Umuthi i-Telzap 40: imiyalo esetshenzisiwe

I-Telzap isidakamizwa esinciphisa ubungozi bokuthola isifo senhliziyo. Ukusebenza kahle kufakazelwe ekuvivinyweni kwemitholampilo nasenkambisweni yezokwelapha.

Igama Lezwe elingafanele

Igama elithi Telmisartan lisetshenziswa njengezwe elingahambisani nomhlaba jikelele.

I-Telzap isidakamizwa esinciphisa ubungozi bokuthola isifo senhliziyo.

I-ATX

Ikhodi ye-ATX C09CA07.

Khipha amafomu nokwakheka

I-Telzap 40 mg iyatholakala ngesimo samathebulethi, ngalinye linomumo we-oblong biconvex. Umbala wamathebhulethi ungaba mhlophe noma ophuzi. Zombili izinhlangothi zisengozini.

Isithako esikhulu esisebenzayo yi-telmisartan. Okuqukethwe kwithebhulethi ngayinye kufinyelela ku-40 mg.

Ukwakheka okusizayo kufaka phakathi okulandelayo:

• i-sorbitol;
• i-meglumine;
• i-magnesium stearate;
• i-sodium hydroxide;
• i-povidone.

Isenzo se-Pharmacological

I-telmisartan ye-izidakamizwa esebenzayo inezici ze-angiotensin II receptor antagonists ezithile. Uma ungenile, umuthi uyakwazi ukudonsa i-angiotensin II ekuxhumeni kwayo ne-receptor. Ngaphezu kwalokho, maqondana nale receptor, akayona i-agonist. I-Telmisartan ixhumana kuphela nama-angiotensin II ATl receptors. Into esebenzayo ayibonisi izakhiwo ezifanayo kwi-AT2 receptor nokunye.

I-telmisartan ye-izidakamizwa esebenzayo inezici ze-angiotensin II receptor antagonists ezithile.

I-Telmisartan ixhumana kuphela nama-angiotensin II ATl receptors.

Lapho usebenzisa umthamo we-80 mg ezigulini, umphumela wegazi we-angiotensin II uvinjiwe.

Ngaphansi kwethonya lomuthi ku-plasma yegazi, i-aldosterone iyancipha. Ngaso leso sikhathi, umsebenzi we-renin uhlala usezingeni elifanayo futhi iziteshi ze-ion azivinjelwe.

I-enzyme eguqula i-Angiotensin ekhuthaza ukubhujiswa kwe-bradykinin ayivinjelwe. Lesi sici sikuvumela ukuthi ususe ubungozi bemiphumela emibi njengokukhwehlela komile.

Lapho usebenzisa umthamo we-80 mg ezigulini, umphumela wegazi we-angiotensin II uvinjiwe. Umphumela utholakala emahoreni angama-3 ngemuva komthamo wokuqala. Isenzo sihlala amahora angama-24. Kubhekwa njengokusebenza ngempumelelo emtholampilo amahora angama-48. Ukudla njalo kwamathebhulethi amaviki ama-4-8 kuholela kumphumela obizwa ngokuthi yi-antihypertensive.

Ukusetshenziswa kweTelzap ezigulini ezinomfutho we-arterial hypertension kunganciphisa umfutho wegazi we-diastolic ne-systolic. Okwamanje, izinga lokushaya kwenhliziyo aliguquki.

Umuthi usetshenziselwa ukwelapha izifo zenhliziyo. Ezigulini esezikhulile ezine-pathologies yesistimu yenhliziyo, amaphilisi aba nomphumela wokunciphisa imvamisa:

• infarction myocardial;
• imivimbo;
• ukufa ngenxa yesifo senhliziyo.

Ukusetshenziswa kweTelzap kunganciphisa umfutho wegazi we-diastolic ne-systolic.

Umuthi usetshenziselwa ukwelapha izifo zenhliziyo.

Amaphilisi anomthelela wokunciphisa imvamisa yemivimbo.

Amathebulethi anomthelela wokunciphisa imvamisa ye-myocardial infarction.

I-Pharmacokinetics

Ngemuva kokuphathwa ngomlomo, umuthi udonswa ngokushesha. Ngokwesilinganiso, i-bioavailability yayo ifinyelela kuma-50%. Ukudla kunganciphisa ukumunca umuthi.

I-Telmisartan ibopha i-alpha-1 acid glycoprotein, i-albhamuin, namanye amaprotheni e-plasma.

I-Metabolism yenzeka ngesikhathi sokuhlangana ne-glucuronic acid. Le khompiyula ayinawo umsebenzi we-pharmacological. Ukukhishwa kwezakhi kwenzeka ngamathumbu. Kulokhu, iningi lomzimba lishiya lingashintshiwe. I-1% kuphela yento ekhishwa ngezinso.

Izinkomba zokusetshenziswa

I-Telzap inqunyelwe iziguli ezinokuxilongwa okulandelayo:

• umfutho wegazi ophambili;
• Uhlobo 2 isifo sikashukela mellitus (lapho kukhona izilonda zezitho ezihlosiwe);
• Izifo zenhliziyo zemvelaphi ye-atherothrombotic (ohlwini lwezifo ezinjengalesi, isifo sohlangothi, isifo senhliziyo esithambile, ukulimala kwemithambo yegazi).

Amacwecwe abuye anconywe njenge-prophylactic yezifo zenhliziyo ezigulini ezisengozini.

I-Telzap inqunyelwe ukuxilongwa okufana ne-hypertension ebalulekile.

I-Telzap ibekelwe ukuhlonza okunjalo njengohlobo 2 sikashukela mellitus (lapho kukhona izilonda zezitho ezihlosiwe).

I-Telzap ibekelwa ukutholakala okunjalo kwezifo zenhliziyo zemvelaphi ye-atherothrombotic.

Amacwecwe abuye anconywe njenge-prophylactic yezifo zenhliziyo.

Uma kwenzeka kunezifo ezithikamezayo ezithinta ipheshana elisondelana, iTelzap iphulwe ngokuphelele.

I-Telzap ihlukaniswe ngokuphelele uma kwenzeka kungabekezelelwa i-fructose yomuntu ngamunye.

I-Telzap ihlukaniswe ngokuphelele ngesikhathi sokuncelisa ibele.

Contraindication

Umuthi uphethwe ngokuphelele:

• nokuzwela okukhulayo kwengxenye esebenzayo esetshenziswayo noma ukwakheka okusizayo;
• uma kwenzeka kunezifo ezithikamezayo ezithinta ipheshana le-biliary;
• ngesikhathi sokukhulelwa nokuncelisa;
• nokungabekezelelani komuntu ngamunye ukuze aqhume;
• izingane ezingaphansi kweminyaka engu-18.

Ngokunakekela

Emiyalweni yokusetshenziswa, inani lama-pathologies aqanjwa, lapho iTelzap inqunywa ngokucophelela ngaphansi kokubhekwa kukadokotela eduze:

• umsebenzi wezinso ongonakalisiwe;
• i-renal artery stenosis;
• hyperkalemia
• i-hyponatremia;
• i-mitral noma i-aortic valve stenosis;
• anciphise umthamo wegazi ojikelezayo ovela ngemuva kokuthatha okokugaya, ukugabha, ukuhudula, noma ukuntuleka kukasawoti ekudleni;
• i-hyperaldosteronism eyinhloko;
• isikhathi sokululama ngemuva kokufakwa kwezinso;
• ukungasebenzi kahle kwesibindi (emnene nokulinganiselayo);
• ukwehluleka kwenhliziyo okukhulu;
• i-hypertrophic cardiomyopathy.

Ngokuqapha, iTelzap ibekelwe iziguli ezinokwehluleka okukhulu kwenhliziyo.

Ngokuqapha, iTelzap ibekelwa iziguli ezinenkinga yokusebenza kwe-renal.

Ngokuqapha, iTelzap inqunyelwe iziguli ezine-renal artery stenosis.

Ngokuqapha, iTelzap ibekelwe iziguli ezinenkinga yokusebenza kwesibindi (emnene nokulinganiselayo).

I-hypertrophic cardiomyopathy eyonakalisayo iyindlela yokufundisa lapho iTelzap inqunywa ngokuqapha ngokweqile.

I-Mitral noma i-aortic valve stenosis iyindlela yokuziphatha lapho iTelzap inqunywa ngokuqapha ngokweqile.

Ukuqapha kuyadingeka lapho usebenzisa la maphilisi ekwelapheni iziguli zomjaho weNegroid.

Ukuqapha kuyadingeka lapho usebenzisa la maphilisi ekwelapheni iziguli zomjaho weNegroid.

Ungayithatha kanjani i-telzap 40 mg

Amacwecwe enzelwe ukuphathwa ngomlomo. Zigwinywa ngaphandle kokuhlafuna bese zishiswa phansi ngengilazi yamanzi. Njengenqubo ejwayelekile yokwelashwa, kunconyelwa ukuthatha ithebhulethi eyi-1 yeTelzap ngosuku ngaphandle kokubhekelwa kokudla. Imithamo incike ezimfanelweni zokuxilongwa.

Okwe-hypertension ye-arterial, umthamo wokuqala onconyiwe yi-1 tablet 40 mg. Uma ungekho umphumela odingekile, umthamo ungakhushulelwa ku-80 mg.

Ukusetshenziswa njenge-prophylactic kwezifo zenhliziyo kuthathwa ngohlobo oluhlukile lomthamo. Kulokhu, umthamo ophelele ngu-80 mg ngosuku.

Ukwelashwa kwesifo sikashukela

Amacwecwe eTelzap afakazele ukuthi ayisiqalo esisebenzayo ekwelashweni okuyinkimbinkimbi ezigulini ezinesifo sikashukela sohlobo 2. Abantu abathola izidakamizwa ze-hypoglycemic kufanele bahlole njalo amazinga abo we-glycemia. Kwezinye izimo, kulungiswa ama-hypoglycemic agents noma i-insulin.

Amacwecwe eTelzap afakazele ukuthi ayisiqalo esisebenzayo ekwelashweni okuyinkimbinkimbi ezigulini ezinesifo sikashukela sohlobo 2.

Imiphumela emibi

Kwezinye iziguli, ukuthatha iTelzap kungavusa ukubukeka kwemiphumela emibi.

Amapheshana wesisu

Ukusuka ohlelweni lokugaya ukudla, isifo sohudo, ubuhlungu besisu, ukugabha, ukugcwala kanye ne-dyspepsia kwenzeka kaningi kunabanye. Izinkinga zokunambitha, ukungakhululeki esifundeni se-epigastric, i-mucosa eyomile emgodini womlomo akuvamile ukubonwa.

Izitho zeHematopoietic

Kunobufakazi bokuthuthuka kwe-thrombocytopenia, eosinophilia ne-hemoglobin ephansi.

Isistimu yezinzwa ephakathi

Ezinye iziguli zikhononda ngokuqwasha, ukudangala, ukukhathazeka okukhulayo. Ezimweni ezingavamile, kukhona ukufiphala.

Kusuka ohlelweni lomchamo

Phakathi kwemiphumela emibi ebizwa ngokuthi ukungasebenzi kahle kwezinso. Phakathi kwalawa ma-pathologies ukwehluleka kwezinso.

Kusuka ohlelweni lokuphefumula

IDyspnea nokukhwehlela akuvamile ukwenzeka. Akuvamile, isifo samaphaphu esijwayelekile senzeka.

Ngemuva kokusebenzisa umuthi, i-dyspnea nokukhwehlela akuvamile ukwenzeka.

Umphumela oseceleni wokusetshenziswa kwomuthi, ovela ohlelweni lokugaya, kaningi kunalokho, kunobuhlungu besisu.

Umphumela wecala lokusetshenziswa kwesidakamizwa, ohlelweni lokugaya ukudla, uhudo kwenzeka kaningi kunabanye.

Ngemuva kokusebenzisa lesi sidakamizwa, ezinye iziguli zikhononda ngokudangala.

Ngemuva kokusebenzisa lesi sidakamizwa, ezinye iziguli zikhononda ngokuqwasha.

Phakathi kwemiphumela emibi ebizwa ngokuthi ukungasebenzi kahle kwezinso.

I-Telzapa ingadala imiphumela emibi, njengokukhula kwe-thrombocytopenia.

Engxenyeni yesikhumba

Ohlelweni lwemiphumela emibi enjalo kufanele kubizwe ngokuthi i-hyperhidrosis, ukulunywa kwesikhumba, ukuqubuka. I-Eczema, i-angioedema, i-erythema, ukuqhuma kwesikhumba esinobuthi kanye nezidakamizwa akuvamile ukutholakala.

Kusuka ohlelweni lwezitho zofuzo

Kwabesifazane, izifo zokuvuvukala zohlelo lokuzala zingavela, ezimweni ezingavamile, ukungasebenzi kahle komjikelezo wokuya esikhathini kuyaqapheleka. Kumadoda, ukungasebenzi kahle kwe-erectile kungenzeka.

Kusuka ohlelweni lwezinhliziyo

Uhlelo lwezinhliziyo ezivamisile ukungaphenduli emicimbini emibi nge-Telzap therapy. Ngaleso sikhathi, iziguli zingenzeka:

• ukufiphala okubangelwa yi-hypotension;
• ukwehla noma ukwanda kwesilinganiso senhliziyo;
• kwehlise umfutho wegazi ngokushintshwa kwesikhundla somzimba.

Uhlelo lwe-Endocrine

Ukusebenzisa umuthi kungahle kwehle ukwehla ushukela wegazi kanye ne-metabolic acidosis.

Ukusebenzisa umuthi kungahle kwehle ukwehla ushukela wegazi kanye ne-metabolic acidosis.

Kuluhlu lwemiphumela emibi yeTelzap, i-hyperhidrosis kufanele ibizwe.

Kwabesifazane, ngemuva kokuphuza umuthi, izifo zokuvuvukala zohlelo lokuzala zingavela.

Uhlelo lwezinhliziyo ezivamisile ukungaphenduli emicimbini emibi nge-Telzap therapy.

Ngemuva kokuthatha iTelzap, ukuphazamiseka kwe-gallbladder kanye nesibindi akuvamile kakhulu.

Ngemuva kokuthatha uhlangothi lweTelzap eceleni kusuka ekungaphendukeni komzimba, i-edema kaQuincke kungenzeka.

Engxenyeni yesibindi ne-biliary

Ukuphazamiseka kwe-gallbladder kanye nesibindi akuvamile kakhulu.

Allergies

Ekuphatheni komzimba, okulandelayo kungenzeka:

• i-rhinitis;
• ukuqhuma kwesikhumba;
• i-laryngeal edema;
• Idumela likaQuincke.

Imiyalo ekhethekile

Noma imiphi imiphumela emibi, yeka ukuthatha lo muthi futhi ufune usizo lodokotela. Ukwehla okukhulu komfutho wegazi kungadala ukushaywa yisifo senhliziyo, ukushaya kwenhliziyo ngomphumela obulalayo.

Ukuhambisana notshwala

Ukuphuza utshwala kuyenqatshelwe ngokuphelele ngesikhathi sokwelashwa ngeTelzap. Ukuxhumana komuthi nge-ethanol kubangela ukwehla komfutho wegazi, okungaholela ekhefeni.

Ukuphuza utshwala kuyenqatshelwe ngokuphelele ngesikhathi sokwelashwa ngeTelzap.

Umthelela ekhonweni lokulawula izindlela

Ayikho imiyalo ekhethekile kulokhu, noma kunjalo, ukusetshenziswa kwomuthi kungadala imiphumela emibi (ukukhathala, isiyezi, ukozela). Unalezi zici engqondweni, shayela ngokuqapha.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Emithini, akukho datha ngomphumela wesidakamizwa esibelethweni. Izifundo zemitholampilo ezilwaneni zikhonjisiwe ukuthi zinomphumela onobuthi ku-fetus. Ngalesi sizathu, ezinye izidakamizwa zibekelwa ukwelapha abesifazane abakhulelwe.

Kwi-trimester yesi-2 neye-3, ukusetshenziswa kwezidakamizwa eqenjini labaphikisi be-angiotensin kungadala isibindi sezinsana, izinso, ukubambezeleka kwe-ossation yesikhumba, oligohydramnios.

Ngesikhathi sokuqunjelwa, ukuqokwa kweTelzap akuvunyelwe ngokuphelele. Ngaphandle kwalokho, ukuncelisa ibele kufanele kuphazanyiswe.

Ukunquma iTelzap 40 mg ezinganeni

Izingane ezingaphansi kweminyaka engu-18 ubudala zenqatshelwe ngokuphelele ukuthatha amaphilisi aqukethe i-telmisartan.

Sebenzisa ebudaleni

Iziguli ezingaphezulu kweminyaka engama-70 azidingi ukulungiswa komthamo. Ukukhishwa kungamacala ane-pathologies yezinso noma isibindi.

Iziguli ezingaphezulu kweminyaka engama-70 azidingi ukulungiswa komthamo.

Isicelo sokusebenza kokulimala kwezinso

Ekulimaleni okukhulu kwezinso, kufanele kusetshenziswe umthamo ongadluli kuma-20 mg wesidakamizwa ngosuku.

Sebenzisa umsebenzi wesibindi okhubazekile

Kwezifo ezinzima zesibindi, iTelzap ayisetshenziswa.

Ukweqisa

Uma umthamo onconyiwe udluliwe, kuvela izimpawu ezilandelayo:

• ukwehla kwenhliziyo;
• Isiyezi
• ukwehla okukhulu komfutho wegazi;
• izimpawu zokwehluleka kwezinso.

Ukuxhumana nezinye izidakamizwa

I-Telzap ivame ukusetshenziswa njengengxenye yokwelashwa okuyinkimbinkimbi, ngakho-ke udinga ukucabanga ngokuhambisana kwamathebulethi nezinye izidakamizwa.

Inhlanganisela ehlanganisiwe

Iziguli ezinesifo sikashukela sohlobo 2 azivunyelwe ukuthatha i-telmisartan namanye ama-inhibitors e-ACE ngasikhathi sinye. Ezimweni eziningi, lokhu kubangela i-hypoglycemia.

Ukuqashwa njalo kwezokwelapha nokulungiswa komthamo kungadingeka ngokusetshenziswa kwe-telmisartan ne-asperin okuhlangene.

Iziguli ezinesifo sikashukela sohlobo 2 azivunyelwe ukuthatha i-telmisartan namanye ama-inhibitors e-ACE ngasikhathi sinye.

I-Telzap ayinconywa ukuba ithathwe kanye ne-heparin.

Akuhlanganisiwe ukuhlanganisa

Imithi enganconywa ukuthi isetshenziswe:

• i-heparin;
• ama-immunosuppressants;
• izidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala;
• ukudla okuqukethe i-potassium;
• i-potassium-sparing diuretics;
• kusho ukuthi iqukethe kuphi i-hydrochlorothiazide.

Inhlanganisela edinga ukuqashelwa

Ukuqashwa njalo kwezokwelapha nokulungiswa komthamo kungadingeka ngokusetshenziswa okuhlangene kwe-telmisartan nemithi elandelayo:

• i-aspirin;
• digoxin;
• i-furosemide;
• izidakamizwa eziqukethe i-lithium;
• ama-barbiturates;
• corticosteroids.

Ama-Analog

Faka esikhundleni iTelzap ngezidakamizwa ezifanayo ekwakhekeni nasekusebenzeni:

• I-Telpres
• UMikardis;
• Telsartan;
• I-Lozap.

Izimo zokuphumula zeTelzap 40 mg kusuka emakhemisi

I-Telzap ingathengwa ekhemisi ngemithi.

Ngingakwazi ukuthenga ngaphandle kadokotela

Imithi ekuleli qembu ayenqunyelwe ukuthi ithengiswe ngaphandle kokuthola umuthi.

Intengo

Izindleko zamacwecwe ama-ruble angama-450-500.

Izimo zokugcina zomuthi

Gcina umuthi emazingeni okushisa angeqi ku-25 ° C.

Isikhathi sokuphelelwa yisikhathi

Ngokuya ngaphansi kwezimo zokugcina, amaphilisi anempilo yeshelufu yeminyaka emi-2.

Umkhiqizi weTelzap 40 mg

Umuthi lo ukhiqizwa eTurkey yinkampani yemithi "Zentiva Saglik Urunlegi Sanai ve Tijaret".

I-analogue yeTelzap yiTelsartan.

I-Analogue yeTelzap - ILoap.

I-analogue yeTelzap nguMikardis.

I-analogue yeTelzap yiTelpres.

Ukubuyekezwa mayelana ne-Telzap 40 mg

Odokotela

U-Ekaterina, udokotela wezinhliziyo, isipiliyoni kwezindlela zokwelapha - iminyaka eyi-11

I-Telzap izisungule njengomuthi osebenzayo futhi ofanele osetshenziswayo. Inesenzo eside, imiphumela emincane embalwa futhi ishibhile.

UVladislav, udokotela wezinhliziyo, onolwazi kwezokwelapha - iminyaka eyi-16

Lawa maphilisi asiza ukuqeda izimpawu zesifo senhliziyo futhi anciphise ubungozi bokushaywa yimizwa nenhliziyo. Isici esibalulekile samathebhulethi inani elincane elilinganayo le-contraindication. Ukwelashwa kubekezelelwa kahle iziguli esezikhulile kanye nabantu abanesifo sikashukela sohlobo 2.

Iziguli

UPolina, oneminyaka engama-52, u-Ufa

Ngiphethwe yisifo senhliziyo. Ukuvimbela izinkinga, udokotela unqume iTelzap. Ngilandela ngokusobala izincomo zesazi sezinhliziyo. Ngizwa kahle, kwakungekho miphumela emibi.

UValery, oneminyaka engama-44, u-Asbest

Nginesifo sikashukela (uhlobo 2 sikashukela). Phakathi kwamathebulethi anqunyelwe, kuneTelzap. Udokotela uxwayise ngokuthi umthamo kumele ubhekwe ngokuqinile. Ngaphezu kwalokho, ngivame ukuhlola izinga le-glycemia. Ngigculisekile ngomphumela kuze kube manje.