I-Hypoglycemic drug Galvus Met - imiyalo esetshenzisiwe

IGalvus Met umuthi ohlanganisiwe we-hypoglycemic wehlisa inani likashukela egazini.

Kusetshenziswa ekwelapheni uhlobo lwesifo sikashukela sohlobo lwe-2 ukuze kuzinze isimo futhi kuvame ukwamukelwa kahle ngumzimba.

Imininingwane ejwayelekile mayelana nomuthi

Ngenxa yemiphumela ye-vildagliptin (into esebenzayo), umthelela owonakalisayo we-peptidase enzyme uyancipha, futhi ukuvela kwe-glucagon-like peptide-1 ne-HIP kukhuphuka kuphela.

Lapho inani lalezi zinto emzimbeni liphezulu kunokwejwayelekile, i-Vildagliptin ithuthukisa umsebenzi wamaseli we-beta maqondana noshukela, okuholela ekwandisweni kokukhula kwe-hormone okwehlisa ushukela.

Kumele kwaziwe ukuthi ukwanda kwemisebenzi ye-beta-cell kuncike ngokuphelele esilinganisweni sokubhujiswa kwabo. Ngalesi sizathu, kubantu abanamazinga e-glucose ajwayelekile, i-vildagliptin ayinawo umthelela ekwakhiweni kwe-insulin.

Into esebenzayo yesidakamizwa yandisa i-glucagon-like peptide-1 futhi inyusa ukuzwela kwamangqamuzana e-alpha eglucose. Ngenxa yalokho, i-glucagon synthesis iyanda. Ukwehla kwesilinganiso saso ngesikhathi senqubo yokudla kuholela ekonyukeni kokuqalwa kwamaseli we-peripheral maqondana ne-hormone eyehlisela ushukela.

Ukwakheka, ifomu lokukhulula

Umuthi usesimweni sezibhebhe, ezihlanganiswa. Eyodwa iqukethe izinto ezimbili ezisebenzayo: i-Vildagliptin (50 mg) neMetformin, equkethe imithamo emithathu - 500 mg, 850 mg no-1000 mg.

Ngaphezu kwabo, ukwakheka komuthi izinto ezinjenge:

• i-magnesium stearic acid;
• i-hydroxypropyl cellulose;
• hydroxypropyl methyl cellulose;
• i-talc;
• titanium dioxide;
• iron oxide ophuzi noma obomvu.

Amacwecwe ahlanganiswe emabhulashini izingcezu eziyishumi. Iphakheji iqukethe amanxeba amathathu.

I-Pharmacology ne-pharmacokinetics

Umphumela wehlisela ushukela kulo muthi uyabonakala ngesenzo sezinto ezimbili ezibalulekile:

• I-Vildagliptin - yandisa umsebenzi wamaseli we-pancreatic ngokumelene noshukela wegazi, okuholela ekwandeni kokuhlanganiswa kwe-insulin;
• I-Metformin - yehlisa inani le-glucose emzimbeni ngokunciphisa izinga lokufakwa kwe-carbohydrate, inciphisa ukwakheka kwe-glucose amaseli wesibindi futhi ithuthukise ukusetshenziswa kwezicubu zomzimba.

Umuthi usetshenziselwa ukudala ukwehla okungaguquki kashukela wegazi emzimbeni. Ngaphezu kwalokho, ezimweni ezingavamile, ukwakhiwa kwe-hypoglycemia kuyaphawulwa.

Kwatholakala ukuthi ukudla akuthinti ijubane kanye nezinga lokutholwa kwalo muthi, kepha ukugcotshwa kwezinto ezisebenzayo kunciphisa kancane, yize konke kuncike kumthamo womuthi.

Ukufakwa kwezidakamizwa kushesha kakhulu. Uma uthatha umuthi ngaphambi kokudla, ubukhona bawo egazini bungabonakala kungakapheli ihora nesigamu. Emzimbeni, umuthi uzoguqulwa uguqulwe waba ngama-metabolites adalulwe umchamo nezindunduma.

Izinkomba kanye ne-contraindication

Isibonakaliso esiyinhloko sokusebenzisa uhlobo lwesifo sikashukela sohlobo 2.

Kunezimo eziningana lapho udinga ukusebenzisa leli thuluzi:

• ngesimo se-monotherapy;
• ngesikhathi sokwelashwa ngeVildagliptin ne-Metformin, esetshenziswa njengomuthi ogcwele;
• ukusetshenziswa kwesidakamizwa kuhlangene nama-ejenti anciphisa ushukela wegazi futhi aqukethe i-sulfanyl urea;
• ukusetshenziswa kwomuthi kuhlangene ne-insulin;
• ukusetshenziswa kwalo muthi njengomuthi osemqoka ekwelapheni isifo sikashukela sohlobo 2, lapho ukudla okudla kungasasizi.

Umphumela wokuphuza umuthi uhlolwa ukwehla okuzinzile kwesilinganiso sikashukela egazini.

Ungasisebenzisa nini isidakamizwa:

• ukungabekezeleli iziguli noma ukuzwela okuphezulu kwezakhi zedivayisi yezokwelapha;
• Uhlobo 1 sikashukela;
• ngaphambi kokuhlinzwa nokudlula kwama-x-ray, indlela ye-radioactive yokuxilongwa;
• nge-metabolism engasebenzi kahle, lapho kutholakala ama-ketones egazini;
• ukungasebenzi kahle kwesibindi kanye nokwehluleka kwaqala ukuthuthuka;
• isimo esingapheli noma esibi senhliziyo noma ukwehluleka ukuphefumula;
• ubuthi obudakayo;
• umsoco ompofu ophansi wekhalori;
• ukukhulelwa nokukhipha umunyu.

Ngaphambi kokuthi uqale ukuthatha amaphilisi, kufanele uqiniseke ukuthi akukho okuphikisana.

Imiyalo yokusebenzisa

Izibhebhe zemithi kumele ziphuzwe ngomlomo zizonke hhayi zihlafunwe.

Ukuze wandise ukuthuthukiswa okungenzeka kwemiphumela emibi, kungcono ukuthatha umuthi ngesikhathi sokudla.

Udokotela ubeka umthamo odingekayo ngokwahlukile esigulini ngasinye, kusukela esinqumweni sakhe sokuthi lingakanani izinga le-glucose lenyuswe, yisiguli eselashwe ukwelashwa nokuthi belisebenza kahle yini.

Umthamo ojwayelekile yithebhulethi elilodwa kabili ngosuku, ekuseni nakusihlwa. Uma umthamo ufana ngosuku, khona-ke udinga ukuphuza umuthi ekuseni.

Imiyalo ekhethekile

Akumele uphuze umuthi lapho kukhona ukungasebenzi kahle kwesibindi, ngenxa yomsebenzi owandisiwe wama-enzyme alesi sitho.

Akunconyelwe ukusebenzisa lo muthi ngesikhathi sokukhulelwa nangesikhathi sokuzala, ngoba ayikho imiphumela eqondile ngomphumela wezinto ezisebenzayo ku-umbungu.

Kodwa-ke, uma i-glucose metabolism emzimbeni okhulelwe iphazamiseka lapho uthatha umuthi, khona-ke kukhona ingozi yokuhlukunyezwa okuzalwa nakho ku-fetus.

Iziguli ezineminyaka yobudala engama-65 ngeke zidinge ukulungisa umthamo.

Uma sikhuluma ngezingane, ngoba umphumela nokuphepha okudingekayo akuzange kuvezwe ngenkathi kuvivinywa umtholampilo, akunconywa ukusebenzisa umuthi ezigulini ezingaphansi kweminyaka yobuningi.

Kunemiyalo eminingi ekhethekile, uma uyilandela, lapho-ke ungavikela imiphumela emibi yokusebenzisa umuthi:

• umuthi awusiwona obambele i-insulin, okufanele ukhunjulwe ezigulini ezinesifo sikashukela sohlobo 1;
• kwinqubo yokusebenzisa umuthi, udinga ukuhlola ngezikhathi ezithile izinga likashukela emzimbeni;
• okungenani kanye ngenyanga, kuyadingeka ukuhlola isimo sezinso, isibindi kanye nenani le-lactic acid;
• ngesikhathi sokusebenzisa umuthi wenqatshelwe ukuqonda iziphuzo ezidakayo, ngoba lokhu kungaholela ekwakhekeni kwe-lactic acidosis;
• umuthi unganciphisa ukumuncwa kwe-vithamini B12, okucasulayo ukuthuthukiswa kwe-anemia.

Ekhemisi, umuthi ungathengwa kuphela ngokubhaliwe.

Imiphumela emibi kanye ne-overdose

Ukusetshenziswa kwamathebulethi kungavusa ukuthuthukiswa kwemiphumela emibi yomuthi, futhi lokhu kuzothinta isimo sezitho nezinhlelo ezilandelayo:

1. Uhlelo lokugaya - uqala ukuzizwa egula, kunobuhlungu esiswini, ujusi wesisu uphonsa ezingxenyeni ezingezansi zesophagus, ukuvuvukala kwamanyikwe kungenzeka, ukunambitheka kwensimbi kungavela emlonyeni, uvithamini B uqala ukudonswa umbi kakhulu.
2. Uhlelo lwezinzwa - izinhlungu, isiyezi, izandla eziqhaqhazelayo.
3. Isibindi kanye nenyongo - i-hepatitis.
4. Uhlelo lwe-musculoskeletal - izinhlungu emalungeni, kwesinye isikhathi emisipha.
5. Izinqubo ze-Metabolic - zenyusa izinga le-uric acid ne-acidity yegazi.
6. Ukungezwani komzimba - ukuqubuka ebusweni besikhumba nokulunywa, i-urticaria. Kungenzeka futhi ukuthuthukisa izimpawu ezinzima kakhulu zokungezwani komzimba, okuvezwa ku-angioedema Quincke noma ukushaqeka kwe-anaphylactic.
7. Ezimweni ezingavamile, kuvela izimpawu ze-hypoglycemia, okungukuthi, ukuthuthumela kwemikhawulo ephezulu, “umjuluko obandayo”. Kulokhu, kunconywa ukuthathwa kwama-carbohydrate (itiye elimnandi, i-confectionery).

Uma imiphumela emibi yesidakamizwa iqala ukukhula, kuyadingeka ukuthi imise ukusetshenziswa kwayo futhi ifune izeluleko zezokwelashwa.

Ukusebenzisana kwezidakamizwa kanye nama-analog

Uma usebenzisa i-Galvus Met neminye eminye imithi, kungenzeka ukuthuthukisa izimo ze-pathological noma ukwengeze / kwehlise ukusebenza kwezidakamizwa ezisetshenziswayo.

Ngokusetshenziswa kanye kanye kweFurosemide, ukugxila egazini lomuthi wesibili kuzokwenyuka, kepha inani lowokuqala lizokwehla.

Ukuthatha i-Nifedipine ngesikhathi sokwelashwa kuholela ekufakweni kokusheshisa, ekucasheni izinso, kanye nokwanda kokuxineka kweMetformin egazini.

Uma isetshenziswa nge-glibenclamide, khona-ke ukuqoqwa kokugcina kuzoqala ukuncipha.

Akunconyelwe ukuthathwa ndawonye neDonazol, ngoba inomphumela we-hyperglycemic. Uma ukuhlanganiswa kwezidakamizwa kumane kudingekile ngenxa yezizathu zezokwelapha, lapho-ke kuyodingeka ukuthi ulungise umthamo weMetformin futhi uqaphe njalo inani leshukela egazini.

I-Diuretic, contracepts, izidakamizwa ze-glucocosteroid, i-calcium blockers, i-Phenothiazine - uma isetshenziswa kanye neGalvus Met, ingadala i-hypoglycemia. Usebenzisa okungenani i-100 mg ye-Chlorpromazine kanye neGalvus Met ngosuku, ungangeza i-glycemia, kanye nokunciphisa ukukhiqizwa kwe-insulin.

Lapho usebenzisa ama-radiopaque agents nge-iodine ngesikhathi sokwelashwa, i-lactic acidosis iqala ukwakha, esekelwa ukwehluleka kwezinso. Uma uthatha izidakamizwa eziqukethe i-ethyl alcohol ngasikhathi sinye, ubungozi be-lactic acidosis nabo buyanda.

IGalvus Met inezichazayo ezilandelayo zokukhiqiza ezifuywayo: Avandamet, Glimecomb kanye neCombogliz Prolong.

I-Avanta iqukethe izinto ezi-2 ezisebenzayo - iRosiglitazone neMetformin. Umuthi usetshenziselwa ukwelapha uhlobo oluzimele lwesifo. I-Rosiglitazone isiza ukwandisa ukuzwela kwamangqamuzana ukungena ku-insulin, futhi iMetformin inciphisa ukwakheka kweglucose kwesibindi.

I-Glimecomb yakhiwe ngeMetformin ne-Glyclazide, ekuvumela ukuthi uzinzise ngokushesha amazinga kashukela. I-contraindicated ukuthi isetshenziswe ngohlobo olune-insulin-isifo sikashukela, ikoma, i-lactation, njll.

IComboglyz Prolong iqukethe iMetformin neSaxagliptin. Isetshenziselwa ukulwa nesifo sikashukela sohlobo 2, lapho kungasenakwenzeka ukunciphisa amazinga kashukela ngokudla nokuzivocavoca umzimba. Akunconyelwe ukusebenzisa ngokungabekezeleli izinto eziqukethwe kuwo, ushukela othembele ku-insulin, izingane, ngesikhathi sokukhulelwa, isikhathi sokukhishwa komzimba.

Imibono yongoti neziguli

Ukusuka kokubuyekezwa kodokotela neziguli ngeGalvus Met, singaphetha ngokuthi umuthi uyasebenza ekwehliseni ushukela wegazi. Imiphumela emibi ayivelakancane futhi imiswa ngokuncipha komthamo womuthi.

Umuthi ungoweqembu lemithi IDDP-4, ubhaliswe eRussia njengekhambi lohlobo 2 lwesifo sikashukela. Kuyasebenza futhi kuphephile impela, kubekezelelwa kahle ngabanesifo sikashukela, akubangeli ukukhuluphala kwesisindo. IGalvus Met ivunyelwe ukuthi isetshenziswe ngokuncipha kokusebenza kwezinso, okungeke kube yinto ephezulu ekwelashweni kwabantu asebekhulile.

U-Olga, i-endocrinologist

Umuthi osungulwe kahle. Ibonisa imiphumela emihle kakhulu yokulawula amazinga kashukela.

ULyudmila, usokhemisi

Uhlobo lwesifo sikashukela sohlobo 2 lwatholakala eminyakeni eyishumi edlule. Ngizamile ukuphuza izidakamizwa eziningi, kepha azange sithuthukise isimo sami kakhulu. Ngemuva kwalokho udokotela weluleke uGalvus. Ngayithatha kabili ngosuku futhi ngokushesha izinga le-glucose laba lejwayelekile, kepha imiphumela emibi yesidakamizwa yavela, okungukuthi, ukuphathwa ikhanda nokuqhuma. Udokotela utuse ukuthi ushintshele ku-50 mg, lokhu kusizile. Okwamanje, isimo sihamba kahle, cishe sikhohliwe ngalesi sifo.

UMaria, oneminyaka engama-35, uNoginsk

Iminyaka engaphezu kweyishumi nanhlanu ibigula isifo sikashukela. Isikhathi eside, ukwelashwa akuzange kulethe imiphumela ebalulekile kuze kube yilapho udokotela etusa ukuthenga i-Galvus Met. Ithuluzi elikhulu, umthamo owodwa ngosuku unele ukuguquguqula amazinga kashukela. Futhi yize intengo iphezulu kakhulu, angiyenqaba umuthi, uyasebenza kakhulu.

UNikolay, oneminyaka engama-61, uVorkuta

Izinto zevidiyo ezivela kuDkt Malysheva mayelana nemikhiqizo engasiza emithini yesifo sikashukela:

Umuthi ungathengwa kunoma iyiphi ikhemisi. Intengo isukela kuma-ruble ayi-1180-1400., Kuya ngesifunda.