Ungayisebenzisa kanjani iLorista 100 yesifo sikashukela

I-Lorista 100 isidakamizwa se-antihypertensive esisebenzayo esenzelwe ukwelashwa okuphathelene nomfutho wegazi ophezulu.

Igama Lezwe elingafanele

Igama lokuhweba lomuthi nguLorista, igama elingabambeki emhlabeni jikelele iLosartan.

I-Lorista 100 isidakamizwa esisebenzayo se-antihypertensive.

I-ATX

Ngokwe-ATX ngezigaba, umuthi weLorista unekhodi C09CA01. Ingxenye yokuqala yekhodi (С09С) isho ukuthi umuthi ungoweqembu lezindlela ezilula ze-angiotensin 2 antagonists (amaprotheni avimbela ukwanda kwengcindezi), ingxenye yesibili yekhodi (A01) igama elithi Lorista, okuyisidakamizwa sokuqala ochungechungeni lwezidakamizwa ezifanayo.

Khipha amafomu nokwakheka

I-Lorista iyatholakala ngesimo samathebhulethi, ehlanganiswa ngokuhlanganiswa kwefilimu okuvikelayo, enesimo se-oval. Isakhi esisebenzayo se-nucleus yi-potassium losartan. Abangenayo bafaka:

• i-cellulose 80, equkethe ama-70% lactose ne-30% cellulose;
• i-magnesium stearate;
• isilika.

Ukuhlanganiswa kwefilimu kufaka:

• propylene glycol;
• i-hypromellose;
• titanium dioxide.

Amacwecwe afakwa emigqonyeni yepulasitiki, atywinwe nge-aluminium foil, ama-7, 10 no-14 ama-PC. Ibhokisi lekhadibhodi lingaqukatha amaphilisi ayi-7 noma ayi-14 (amaphilisi ama-1 noma ama-2 ama-7 ama-pcs.), Amaphilisi angama-30, angama-60 kanye nama-90 (amaphakethe angama-3, ayi-6 kanye nama-9 ama-pcs ayi-10. Ngokulandelana).

Isithako esikhulu esisebenzayo seLorista 100 yi-losartan.

Isenzo se-Pharmacological

I-Angiotensin 2 iprotheni ekhuthaza ukwanda kwengcindezi yegazi. Umphumela wayo kuma-protein surface cell (AT receptors) uholela ku:

• ukunciphisa isikhathi eside nokuqina kwemithambo yegazi;
• ukugcinwa kwe-fluid kanye ne-sodium, okwandisa inani lokujikeleza kwegazi emzimbeni;
• ukwandisa ukuqoqwa kwe-aldosterone, vasopressin, norepinephrine.

Ngaphezu kwalokho, njengomphumela we-vasospasm ende nokugeleza ngokweqile, izicubu zenhliziyo ziphoqelelwa ukuba zisebenze ngomthwalo owengeziwe, okuholela ekuthuthukisweni kwe-hypertrophy kodonga lwe-myocardial. Uma izinyathelo zingathathwanga, umfutho wegazi ophakeme kanye ne-hypertrophy ye-ventricle yangakwesobunxele kuzodala ukudangala nokuwohloka kwamangqamuzana emisipha yenhliziyo, okuzoholela ekwehlulekeni kwenhliziyo, ukungasebenzi kahle kwegazi ezithweni zezitho, ikakhulukazi ubuchopho, amehlo nezinso.

Umgomo oyisisekelo wokwelashwa kwe-antihypertensive ukuvimba imiphumela ye-angiotensin 2 kumaseli womzimba. I-Lorista isidakamizwa esivimba ngempumelelo zonke izenzo zomzimba zale proteni.

Ngemuva kokumunca, uLorista uyangenwa futhi womzimba esibindini.

I-Pharmacokinetics

Ngemuva kokungena emzimbeni, umuthi uyangenwa bese ufakwa esibindini, uhlukaniswe ngama-metabolites asebenzayo futhi angasebenzi. Iqoqo eliphakeme kakhulu lomuthi osegazini liqoshwa ngemuva kwehora eli-1, kanye ne-metabolite yayo esebenzayo ngemuva kwamahora angama-3-4. Umuthi udonswa ngezinso namathumbu.

Ucwaningo lweziguli zabesilisa nabesifazane abathatha i-Lorista luveze ukuthi ukugcwala kwe-losartan egazini kwabesifazane kuphindeke izikhathi ezingama-2 kunakubesilisa, kanti nokuhlushwa kwe-metabolite yayo kuyafana.

Kodwa-ke, iqiniso elinjalo alinakubaluleka komtholampilo.

Yini esiza?

I-Lorista ibekelwe izifo ezifana:

• i-arterial hypertension;
• ukwehluleka kwenhliziyo okungapheli.

Ngaphezu kwalokho, umuthi usetshenziselwa:

• ukuvikela izinso zeziguli ezinesifo sikashukela sohlobo lwe-2 kusuka ekuqhubekeni kwokwehluleka kwezinso, ukuthuthukiswa kwesigaba esibulalayo sesi sifo, esidinga ukuthunyelwa kwesitho, ukwehlisa izinga le-proteinuria kanye nokufa kwabantu kulezi zinhlobo zezifo;
• banciphise ubungozi bokuqalwa kwe-myocardial infarction, unhlangothi, kanye nokufa ngenxa yentuthuko yokwehluleka kwenhliziyo.

Ngiyiphi ingcindezi okufanele ngiyithathe?

I-Lorista ayisiyo yezidakamizwa ezinciphisa ngokushesha umfutho wegazi, kepha umuthi ohloselwe ukwelashwa okuhleliwe kwesikhathi eside kwegazi ngokweqile. Kuthathwa izinyanga ezimbalwa futhi kuphela njengoba kushiwo ngudokotela.

I-Lorista ayinqunyelwe ukwephulwa okunamandla kwesibindi.

Contraindication

Umuthi awunqunyelwe ezimweni lapho isiguli sihlupheka:

• ukungabekezelelani komuntu ngamunye kunoma yiziphi izinto ezakha umuthi;
• ukwephulwa okukhulu kwesibindi;
• ama-pathologies wepheshana elisebenzayo;
• ukungabekezelelani kokuzala kwe-lactose;
• i-glucose-galactose malabsorption syndrome;
• ukuntuleka kwe-lactose;
• ukomisa;
• hyperkalemia
• isifo sikashukela i-mellitus noma ngokulinganisela kokungasebenzi kahle kwezinso futhi kuthatha i-Aliskiren.

I-Lorista ayenqatshelwe ngokuphelele ukusetshenziswa ngesikhathi sokukhulelwa nokukhishwa, kanye nasezigulini ezingaphansi kweminyaka engu-18. Endabeni yokugcina, akukho datha ekusebenzeni nasekuphepheni kokuphuza lo muthi.

I-Lorista inqatshelwe ngokuqinile ukusetshenziswa ngesikhathi sokukhulelwa.

Ngokunakekela

Ukuqapha ikakhulukazi lapho uthatha uLorista kufanele kuthathwe uma isiguli:

• uhlushwa ukuncipha okuqhubekayo kwemithambo yazo zombili izinso (noma i-1 artery uma kuphela izinso);
• isesimweni ngemuva kokufakelwa kwezinso;
• ogulayo nge-aortic stenosis noma i-mitral valve;
• unesifo se-hypertrophic cardiomyopathy;
• ngigula kakhulu i-cardiac arrhythmia noma ischemia;
• unesifo se-cerebrovascular isifo;
• inomlando wokuthi kungenzeka i-angioedema;
• unesifo somoya (asthma);
• inesilinganiso esinciphile sokujikeleza kwegazi ngenxa yokuthatha i-diuretics.

Ungamthatha kanjani uLorista 100?

Umuthi uthathwa isikhathi esingu-1 ngosuku, kungakhathalekile isikhathi noma isidlo. Ngomfutho wegazi ophakeme, umthamo wokuqala ngu-50 mg. Ingcindezi kufanele izinzise ngemuva kwamasonto angama-3-6. Uma lokhu kungenzeki, umthamo wenyuselwa ku-100 mg. Lomthamo uwukuvumela okuphezulu.

Ekuhlulekeni kwenhliziyo okungapheli, ukwelashwa kwezidakamizwa kuqala ngethamo elincane le-12,5 mg futhi lenyuka njalo isonto, ukuletha ku-50 noma ku-100 mg.

Iziguli ezinokungasebenzi kahle kwesibindi zinconywa ukuba zisebenzise umthamo ophuzile nomuthi, onqunywa udokotela ngokuya ngesimo sesiguli.

Ngokuncipha okuqhubekayo kwemithambo yezinso zombili, udinga ukuqaphela ngenkathi uthatha uLorista.

I-Rhinitis imiphumela emibi engatheni ngemuva kokuthatha uLorista.

I-Lorista ayinqunyelwe i-hyperkalemia.

Ngoshukela

Ngohlobo 2 sikashukela, umuthi unqunywa kumthamo we-50 noma 100 mg, ngokuya ngesimo sesiguli. I-Lorista ingathathwa ihlanganiswe nezinye izidakamizwa ze-antihypertensive (i-diuretics, i-alpha ne-beta adrenergic blockers), i-insulin nezinye izidakamizwa ze-hypoglycemic, ngokwesibonelo, ama-glitazones, ama-sulfonylurea derivatives, njll.

Imiphumela emibi uLorista 100

I-Lorista ibekezelelwa kahle futhi kuyaqabukela kudala imiphumela emibi kakhulu. Imvamisa, ukusabela okuvela ku:

• uhlelo lokuphefumula - ngesimo sokuphefumula komoya, i-sinusitis, i-laryngitis, i-rhinitis;
• isikhumba - ngesimo sokuqhuma kwesikhumba nokulunywa;
• uhlelo lwenhliziyo - ngesimo se-angina pectoris, i-hypotension, i-fibrillation ye-atrial, ukuqina;
• isibindi nezinso - ngendlela yokusebenza kokuphazamiseka kwezitho zomzimba;
• izicubu zemisipha nezisebenzayo - ngesimo se-myalgia noma i-arthralgia.

Akunamiphumela emibi evela emasosheni omzimba ekhonjisiwe.

Amapheshana wesisu

Kuqabukela kakhulu ukuthi isiguli sizwe ubuhlungu besisu noma ukuphazamiseka ekusebenzeni kwendlela yesisu - ngesimo sokucanuzelelwa kwenhliziyo, ukuhlanza, ukuqunjelwa noma isifo sohudo, i-pancreatitis.

Izitho zeHematopoietic

I-anemia ivame ukukhula, futhi kuyaqabukela kakhulu i-thrombocytopenia.

Isistimu yezinzwa ephakathi

Esikhathini esiningi, isiyezi kwenzeka, kuyaqabukela - ikhanda, ukozela, i-migraine, ukuphazamiseka kokulala, ukukhathazeka, ukudideka, ukudangala, amaphupho amabi, ukukhubazeka kwememori.

Ngesikhathi sokwelashwa kukaLorista, ukushayela kuvunyelwe.

Allergies

Kuyivelakancane ukuthatha umuthi kungadala i-vasculitis yesikhumba, i-angioedema yobuso nepheshana lokuphefumula, ukusabela kwe-anaphylactic.

Umthelela ekhonweni lokulawula izindlela

Ngesikhathi sokwelashwa kukaLorista, ukushayela kuvunyelwe. Okuhlukile kungaba yizimo lapho isiguli sisabela ngendlela ethile kulowo muthi ngendlela yesiyezi, ikakhulukazi esigabeni sokuqala sokwelashwa, lapho umzimba usujwayela umuthi.

Imiyalo ekhethekile

1. Umuthi awunconyelwe ukuthi usetshenziswe yiziguli ezihlushwa i-hyperaldosteronism eyisisekelo, ngoba ayiniki umphumela omuhle.
2. Iziguli ezihlushwa ukungalingani kwamanzi-electrolyte kufanele zichazwe nge-Lorista kumithamo encishisiwe ukugwema ukuthuthukiswa kwe-hypotension ye-arterial.
3. Uma imbangela yomfutho wegazi ophakeme kungukungasebenzi kwezindlala ze-parathyroid, khona-ke iLorista idinga ukuthathwa ngokuhlanganiswa nezidakamizwa ezenza ijwayelekile ingemuva le-hormonal futhi leseke ukusebenza kwezinso.

Sebenzisa ebudaleni

Akukho ukulungiswa komthamo okudingekayo.

Ukuqokwa kweLorista izingane eziyi-100

Umuthi awubekelwe izingane kanye nentsha engaphansi kweminyaka engu-18, ngoba akukho datha eyanele ngemiphumela yayo ekutholeni komzimba okhulayo.

ILorista ayibekelwe izingane nentsha engaphansi kweminyaka engu-18.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Isikhathi sokukhulelwa kuwukuphikisana nokusetshenziswa kweLorista, ngoba lokhu kungadala ukukhubazeka okunzima ekukhuleni kwesibeletho, kufaka phakathi ukufa kwakhe. Ngakho-ke, lapho kutholwa ukukhulelwa, umuthi umiswa ngokushesha bese kukhethwa enye indlela yokwelashwa.

Lapho uhlela ukukhulelwa kwabesifazane abathatha i-Lorista, kufanele uqale uqede inkambo yokwelashwa.

Ukuhlolwa kwezilwane kukhombisile ukuthi ukusetshenziswa komuthi ezigabeni ezahlukahlukene zokukhulelwa kuvame ukuholela kuma-oligohydramnios (oligohydramnios) kumama futhi, ngenxa yalokho, kuma-pathologies e-fetus afana nalawa:

• ukuguqulwa kwamathambo
• I-hypoplasia yamaphaphu;
• hypoplasia yesigaxa;
• ukwehluleka kwezinso;
• i-hypertension ye-arterial;
• i-anuria

Ezimweni lapho kungenakwenzeka ukuthi owesifazane okhulelwe akhethe enye indlela yokwelashwa, kuyadingeka:

1. Xwayisa owesifazane ngemiphumela engaba khona yengane.
2. Hlala uvivinya isimo se-fetus ukuze ubone umonakalo ongalungiseki.
3. Lahla umuthi uma ungakhula u-oligohydramnios (ugesi olunganele we-amniotic). Ukusetshenziswa okuqhubekayo kungenzeka kuphela uma kubalulekile kumama

Akunamininingwane yokuthi ama-losartan adlulela kubisi lwebele. Ngakho-ke, ngesikhathi sokuncelisa, uLorista kufanele alahlwe, futhi uma lokhu kungenzeki, khona-ke ukuncelisa kufanele kuphazanyiswe.

I-Fluconazole inciphisa ukuqoqwa kweLorista ku-plasma.

I-Overdose Lorista 100

Imininingwane mayelana ne-overdose yesidakamizwa ayanele. Ngokunokwenzeka, i-overdose ingabonakala ngendlela yokuncipha okukhulu komfutho wegazi, i-tachycardia noma i-bradycardia. Ezimweni ezinjalo, ukwelashwa okubonakalayo okubonakalayo kufanelekile. I-Hemodialysis ayikhiphi i-losartan kanye ne-metabolite yayo esebenzayo.

Ukuxhumana nezinye izidakamizwa

1. I-Lorista iyahambisana nokwelapha:
   • nge-hydrochlorothiazide;
   • nge-warfarin;
   • nge-phenobarbital;
   • nge-digoxin;
   • nge-cimetidine;
   • nge ketoconazole;
   • nge-erythromycin;
   • nge-sulfinpyrazone;
   • nge-probenecid.
2. I-Fluconazole ne-rifampicin kunciphisa ukunakekelwa kweLorista kuma-plasma egazi.
3. Ukusetshenziswa kanyekanye kwezidakamizwa ngosawoti we-potassium kanye nezithasiselo eziqukethe i-potassium kuholela ekwandeni kokuhlushwa kwe-potassium ku-serum yegazi.
4. I-Lorista ikhuthaza ukuqedwa kwe-lithium, ngakho-ke lapho uthatha izidakamizwa ngokuphelele, kuyadingeka ukubheka izinga le-lithium ku-serum yegazi.
5. Ukusetshenziswa okuhlanganisiwe kweLorista nama-NSAIDs kunciphisa umphumela we-hypotensive.
6. Ukwemukelwa okuyinkimbinkimbi kweLorista ngama-antidepressants nama-antipsychotic kuvame ukudala i-hypotension.
7. Ukwemukelwa kweLorista ne-glycosides yenhliziyo kungavusa i-arrhythmia ne-tricyularia ye-ventricular.

I-Lozap iyi-analogue yeLorista.

Ukuhambisana notshwala

Abantu abahlushwa umfutho wegazi ophakeme abaphakanyisiwe ukuthi baphuze utshwala ngisho nakwahle kakhulu, ngoba utshwala busiza ukukhuphula umfutho wegazi nokuphazamisa ukusebenza kwemisipha yenhliziyo. Ukuphuza utshwala okuhlanganayo neLorista kuvame ukuholela ekwehlulekeni kokuphefumula, ukujikeleza okumpofu, ubuthakathaka neminye imiphumela emibi, ngakho odokotela abancomi ukuhlanganisa umuthi neziphuzo ezinamandla.

Ama-Analog

Analogs of Lorista yilezi:

1. I-Lozap (iSlovak);
2. Presartan 100 (India);
3. ILosartan Krka (iSlovenia);
4. ULorista N (Russia);
5. I-Losartan Pfizer (India, USA);
6. IPulsar (EPoland).

Imibandela yekhefu lekhemisi

Ngokusho kwemiyalo esetshenzisiwe, uLorista usatshalaliswa emakhemisi kuphela ngomuthi odingekayo.

I-Presartan-100 - i-analogue yeLorista.

Ngingakwazi ukuthenga ngaphandle kadokotela?

I-Lorista ingathengwa ekhemisi ngaphandle kwemithi kadokotela.

Intengo yeLorista 100

Izindleko zamathebhulethi angama-30 esidakamizwa emakhemisi aseMoscow cishe ama-ruble angama-300., Amaphilisi angama-60 - ama-ruble angama-500., Amaphilisi angama-90 - ama-ruble ayi-680.

Izimo zokugcina zomuthi

I-Lorista igcinwa endaweni yokushisa yegumbi engeqi ku + 25 ° C.

Isikhathi sokuphelelwa yisikhathi

Impilo yeshalofu yesidakamizwa yiminyaka emi-5.

Umkhiqizi

Izinkampani zamakhemikhali zikhipha iLorista:

• I-LLC "KRKA-RUS", iRussia, i-Istra;
• I-JSC "Krka, dd, iNovo mesto", iSlovenia, iNovo mesto.

Ukubuyekezwa ku-Lorista 100

I-Lorista inezibuyekezo eziningi ezinhle ezivela kubo bobabili odokotela kanye neziguli.

Izazi zezenhliziyo

UVitaliy, oneminyaka engama-48, oneminyaka engama-23, uNovorossiysk: "Imvamisa ngisebenzisa uLorista kwezokwelapha. Umuthi uzitholele ngokwawo ekuhlanganisweni kwe-hypertension kanye ne-gout, ngoba ngaphezu kwengcindezi, kusiza ukunciphisa i-uric acid egazini futhi inomphumela wokubuyisa enhliziyweni. "Ukusebenza ngempumelelo kwalapha kuncike kakhulu ekutheni umthamo wakhethwa kahle kangakanani, kucatshangelwe imvume ye-creatinine nesisindo somzimba."

U-Olga, oneminyaka engama-50, iminyaka engama-25 yesipiliyoni, eMoscow: "I-Lorista iyithuluzi elingabizi futhi elisebenzayo ekwelashweni kwe-arterial hypertension, enezinzuzo ezi-2 ezibalulekile: umthelela omnene esigulini kanye nokungabikho kokhwehlela owomile - umthelela oseceleni ohambisana nezidakamizwa eziningi zomphumela ofanayo wokwelapha."

Iziguli

UMarina, oneminyaka engama-50, uNizhny Novgorod: "Ngiphile impilo yami yonke emaphandleni, kepha angikwazi ukuzibiza ngiphilile: Ngihlushwa ukuhluleka kwenhliziyo isikhathi esingaphezu kweminyaka eyi-10, okuqhubekayo. Ayikho indlela yokwelashwa njalo - ipulazi elikhulu elingashiywa. I-Lorista ukuphela kwensindiso "Kugcina ingcindezi kanye nokushaya kwenhliziyo kujwayelekile, kwandisa ukukhuthazeka ngokomzimba. IDyspnea idlulile selokhu ngaqala ukuthatha umuthi."

UVictoria, oneminyaka engu-56, uVoronezh: "Sekuphele iminyaka eyi-10 ngiphathwa umfutho wegazi ophakeme, ngizame kakhulu izidakamizwa ezokwehlisa umfutho wegazi, kepha ngaso sonke isikhathi kwaba nemiphumela emibi. ULorista wavele wavela: ukukhohlela, noma isiyezi, izinga lokushaya, ukuvuvukala kwahamba, ukuqina komzimba kuye kwanda. "