetin ingasetshenziswa ngokuhambisana nezinsizakalo ze-sulfonylurea. Kulokhu, ukuqapha ngokucophelela ukugxilisa ushukela wegazi kuyadingeka.
IFetetin ngesikhathi sokwenza i-monotherapy ayithinti amandla okusebenza ngezinqubo eziyinkimbinkimbi nokushayela izimoto. Uma umuthi uhlanganiswa nezinye izidakamizwa ze-hypoglycemic, ukuthuthukiswa kwe-hypoglycemia kungenzeka, lapho kungekho khona amandla okushayela imoto nokusebenza ngezinqubo eziyinkimbinkimbi ezidinga ukunakwa okukhulu.
Ukuphendula okungafani
Kusuka ohlelweni lokugaya:
- ukunambitheka kwensimbi;
- isicanucanu, ukuhlanza
- ifulethi, isisu;
- ukulahleka kwesifiso
- Ubuhlungu besisu.
Kusuka kwizitho ze-hemopoietic, kwezinye izimo i-megalobast anemia iyabonakala.
Mayelana nemetabolism:
- kudinga ukuyekwa kokwelashwa, i-lactic acidosis iyivelakancane;
- ukwelashwa okuhlala isikhathi eside, i-hypovitaminosis B12 iba.
Uhlelo lwe-endocrine emithini eyanele lungaphendula nge-hypoglycemia.
Ukubonakaliswa kwe-allergic: ukuqhuma kwesikhumba.
Ukuxhumana nezinye izidakamizwa
Umphumela we-hypoglycemic we-metformin ungathuthukiswa uma usetshenziswa kanye kanye:
- insulin;
- izinto ezithathwe kuma-sulfonylurea;
- oxytetracycline;
- i-acarbose;
- izidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala;
- cyclophosphamide;
- i-angiotensin eguqula ama-enzyme inhibitors;
- i-monoamine oxidase inhibitors;
- Ama-block-blockers;
- okuphuma ku-clofibrate.
Ukwehla komphumela we-hypoglycemic we-metformin ubonwa ngokusetshenziswa kanyekanye no:
- i-loop ne-thiazide diuretics;
- izindlela zokuvimbela inzalo ngomlomo;
- glucocorticosteroids;
- i-glucagon;
- epinephrine;
- okususelwa ku-phenothiazine;
- i-sympathomimetics;
- dericatives ye-nicotinic acid;
- ama-hormone egilo.
Contraindication
Ungathathi i-FORMETINE nge:
- ukulimazeka okukhulu kwezinso;
- isifo sikashukela sikashukela, i-precoma, ikoma;
- ukuphefumula nokuhluleka kwenhliziyo;
- ukomisa;
- ingozi ye-cerebrovascular eyingozi;
- ukudakwa okungapheli kanye nezinye izimo ezifaka isandla ekuthuthukiseni i-lactic acidosis;
- ngesikhathi sokukhulelwa nokuqunjelwa;
- hypersensitivity kuzakhi zomuthi;
- ukulimala nokungenelela okungathi sína kokuhlinzwa;
- izifo ezithathelwanayo ezinzima;
- ukudakwa kakhulu kwezidakamizwa;
- i-lactic acidosis.
Umyalo ohambisana nalokhu uthi izifundo ze-X-ray kanye ne-radioisotope ngokwethulwa kwento equkethe iodine ehlukile akufanele zandulelwe ukusetshenziswa kweFormetin kungakapheli izinsuku ezi-2.
I-formethine ayinconywa ukuthi isetshenziswe ngabantu abangaphezu kweminyaka engama-60 abasebenza kanzima. Uma lo mthetho ungabhekwa, iziguli ezinjalo zingakha i-lactic acidosis.
Okushiwo yimiyalo ngokweqile
Imiyalo yomuthi iFomumetin uxwayisa ngokuthi nge-overdose, kungenzeka ukuthi kukhule i-lactic acidosis ngomphumela obulalayo. Imbangela yalesi simo kungaba ukunqwabelana komuthi emzimbeni ngenxa yomsebenzi wezinso ongasebenzi.
Izimpawu ezilandelayo yizimpawu zokuqala ze-lactic acidosis:
- Isicanucanu, ukuhlanza.
- Uhudo, ubuhlungu besisu.
- Ubuthakathaka, i-hypothermia.
- Isiyezi
- Ubuhlungu bemisipha.
- I-Reflex bradyarrhythmia.
- Yehlisa umfutho wegazi.
- Ukungazi kahle nokukhubazeka komzimba
Uma isiguli sinezimpawu zokuqala ze-lactic acidosis, uFomu kufanele akhishwe ngaphandle kwezindlela zokwelapha, isiguli kufanele sidluliselwe esibhedlela lapho udokotela anganquma khona ukuthi lactate ihlolwe futhi enze ukuxilongwa okungafanele.
Indlela ephumelela kakhulu yokuqeda i-metformin ne-lactate emzimbeni yi-hemodialysis, kanye nokwelashwa okubonakalayo okwenziwa ngayo.
Ifomula - isitoreji, intengo
Impilo yeshelf yezidakamizwa yizinyanga ezingama-24, emva kwalokho iFometin angeke isetshenziswe. Umuthi ungowalolo hlu B. Kufanele lugcinwe endaweni emnyama engatholakali ezinganeni ngamazinga okushisa angaphansi kwama-25 ° C.
Umkhiqizi - Ikhemisi.
Ukukhishwa kwefomu - amaphilisi we-850 mg. Izingcezu ezingama-60.
Intengo - ama-ruble ayi-177.
Umkhiqizi - Ikhemisi.
Ukukhishwa ifomu - amaphilisi 1gr. Izingcezu ezingama-60.
Intengo - 252 rub.
Amanye ama-analogu abiza kakhulu.
