Nikeza i-insulin Aspart ukukhokhela ushukela

Ukulungisa amazinga kashukela egazi, abanesifo sikashukela banikezwa amalungiselelo e-insulin. Enye yezinhlobonhlobo zama ejenti e-injog hypclycemic ejenti yi-insulin aspart.

Umuthi yi-analogue ye-bioengineered ye-insulin yabantu, inesikhathi esifushane sokwenza. Isetshenziswa njengengxenye yokwelapha eyinhloko yesifo sikashukela i-mellitus futhi iphinda ifake isidingo se-insulin, ngokwephula ukukhiqizwa kwe-hormone engasasebenzi.

Incazelo yesidakamizwa

Umuthi uyatholakala ngesimo sesisombululo semijovo engangeneki neyangaphakathi. I-Aspart insulin ingeyohlobo lwezidakamizwa ezikhiqizwa kusetshenziswa ubuchwepheshe be-bioengineering. Kutholakala ngokuhlanganisa kabusha i-DNA yesigaxa se-Saccharomyces cerevisiae, kufakwe elinye lama-amino acid.

Isenzo se-pharmacological sento esebenzayo sihlose ukufakwa kweglucose, ukuze sinciphise ushukela wegazi ezigulini ezinesifo sikashukela mellitus.

I-insulin aspart yakha i-insulin receptor complex enikezela izinqubo ezilandelayo:

• Ukuthathwa kwezothutho kanye noshukela;
• Ukuhlanganiswa kwe-enzyme;
• Glycogenogeneis;
• I-lipid metabolism inqubo yokuthathwa kwe-glucose;
• Ukulondolozwa kwe-glycogen kuma-hepatocytes.

Kunezinhlobo ezimbili lapho kukhiqizwa khona i-aspart:

1. Isigaba esisodwa. Isixazululo esicacile, sinesenzo esifushane (amahora angu-3-5), ngemuva kokuphathwa kobuhlakani. Yabela ukulawula i-glycemia lapho udla ukudla kwe-carbohydrate.
2. Biphasic. Ukulungiselela okuhlangene ngohlobo lokumiswa kunqunyelwe kuphela ekwelapheni isifo sikashukela sohlobo 2. kusekelwe kwinhlanganisela ye-insulin emfishane nomuthi osebenza ngokuaphakathi. Umphumela wehlisela ushukela uthatha amahora angama-6.

Njengoba ifomu lesigaba esisodwa linesikhathi esifushane sokufakwa kanye ne-metabolism, isetshenziswa njengengxenye yokwelapha okuyinkimbinkimbi nge-insulin esebenza isikhathi eside. Izidakamizwa ze-Biphasic zisetshenziswa njengenye indlela yezidakamizwa ezinciphisa ushukela ngomlomo, noma zihlanganiswa nazo.

Igama lokuhweba nefomu lokukhulula

I-Aspart ikhiqizwa ngesimo esimsulwa futhi njengengxenye yamalungiselelo ayinkimbinkimbi. Kunezindlela eziningi zomthamo lapho i-insulin aspart isebenza njengesithako esiyisisekelo esisebenzayo. Igama lokuhweba lincike ekwakhekeni nasefomini lomuthi.

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Imiyalo yokusebenzisa

Indlela yokusebenzisa kanye nomthamo wesidakamizwa kuya ngefomu lomthamo, uhlobo lwesifo, ukuba khona kwe-pathologies ehambisanayo nobudala besiguli.

Izincomo ezijwayelekile, zazo zombili izinhlobo ze-aspart, zingokulandelayo:

• Imijovo ibekwa ngokunqenqemeni (kungqimba lwamafutha), ngoba i-insulin emfushane iyalahlekelwa ngokwengxenye izakhiwo zayo futhi ikhishwa ngokushesha emzimbeni, ngomjovo we-intramuscular;
• Izindawo zokujova kumele zishintshwe njalo, ngoba amafutha angakheka kungqimba olunamafutha.
• Izindawo zeLipodystrophic;
• Izinaliti azinconywa ukuthi ziphinde zisetshenziswe ukuvikela ukutheleleka.

Ungayisebenzisa kanjani i-insulin aspart? Imiyalo yokusebenzisa iqukethe imiyalo ehlukile yemithi yesigaba esisodwa kanye nesigaba ezimbili.

Ukusetshenziswa kwe-aspart eyodwa yesigaba

Ummeleli walesi sigaba semithi ye-hypoglycemic yi-NovoRapid. Kuyisidakamizwa esisebenza ngokushesha esisebenza isikhathi esifushane. Umphumela we-glycemic ubonakala ngemuva kwemizuzu eyi-10 ukuya kwengama-20, ngemuva kokujova noma ukuthambisa okungashisi. Umphumela omkhulu ubonwa ngemuva kwemizuzu engama-40 futhi kancane kancane uyancipha, ufinyelela ubuncane ngemuva kwamahora angama-5.

Ukuze ulondoloze i-glycemia ejwayelekile, ngaphandle kweziqephu zokwanda noma ukuncipha koshukela (ngaphandle kwebanga elijwayelekile), ukuqapha ngokucophelela amazinga weglucose kuyadingeka.

Kwenziwa kusetshenziswa izindlela ezilandelayo:

• Imitha kashukela wegazi;
• Uhlelo lwe-CGMS lokwelashwa kwepampu (uhlelo lokuqapha ushukela).

Izilinganiso kufanele zithathwe ngaphambi nangemva kokudla. Ukubalwa okulungile komthamo owodwa womuthi, izinga likashukela ngaphambi kokudla kuthathelwa ingqalelo, futhi amanani we-postprandial asetshenziswa ukulungisa izinkomba.

I-NovoRapid iphathwe ngaphandle kokusebenzisa isirinji ye-insulin engu-U 100, isiponji sepeni noma iphampu ye-insulin. Ukuphathwa kwe-Intravenous kuvunyelwe kuphela ngabasebenzi bezokwelapha abaqeqeshiwe, ezimweni zokunakekelwa okuphuthumayo. Inani lamayunithi omjovo owodwa womuthi linqunywa ngudokotela ohambelayo.

Isidingo sansuku zonke sibalwa ngawodwana, ngokuya ngobuzwela besiguli nesisindo somzimba. Isidingo esijwayelekile sansuku zonke sisebangeni lesisindo somzimba esingu-0.5-1 U / kg. Awukwazi ukufaka umthamo wansuku zonke we-aspart ngokushesha, ngoba lokhu kuzoholela ku-hypoglycemia ne-coma. Umthamo owodwa ubalwa ngokwahlukana ngokudla ngakunye kokudla kwe-carbohydrate.

Isidingo ngasinye se-insulin esisebenza ngokufushane sincike ekusebenzeni kwe-hormonal nasemzimbeni, kanye nesikhathi sosuku. Ngamahora okusa, isidingo singakhuphuka, kuthi ngemuva kokuzivocavoca kakhulu ngokomzimba noma kusihlwa - kungancipha.

Ukusetshenziswa kwe-biphasic aspart

I-NovoMix (ummeleli we-biphasic aspart) isetshenziselwa iziguli ezinesifo sohlobo 2. Umthamo onconyiwe, ekuqaleni kwezokwelapha, amayunithi ayi-12, ophekwa kusihlwa, ngaphambi kokudla. Ukuthola umphumela olawulwa ngokwengeziwe, kuhlongozwa ukuhlukanisa umthamo owodwa kumithamo emibili. Ngalesi singeniso, babeka amayunithi ama-6 weNovoMix ngaphambi kokudla kwasekuseni nakusihlwa, nangaphambi kokudla.

Ukuphathwa okulula kuphela kwe-biphasic aspart kuvunyelwe. Ukulawula amazinga kashukela nokulungiswa kwamadosi, kuyadingeka ukukala amazinga wegazi. Ukulungiswa kwe-dose kwenziwa ngemuva kokudweba uhlelo lwephrofayili, kucatshangelwa izinga lokuzila ushukela (ekuseni, esiswini esingenalutho), izinsuku ezintathu.

Contraindication kanye nemiphumela emibi

Kunezici eziningana eziphakamisa ukusebenzisa i-insulin aspart ngokuqapha. Contraindication kanye nemikhawulo kusebenza kuzo zombili izinhlobo zesigaba esisodwa nezindlela ezihlanganisiwe zomuthi. Ukwephulwa okuyinhloko ukungabekezelelani ngakunye kwento esemqoka nezinto ezingeziwe ezakha umuthi.

Imikhawulo eminingana yaziwa ngokusetshenziswa okuhlangene kwe-aspart, nezinye izidakamizwa:

1. Ama-Sulfites nezidakamizwa zeqembu le-thiol abhubhisa i-aspart;
2. Amathebulethi e-Hypoglycemic, i-thioctic acid, i-beta-blockers, kanye neminye imithi elwa namagciwane ikhuthaza umphumela we-hypoglycemic;
3. Iqembu le-thiazolidinedione likhulisa ubungozi bokwehluleka kwenhliziyo.

Ezimweni ezingavamile, ama-antibodies akhiwa egazini anciphisa umphumela we-glycemic we-aspart. Ukuphathwa okungafanele noma okweqisayo komuthi, ngokubalwa okungalungile komthamo owodwa, kungadala i-hyperglycemia noma i-hypoglycemia.

ISIVIVINYO Ukweqisa izidakamizwa kuholela ekhefeni nasekufeni.

Imiphumela emibi ingeyendawo ngokwemvelo, ibonakala endaweni yomjovo. Ngemuva komjovo, ubomvu obuncane noma ukuvuvukala, ukulunywa, ama-hematomas amancane angabhekwa. Ngokuhoxiswa okubukhali kwesiguli esimweni sesikhathi eside se-hypoglycemic, i-neuropathy yesikhashana yezinhlungu kanye ne-retinopathy yesifo sikashukela ingaqala.

Izindleko nama-analogues

Izindleko zesidakamizwa zincike ohlotsheni ekhiqizwa ngalo i-insulin. Intengo yezidakamizwa kanye nama-analogic iboniswa etafuleni.

Ama-analoggs e-aspart anomthelela ofanayo, kepha enziwa ngesisekelo sezinto ezithile ezisebenzayo. Le mishanguzo yenzelwe ukusetshenziswa kadokotela.

I-insulin aspart yi-ejenti ephumelela ye-hypoglycemic. Alunayo inombolo enkulu ye-contraindication futhi isetshenziswa njengengxenye yokwelapha okuyinkimbinkimbi yesifo sikashukela mellitus, zombili izinhlobo. Umuthi ufanele izingane nezingane kanye nabadala.