I-Diabetesalong - imiyalo esetshenzisiwe

Isifo sikashukela yisifo esingalapheki. Isiguli siphoqelelwa ukuthi siphuze imishanguzo elawula ushukela wegazi kuyo yonke impilo yakhe.

Ezigulini ezinesifo sikashukela sohlobo 1, lokhu kuyi-insulin, kanti uhlobo lwesibili izidakamizwa ezenziwa nge-sulfonylurea.

I-Diabetesalong isidakamizwa se-hypoglycemic esibekelwe abantu abanoshukela wegazi omkhulu ukusinciphisa.

Umuthi uphuzwa ngomlomo, futhi ngenxa yesenzo eside, kusetshenziswa i-1, kaningi kathathu ngosuku.

Umuthi ubekwa njengethuluzi elizimele noma ohlelweni lokwelapha oluhlanganisiwe. Kusetshenziswa ezimweni lapho ukulandela ukudla kungasizi, kepha ukuphuza umuthi kufanele njalo kuhambisane nokulungiswa komsoco.

Ukwakheka, ifomu lokukhulula

I-Diabetesalong iyatholakala ngesimo samaphilisi amhlophe ayindilinga. Zigcwele emabhulini ezingcezu eziyi-10 kanye nebhokisi lekhadibhodi, lapho kungaba khona amapuleti amathathu kuya kwayi-6.

Umuthi utholakala kumithamo emibili: 30 mg no-60 mg wento esebenzayo, eyi-gliclazide.

Izici ezisizayo zomuthi:

• i-colloidal silicon dioxide;
• i-lactose monohydrate;
• i-calcium stearate;
• i-pyromellose;
• i-talcum powder.

Ifomu lomthamo lingaba sesimweni samathebulethi ngokukhishwa okuguqulwayo noma isenzo eside.

I-Pharmacology ne-pharmacokinetics

Isithako esikhulu esisebenzayo yi-gliclazide, ngesimo samakhemikhali sisuselwa kwisofu yesizukulwane sesibili. I-Gliclazide ikhombisa imisebenzi ephezulu yokukhetha kanye ne-bioavailability.

Iyamelana nemvelo ehlukahlukene yemvelo futhi inemiphumela elandelayo:

• kwandisa ukukhiqizwa i-insulin yakho uqobo, ukuvumela ukuthi unciphise umthamo we-hormone elifakiwe;
• ejwayelekile i-carbohydrate metabolism;
• kwandisa umsebenzi wamaseli we-pancreatic beta;
• kunciphisa i-platelet fusion, evimbela i-thrombosis namanye ama-pathologies emithambo yegazi.

I-Diabetesalong igxilwe ngokuphelele ngemuva kokuphatha. Ukuqongelela kancane kancane egazini, kufinyelela ekugxilweni okukhulu emahoreni angama-4-6 ngemuva kokuphatha, kukhombisa ukusebenza kwawo amahora angama-10-12, khona-ke ukugcwala kwawo kuncipha kakhulu futhi emva kwamahora ayi-12 umuthi ususwe ngokuphelele emzimbeni.

I-Gliclazide yenziwa kakhulu yisibindi, futhi yakhishwa yizinso.

Izinkomba kanye ne-contraindication

Isizathu sokuthatha i-Diabetesalong ukutholakala kwesiguli isifo sikashukela sohlobo 2. Umuthi unqunyelwe ukwehlisa ushukela wegazi lapho ukuhambisana nemikhawulo yokudla kunconyelwe kungasizi.

Futhi, umuthi ubekwa njenge-prophylactic yezinkinga ezibangelwa isifo sikashukela, ikakhulukazi ushintsho ekwakhiweni kwemithambo yegazi ngaphansi kwethonya le-glycemia ephezulu.

Kunokuphambana kwesidakamizwa, kufaka phakathi:

• thayipha i-1 isifo sikashukela;
• ukuthatha i-miconazole;
• ukwehluleka okukhulu kwe-hepatic ne-reso;
• isikhathi sokukhulelwa nokuncelisa;
• ukuba khona kwe-ketoacidosis yesifo sikashukela, ikoma noma i-precoma;
• ukuzwela okuphezulu kuzakhi ezakha umuthi;
• ukwephulwa kwe-lactose metabolism;
• ubudala kuya ebudaleni.

Ukuqapha futhi ngaphansi kokuqondisa udokotela kuphela, umuthi uyasetshenziswa:

• ebudaleni;
• abantu okudla kwabo okungajwayelekile;
• iziguli ezinezilonda zenhliziyo;
• iziguli ezihlushwa ukuntuleka kwe-glucose-6-phosphate dehydrogenase;
• ngemuva kokwelashwa isikhathi eside kwe-glucocorticosteroid;
• ukuhlushwa uphuzo oludakayo;
• ukuba nokwehluleka kwezinso noma kwesibindi.

Kulokhu, udokotela kumele athathe isinqumo ngesisekelo sedatha etholakalayo.

Izinto zevidiyo ezivela kosokhemisi:

Imiyalo yokusebenzisa

Imithamo kanye nemvamisa yokusetshenziswa kweDiabetesalong kunqunywe ngudokotela, kuncike kumingcele ngayinye yesiguli futhi ingahluka kakhulu kumuntu kuya kumuntu. Ngokusho kwemiyalo, ukwamukela kwenziwa okungenani i-1-2 ngosuku imizuzu engama-20 ngaphambi kokudla. Le ndlela izovumela ukusetshenziswa kahle kwezakhiwo ze-gliclazide.

Umuthi uthathwa ngomlomo bese ugezwa ngamanzi amancane. Umthamo unqunywa indlela yokukhetha. Kulesi simo, kufanele uqale ngama-30 mg ngosuku, uma kungekho umphumela wokwelapha, umthamo uyakhuphuka kancane kancane ngama-30 mg ukuya ku-120 mg. Lona umthamo omkhulu ngenhla ongasebenzisi ukuthi unconywe.

Awukwazi ukwengeza ngokuzimela umthamo uma kungenye yezindlela elahlekile, ngoba umuthi uholela ekunciphiseni koshukela wegazi, okungaholela ku-hypoglycemia.

Iziguli ezikhethekile

Kubantu asebekhulile abangaphezulu kweminyaka engama-65, kungadingeka ukulungiswa komthamo. Ngokuvamile, isidakamizwa sisetshenziswa ngokuya ngemithetho efanayo.

Ngesikhathi sokukhulelwa, umuthi unconyelwa ukuthi ushintshwe nge-insulin ukwelashwa kuze kube ukulethwa Akunasipiliyoni ngokusetshenziswa kweDiabetesalong neminye izidakamizwa esekwe glycoside ngesikhathi sokukhulelwa, ngakho-ke akunakwenzeka ukuthola umphumela wayo kuzingane.

Ngesikhathi sokuqunjelwa, umuthi nawo awukwazi ukusetshenziswa, ngoba kungenzeka ukuthi kube nokukhula kwe-neonatal hypoglycemia enganeni. Ngakho-ke, ukuncelisa owesifazane ogulayo kwenqatshelwe.

Iziguli ezihluleka ukwehluleka kwezinso nezinye izindlela kufanele zinamathele kumithamo ephansi, okubaluleke kakhulu, kufanele ziqashwe njalo ngudokotela ozobakhona.

Imiyalo ekhethekile

Isimo esibalulekile sokuthatha i-Diabetalong wukudla okujwayelekile. Kufanele ihambisane nezincomo zaleli qembu leziguli futhi ilungiswe ngesikhathi. Lokhu kuyadingeka ukuqeda ubungozi be-hypoglycemia, okungenzeka ngenxa yokuntuleka komthombo wamandla egazini.

Izizathu ezibangela ukuba khona kwe-hypoglycemia zingaba:

• ukungaqashelwa isiguli ngesimo sakhe;
• ukungalandelani kombuso namanani omsoco, indlala, ukudla okungalungisiwe;
• ukwehluleka kwezinso noma kwesibindi;
• ukweqisa izidakamizwa;
• izifo zesistimu ye-endocrine;
• ukungaziphathi kahle kwezinga lomsebenzi womzimba kanye nenani lama-carbohydrate atholakele;
• ukuphathwa okufanayo kwezidakamizwa eziningana.

Imiphumela emibi kanye ne-overdose

Imiphumela emibi esemqoka yokuphuza lo muthi yile:

• ikhanda
• i-hemolytic hlobo anemia;
• ukwephula ukunambitheka;
• komzimba, uvame ukubonakala ngendlela yokuqhuma kwesikhumba.

Ezinye izinkomba zingavela:

• iminyakazo
• Isiyezi
• ukwephulwa kokuzwela;
• ethuthumela
• ukwephulwa kokuphefumula nokugwinya umsebenzi;
• ukwanda kwengcindezi;
• ikhwalithi yokwehla kombono;
• i-hepatitis yohlobo lwe-cholestatic.

Kulokhu, kuyadingeka ukuyeka ukuthatha lo muthi bese ukhetha ama-analogues asuselwa kwezinye izakhi.

Umuthi okweqisa izidakamizwa kungenzeka uma ngokuzimele udlula inani lemishanguzo eyenziwe. Umphumela wayo ophambili yi-hypoglycemia, kuze kufinyelele ku-coma.

Ngama-hypoglycemia angaxilongiwe, umthamo kumele wehliswe, futhi nenani lama-carbohydrate ekudleni kufanele lenyuswe. Endabeni ye-hypoglycemic coma, kunikezwa isixazululo soshukela osingene ngaphakathi.

Ukuxhumana neminye imithi

I-Diabetesalong ixhumana ngezinto eziningi, ngakho-ke ngaphambi kokuqala ukuyithatha, kufanele uzijwayeze nalesi sici.

Ngakho-ke, uma kwenzeka ungaphatha ngasikhathi sinye:

• ngotshwala bungadala i-hypoglycemia;
• ngeDanazol, kuvela isifo sikashukela, esinciphisa umphumela wesidakamizwa;
• nge-miconazole, umphumela we-gliclazide uyathuthukiswa, ongasiza ekwakhiweni kwe-hypoglycemia, into efanayo yenzeka namanye ama-hypoglycemic agents;
• nge-chlorpromazine, enciphisa ukukhiqizwa kwe-insulin, ukusebenza kahle komuthi kuncishiswa kakhulu;
• nge-tetracosactide ne-glucocorticosteroids kungaholela ekwakhiweni kwe-ketoacidosis kanye nokwehla kokubekezelelana kwe-carbohydrate;
• ne-Wafarin namanye ama-coagulants athuthukisa umphumela wawo.

Ama-Analog

Ukubuyekezwa kodokotela kukhombisa ukuthi iDiabetesalong isebenza kakhulu ekwehliseni ushukela wegazi, noma kunjalo, ayikwazi ukusetshenziswa njalo.

Kulokhu, kuqondiswa izifanekiselo zeDiabetesalong, okukuningi impela:

• UDiabinax;
• I-Glyclazide-Akos;
• I-Glucophage ende;
• UGlidiab MV;
• IGliclazide MV;
• I-Diabeteson MV;
• Isifo sikashukela;
• Glucostabil nabanye.

I-Diabetesalong ne-Diabeteson zakhiwa ngesisekelo se-ingredient efanayo, kepha umuthi wesibili ubhekwa njengosebenza kangcono, ngoba umphumela wezenzo zawo utholakala ngokushesha, kepha izindleko zalo muthi ziphindwe izikhathi ezi-2. I-Glyclazide iyi-analogue ecishe iphelele.

IGlucophage yinde iqukethe i-metformin ekwakhiweni kwayo futhi ingahlanganiswa ne-insulin nezinye izidakamizwa ukwehlisa ushukela wegazi.