I-Baeta ilungiselelo elenziwa ngokwenziwa kwe-extenatide yethi, enomphumela we-hypoglycemic.
Lo mphumela utholwa ngokusebenza ngokusebenza kwama-receptors we-glucagon-peptide-1 futhi uvuselele ukwakheka kwe-hormone ye-insulin yi-beta-cell ye-pancreatic gland, esiza ekwehliseni izinga le-glucose egazini.
Phakathi kwemiphumela yokwelashwa yeBeat yile:
- ukwehlisa amazinga kashukela egazini nokuvimbela ukuthuthukiswa kwezimpawu ze-hyperglycemia;
- ukwehla kokukhiqizwa kwe-glucagon okuthuthukisiwe ekuphenduleni kwe-hyperglycemia ezigulini ezinesifo sikashukela sohlobo 2;
- ukubambezela ukuphuma kokuqukethwe esiswini nokucindezela imizwa yokulamba.
Umuthi iBeata uboniswa ukuthi usetshenziselwe kuphela iziguli ezinesifo sikashukela sohlobo 2. Kunqunyelwe ukulawula izinga le-glycemia ezigulini ezithola ukwelashwa kwe-antidiabetesic derivatives ne-sformonylurea kanye ne-metformin.
Izici zohlelo lokusebenza
Umuthi uphathwa ngokungaziphathi engxenyeni ephezulu noma ephakathi yesithathu yehlombe, ethangeni, futhi nasiswini sesisu. Njengomthetho, kunconyelwa ukuthi kuguqulwe namanye amasayithi ukugwema ukwakheka kwama-conglomerates angama-subcutaneous.
I-syringe pen Baeta
Ukulimala kufanele kwenziwe ngokuhambisana nayo yonke imithetho yokusebenzisa ipeni lesirinji. Umuthi kufanele unikezwe ihora elilodwa ngaphambi kokudla okuyinhloko ngezikhathi ezithile zamahora ayi-6.
Umthamo
Udokotela kuphela okufanele athathe umuthi umuthi, ngokususelwa kuzinkomba ezinjenge-glucose yegazi, umthamo womuthi ophambili we-hypoglycemic, ukuba khona kwezifo ezifanayo, nokunye okunjalo.
Imvamisa umthamo wokuqala weBaeta ungama-5 mcg kabili ngosuku amasonto amane.
Ngaphezu kwalokho, inani lezinto ezisetshenziswayo zingakhushulwa zibe yi-10 μg ngosuku (uma kunesidingo). Akunconyelwe ukwedlula umthamo wama-mcg angaphezu kwe-10.
Izimpawu zokweqisa izidakamizwa zitholakala kusetshenziswa izinto ezingaphezu kwe-100 μg ngosuku futhi zibonakala njengokuhlanza okunamandla okuphikisana nesizinda se-hypoglycemia esithuthuka ngokushesha.
Imiphumela emibi
Ukusetshenziswa kwemithi yokwenziwa eminingi kuhambisana nokuvela kokungahambi kahle kweziguli eziningana.
I-Baeta akuyona umehluko kulo mthetho futhi ingavusa ukubukeka kwemiphumela elandelayo engathandeki kumuntu:
- ukungezwani komzimba ekuphenduleni ekuphathweni komuthi, okungabonakala njengokuphendula kwasendaweni (ukushesha, ukulunywa) noma ukusabela ngokujwayelekile (kwe-edema ye-Quincke's;
- kusuka ezithweni zokugaya ukudla, ukuhlanza, isicanucanu, kanye ne-dyspepsia, ukwephulwa kwenqubo ejwayelekile yokuhamba kwamathumbu, ukuthopha, isisugogastric Reflux kanye nokugoba komoya, izinhlungu esiswini nasesibelethweni zivame ukutholakala;
- ukopha emzimbeni ngemuva kokuhlanza okukhulu;
- ukuvuvukala okukhulu kwamanyikwe;
- ukwehluleka kwezinso okwenzeka kakhulu futhi isimo esijwayelekile esande kakhulu ezigulini ezinesifo esingamahlalakhona;
- ukulimala kohlelo lwezinzwa oluphakathi, kuboniswa ngesimo sokuthuthumela, ikhanda, ukozela, ubuthakathaka obujwayelekile.
Sebenzisa ngesikhathi sokukhulelwa
Ochwepheshe abancomi ukusetshenziswa kwalesi sidakamizwa kwabesifazane abalindele ukuzalwa kwengane.
Lokhu kungenxa yemiphumela emibi engaba khona ye-exenatide esibelethweni ekhula esibelethweni.
Uma ukukhulelwa kwenzeka ngenkathi uthatha lo muthi, khona-ke owesifazane uyacelwa ukuba awushiye ngenxa yomjovo we-insulin. Ngeshwa, okwamanje akukho mininingwane yokuthi le nto yokwenziwa idlulela kubisi lwebele noma cha.
Ngaphandle kwalokhu, odokotela abancomi ngokuqinile ukuthatha iBayetu ngesikhathi sokuqunjelwa, okusiza ukuvikela umzimba wengane ekungeneni kwezakhi zamakhemikhali zomuthi.
Contraindication
Phakathi kokuphikisana okuningana kokusetshenziswa kwomuthi kufanele kuqokonyiswe:
- ukungabekezelelani komuntu ngamunye ezingxenyeni zomuthi;
- ukwehluleka kwezinso kokugcina;
- thayipha i-1 isifo sikashukela;
- isifo sikashukela sikashukela;
- ukuhlukahluka okukhulu kwenkambo ye-pathologies ye-digetive sphere, kufaka phakathi i-intestinal paresis, ukopha okungaphakathi kwamathumbu, ukugcotshwa kokunye nokunye okunjalo.
Ama-Analog
I-Bayeta ine-analogues elandelayo:
- Victoza. Umuthi usetshenziselwa ukwelapha isifo sikashukela sohlobo lwe-2 kubantu abadala ukuze kufinyelelwe ukulawulwa kwe-glycemic kuhlangene nabaphatheli be-hypoglycemic yomlomo kanye / noma i-insal insulin. Lokhu kudingekile ikakhulukazi ezimweni lapho izidakamizwa ezinomphumela we-hypoglycemic, kanye nokudla nokuzivocavoca, zinganikezeli ukulawula okwanele ushukela wegazi;
- Guarem. Isidakamizwa sikhonjiswa sikashukela i-mellitus kubantu abadala abakhuluphele, kanye nasezigulini lapho ukwelashwa ngenxa yokudla kuphela kunganikeli imiphumela efunwayo. Isidakamizwa, ngaphezu komphumela we-hypoglycemic, sithinta izinga le-cholesterol egazini, sinomthelela ekunciphisweni kwaso;
- Attokana. Umuthi usetshenziswa ezigulini zabantu abadala ezinesifo sikashukela sohlobo lwe-2 ukuze kulawulwe i-glycemia, kanye nokwelashwa kweziguli ezingakwazi ukusebenzisa i-metformin ngenxa yokungazinaki kwezakhi zakhona noma ukuba khona kokuphulwa okuningana okusetshenziswayo, nokuthi yikuphi ukudla nokuzivocavoca okungavumeli ukulawulwa okwanele glycemia. Namuhla, umuthi okunzima ukuwuthola uyathengiswa.
Izindleko
Izindleko zomuthi zincike ezicini eziningana:
- inqubomgomo yamanani wokusabalalisa umuthi;
- indlela yokukhishwa komuthi;
- isifunda sokuthengiswa kwezidakamizwa.
Ngokuvamile, ezweni lethu, intengo yokuqala yomuthi isuka kuma-ruble ayizinkulungwane ezingama-5 ngepeni yesirinji equkethe u-1,2 ml wesidakamizwa. Futhi emakhemisi ungathola iBayetu kusuka kuma-ruble ayizinkulungwane eziyi-7 ngephakeji ngalinye ngomthamo ongu-2.4 ml wento yokwelapha.
Ukubuyekezwa
Ngokw Ucwaningo lwezibalo nocwaningo lweziguli ezihlala ziwuthatha umuthi, kungenzeka ukuthi uqinisekise ukuthi lesi sidakamizwa siyathandwa phakathi kwabanesifo sikashukela ngenxa yomthelela waso ophansi, ukungabi bikho kwamacala ahambisana nokuthuthuka kwemiphumela emibi, kanye nokusebenza kahle.
Amavidiyo ahlobene
Ungayisebenzisa kanjani ipeni yesirinji yeBayeta:
Ngokusekelwe ekubuyekezweni okuningi kweziguli ezinesifo sikashukela sohlobo 2 esasinqunyelwe i-Byeta njenge-monotherapy noma njengezindlela zokwelapha ezengeziwe, kuphephile ukusho ukuthi lo muthi uyindlela enhle yokulungisa i-hyperglycemia futhi ikuvumela ukuba ufinyelele ngokushesha umphumela oyifunayo.
I-Byeta yenza sikwazi ukugcina ushukela wegazi ngezinga elijwayelekile, ukuvikela ukuqina kwesisindo futhi ilwe namanye amaphawundi awengeziwe.
