Izidakamizwa zesifo sikashukela zihlukahlukene kakhulu. Lokhu kufaka isidakamizwa uJanuvia.
Impumelelo yokwelashwa nayo ihambisana nokuhambisana nemiyalo, ngakho-ke kufanele wazi ukuthi yimiphi imithetho yayo eyisisekelo.
Lo mkhiqizo wenziwa eNetherlands. Yithebhulethi enomphumela we-hypoglycemic, eyenziwe ngesisekelo se-Sitagliptin. Umuthi ungathengwa kuphela ngokubhaliwe.
Ukwakheka, ifomu lokukhulula
Isakhi esiyinhloko salo muthi yi-sitagliptin. Yisenzo sakhe esenza lo muthi uphumelele kushukela. Kumakhemisi ungathola izinhlobo eziningana zezimali - ngokuya ngenani lezinto ezisebenzayo. Ungaqukatha u-25, 50 no-100 mg.
Izithako ezilandelayo ezisizayo zengezwa kukho:
- i-sodium stearyl fumarate;
- calcium hydrogen phosphate;
- i-microcrystalline cellulose;
- i-croscarmellose sodium;
- i-magnesium stereate;
- i-macrogol;
- titanium dioxide;
- i-talcum powder.
Izibhebhe ziyindilinga, i-biconvex. Umbala wazo u-beige, ngalinye liqoshwe ngo- "277". Zibekwa emaphaketheni ama-contour ngenani lama-14 ama-PC. Ibhokisi lekhadibhodi lingaqukatha amaphakheji amaningi anjalo (2-7).
I-Pharmacology ne-pharmacokinetics
I-Sitagliptin
Umphumela wesidakamizwa emzimbeni kungenxa yezimpawu zesakhi saso esisebenzayo. I-Sitagliptin (ifomula esesithombeni) ifaka isandla ekukhiqizweni okusebenzayo kwe-insulin ngamanyikwe, ngenxa yokuthi ushukela owutholile emzimbeni usatshalaliswa ngokushesha izicubu.
Ukwanda kwesilinganiso sokuhlanganiswa kwe-insulin kuthinta isibindi, sikuvimbele ekukhiqizeni ushukela ngokweqile. Lokhu kunikeza ukwehla kokuxwilwa koshukela egazini likashukela futhi kuthuthukisa inhlala-kahle yakhe.
Ukuqunjelwa kwento esebenzayo kwenzeka ngokushesha okukhulu. Le ngxenye ifinyelela ekusebenzeni kwayo okuphezulu cishe ihora ngemuva kokudla uJanuvia futhi ihlala amanye amahora ama-3. Ngaphezu kwalokho, into iqala ukususwa kancane kancane emzimbeni, nomphumela wayo ube buthaka.
Ukuxhumana namaprotheni e-plasma kwakha inani elincane le-sitagliptin. Ngokwe-metabolism, isakhi cishe siguqulwa. Ukwembiwa kwengxenye ebalulekile yalokho kwenziwa izinso. Inani elisele liqedwa ngamalongwe.
Izinkomba kanye ne-contraindication
Ngokwemiyalo, lesi sidakamizwa sisiza ngohlobo 2 sikashukela. Ingasetshenziswa ngokuhambisana nezinye izidakamizwa noma uhlobo lwe-monotherapy, olunikezwa ngokudla.
Kepha ukuba khona kwalokhu kutholwa akusho ukuthi kufanele uqale uthathe lo muthi. Umuthi kufanele unqunywe ngudokotela ngemuva kokuhlolwa futhi achaze ngokuningiliziwe imithetho yokusetshenziswa. Lokhu kubalulekile ngoba uJanuvia une-contraindication, engenza ukuthi kube yingozi ukuyisebenzisa.
Phakathi kwazo khuluma:
- i-ketoacidosis yemvelaphi yesifo sikashukela;
- thayipha i-1 isifo sikashukela;
- ukungabekezeleli ekwakhekeni;
- izingane nentsha;
- ukukhulelwa
- inkathi yokuncelisa.
Kukhona futhi izimo lapho umkhiqizo ungasetshenziswa khona, kepha ukuqaphela kuyadingeka. Imvamisa, kunikezwa izindlela ezikhethekile ezigulini ezinesifo sezinso esinzima.
Uchwepheshe angabanikeza uJanuvia kubo, kepha kufanele abhekane nokukhethwa komthamo womuthi. Ngaphezu kwalokho, udinga ukubheka ukusebenza kwezinso ngezikhathi ezithile.
Imiyalo yokusebenzisa
Umuthi kufanele uthathwe ngokuqinile njengoba kuchazwe udokotela futhi unaka zonke izincomo zawo. Kubaluleke kakhulu ukukhetha umthamo ofanele kakhulu esimweni ngasinye, ukuze ungazidabukisi izinkinga. Ukunakwa ikakhulukazi kufanele kukhokhwe ezifweni ezengeziwe ezengeziwe.
Umthamo ojwayelekile wesidakamizwa, ngaphandle kokuthi kuboniswe ngenye indlela, ngu-100 mg. Kepha ukwenza isiqiniseko sokuthi ingxenye enjalo ilungele ukwelashwa kungenzeka kuphela ngesikhathi sokuhlolwa.
Ukudla akukuphazamisi ukusebenza kukaJanuvia. ngakho-ke, ungaphuza amaphilisi nganoma yisiphi isikhathi. Lapho weqa ingxenye elandelayo, ungathathi kabili inani. Udinga nje ukuthatha iphilisi ngokushesha nje lapho ukhumbula ngalo.
Noma ngeseluleko sikadokotela, udinga ukubheka inhlala-kahle yakho futhi ulawule izinga likashukela, ulungisa umthamo womuthi uma kunesidingo.
Iziguli ezikhethekile
Kwezinye iziguli, akusikisela ukusebenzisa imithetho kadokotela ejwayelekile. Banemodi ekhethekile. Abamele amanye amaqembu abavunyelwe ukuthola iJanuvia; ukunakekelwa okukhethekile kuyadingeka maqondana namanye.
Lokhu kufaka phakathi:
- Abesifazane abakhulelwe. Akunamininingwane ngemiphumela yomuthi ezigulini ezinjalo, ngoba izifundo kule ndawo azenziwanga. Ukugwema izingozi ezingaba khona, nesifo sikashukela kwabesifazane abakhulelwe, odokotela banikeza eminye imishanguzo.
- Omama abahlengikazi. Akukaziwa ukuthi isithako esisebenzayo sidlulela yini ebisini lobisi. Kulokhu, kunzima ukuthola ukuthi le nto ingamthinta kanjani umntwana. Ngakho-ke, nge-lactation, akunakwenzeka ukusebenzisa iJanuvia.
- Izingane nentsha. Imiyalo yomuthi ayihlinzeki ekwelashweni kweziguli ezingaphansi kweminyaka engu-18. Ngakho-ke, isifo sikashukela ezigulini ezinjalo selashwa ngezinye izindlela.
- Abantu abadala. ISitagliptin ayithathwa njengeyingozi kubantu abakulesi sigaba. Uma kungekho zinkinga zempilo, uhlelo olujwayelekile lokuphuza umuthi luyavunyelwa, yize kukhona izinguquko ezihlobene nobudala emzimbeni. Kepha udokotela kumele aqaphele inkambo yokwelashwa ikakhulukazi ngokucophelela.
Kuzo zonke ezinye izimo, kuncike esithombeni somtholampilo walesi sifo kanye nezimpawu zomzimba.
Imiyalo ekhethekile
Imvamisa, lapho kunqunywa izidakamizwa zesifo sikashukela, kuthathwa izindlela ezikhethekile ezigulini ezihlangabezana nezifo zesibindi nezinso. Lokhu kungenxa yomphumela walezi zidakamizwa kulezi zitho zomzimba.
Uma usebenzisa uJanuvia kulezi zimo, kufanele uhambisane nezincomo ezilandelayo:
- Uma kwenzeka unesifo sezinso, kuyadingeka ukulungisa umthamo womuthi. Lokhu kuyiqiniso ikakhulukazi ezigulini ezinezindlela ezinzima zokwehluleka kwezinso. Udinga ukubheka njalo amazinga kashukela bese uhlola izinso ngezikhathi ezithile.
- Ngama-pathologies wesibindi, udinga ukugxila esimweni sesiguli. Imvamisa, ukulungiswa komthamo akudingeki uma ngabe ukukhula kwesifo kungelibi. Ngezindlela eziyinkimbinkimbi zokuhluleka kwesibindi, kunconywa ukuyeka ukusetshenziswa kwaleli thuluzi.
Lo muthi awuthinti amandla omuntu wokugxilisa ingqondo kanye nesivinini sokuphendula kwakhe. Ngakho-ke, lapho uyisebenzisa, ungahlanganyela kunoma yiluphi uhlobo lomsebenzi.
Imiphumela emibi kanye ne-overdose
Noma ngabe kunquma umuthi ngudokotela, kukhona amathuba emiphumela emibi.
Lokhu kufaka phakathi:
- i-nasopharyngitis;
- ikhanda
- ukuphefumula kwenhliziyo;
- Ubuhlungu besisu
- ukuqunjelwa.
Uma betholakele, isiguli kufanele sibonane nodokotela ukuthola ukuthi ziyingozi kangakanani lezi zibonakaliso. Kwesinye isikhathi uchwepheshe uphoqelelwa ukwenqaba ukwelashwa nalesi sidakamizwa ngqo ngenxa yemiphumela emibi.
Cishe akukho lwazi mayelana nokudla ngokweqile kwe-Yanuvia. Lapho uthatha inani elikhulu lalesi sidakamizwa, imiphumela emibi ingaqina. Ukuze ulwe nalezi zigameko, kusetshenziswa i-gastric lavage nemiphumela yezimpawu.
Thayipha amavidiyo wesifo sikashukela esingu-2:
Ukusebenzisana kwezidakamizwa kanye nama-analog
Uma isiguli singenaso nje isifo sikashukela, khona-ke ukwelashwa kwakhe kudinga ukunakekelwa okukhethekile. Akuyona yonke izidakamizwa engahlanganiswa nenye, kwesinye isikhathi ukusetshenziswa okuhlangene kwezidakamizwa ezithile kuholela ekuphambukeni kwesenzo sabo.
UJanuvia uthathwa ephephile kulokhu, njengoba ezinye izidakamizwa zinomphumela omncane kuwo.
Izinguquko ezincane ekusebenzeni kwazo zingavela ngokusetshenziswa kanyekanye kwalesi sidakamizwa nge-digoxin ne-cyclosporine. Ngokuya ngokuthi ziguqulwe kanjani lezi zinguquko, kukhethwa umthamo.
Njengoba lo muthi ubiza kakhulu, iziguli zivame ukucelwa ukuba zizinike ama-analogues ashibhile.
Ochwepheshe babakhetha kulezi zindlela ezilandelayo:
- Trazenta;
- Galvus;
- Onglisa;
- UNesina.
Noma yimuphi udokotela kufanele anqume noma iyiphi yale mithi ngemuva kokuhlola isiguli. Ngaphandle kwalokho, ukuthuthukiswa kwezinkinga kungacasulwa. Kubalulekile futhi ukulandela imithetho yokudlulisa isiguli sisuka komunye umuthi siye kwesinye.
Umbono wodokotela neziguli
Uma kuqhathaniswa nokubuyekezwa, odokotela abavami ukunquma uJanuvia ikakhulukazi ngenxa yezindleko eziphakeme zomuthi. Ezigulini, lesi sidakamizwa naso asithandwa kakhulu ngenxa yentengo ephezulu nemiphumela emibi.
Ngabeka uJanuvius amahlandla ambalwa. Lona umuthi omuhle owehlisa ngempumelelo amazinga kashukela. Kepha kuyabiza kakhulu, futhi iziguli zivame ukwenqaba. Labo abayinikeza mahhala noma ngentengo ekhethekile, futhi abaneliseki ngaso sonke isikhathi, ngoba banemiphumela emibi. Manje, ngokuqhubekayo, yiziguli zami ezimbili kuphela ezisebenzisa lo muthi. Ubafanela ngaphezu kweminye imithi.
Elena Dmitrievna, udokotela
Sebenzisa lesi sidakamizwa kuphela ngemuva kocwaningo olunemininingwane. I-contraindication engakhonjwanga iholela emiphumeleni emibi, iziguli zihlushwa imiphumela emibi, futhi imiphumela iyiz zero. Kodwa labo ikhambi elifanele kubo bavame ukwaneliswa ngalo, bakhononda kuphela ngezindleko eziphakeme. Zonke ngazinye.
Alexander Borisovich, udokotela
Angizange ngithathe isikhathi eside uJanuvia. Ikhambi lihle, ushukela ugcinwa uvamile futhi ngaphandle kwemiphumela emibi. Kepha kuyabiza kakhulu, ngincamela i-analogue eshibhile.
U-Irina, oneminyaka engama-41
Ekuqaleni ngangifuna ukuyeka lesi sidakamizwa. Ngangihlushwa ukuqwasha nobuthakathaka obuqhubekayo ngenxa yokuntuleka kokulala. Ushukela ubuyela kokujwayelekile, kepha ngangizizwa kabi kakhulu. Bese kudlule - kusobala ukuthi umzimba usetshenziselwe yona. Manje konke kungifanele.
USergey, oneminyaka engama-34 ubudala
Intengo yeJanuvia ithinteka ekuhlakazweni kwento esebenzayo nenombolo yamayunithi kwiphakeji. Ngephakethe elinomthamo weCitagliptin kuma-100 mg (ama-28 ama-pcs.), Kuzofanela unikeze ama-ruble angama-2200-2700.
