Isidakamizwa Hinapril: iziyalezo zokusetshenziswa

Umuthi owenziwe eRussia ekwelapheni umfutho wegazi ophakeme kanye nokwehluleka kwenhliziyo okungamahlalakhona. Isenzo sisuselwa ku-vasodilation. Umphumela ozinzile wemitholampilo ukhula emavikini angama-2-3 ngemuva kokuqala kokwelashwa.

Igama Lezwe elingafanele

IHinapril. Igama lesiLatini yiChinaprilum.

Umuthi owenziwe eRussia wokwelapha umfutho wegazi ophakeme kanye nokwehluleka kwenhliziyo okungamahlalakhona.

I-ATX

C09AA06

Khipha amafomu nokwakheka

Kutholakala ngesimo samathebulethi ekuhlanganiseni kwefilimu umthamo we-5.10, 20 noma 40 mg wento esebenzayo. Ku-1 blister - 10 amaphilisi. Amabhola agcwele ebhokisini lekhadibhodi ama-3 ama-pcs.

Ukwenziwa kwethebhulethi kufaka phakathi into esebenzayo enegama elifanayo lezidakamizwa (i-powder emhlophe, i-soluble emanzini) nezinye izinto ezengeziwe - izinto zokubopha, udayi, i-thickener, njll.

Isenzo se-Pharmacological

Isenzo somuthi sisuselwa kuzakhiwo ze-quinapril ukuvimbela i-exopeptidase futhi ngaleyo ndlela sinciphise ukwakheka kwamahomoni e-oligopeptide abangela i-vasoconstriction.

Ngenxa yalomphumela, imithambo ye-peripheral iyanda, ukuhanjiswa kwegazi kwe-myocardial kuthuthukisa ngemuva kwe-ischemia, ukuhamba kwegazi ezinso nasezinhlanjeni ze-coronary kuyanda, ukumelana nokucindezelwa ngokomzimba kuyanda, inani le-arrhythmias ye-ventricular liyancipha, umfutho wegazi kanye nengozi yokuncipha kwe-thrombosis.

I-Pharmacokinetics

Izinga lokufinyelela ekuhlolweni okukhulu komuthi egazini lihora eli-1 ngemuva kokuphathwa ngomlomo. Isenzo sihlala ngokuya ngethamo elithathiwe.

Izinga lokufinyelela ekuhlolweni okukhulu komuthi egazini lihora eli-1 ngemuva kokuphathwa ngomlomo.

Ukuqunjelwa esiswini cishe kungama-60%, kepha kungaba kubi kakhulu ngokudla kanyekanye kokudla okunamafutha kakhulu.

Yakha ama-metabolites esibindini, ikakhulukazi i-quinaprilat, evame ukubopha amaprotheni e-plasma ngamaphesenti angaphezu kwama-90.

Igcotshwa ngokusebenzisa izinso namathumbu.

Izinkomba zokusetshenziswa

Isetshenziselwa kokubili i-monotherapy futhi ihlanganiswe nezifo ezifana:

• i-hypertension ye-arterial (eyokuqala, yokulungisa kabusha, necacisiwe yesibili);
• ukuhluleka kwenhliziyo (i-diastolic, inhliziyo, ne-diastolic dysfunction, rastidity rigidity, ukwehluleka kwenhliziyo).

Ngomfutho wegazi ophakeme, ukuphathwa kanyekanye nge-potassium-sparing diuretics ne-beta-blockers kungenzeka, futhi nokwehluleka kwenhliziyo - ngabathinteli be-beta-blocker yentliziyo, njll.

Contraindication

Umuthi we-contraindised kulezi zimo ezilandelayo:

• hyperreaction kwento esebenzayo noma ezinye izinto zethebhulethi;
• ukukhulelwa nokuqunjelwa;
• izingane nentsha (kuze kube iminyaka eyi-18);
• ukuba khona komlando we-angioedema;
• isifo sikashukela se-nephropathy;
• umsebenzi wezinso ongonakalisiwe;
• i-hypertension ye-arterial;
• hyperkalemia

Isidakamizwa sikhonjiswa nge-arterial hypertension.

UHinapril ubekelwe ukwelashwa kokuhluleka kwenhliziyo.

Kwenqatshelwe ukusebenzisa i-hinapril ngesikhathi sokukhulelwa.

Umuthi uphambaniswe ne-lactation.

Lesi sidakamizwa sifakwa kubantu abangaphansi kweminyaka engu-18 ubudala.

Isifo sikashukela i-nephropathy kuwukuphikisa ukusetshenziswa komuthi.

Kufanelekile ukulahla ukwelashwa nge-quinapril uma kwenzeka ukungasebenzi kahle kwesibindi.

Ukuqokwa kungenzeka, kepha ngokuqapha nangaphansi kokubhekwa njalo kwabasebenzi bezokwelapha uma kwenzeka kuba:

• ingozi ye-cerebrovascular;
• isifo sokuqina kwemithambo yegazi emilenzeni;
• i-mitral valve stenosis;
• i-cardiopathy ethintekayo enezinguquko ze-hypertrophic;
• izinso ezidlulisiwe;
• ukuphazamiseka ku-purine metabolism (gout);
• izifo ezithinta izicubu ze-autoimmune systemic;
• isifo sikashukela mellitus;
• isidingo se-mTOR ne-DPP-4 enhibitors;
• Izifo ezithikamezayo zohlelo lwe-bronchopulmonary in fomu.

Kungcono ukugwema ukuthatha lezi zibhebhe ezigulini ezinezifo zesibindi ezithuthukile ukuze ugweme ukuthuthukiswa kwe-hepatic coma.

Ungayithatha kanjani i-quinapril?

Thatha ngomlomo, ngaphandle kokudla. Ithebhulethi ligwinywa ngaphandle kokuhlafuna, ligezwe ngenani elincane lamanzi.

Nge-hypertension, i-monoprint kungenzeka, futhi ngokuhlanganiswa namanye ama-ejenti.

Endabeni ye-monotherapy, ukwelashwa kuqalwa ngomthamo we-10 mg kanye bese kuthi kancane kancane ukhuphuke ufike kuma-20 noma ama-40 mg, ngokuya ngokuzuzwa komphumela wekliniki.

Nge-hypertension, i-monoprint kungenzeka, futhi ngokuhlanganiswa namanye ama-ejenti.

Ekuhlanganisweni kokwelashwa nge-diuretics, kusuka ku-5 mg ngosuku kubekelwa kanye kanye nokwanda ezinsukwini ezilandelayo kuze kube yilapho umphumela olindelekile ufinyelelwe, kepha hhayi ngaphezulu kwesilinganiso esinconyelwe nsuku zonke.

Khulisa umthamo cishe kanye ngenyanga. Okuphezulu okuvunyelwe ngosuku kungaphezu kuka-80 mg wesidakamizwa.

Ukwehluleka kwenhliziyo kudinga ukwelashwa okuxubile. Kulokhu, umuthi uqalwa nge-5 mg izikhathi ezingama-1-2 ngosuku, ulandelwa ukwanda kwesimo sokubekezelela okuhle hhayi ngaphezu kokukhuphuka okungu-1 ngeviki.

Ngomsebenzi wokuphazamiseka wezinso, umthamo wesidakamizwa uqokwa ngokuya ngezinga lokuqalwa kwe-creatinine - okuphezulu inkomba, kukhulu umthamo. Kungenzeka ukwandisa isibalo sithathe kuphela ikliniki, ukuqina kwezibalo zegazi nokusebenza kwezinso.

Ngoshukela

Ezigulini ezinesifo sikashukela i-mellitus, lapho sithatha lesi sidakamizwa se-antihypertensive, ukugadwa okungajwayelekile kwezokwelapha kuyadingeka ngokukhethwa komthamo ofanele womuthi we-hypoglycemic ne-Insulin, ngoba umphumela wawo uyathuthukiswa.

Imiphumela emibi ye-hinapril

Kungahle kube nemiphumela emibi evela ku-hematopoiesis, i-pakati yezinzwa yokuphefumula, izitho zokuphefumula nezokuchama, amasistimu wokugaya kanye nenhliziyo, isikhumba, esivame ukungabizwa kakhulu. Ezimweni eziyi-100 zokunqunywa, yi-6% kuphela yamacala okuhoxa okumele kubalwe ngawo.

Kwesinye isikhathi kukhona ukwephulwa kokuphefumula kanye nokubona, ukuncipha kwe-potency, izinhlungu emhlane nesifuba, njll.

Ngenkathi uthatha i-hinapril, ubuhlungu besifuba kungenzeka.

Kwesinye isikhathi i-hinapril yayivusa ubuhlungu emuva.

IHinapril ingadala ukwehluleka ukuphefumula.

Kwezinye izimo, umuthi uvuse ukungasebenzi kahle kokubuka.

IHinapril ingadala isicanucanu nokuhlanza.

I-pancreatitis imiphumela emibi ye-hinapril.

Ukwelashwa kwe-Hinapril kungahle kuphumele emzimbeni.

Amapheshana wesisu

Ukuvela kwenhliziyo isicanucanu, ukuhlanza, i-dyspepsia, i-pancreatitis, i-hepatic coma, i-necrosis yesibindi, i-angioedema yamathumbu.

Izitho zeHematopoietic

I-anemia, i-thrombocytopenia, i-neutropenia, i-hyperkalemia, ukuqina kwe-creatinine.

Isistimu yezinzwa ephakathi

Ukuhlala ikhanda kanye nesiyezi. Kwesinye isikhathi i-paresthesia, ukudangala nokuqwasha.

Kusuka ohlelweni lomchamo

Ukwehluleka kwezinso okwenzeka kakhulu, izifo ezithinta umchamo.

Engxenyeni yesikhumba

Imiphumela emibi ibonakaliswa yi-pemphigus, izimpandla, ukukhuphuka kokujuluka, i-photosensitivity, kanye ne-dermatitis.

Kusuka ohlelweni lwezinhliziyo

I-Hypotension, i-failing, ukuphazamiseka kwesigqi senhliziyo, unhlangothi, ukuphumula kwezindonga zemithambo yegazi.

Kwezinye izimo, ukuthatha lo muthi kubangela isimo esidabukisayo.

UHinapril uvusa ukuqwasha.

Engxenyeni yesikhumba, imiphumela emibi ingabonakala ngezimpandla.

Ngokuphikisana nesizinda sokuphuza umuthi, isiguli singaphazamiseka ngokujuluka kokujuluka.

Ukusabela komzimba kungavela ku-hinapril.

IHinapril ingadala ukuphazamiseka kwesigqi senhliziyo.

Phakathi kwemiphumela emibi yesidakamizwa kukhona isiyezi nokukhanda njalo.

Allergies

Ukushaqeka kwe-Anaphylactic kanye ne-edema kaQuincke kungenzeka.

Umthelela ekhonweni lokulawula izindlela

Ukuqapha kuyadingeka lapho ushayela futhi usebenza, kudinga ukunakwa okukhulu, ngoba phakathi kwemiphumela emibi - ukwehla okubukhali kwengcindezi yegazi nesiyezi.

Imiyalo ekhethekile

Ngokwenyuka kwezinga lokushisa lomzimba noma i-tonillitis, ukuhlolwa kwegazi kufanele kwenziwe ngaphandle kokukhipha i-neutropenia.

Ngaphambi kokuhlinzwa, kufaka phakathi amazinyo, udokotela kumele axwayiswe ngokuqokwa kwezimali ezichazwe ngaphambilini.

Sebenzisa ebudaleni

Izinyathelo zokuqapha zibekelwa ukuguga ngenxa yesilinganiso esinciphile sokuqothulwa kwaso emzimbeni.

Isabelo sezingane

Ayisebenzi kuze kube yiminyaka eyi-18.

Ngokuqapha, i-hinapril ichazwa ukuguga ngenxa yesilinganiso esinciphile sokuphuma kwayo emzimbeni.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ngesikhathi sokukhulelwa nalapho uncelisa ingane ibele, ukusetshenziswa kwe-ACE inhibitors akuvunyelwe ngokuphelele. Inamandla okuphazamisa intuthuko futhi ibangele ukufa kwengane. Ngesikhathi sokuncelisa, lingadlulela ebisini futhi libangele ukusabela okubi enganeni.

Ukweqisa kwe-quinapril

Ngemuva kokuthatha inani ngokweqile komthamo ophelele, ukungaboni kahle, ukuqina komqondo kanye nesiyezi kungenzeka. Ukwelapha kuleli cala kunqunywe ngokusekelwe kwizimpawu.

Ukuxhumana nezinye izidakamizwa

Ngcono umphumela we-antihypertensive: ama-analcics ama-narcotic, amalungiselelo wegolide, i-anesthetics, i-diuretics, i-ACE inhibitors.

Yehlisa umphumela we-sodium chloride, ama-estrogens, izidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala.

Yehlisa ukufakwa kwe-tetracycline.

Endabeni yokusetshenziswa ngasikhathi sinye ngamalungiselelo e-lithium, ukudakwa kwe-lithium kungenzeka.

Ithuthukisa isenzo semithi ye-insulin ne-hypoglycemic.

IHinapril inciphisa ukumuncwa kwe-tetracycline.

Akunconywa ukuhlanganisa ne-Aliskiren, ama-immunosuppressants, ama-mTOR noma ama-enzyme e-DPP-4, kanye nezidakamizwa ezivimbela ukusebenza komongo.

Ukuhambisana notshwala

Utshwala bukhulisa umphumela we-hypertensive, ngakho-ke, ukusetshenziswa okuhlanganisiwe ku-contraindication.

Ama-Analog

Ngokufanayo, amaphilisi we-film-camera aqukethe futhi anezithako ezifanayo ezisebenzayo ekwakhiweni:

1. I-Accupro - 5.10, 20 noma 40 mg (Germany).
2. I-Akkuzid - 10 noma 20 mg (Germany). Umuthi ohlangene. Inento yesibili esebenzayo - hydrochlorothiazide.
3. IHinapril C3 - 5.10, 20 noma 40 mg (Russia).
4. I-Quinafar - 10 mg (Hungary).

Amacwecwe afanayo eqenjini lezemithi:

1. I-Amprilan - 1.25; 2,5; I-5 ne-10 mg (iSlovenia).
2. UVasolapril - 10 noma 20 mg (eTurkey).
3. I-Diropress - 5, 10 noma 20 mg (iSlovenia).
4. I-Captopril - 25 noma 50 mg (iRussia, India).
5. I-Monopril - 20 mg (ePoland).
6. I-Perineva - 4 noma 8 mg (iRussia / iSlovenia).

Analogs zingaba zezigaba zamanani ezahlukahlukene.

Imibandela yekhefu lekhemisi

Ngingakwazi ukuthenga ngaphandle kadokotela?

Ikhishwa kuphela ngomuthi odokotela oholayo.

Intengo yeHinapril

Isigaba sentengo emaphakathi

Uhla lwamanani lusuka kuma-ruble angama-200 kuye kwangama-250 ngephakeji ngalinye, kuya ngomthamo.

Izimo zokugcina zomuthi

Isitoreji emazingeni okushisa asekamelweni (hhayi ngaphezu kwe- + 25ºC) endaweni emnyama, lapho izingane zingazitholi nezilwane ezifuywayo.

Isikhathi sokuphelelwa yisikhathi

Impilo yeshelf yeminyaka emithathu kusukela ngosuku lokukhipha nangemuva kokuphelelwa yisikhathi kumele ilahlwe.

Umkhiqizi

Kwenziwa eRussia enkampanini yezokwelapha i-ZAO Severnaya Zvezda.

Ukubuyekezwa kweHinapril

Odokotela

U-Irina, udokotela womndeni, uTver

Nginikeza iziguli ezine-hypertension ye-arterial ngemuva kokuqoqa i-anamnesis kanye nokuhlolwa okuphelele. Ngivame ukuhlanganisa nama-diuretics ngokuya ngezinkomba. Umuthi uyasebenza, kepha ngaso sonke isikhathi kufanele ubheke ngokucophelela ukuba khona kwe-contraindication yomuntu ngamunye, ngoba imiphumela emibi eyingozi kungenzeka.

USergey, udokotela wenhliziyo, u-Astrakhan

Ekwehlulekeni kwenhliziyo, isidakamizwa esinjalo sinikeza impumuzo esheshayo, kepha ngaphambi kokuqokwa, kufanele ngaso sonke isikhathi uhlole futhi ufunde umlando wezokwelapha.

Iziguli

U-Ana, oneminyaka engama-52, uVolgograd

Ngiphuza amaphilisi njengoba kuchazwe ngudokotela wami njengethuluzi lokusekelwa kwegazi elinamandla. Emiphumeleni emibi, ngikwazi ukuqaphela ukozela okuncane kakhulu ekuqaleni konyango.

USophia, oneminyaka engama-39, uVologda

Kungekudala kakhulu, izinkinga zokucindezela zaqala. Ngaya kudokotela wezokwelapha futhi lapho, ngemuva kokuhlolwa, la mapilisi anqunywa. Manje ingcindezi icishe ibe yinto ejwayelekile, ngaphandle kokuthi uma kunesiphithiphithi esinzima, futhi akukho miphumela emibi ebonwa ngaphandle.