Isifo sikashukela se-pancreatogenic

Njengoba izibalo zibonisa, i-mancitus ye-pancreatogenic sikhula ku-30% yeziguli ezinokulimazeka okungama-pancreas. Ukwelashwa kwalesi sifo kuyinkimbinkimbi impela. Amathuba okululama ngokugcwele mancane.

Yini le

Ukuqonda ukuthi siyini isifo sikashukela se-pancreatogenic nokuthi sikhula kanjani, kubalulekile ukusho amagama ambalwa ngokusebenza kwamanyikwe. Lesi sitho siqukethe amaseli ama-exocrine akhiqiza imfihlo ekhethekile edingekayo yokugaya ukudla. Phakathi kwalawa maseli kukhona iziqhingi zeLangerhans, "imisebenzi" yazo kubandakanya ukukhiqizwa kwe-insulin neglucagon. Ziqukethe amaseli e-endocrine.

Njengoba amaseli e-exocrine ne-endocrine etholakala esondelene kakhulu, lapho izinqubo zokuvuvukala zenzeka kwenye yazo, ezinye ziyathinteka. Lokho wukuthi, ngaphezu kweqiniso lokuthi ukukhiqizwa kwejusi ye-enzyme kuyaphazamiseka, kukhona ukungasebenzi kahle ekwenziweni kwamahomoni adingekayo ekuqhekekeni ngokuphelele kwe-glucose nokuguqulwa kwayo kube amandla. Futhi ngenxa yalesi sizathu, i-pancreatitis kanye nesifo sikashukela kuvame ukuvela ngasikhathi sinye.

Izizathu

Njengoba kushiwo ngenhla, imbangela enkulu yokwanda kwesifo sikashukela sohlobo 3 izinqubo zokuvuvukala ezenzeka kumaseli wamanyikwe. Kepha hhayi kuphela i-pancreatitis ebabayo noma engamahlalakhona engavusa ukuvela kwalesi sifo. Kukhona amanye ama-pathologies we-pancreatic angaholela kwisifo sikashukela se-pancreatogenic kubantu. Yilezi:

• i-pancreatic necrosis, ebonakala ngokungasebenzi kahle kwe-pancreas, lapho iqala khona ukugaya amaseli ayo, ibangele ukufa kwabo;
• izifo ze-pancreatic oncological, lapho amangqamuzana esitho esonakalisiwe, ayeka ukusebenza ngokujwayelekile futhi kancane kancane afe;
• ukulimala okugcinwe ngesikhathi sokungenelela noma ukungenelela kokuhlinzwa lapho ubuqotho be-pancreas bulinyazwe khona, kulandelwa ukuthuthukiswa kwezinqubo zokuvuvukala;
• ukuhlukaniswa ngokwengxenye kwamanyikwe, ngokwesibonelo, lapho kutholakala isimila noma esinye isifo, lapho ukususwa kwengxenye yesitho kungukuphela kwendlela ephumelelayo yokusindisa umuntu;
• i-cystic fibrosis, okuyisifo esiyindlalifa lapho kuthinteka khona izindlala ze-endocrine;
• i-hemochromatosis, ebonakala ngokuphulwa kokushintshaniswa kwemibala equkethe i-iron emzimbeni, okufaka ukungasebenzi kahle kwezitho eziningi, kufaka phakathi i-pancreas;
• i-pancreatopathy ebonakala nge-pancreatic hyperfunctionality.

Kubalulekile ukubheka njalo izinga likashukela egazini, ngoba ukuphambuka kwalo kusuka kokujwayelekile okungaba yizimpawu zokuqala ezibonisa ukwephulwa kwemisebenzi yamanyikwe

Ukufingqa, kufanele kuqashelwe ukuthi ukuthuthukiswa kwe-pancreatogenicabetes mellitus ngandlela thile kuhlobene nokuphulwa kwamanyikwe. Ngakho-ke, phambi kwezifo ezinjalo, iziguli ziyelulekwa ukuthi zihlolwe njalo emitholampilo ukuze zisheshe zikhombe ukwenzeka kwezinkinga futhi ziqale ukwelashwa kwazo.

Kumele kuqashelwe ukuthi izifo ezinjenge-pancreatitis kanye nesifo sikashukela zivame ukukhula ngasikhathi sinye kulabo bantu abakhuluphele ngokweqile kanye ne-hyperlipidemia. Futhi uma konke kucace ngesisindo ngokweqile, khona-ke nge-hyperlipidemia akuyona ngokuphelele, ngoba abaningi abazi nokuthi hlobo luni lwesifo. Futhi kuyisimo lapho izinto eziyingozi ziqala ukuqongelela egazini, okungukuthi i-lipids, phakathi kwazo kukhona i-cholesterol, amafutha kanye ne-triglycerides.

I-peculiarity ye-hyperlipidemia ukuthi ikhula ikakhulukazi kubantu abahlushwa ukukhuluphala, isifo sikashukela noma isifo se-cholesterol. Cishe asymptomatic. Uma kunezimpawu ze-hyperlipidemia, zivame ukuvilapha, futhi abantu abazinaki nje. Ngakho-ke, bafunda ngobukhona bale nkinga kuphela lapho bahlolwa ama-pathologies ahluke ngokuphelele.

Ngokusho kodokotela abaningi, abantu abakhuluphele futhi abathathi zinyathelo zokuqeda le nkinga, baveza imizimba yabo ezingozini ezinkulu. Ngempela, lapho sikhona ngokweqile kwesisindo somzimba, izingozi zokuthola ukuvuvukala okungapheli kwama-pancreas zanda kaningana. Ngasikhathi sinye, amathuba okuhluleka kwe-endocrine ayanda, okubandakanya nokubonakala kwalesi sifo.

Ukukhuluphala kubangela hhayi kuphela ukuthuthukiswa kwe-pancreatogenicabetes mellitus, kodwa futhi nokuvela kwezinye izinkinga zezempilo.

Ngaphezu kwalokho, iziguli ezine-pancreatitis eyingozi ngenxa yokukhuluphala zivame ukuthuthukisa i-hyperglycemia, ebonakala ngokwanda okukhulu koshukela wegazi. Ezimweni eziningi, iphela ngokuqala kwenkinga ye-hyperglycemic.

Ukuvela kwe-hyperglycemia ikakhulukazi kuhlotshaniswa nale ndaba:

• ukudumba okukhulu kwamanyikwe okubangelwa izinqubo zokuvuvukala;
• Umphumela we-inhibitory we-trypsin ku-insulin synthesis, izinga okuqhamuka ngalo ngemuva kokuvuvukala okukhulu likhuphuka kaningana.

Izici zenkathi yesifo sikashukela se-pancreatogenic

I-pancreatogenicabetes mellitus inezici zayo zokuthuthuka. Njengomthetho, abantu abahlaselwe yilesi sifo banomzimba omncane futhi bayi-choleric. Ngokungafani nohlobo 1 sikashukela nohlobo 2 sikashukela, ezigulini ezinesifo sikashukela sohlobo 3, ukwanda koshukela wegazi kubekezelelwa yiziguli ngokujwayelekile. Ngaphezu kwalokho, bangazizwa kahle ngisho nakulezo zimo lapho izinga likashukela wegazi likhuphuka liye kumamaki afana ne-10-11 mmol / l. Esikhathini sikashukela ojwayelekile, ukwanda okunjalo kwe-glucose kuholela ekuwohlokeni okubukhali enhlalakahleni, futhi kulokhu, akukho zimpawu eziphawuliwe.

Ngaphezu kwalokho, ekwakhiweni kwalesi sifo, ukubekelwa ifa akunandaba. Kungenzeka futhi kulabo bantu emindenini yabo engakaze ibonwe. Ngaso leso sikhathi, i-pancreatogenicabetes mellitus ayinakho ukumelana ne-insulin futhi ayibonakali ngenkambo enkulu. Kepha abantu abahlushwa yikho, njengeziguli ezinesifo sikashukela sohlobo 1 nohlobo 2 sikashukela, basengozini enkulu yokutheleleka njalo nezifo zesikhumba. Ngesikhathi sokuqhubeka kwayo, amanxeba nokuhlukumezeka emzimbeni kuphulukisa isikhathi eside kakhulu futhi izingozi zokuphakanyiswa kwazo ngokwakhiwa okulandelayo kwe-gangrene zikhona.

Isifo sikashukela se-pancreatogenic sithuthukisa cishe njenge-asymptomatic. Izimpawu zokuqala zokuvela kwayo zivela kuphela ngemuva kweminyaka eminingana yokuhlaselwa kobuhlungu obuhleliwe esiswini.

Ubuhlungu besisu kungaba uphawu kuphela lwesifo sikashukela se-pancreatogenic

Isici sayo esihlukile ukuthi inomkhuba wokwehla ushukela wegazi futhi okuvamisile ukunikeza izinkinga. Ngaphezu kwalokho, ngokungafani ne-T1DM ne-T2DM, isabela kahle ekwelashweni futhi ayidingi ukusetshenziswa okuqhubekayo kwemithi equkethe i-insulin. Njengoba ukwelashwa kwakhe, ukusebenza ngokomzimba okulinganiselayo, ukudla, ukwenqaba imikhuba emibi nokusetshenziswa kwezidakamizwa ezihlobene ne-sulvonylurea kanye ne-saltids kuyasetshenziswa.

Izimpawu

Njengoba kushiwo ngenhla, i-pancreatogenic sikashukela i-mellitus ingakhula ngokufana iminyaka eminingi. Futhi okuwukuphela kwento engahlukumeza iziguli kubuhlungu besisu besikhathi esithile kanye nokwanda koshukela wegazi.

Yini ebangela isifo sikashukela

Kodwa-ke, uma lesi sifo sihambisana ne-hyperinsulinism (lesi simo sivame ukwenzeka ngokuvuvukala okungapheli kwezifo zepancreas kanye ne-endocrine), khona-ke isithombe sasemtholampilo esivamile kungenzeka sengezelwe yizimpawu ezinjalo:

• umuzwa ongapheli wendlala;
• ukuncipha kwemisipha;
• ubuthakathaka
• ukujuluka komoya obandayo;
• ethuthumela
• ukuvusa imizwa ngokweqile.

Imvamisa, i-hyperinsulinism ehambisana ne-pancreatogenic sikashukela mellitus icasulisa ukubukeka kokuxhamazela kanye nezimo zokwehluleka. Ngaphezu kwalokho, ngalesi sifo, ukuvuleka kwezindonga ze-vascular kuyaphazamiseka futhi ukuthinteka kwabo kukhuphuka, okuholela ekubonakaleni kwe-edema kanye namaqhubu abonakala emzimbeni ngaphandle kwesizathu.

Ukwelashwa

Isici esiyinhloko ekwelapheni i-pancreatogenicabetes mellitus sidla. Isiguli kudingeka siqaphele kakhulu lapho sikhetha ukudla. Kubaluleke kakhulu ukunaka ngokukhethekile ukulungiswa kokuntuleka kwamaprotheni-amandla, kanye nokuvimbela ukuqhubeka kwesisindo, ngoba lokhu kungaholela ekukhathaleni.

Uhlu olusondele lwemikhiqizo evunyelwe neyenqatshelwe yesifo sikashukela se-pancreatogenic

Ngaphezu kwalokho, kuyadingeka ukuthi uthathe imishanguzo ebuyisela i-electrolyte emzimbeni futhi iphinde ibuyise izinqolobane zamavithamini namaminerali ukuze kugwemeke ukubonakala kwe-hypovitaminosis, okuvela kuzo lapho kuhlupheka khona zonke izitho nezinhlelo zomuntu ngaphakathi, kubandakanya namanyikwe.

Okubalulekile ekwelashweni kwalesi sifo ukunxephezela kokungapheleli kwe-pocrreatic pancreatic. Ngale njongo, kuthathwa amalungiselelo akhethekile athuthukisa ukuvutshelwa kwesitho nokukhulisa impahla yaso yokuphinda yenziwe.

Ebusweni bezinhlungu ezinzima esiswini, ama-analgesics asetshenziswa. Kubaluleke kakhulu ukuthi zihlobane nezidakamizwa ezingezona ze-narcotic. Lokhu kuzovikela umlutha nezinye izinkinga zempilo.

Kwezinye izimo, ukungenelela kokuhlinzwa kusetshenziselwa ukwelapha i-pancreatogenicabetes mellitus. Kwesinye isikhathi kungukuphela kwekhambi lesifo. Uma ungenalo ukuhlinzwa, khona-ke kukhona izingozi eziphakeme ze-pacreatomy. Uma libonakala, khona-ke kungadingeka ukusebenzisa i-insulin elula. Kusetshenziswa inani elingeqi kumayunithi angama-30. Futhi umthamo wawo oqondile wesiguli ubalwa ngawodwana, kucatshangelwa izici ezithile:

• izinga loshukela wegazi lesiguli (ligadiwe isonto lonke ngaphansi kwezimo zokuma noma ekhaya lisebenzisa i-glucometer, yonke imiphumela ibhalwe kudayari);
• ikhwalithi nobunjalo bokudla kwesiguli (kubheka inani lokudla, inani lamandla lokudla okusetshenzisiwe, inani lamafutha, ama-carbohydrate namaprotheni ekudleni);
• izinga lomsebenzi womzimba.

Futhi lapha kubaluleke kakhulu ukusebenzisa izidakamizwa eziqukethe i-insulin kahle. Uma izinga likashukela wegazi likububanzi be-4-4.5 mmol / l, khona-ke akufanele isetshenziswe kunoma yikuphi. Njengoba le mishanguzo isiza ukwehlisa amazinga eglucose futhi ingadala ukuqala kwe-hypoglycemia noma, okubi kakhulu, inkinga ye-hypoglycemic, lapho umuntu angawela enkingeni noma afe.

Ngemuva kokuthi odokotela bakwazi ukwengeza i-carbohydrate metabolism nomsebenzi we-pancreatic, kusetshenziswa umuthi ohloselwe ukuqinisa amazinga kashukela egazini. Uhlobo luni lwezidakamizwa zale nhloso ezizosetshenziswa, udokotela kuphela onquma, ebheka lezi zinto ezingenhla.

Ukwelashwa kwe-pancreatogenicabetes mellitus akulethi ubunzima obukhulu uma isiguli saphendula ngokushesha ekwakhiweni kwalesi sifo futhi saphendukela kudokotela ukuze athole usizo. Ngakho-ke, lalelisisa impilo yakho futhi lapho kuvela izimpawu zokuqala zalesi sifo (okungukuthi, isisu esibuhlungu), iya kuchwepheshe bese ulandela zonke izincomo zakhe. Kungale ndlela kuphela lapho uzokwazi ukugcina impilo yakho iminyaka ezayo!