Amathebulethi omlomo I-Tricor yomabili i-145 ne-160 mg yakhiwa ngento esebenzayo ngesimo se-fenofibrate.
Ngokuqondene nesenzo se-pharmacological, kungokwehlisa i-lipid (noma kwehlise ukuqoqwa kwama-lipids). Umuthi ungowesigaba se-pharmacological of fibrate.
Isimilo esivamile
Ngokuyisisekelo, umuthi usetshenziselwa ama-pathologies ahambisana ne:
- ngazo zombili i-insulin ezincike ku-insulin nezingasekeli i-insulin;
- nge-hypercholesterolemia (cholesterol ephezulu egazini), hyperglyceridemia (triglycerides ngokweqile);
- nge-hyperlipidemia exubekile (amazinga aphezulu egazi we-cholesterol namafutha, ne-triglyceride);
- kanye nezinye hyperlipidemia.
Ngokuqondene nemininingwane yobulungu bukaTricor eqenjini elithile lomtholampilo nakwezokwelapha, abakhiqizi bayayala amaRecipharm Monts, kanye neLaborenis Fournier S.A. umane ungekho.
Isenzo se-Pharmacological kanye nezinkomba
Ngesikhathi sokuhlolwa kwezidakamizwa Tricor ngqo emitholampilo, izifundo ezigulini ziveze ukuthi ngosizo lwe-fenofibrate, izinga le-cholesterol ephelele ezigulini incishiswa ngama-20, noma ngisho nawo wonke ama-25%, futhi maqondana nokwehlisa ama-triglycerides abo, le nkomba iqala kusuka 40 kuye kuma-55%.
Amapilisi uTricor 145 mg
Ngaphezu kwalokho, ezigulini ezine-hypercholesterolemia, isilinganiso sesamba ne-LDL cholesterol siyancipha. Kufanele kukhunjulwe ukuthi lesi silinganiso singesinye sezona zincazelo zengozi eyandayo yesifo senhliziyo ezi-coronary.
Izidakamizwa kuboniswe njengesijobelelo kwezokwelapha ezingezona izidakamizwa. Kuya njengokuvivinya umzimba okuhlukahlukene, izindlela zokunciphisa umzimba, kanye nokusetshenziswa kokudla kwezifo:
- i-hypertriglycemia enkulu;
- i-hyperlipidemia exubekile, uma kukhona ama-contraindication ama-statins (izidakamizwa ezokwehlisa i-cholesterol egazini);
- i-hyperlipidimia exubekile. Lapho iziguli zinobungozi obukhulu bokukhubazeka kwenhliziyo nemithambo yegazi;
- futhi amaphilisi kubekwa phambi kwesifo sikashukela ecaleni lapho ukudla nokuzivocavoca kungasebenzi.
Umphumela wokwelapha
I-Fenofibrate yinto esetshenziswa ku-fibric acid. Ishintsha isilinganiso se-lipids esegazini.
Ngesikhathi sokwelashwa, lezi zinguquko ezilandelayo ziyabonakala:
- imvume ekhuphukayo noma ukuhlanzwa kwegazi;
- ezigulini ezinobungozi be-CHD, izinga le-atherogenic lipoproteins liyancipha (isilinganiso, esandisa ubungozi be-atherosulinosis) noma "okubi" cholesterol;
- kugqugquzela ukwanda kwe-cholesterol "enhle";
- amandla we-depravascular deposits ancishiswa kakhulu;
- izinga le-fibriogen liyancipha;
- igazi linciphisa okuqukethwe yi-uric acid, kanye ne-protein C-reactive action ku-plasma yayo.
Okuqukethwe okuphezulu kwe-fenofibrate egazini kwenzeka emahoreni ambalwa ngemuva kokuthatha isiguli Tricor.
Kukhishwa ngokuphelele ezinsukwini ezingama-6-7 ikakhulu ngomchamo. Ngasikhathi sinye, i-fenofibrate ayikhululwa ngesikhathi sokudalwa kwe-hemodialysis, ngoba kubonakala sengathi iboshelwe ngokuqinile kwi-albhamu ye-plasma (iprotheni enkulu).
Contraindication
Uhlu lwe-contraindication olukhonjwe kwinqubo yocwaningo, kanye nomphumela wenkambiso yokusebenzisa iTreycor, imi ngalendlela elandelayo:
- izinga eliphakeme lokuzwela lomzimba ukuze wenze i-fenofibrate, kanye nezinye izinto zomuthi;
- i-hepatic, ukwehluleka kwezinso;
- ukuqina kwesibindi;
- iminyaka engaphansi kweminyaka eyi-18;
- i-photosensitivity (ukuzwela okukhulayo kolwelwesi lwe-mucous nesikhumba kuzo zombili i-ultraviolet nokubukeka kwemisebe ebonakalayo), kanye ne-Phototoxicity;
- isifo se-gallbladder;
- ukubonakaliswa kokungezwani namantongomane no-oyela wawo, emikhiqizweni ye-soy, eyembulwa kwinqubo yokuqoqa i-anamnesis noma ukuxoxisana nesiguli ngaphambi kokuyalela umuthi;
- ukucaphuka.
Ngokuqapha, uTricor unqunywa lapho isiguli:
- usebenzisa kabi utshwala;
- uphethwe yi-hypothyroidism noma unesifo esinqabile sama-hormone egilo;
- ebudaleni;
- inezifo zemisipha yefa.
Ukukhulelwa
Ngokuqondene nemininingwane yokuhlolwa kwezempilo emtholampilo nasenqubeni yokusebenzisa umuthi ngabesifazane abakhulelwe, akwanele.
Isibonelo, ocwaningweni lwezilwane, umphumela we-tetratogenic (ukuthuthukiswa kombungu ophansi ngaphansi kwethonya lomuthi) awutholakalanga.
Ngaphezu kwalokho, lapho kwenziwa izivivinyo zangaphambi kokutholwa, i-embryotoxicity yaboniswa ngenxa yokusetshenziswa komunye wabesifazane abakhulelwe ngethamo elikhulu lomuthi. Kodwa-ke, ingozi kwabesifazane abakhulelwe ibingakaqunywa ngokuphelele.
Imihla nemihla
Umuthi uphuzwa ngomlomo, ngenkathi ugeza ithebhulethi ngamanzi. Isikhathi sokudla siyimpikiswano futhi asincike ekudleni (uTricor 145). Ukwemukelwa kweTricorr 160 kufanele kwenziwe kanyekanye nokudla.
Umthamo weziguli yithebhulethi elilodwa ngosuku.
Ngaphezu kwalokho, uma iziguli ngaphambilini zithathe i-tablet engama-160 milligrams weTricor, lapho zingakwazi, uma kunesidingo, ziguqele ekuthatheni ama-milligrams angama-145 omuthi, futhi ngaphandle kokulungiswa komthamo. Iziguli esezikhulile kufanele zisebenzise umthamo ojwayelekile - hhayi ngaphezulu kwethebhulethi elilodwa ngosuku kanye.
Umuthi unesikhathi eside sokuwusebenzisa, kuyilapho kufanele unamathele ekudleni okuchazwe ngaphambilini. Ukuhlolwa kokusebenza kwe-Tricoror therapy kufanele kwenziwe kuphela ngudokotela oholayo lapho kuhlaziywa okuqukethwe womabili ama-lipids (amafutha nezinto ezifanayo), ne-LDL, i-cholesterol ephelele, kanye nokuqukethwe kwe-triglycerides.
Esimweni lapho izinyanga eziningi umphumela wezokwelapha ungabonakali, khona-ke ezinye izindlela zokwelapha ezingafani kufanele zibhekwe.
Ukusebenzelana kwezidakamizwa
I-Fenofibrate uma isetshenziswa ndawonye nama-anticoagulants omlomo (izidakamizwa eziqeda i-thrombosis) ithuthukisa umphumela wokugcina ubeke engcupheni eyengeziwe yokuphuma kwegazi, okubangelwa ukuthi izidakamizwa ze-antithrombotic zivame ukususwa kulezo zingosi ezivame ukuba ngamaprotheni azibopha kuyi-plasma yegazi.
Ngakho-ke, ekuqaleni kokwelashwa nge-fenofibrate, umuntu kufanele anciphise ukuthathwa kwemithi enjalo ngomunye wesithathu bese ngokuhamba kwesikhathi akhethe umthamo ofanele kakhulu ngokuya ngezinga le-INR (isilinganiso esijwayelekile samazwe omhlaba). Ngokuqondene nokusetshenziswa okuhlanganyelwe ngomuthi onjengeCyclosporine, kunemicimbi eminingana yemiphumela emibi yokuphathwa kwayo kanye nefenofibrate.
Uma lokhu kudingekile, khona-ke kuyadingeka ukuqapha imisebenzi yesibindi, bese kuvela ushintsho olubi ekuhlaziyweni kwayo, ngokushesha ususe uTricor. Iziguli ezitholakala zine-hyperlipodemia, ukuthatha izidakamizwa ama-hormonal noma izindlela zokuvimbela inzalo kufanele zithole uhlobo lwalesi sifo, ngoba kungaba uhlobo lwasisekelo noma lwesibili.
Ngokuqondene nohlobo lwesibili lwesifo, lungabangelwa ukungena kwe-estrogen, okuthi kwezinye izikhathi kuqinisekiswe yi-anamnesis noma ukubuzwa kweziguli.
Kwesinye isikhathi, ngenkathi kusetshenziswa uTricor ngezidakamizwa ezithile, kukhuphuka i-transaminase (le ngama-enzyme ngaphakathi kweseli edlulisa ama-molekyuli e-amino acid) esibindini.
Ngasikhathi sinye, kunencazelo yezinkinga ezihlobene nokuthatha i-Tricor ngesimo se-pancreatitis. Lezi zinqubo zokuvuvukala zihlotshaniswa zombili nomphumela oqondile wesidakamizwa, kanye nokuba khona kwamatshe noma ukwakheka kokudilika ngendlela yokwakheka okuqinile gallbladder, okuphazamisa ukusebenza okuvamile kwe-bile duct.
Iziguli ezinqunyelwe i-myopathy (ifa lemisipha yenzalo), kanye nalezo ezingaphezulu kweminyaka engama-70, zingaba nokubonakaliswa kwe-rhabdomyolysis (i-pathology yokubhujiswa kwamangqamuzana emisipha) ngenxa yemiphumela ye-fenofibrate.
Inhloso yesidakamizwa ichazwa kuphela uma umphumela wokwelapha uphakeme kakhulu kunezingozi nemiphumela ye-rhabdomyolysis.
Intengo nezimpawu
Intengo yeTricor kumakhemisi ingasukela kuma-ruble angama-500 kuye kwangama-850, ngokuya ngesisindo (i-145 noma i-160 mg) ngamapharamitha, kanye nakwabakhiqizi bawo. Ngaphezu kwalokho, intengo yangempela ingahlukahluka kakhulu kumanani avezwe kumasayithi ekhemisi.
Njengomfanekiso kaTricor, izidakamizwa ezifana:
- I-Innogem
- Lipofem;
- I-Lipicard
- I-Lipanorm.
Ashibhile kakhulu kuneTricor, anezinhlu zawo zokuphambana, kanye nomthamo, okufanele unqunywe ngudokotela. Ukusetshenziswa kwabo okuzimele akwamukeleki.
I-Tricor: ukubuyekezwa
Ukubuyekezwa ku-Tricor yezidakamizwa kukhona okuhle kakhulu:
- UYuri, Lipetsk, oneminyaka engama-46. Ngokuqondene noshukela, akulinciphisi, futhi uTricor ulwa kahle ne-cholesterol. Kodwa-ke, ukulawula kuyadingeka kusetshenziswa i-biochemistry;
- U-Elena, Belgorod, oneminyaka engama-38. Isimo ngokujwayelekile sesithuthukile. Sekuphele inyanga ngiphuza amaphilisi, kubukeka sengathi ngiphelelwe yisisindo. Kungekudala, ngokugcizelelwa udokotela, ngizohlolwa. Ngibheke phambili esikhathini esiyizinyanga ezintathu sokwamukelwa;
- IBoris, eMoscow, eneminyaka engama-55. Ngiphuza umuthi iTricor ezifundweni ezinyangeni ezintathu. Isebenza kahle kimi ukwehlisa ama-triglycerides.
Amavidiyo ahlobene
Konke okudingeka ukwazi mayelana noTricor kuvidiyo:
